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  1. Article ; Online: Jejunal arteriovenous malformation and multiple acquired extrahepatic portosystemic shunts in a juvenile dog, presenting with melena.

    Zurita, M / Herrmann, A / Ryan, T / Carrera, I / Di Bella, A

    The Journal of small animal practice

    2023  Volume 64, Issue 7, Page(s) 485–489

    Abstract: A juvenile dog referred with a 1-month history of persistent melena and severe anaemia, was diagnosed with a jejunal arteriovenous malformation, and multiple acquired extrahepatic portosystemic shunts. A midline coeliotomy was performed, the jejunal ... ...

    Abstract A juvenile dog referred with a 1-month history of persistent melena and severe anaemia, was diagnosed with a jejunal arteriovenous malformation, and multiple acquired extrahepatic portosystemic shunts. A midline coeliotomy was performed, the jejunal arteriovenous malformation was localised intraoperatively and was successfully removed via an enterectomy. Histopathology confirmed a true arteriovenous malformation. Despite the initial improvement, the patient developed seizure episodes secondary to hepatic encephalopathy 8 months after surgery. Fifteen months after surgery, the owner opted for euthanasia due to the ongoing seizure episodes. Post-mortem histologic examination of the liver showed features consistent with portal vein hypoplasia. A congenital arteriovenous malformation should be considered as a differential diagnosis in juvenile patients with a chronic history of haemorrhage from the gastrointestinal tract. In addition, acquired portosystemic shunts may occur in patients with portal vein hypoplasia and jejunal arteriovenous malformations.
    MeSH term(s) Dogs ; Animals ; Portal Vein/abnormalities ; Melena/pathology ; Melena/surgery ; Melena/veterinary ; Portasystemic Shunt, Transjugular Intrahepatic/veterinary ; Liver/pathology ; Arteriovenous Malformations/complications ; Arteriovenous Malformations/surgery ; Arteriovenous Malformations/veterinary ; Vascular Malformations/pathology ; Vascular Malformations/veterinary ; Dog Diseases/diagnosis ; Dog Diseases/etiology ; Dog Diseases/surgery
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Case Reports
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.13617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Evaluation of Resting Serum Bile Acid Concentrations in Dogs with Sepsis.

    Baptista, Lara / Pollard, Danica / Di Bella, Andrea

    Veterinary sciences

    2022  Volume 9, Issue 11

    Abstract: Recent studies in the human literature suggest that serum bile acid concentrations could be an early predictor of short-term survival in critically ill patients. However, there is no available information in the veterinary literature regarding serum bile ...

    Abstract Recent studies in the human literature suggest that serum bile acid concentrations could be an early predictor of short-term survival in critically ill patients. However, there is no available information in the veterinary literature regarding serum bile acid concentrations in dogs with sepsis. We aimed to evaluate if resting serum bile acid concentrations differ between septic and non-septic dogs. This was a retrospective observational study, of medical records at a single referral center over a twelve-year period. Twenty-six client-owned dogs diagnosed with sepsis were identified. Twenty-one dogs presenting with a non-hepatobiliary systemic disease and twenty-nine dogs admitted for an elective orthopedic procedure, considered otherwise healthy, were selected as control groups. Resting serum bile acid concentrations were significantly higher in the septic compared to the non-septic groups (ill control and orthopedic control groups). However, when assessing bile acid concentrations between groups individually, no difference was identified between the septic and the orthopedic control group. These results should be interpreted cautiously.
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9110627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Jejunal arteriovenous malformation and multiple acquired extrahepatic portosystemic shunts in a juvenile dog, presenting with melena

    Zurita, M. / Herrmann, A. / Ryan, T. / Carrera, I. / Di Bella, A.

    Journal of Small Animal Practice. 2023 July, v. 64, no. 7 p.485-489

    2023  

    Abstract: A juvenile dog referred with a 1‐month history of persistent melena and severe anaemia, was diagnosed with a jejunal arteriovenous malformation, and multiple acquired extrahepatic portosystemic shunts. A midline coeliotomy was performed, the jejunal ... ...

    Abstract A juvenile dog referred with a 1‐month history of persistent melena and severe anaemia, was diagnosed with a jejunal arteriovenous malformation, and multiple acquired extrahepatic portosystemic shunts. A midline coeliotomy was performed, the jejunal arteriovenous malformation was localised intraoperatively and was successfully removed via an enterectomy. Histopathology confirmed a true arteriovenous malformation. Despite the initial improvement, the patient developed seizure episodes secondary to hepatic encephalopathy 8 months after surgery. Fifteen months after surgery, the owner opted for euthanasia due to the ongoing seizure episodes. Post‐mortem histologic examination of the liver showed features consistent with portal vein hypoplasia. A congenital arteriovenous malformation should be considered as a differential diagnosis in juvenile patients with a chronic history of haemorrhage from the gastrointestinal tract. In addition, acquired portosystemic shunts may occur in patients with portal vein hypoplasia and jejunal arteriovenous malformations.
    Keywords abnormal development ; anemia ; digestive tract ; dogs ; encephalopathy ; euthanasia ; hemorrhage ; histology ; histopathology ; jejunum ; juveniles ; liver ; patients ; portal vein ; small animal practice ; surgery
    Language English
    Dates of publication 2023-07
    Size p. 485-489.
    Publishing place Blackwell Publishing Ltd
    Document type Article ; Online
    Note Case Reports
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.13617
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Mycophenolate mofetil and telmisartan for the treatment of proteinuria secondary to minimal change disease podocytopathy in a dog.

    Travail, Victoria / Cianciolo, Rachel E / Peak, Kerry / Di Bella, Andrea

    Journal of veterinary internal medicine

    2022  Volume 36, Issue 6, Page(s) 2187–2190

    Abstract: A 3-year-old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings ... ...

    Abstract A 3-year-old entire female Springer Spaniel, with a previous diagnosis of meningoencephalitis of unknown origin diagnosed 2 years before presentation and treated with long term administration of prednisolone, developed proteinuria. Laboratory findings revealed hypoalbuminemia, hypercholesterolemia, and proteinuria. Further investigations excluded underlying causes. Renal biopsies were performed. The glomeruli and the tubulointerstitial compartment did not show any anomalies on light microscopy and immunofluorescence staining did not reveal abnormalities. Transmission electron microscopy revealed moderate podocyte injury consisting of foot process effacement and microvillus transformation of the cytoplasm. The dog was diagnosed with primary minimal change disease of the podocytes and treated with telmisartan and mycophenolate mofetil. Abnormalities of serum albumin, cholesterol, and proteinuria resolved within 4 weeks. Minimal change disease has been reported in dogs, but this is a case report of proteinuria secondary to minimal change disease successfully treated with mycophenolate mofetil and telmisartan.
    MeSH term(s) Dogs ; Female ; Animals ; Nephrosis, Lipoid/drug therapy ; Nephrosis, Lipoid/veterinary ; Nephrosis, Lipoid/complications ; Mycophenolic Acid/therapeutic use ; Telmisartan/therapeutic use ; Proteinuria/drug therapy ; Proteinuria/veterinary ; Kidney Glomerulus/pathology ; Dog Diseases/drug therapy ; Dog Diseases/pathology
    Chemical Substances Mycophenolic Acid (HU9DX48N0T) ; Telmisartan (U5SYW473RQ)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 92798-3
    ISSN 1939-1676 ; 0891-6640
    ISSN (online) 1939-1676
    ISSN 0891-6640
    DOI 10.1111/jvim.16534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Primary penile adenocarcinoma with concurrent hypercalcaemia of malignancy in a dog.

    Furtado, A R R / Parrinello, L / Merlo, M / Di Bella, A

    The Journal of small animal practice

    2015  Volume 56, Issue 4, Page(s) 289–292

    Abstract: A 13-year-old male neutered Siberian husky crossbreed dog was presented with a 3-week history of haematuria and penile swelling. Clinical examination and computed tomography demonstrated a soft-tissue mass located at the base of the penis without signs ... ...

    Abstract A 13-year-old male neutered Siberian husky crossbreed dog was presented with a 3-week history of haematuria and penile swelling. Clinical examination and computed tomography demonstrated a soft-tissue mass located at the base of the penis without signs of other primary tumours or metastasis. Clinicopathological findings revealed paraneoplastic hypercalcaemia. Fine-needle aspiration cytology of the mass suggested an epithelial tumour with several criteria of malignancy present. Following surgical excision of the mass, the hypercalcaemia resolved. Histopathology and immunohistochemistry revealed features consistent with an adenocarcinoma. Despite thorough examination, no perineal or anal sac tumour was found. To the authors' knowledge, this is the first reported case of a penile adenocarcinoma with hypercalcaemia of malignancy.
    MeSH term(s) Adenocarcinoma/complications ; Adenocarcinoma/diagnosis ; Adenocarcinoma/veterinary ; Animals ; Diagnosis, Differential ; Dog Diseases/diagnosis ; Dog Diseases/diagnostic imaging ; Dog Diseases/surgery ; Dogs ; Hypercalcemia/complications ; Hypercalcemia/diagnosis ; Hypercalcemia/veterinary ; Male ; Penile Neoplasms/complications ; Penile Neoplasms/diagnosis ; Penile Neoplasms/veterinary ; Tomography, X-Ray Computed/veterinary
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 410743-3
    ISSN 1748-5827 ; 0022-4510 ; 1748-5827
    ISSN (online) 1748-5827
    ISSN 0022-4510 ; 1748-5827
    DOI 10.1111/jsap.12285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Open abdomen management for massive intestinal infarction due to acute splanchnic venous thrombosis in a patient with protein S deficiency. A case report.

    Di Bella, Annamaria / Bruscino, Alessandro / Alemanno, Giovanni / Bergamini, Carlo / Prosperi, Paolo

    International journal of surgery case reports

    2020  Volume 72, Page(s) 122–126

    Abstract: Introduction: Acute mesenteric ischemia (AMI) refers to the sudden onset of intestinal hypoperfusion that can also result from splanchnic venous occlusion. The portomesenteric venous system (PMVS) is an unusual site of thrombosis in patients with ... ...

    Abstract Introduction: Acute mesenteric ischemia (AMI) refers to the sudden onset of intestinal hypoperfusion that can also result from splanchnic venous occlusion. The portomesenteric venous system (PMVS) is an unusual site of thrombosis in patients with protein S deficiency and its obstruction is a rare cause of AMI. Aim of this report is to illustrate a successful strategy in a case of massive small bowel infarction managed with an open abdomen (OA) approach.
    Case presentation: A 64 year-old woman presented to the emergency department with acute abdominal pain, rectal bleeding, diarrhea and vomiting. Contrast-enhanced computed tomography (CECT) showed small bowel ischemia and the complete occlusion of all the PMVS branches. Surgery was performed with an OA approach and anticoagulation was immediately begun. Further workup revealed isolated protein S deficiency and history of atrophic gastritis. Thromboprophylaxis with warfarin was started on discharge and no recurrence of thrombotic events was recorded during the one-year follow-up.
    Discussion: PMVS thrombosis related to protein S deficiency is a rare condition that can rapidly lead to an acute abdomen. CECT is the gold standard, because it detects splanchnic thrombosis and its possible complications, like bowel ischemia. In case of surgery, a planned second-look operation is the best strategy to assess bowel viability and possible ischemic progression.
    Conclusions: OA management plays a fundamental role in case of resection for bowel ischemia. Patients with thrombosis at an uncommon site should be further investigated for prothrombotic states.
    Language English
    Publishing date 2020-06-06
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.05.076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Managing Circadian Disruption due to Hospitalization: A Pilot Randomized Controlled Trial of the CircadianCare Inpatient Management System.

    Mangini, Chiara / Zarantonello, Lisa / Formentin, Chiara / Giusti, Gianluca / Domenie, Esther D / Ruggerini, Domenico / Costa, Rodolfo / Skene, Debra J / Basso, Daniela / Battagliarin, Lisa / Di Bella, Antonino / Angeli, Paolo / Montagnese, Sara

    Journal of biological rhythms

    2023  Volume 39, Issue 2, Page(s) 183–199

    Abstract: The objective of the present study was to test the effects of an inpatient management system (CircadianCare) aimed at limiting the negative impact of hospitalization on sleep by enhancing circadian rhythmicity. Fifty inpatients were randomized to either ... ...

    Abstract The objective of the present study was to test the effects of an inpatient management system (CircadianCare) aimed at limiting the negative impact of hospitalization on sleep by enhancing circadian rhythmicity. Fifty inpatients were randomized to either CircadianCare (
    MeSH term(s) Humans ; Male ; Circadian Rhythm ; Hospitalization ; Inpatients ; Melatonin ; Pilot Projects ; Sleep ; Sleep Initiation and Maintenance Disorders/etiology ; Sleep Initiation and Maintenance Disorders/therapy ; Middle Aged ; Aged
    Chemical Substances Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 896387-3
    ISSN 1552-4531 ; 0748-7304
    ISSN (online) 1552-4531
    ISSN 0748-7304
    DOI 10.1177/07487304231213916
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Assessing the Concurrent Validity and Interrater Reliability of Patient-Led Screening Using the Malnutrition Screening Tool in the Ambulatory Cancer Care Outpatient Setting

    Di Bella, Alexandra / Croisier, Emilie / Blake, Claire / Pelecanos, Anita / Bauer, Judy / Brown, Teresa

    Academy of Nutrition and Dietetics Journal of the Academy of Nutrition and Dietetics. 2019 Oct. 21,

    2019  

    Abstract: The prevalence of malnutrition in cancer patients is reported as high as 65%; however, malnutrition screening is often substandard. The Malnutrition Screening Tool (MST) has been validated for use by health care professionals to detect at-risk patients; ... ...

    Abstract The prevalence of malnutrition in cancer patients is reported as high as 65%; however, malnutrition screening is often substandard. The Malnutrition Screening Tool (MST) has been validated for use by health care professionals to detect at-risk patients; however, there is a gap in the literature regarding validation of patient-led MST screening.The aim of the study was to assess the concurrent validity of patient-led MST against the Subjective Global Assessment (SGA) and the interrater reliability of patient-led MST against dietitian-led MST in patients attending ambulatory cancer care services for chemotherapy or supportive treatments.A single-site diagnostic accuracy study of 201 patients between May and June 2017 attending the ambulatory cancer care setting at an Australian metropolitan tertiary hospital in Queensland.The primary outcome measures were concurrent validity and interrater reliability of MST scores as determined by patients (patient-MST), dietitians (dietitian-MST), and SGA as completed by the dietitian.Concurrent validity of patient-led MST scores against the SGA was determined using specificity, sensitivity, positive predictive values, and negative predictive values. Interrater reliability of patient-MST and dietitian-MST was assessed using κ coefficient.The ability of the patient-led MST scores (0 to 1 vs 2 to 5) to indicate nutrition status was found to have a sensitivity of 94% (95% CI 81% to 99%), a specificity of 86% (95% CI 79% to 91%), and an area under the receiver operating characteristic curve of 0.93 (95% CI 0.89 to 0.96). The positive predictive value was 59% (95% CI 45% to 71%), and the negative predictive value was 99% (95% CI 95% to 100%). A weighted κ of 0.83 (95% CI 0.82 to 0.87) between patient-MST and dietitian-MST was found.Patient-led MST screening is a reliable and valid measure that can accurately identify ambulatory cancer care patients as at risk or not at risk of malnutrition.
    Keywords confidence interval ; dietitians ; drug therapy ; hospitals ; malnutrition ; neoplasms ; nutritional status ; patients ; risk ; screening
    Language English
    Dates of publication 2019-1021
    Publishing place Elsevier Inc.
    Document type Article
    Note Pre-press version
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2019.10.015
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Laparoscopic assisted balloon enteroscopy to detect obscure gastrointestinal bleeding sources missed by capsule endoscopy.

    Bisogni, Damiano / Alemanno, Giovanni / Galli, Andrea / Di Bella, Annamaria / Novelli, Luca / Innocenti, Tommaso / Prosperi, Paolo

    Journal of minimal access surgery

    2021  Volume 17, Issue 1, Page(s) 104–107

    Abstract: Jejunoileal neuroendocrine tumours (NETs) are frequently multifocal and represent a consistent source of obscure gastrointestinal bleeding (OGIB). We report the real-life case of a female presenting to our attention for severe episodes of haematochezia ... ...

    Abstract Jejunoileal neuroendocrine tumours (NETs) are frequently multifocal and represent a consistent source of obscure gastrointestinal bleeding (OGIB). We report the real-life case of a female presenting to our attention for severe episodes of haematochezia caused by multiple localisation of jejunoileal NETs. A discrepancy between pre-operative total body contrast-enhancement computed tomography scan and capsule endoscopy (CE) emerged, in terms of numbers of lesions, so that, as completeness, an intraoperative balloon-assisted enteroscopy (BAE) was carried out, leading to the detection of the multiple lesions missed during CE. In case of obscure gastrointestinal bleeding sources missed by capsule endoscopy, laparoscopic-assisted balloon enteroscopy plays an essential role, allowing both to assess a precise diagnosis and to resect the intestinal bleeding tract.
    Language English
    Publishing date 2021-01-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 2186884-0
    ISSN 1998-3921 ; 0972-9941
    ISSN (online) 1998-3921
    ISSN 0972-9941
    DOI 10.4103/jmas.JMAS_6_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Assessing the Concurrent Validity and Interrater Reliability of Patient-Led Screening Using the Malnutrition Screening Tool in the Ambulatory Cancer Care Outpatient Setting.

    Di Bella, Alexandra / Croisier, Emilie / Blake, Claire / Pelecanos, Anita / Bauer, Judy / Brown, Teresa

    Journal of the Academy of Nutrition and Dietetics

    2019  Volume 120, Issue 7, Page(s) 1210–1215

    Abstract: Background: The prevalence of malnutrition in cancer patients is reported as high as 65%; however, malnutrition screening is often substandard. The Malnutrition Screening Tool (MST) has been validated for use by health care professionals to detect at- ... ...

    Abstract Background: The prevalence of malnutrition in cancer patients is reported as high as 65%; however, malnutrition screening is often substandard. The Malnutrition Screening Tool (MST) has been validated for use by health care professionals to detect at-risk patients; however, there is a gap in the literature regarding validation of patient-led MST screening.
    Objective: The aim of the study was to assess the concurrent validity of patient-led MST against the Subjective Global Assessment (SGA) and the interrater reliability of patient-led MST against dietitian-led MST in patients attending ambulatory cancer care services for chemotherapy or supportive treatments.
    Design/participants: A single-site diagnostic accuracy study of 201 patients between May and June 2017 attending the ambulatory cancer care setting at an Australian metropolitan tertiary hospital in Queensland.
    Main outcome measurements: The primary outcome measures were concurrent validity and interrater reliability of MST scores as determined by patients (patient-MST), dietitians (dietitian-MST), and SGA as completed by the dietitian.
    Statistical analysis: Concurrent validity of patient-led MST scores against the SGA was determined using specificity, sensitivity, positive predictive values, and negative predictive values. Interrater reliability of patient-MST and dietitian-MST was assessed using κ coefficient.
    Results: The ability of the patient-led MST scores (0 to 1 vs 2 to 5) to indicate nutrition status was found to have a sensitivity of 94% (95% CI 81% to 99%), a specificity of 86% (95% CI 79% to 91%), and an area under the receiver operating characteristic curve of 0.93 (95% CI 0.89 to 0.96). The positive predictive value was 59% (95% CI 45% to 71%), and the negative predictive value was 99% (95% CI 95% to 100%). A weighted κ of 0.83 (95% CI 0.82 to 0.87) between patient-MST and dietitian-MST was found.
    Conclusion: Patient-led MST screening is a reliable and valid measure that can accurately identify ambulatory cancer care patients as at risk or not at risk of malnutrition.
    MeSH term(s) Aged ; Ambulatory Care/methods ; Australia ; Cross-Sectional Studies ; Female ; Humans ; Male ; Malnutrition/complications ; Malnutrition/diagnosis ; Mass Screening/methods ; Middle Aged ; Neoplasms/complications ; Neoplasms/therapy ; Nutrition Assessment ; Nutritional Status ; Nutritionists ; Outpatients ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity
    Language English
    Publishing date 2019-12-28
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Validation Study
    ZDB-ID 2646718-5
    ISSN 2212-2672
    ISSN 2212-2672
    DOI 10.1016/j.jand.2019.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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