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Article ; Online: Manual development and efficacy of Mindful Living Group activities to promote trauma healing during the COVID-19 pandemic in China

Ya-Nan Niu / Di Long

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: IntroductionDisasters can be traumatic with a profound and lasting impact on individuals. During the COVID-19 pandemic, our team developed the Mindful Living Group (MLG) activities manual based on Eastern body-mind wisdom and Western trauma healing ... ...

Abstract	IntroductionDisasters can be traumatic with a profound and lasting impact on individuals. During the COVID-19 pandemic, our team developed the Mindful Living Group (MLG) activities manual based on Eastern body-mind wisdom and Western trauma healing theory to provide psychological assistance for trauma healing.MethodsIn this study, we introduce a framework developed for the 10-session MLG activities manual, which consists of three core modules. Thirty-one participants living all over the country who had experienced traumatic stress resulting from the COVID-19 pandemic received the MLG intervention. This single-arm intervention study offered psychological assistance during the pandemic. The MLG intervention included 10 weekly 2-h sessions held online. Participants completed the initial interview, pre-test, post-test, and 1-month follow-up interviews. The effectiveness of the MLG activities manual was evaluated using psychological measures, including Self-Rating Depression Scale, Self-Rating Anxiety Scale, Mindful Attention Awareness Scale, Post-traumatic Growth Inventory, General Self-Efficacy Scale, and the Perceived Social Support Scale.ResultsCompared with the pretest level, the post-test levels of depression (F = 42.78, p < 0.001, η2 = 0.59) and anxiety (F = 23.40, p < 0.001, η2 = 0.44) were significantly lower; and mindfulness (F = 12.98, p =0.001, η2 =0.30), posttraumatic growth (F = 27.06, p < 0.001, η2 = 0.48), general self-efficacy (F = 13.20, p = 0.001, η2 = 0.31), and perceived social support (F = 16.27, p < 0.001, η2 = 0.35) were significantly higher (ANOVA). Further correlation analysis revealed a significant negative relationship of mindfulness with both depression (r = −0.43, p = 0.015) and anxiety (r = −0.35, p = 0.053), and significant positive relationships of mindfulness with posttraumatic growth (r = 0.40, p = 0.025), general self-efficacy (r = 0.52, p = 0.003), and perceived social support (r = 0.40, p = 0.024).DiscussionThese preliminary findings showed the effectiveness of MLG ...
Keywords	Mindful Living Group ; COVID-19 pandemic ; trauma healing ; body-mind wisdom ; Plum Village mindfulness practice ; interbeing ; Public aspects of medicine ; RA1-1270
Subject code	150
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Dose-Painting Linear Accelerator Radiosurgery of Glomus Jugulare With Dosimetric Comparison to Gamma Knife.

Valderrama, Alessandro / Di, Long / Bossart, Elizabeth / Eshraghi, Adrien A / Mellon, Eric A

Cureus

2024 Volume 16, Issue 2, Page(s) e55070

Abstract: Objectives In this study, we outline our rationale for delivering a dose of ≥15 Gy in stereotactic radiosurgery (SRS) of glomus jugulare tumor (GJT) while ensuring the avoidance of complications associated with doses >13 Gy to the facial nerve. To avoid ... ...

Abstract	Objectives In this study, we outline our rationale for delivering a dose of ≥15 Gy in stereotactic radiosurgery (SRS) of glomus jugulare tumor (GJT) while ensuring the avoidance of complications associated with doses >13 Gy to the facial nerve. To avoid such complications, we initially utilized the Gamma Knife Perfexion (GK) system (Elekta Instrument AB, Stockholm, Sweden) at our institution but encountered challenges related to lengthy treatment times and difficulty in sculpting doses to minimize doses to spare the facial nerve. As a potential solution, we propose the use of HyperArc (Varian Medical Systems, Palo Alto, CA), a newly developed automated delivery platform for linear accelerator (LINAC)-based SRS. HyperArc offers the potential for faster treatment and more complex shaping of the radiotherapy dose with multiple arcs and multi-leaf collimators. Methods We retrospectively reviewed nine cases of patients with GJT treated with HyperArc. Patients' demographic and treatment data were collected. Additionally, simulated GK treatment plans were created and compared with HyperArc plans to assess time savings, PTV coverage, and plan quality. Results One male and eight female patients, with a mean age of 63.9 years, were included. Treatments were delivered on average in 29 minutes, achieving 95-100% of the tumor while limiting the facial nerve to <13 Gy. Treatments replanned using our GK system could achieve only 92-99% tumor coverage while respecting facial nerve constraints, with average treatment times of 180 minutes. Comparable plan quality parameters were attained with both modalities. Conclusions The HyperArc system provides a qualitatively satisfactory and rapid treatment delivery of a highly sculpted radiotherapy dose to maximize tumor coverage and minimize facial nerve complications.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55070
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer

Di Long / Kai Chen / Yinmo Yang / Xiaodong Tian

Frontiers in Bioscience-Landmark, Vol 26, Iss 12, Pp 1689-

potential therapeutical target

2021 Volume 1696

Abstract: Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis ...

Abstract	Pancreatic cancer is still one of the most perilous malignant tumors with a very poor prognosis. Despite the progress in the diagnosis and treatment of pancreatic cancer, the overall 5-year survival rate after diagnosis is less than 10%. The pathogenesis of pancreatic cancer has not been fully clarified, but multiple factors are involved. The poor efficacy of traditional therapies for pancreatic cancer is mainly related to complex tumor microenvironment. In recent years, accumulating studies have demonstrated the role of autophagy and apoptosis triggered by endoplasmic reticulum stress in pancreatic cancer. In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor microenvironment. Here we summarize recent progress in our understanding of the role of unfolded protein response activated by endoplasmic reticulum stress in tumorigenesis of pancreatic cancer, and highlight the potential of the cascade of unfolded protein response as therapeutic target for pancreatic cancer.
Keywords	endoplasmic reticulum stress ; unfolded protein response ; pancreatic cancer ; apoptosis ; Biochemistry ; QD415-436 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	IMR Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Meta-Analysis in Using Satellite Precipitation Products for Drought Monitoring

Gilbert Hinge / Mohamed M. Mohamed / Di Long / Mohamed A. Hamouda

Remote Sensing, Vol 13, Iss 4353, p

Lessons Learnt and Way Forward

2021 Volume 4353

Abstract: In recent years, satellite precipitation products (SPPs) have emerged as an essential source of data and information. This work intends to summarize lessons learnt on using SPPs for drought monitoring and to propose ways forward in this field of research. ...

Abstract	In recent years, satellite precipitation products (SPPs) have emerged as an essential source of data and information. This work intends to summarize lessons learnt on using SPPs for drought monitoring and to propose ways forward in this field of research. A thorough literature review was conducted to review three aspects: effects of climate type, data record length, and time scale on SPPs performance. The conducted meta-analysis showed that the performance of SPPs for drought monitoring largely depends upon the climate type of the location and length of the data record. SPPs drought monitoring performance was shown to be higher in temperate and tropical climates than in dry and continental ones. SPPs were found to perform better with an increase in data record length. From a general standpoint, SPPs offer great potential for drought monitoring, but the performance of SPPs needs to be improved for operational purposes. The present study discusses blending SPPs with in situ data and other lessons learned, as well as future directions of using SPPs for drought applications.
Keywords	drought ; Koppen climate ; drought monitoring ; satellite precipitation products ; Science ; Q
Subject code	330
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Management of Refractory Post-operative Osteomyelitis and Discitis: A Case Report.

DeLong, Chase A / Bashti, Malek / Di, Long / Shah, Sumedh S / Jaman, Emade / Basil, Gregory W

Cureus

2024 Volume 16, Issue 1, Page(s) e52620

Abstract: Vertebral osteomyelitis/discitis is a relatively rare disease but is a known potential complication of spinal surgical intervention. In general, the first-line treatment for this condition is targeted antibiotic therapy with surgical intervention only ... ...

Abstract	Vertebral osteomyelitis/discitis is a relatively rare disease but is a known potential complication of spinal surgical intervention. In general, the first-line treatment for this condition is targeted antibiotic therapy with surgical intervention only utilized in refractory cases with evidence of extensive damage, structural instability, or abscess formation. However, surgical best practices have not been established for osteomyelitis, including indications for anterior lateral interbody fusion (ALIF), posterior lateral interbody fusion (PLIF), or direct lateral interbody fusion (DLIF). This case provides a discussion of the indications that led to a direct lateral approach in the setting of refractory osteomyelitis/discitis, supporting factors that led to its success, and the efficacy of utilizing intraoperative neuromonitoring in cases of infection.
Language	English
Publishing date	2024-01-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Reply to the Letter to the Editor Regarding "The Use of Carbon Fiber-Reinforced Instrumentation in Patients with Spinal Oncologic Tumors: A Systematic Review of Literature and Future Directions".

Bashti, Malek / Perez-Roman, Roberto J / Boddu, James V / Di, Long / Bryant, Jean-Paul / Amadasu, Efosa / Gyedu, Joseph S / Wang, Michael Y

World neurosurgery

2024 Volume 181, Page(s) 199–200

MeSH term(s)	Humans ; Carbon Fiber ; Central Nervous System Neoplasms ; Spinal Cord Neoplasms ; Spinal Neoplasms
Chemical Substances	Carbon Fiber
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.06.147
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MicroRNAs as potential therapeutic targets for pancreatic cancer

Xiangyu Chu / Dan Wei / Xinxin Liu / Di Long / Xiaodong Tian / Yinmo Yang / Jing Ni

Chinese Medical Journal, Vol 135, Iss 1, Pp 4-

2022 Volume 10

Abstract: Abstract. Pancreatic cancer is one of the most aggressive malignancies. The poor prognosis of pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive nature coupled with the inadequate efficacy of ... ...

Abstract	Abstract. Pancreatic cancer is one of the most aggressive malignancies. The poor prognosis of pancreatic cancer patients is mainly attributed to low diagnostic rate at the early stage, highly aggressive nature coupled with the inadequate efficacy of current chemotherapeutic regimens. Novel therapeutic strategies are urgently needed for pancreatic cancer. MicroRNAs (miRNAs) play an important regulatory role in key processes of cancer development. The aberrant expression of miRNAs is often involved in the initiation, progression, and metastasis of pancreatic cancer. The discovery of tumor suppressor miRNAs provides prospects for the development of a novel treatment strategy for pancreatic cancer. We reviewed recent progress on the understanding of the role of miRNAs in pancreatic cancer, highlighted the efficient application of miRNAs-based therapies for pancreatic cancer in animal models and clinical trials, and proposed future prospects. This review focuses on the promise of integrating miRNAs into the treatment of pancreatic cancer and provides guidance for the development of precision medicine for pancreatic cancer.
Keywords	Medicine ; R
Subject code	610 ; 500
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health inequities as measured by the EQ-5D-5L during COVID-19

Erica I Lubetkin / Di Long / Juanita A Haagsma / Mathieu F Janssen / Gouke J Bonsel

PLoS ONE, Vol 17, Iss 7, p e

Results from New York in healthy and diseased persons.

2022 Volume 0272252

Abstract: Introduction The effects of the COVID-19 pandemic caused considerable psychological and physical effects in healthy and diseased New Yorkers aside from the effects in those who were infected. We investigated the relationship between known risk-enhancing ... ...

Abstract	Introduction The effects of the COVID-19 pandemic caused considerable psychological and physical effects in healthy and diseased New Yorkers aside from the effects in those who were infected. We investigated the relationship between known risk-enhancing and health-promoting factors (social and medical), comorbidity indicators, and, as the primary outcome, health-related quality of life (HRQoL). Methods Between April 22 and May 5, 2020, a market research agency (Dynata) administered a digital survey including the EQ-5D-5L and items related to individual characteristics, social position, occupational and insurance status, living situation, exposures (smoking and COVID-19), detailed chronic conditions, and experienced access to care to an existing internet panel representative of New Yorkers. Results 2684 persons completed the questionnaire. The median age was 48 years old, and most respondents were non-Hispanic white (74%) and reported at least higher vocational training or a university education (83%). During COVID-19, mean HRQoL scores were 0.82 for the EQ-5D-5L index and 79.3 for the EQ VAS. Scores varied for healthy and diseased respondents differently by the above determinants. Lower age, impaired occupational status, loss of health insurance, and limited access to care exerted more influence on EQ-5D-5L scores of diseased persons compared to healthy persons. Among diseased persons, the number of chronic conditions and limited access to health care had the strongest association with EQ-5D-5L scores. While EQ-5D-5L scores improved with increasing age, gender had no noticeable effect. Deprivation factors showed moderate effects, which largely disappeared in (stratified) multivariable analysis, suggesting mediation through excess chronic morbidity and poor healthcare access. Generally, modifying effects were larger in the EQ-5D-5L as compared to the EQ VAS. Conclusions Almost all factors relating to a disadvantaged position showed a negative association with HRQoL. In diseased respondents, pre-existing chronic ...
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of virtual magnetic resonance imaging to compensate for brain shift during image-guided surgery: illustrative case.

Kim, John T / Di, Long / Etame, Arnold B / Olson, Sarah / Vogelbaum, Michael A / Tran, Nam D

Journal of neurosurgery. Case lessons

2022 Volume 3, Issue 24, Page(s) CASE21683

Abstract: Background: Maximal safe resection is the paramount objective in the surgical management of malignant brain tumors. It is facilitated through use of image-guided neuronavigation. Intraoperative image guidance systems use preoperative magnetic resonance ... ...

Abstract	Background: Maximal safe resection is the paramount objective in the surgical management of malignant brain tumors. It is facilitated through use of image-guided neuronavigation. Intraoperative image guidance systems use preoperative magnetic resonance imaging (MRI) as the navigational map. The accuracy of neuronavigation is limited by intraoperative brain shift and can become less accurate over the course of the procedure. Intraoperative MRI can compensate for dynamic brain shift but requires significant space and capital investment, often unavailable at many centers. Observations: The authors described a case in which an image fusion algorithm was used in conjunction with an intraoperative computed tomography (CT) system to compensate for brain shift during resection of a brainstem hemorrhagic melanoma metastasis. Following initial debulking of the hemorrhagic metastasis, intraoperative CT was performed to ascertain extent of resection. An elastic image fusion (EIF) algorithm was used to create virtual MRI relative to both the intraoperative CT scan and preoperative MRI, which facilitated complete resection of the tumor while preserving critical brainstem anatomy. Lessons: EIF algorithms can be used with multimodal images (preoperative MRI and intraoperative CT) and create an updated virtual MRI data set to compensate for brain shift in neurosurgery and aid in maximum safe resection of malignant brain tumors.
Language	English
Publishing date	2022-06-13
Publishing country	United States
Document type	Case Reports
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE21683
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Health-Related Quality of Life and Mental Well-Being during the COVID-19 Pandemic in Five Countries

Di Long / Gouke J. Bonsel / Erica I. Lubetkin / John N. Yfantopoulos / Mathieu F. Janssen / Juanita A. Haagsma

Journal of Clinical Medicine, Vol 11, Iss 6467, p

A One-Year Longitudinal Study

2022 Volume 6467

Abstract: This study aimed to investigate socioeconomic and health-related determinants and recent life events and their relation to changes in health-related quality of life (HRQoL) and mental well-being during the first year of the COVID-19 pandemic. A web-based ...

Abstract	This study aimed to investigate socioeconomic and health-related determinants and recent life events and their relation to changes in health-related quality of life (HRQoL) and mental well-being during the first year of the COVID-19 pandemic. A web-based survey was administered repeatedly to participants from Greece, Italy, the Netherlands, the United Kingdom, and the United States. Primary outcome measures were HRQoL (measured by EQ-5D-5L) and mental well-being (measured by WHO-5). Linear regression analyses were performed to estimate the impact of determinants on HRQoL and well-being. In total, 6765 respondents completed the questionnaire at T1 (April–May 2020) and T2 (May–June 2021). Regarding results, 33% showed improved HRQoL at T2, whereas 31% deteriorated. In terms of mental well-being, 44% improved and 41% deteriorated. The greatest deterioration in HRQoL and mental well-being from T1 to T2 was observed with an increasing number of chronic conditions. The effect of negative life events on HRQoL and mental well-being was larger than the effect of positive life events. We conclude that slightly more respondents showed improved rather than deteriorated HRQoL and mental well-being, with some variation by outcome measure and country.
Keywords	health-related quality of Life ; mental well-being ; EQ-5D-5L ; WHO-5 ; longitudinal ; COVID-19 ; Medicine ; R
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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