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Article: Radiological findings in Erdheim Chester disease: A very rare multisistemic disease.

Chiocchi, Marcello / Luciano, Alessandra / De Stasio, Vincenzo / Pugliese, Luca / Di Donna, Carlo / Cerocchi, Martina / Gigliotti, Paola / Carini, Alessandro / Chirico, Flavia / Camedda, Riccardo / Di Biagio, Daniele / Sbordone, Paolo Francesco / Garaci, Francesco / Floris, Roberto

Radiology case reports

2023 Volume 18, Issue 5, Page(s) 2047–2054

Abstract: Erdheim-Chester disease is an uncommon non-Langerhans cell histiocytosis affecting multiple systems. There is limited knowledge on the imaging capabilities of this disease. We present an extremely rare case of Erdheim-Chester illness in a 67-year-old man ...

Abstract	Erdheim-Chester disease is an uncommon non-Langerhans cell histiocytosis affecting multiple systems. There is limited knowledge on the imaging capabilities of this disease. We present an extremely rare case of Erdheim-Chester illness in a 67-year-old man with multisystem involvement, including the cardiovascular system, skeleton, retroperitoneum (renal and adrenal infiltration) and the neurologic system. The involvement of the various organs was thoroughly assessed using multimodal imaging modalities such as computed tomography, magnetic resonance imaging, positron emission tomography and bone scintigraphy. Erdheim-Chester illness was revealed by a bone biopsy. Especially when there is cardiac and cerebral involvement, Erdheim-Chester illness is a rare condition with a poor prognosis. Knowing the imaging characteristics of Erdheim-Chester disease may be helpful in understanding the radiological results of many organs affected by the disease as described and discussed in the current case report.
Language	English
Publishing date	2023-03-26
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2023.02.063
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Article: The Brain Metabolic Correlates of the Main Indices of Neuropsychological Assessment in Alzheimer's Disease.

Chiaravalloti, Agostino / Ricci, Maria / Di Biagio, Daniele / Filippi, Luca / Martorana, Alessandro / Schillaci, Orazio

Journal of personalized medicine

2020 Volume 10, Issue 2

Abstract: Background: The study aimed to investigate the relationships between F-18 fluorodeoxyglucose (18F)FDG uptake and neuropsychological assessment in Alzheimer's disease (AD).: Methods: We evaluated 116 subjects with AD according to the NINCDS-ADRDA ... ...

Abstract	Background: The study aimed to investigate the relationships between F-18 fluorodeoxyglucose (18F)FDG uptake and neuropsychological assessment in Alzheimer's disease (AD). Methods: We evaluated 116 subjects with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a brain PET/CT with (18F)FDG, cerebrospinal fluid (CSF) assay, mini-mental state examination (MMSE) and further neuropsychological tests: Rey auditory verbal learning test, immediate recall (RAVLT immediate); Rey auditory verbal learning test, delayed recall (RAVLT, delayed); Rey complex figure test, copy (RCFT, copy); Rey complex figure test, delayed recall (RCFT, delayed); Raven's colored progressive matrices (RCPM); phonological word fluency test (PWF) and Stroop test. We performed the statistical analysis by using statistical parametric mapping (SPM12; Wellcome Department of Cognitive Neurology, London, UK). Results: A significant relationship has been reported between (18F)FDG uptake and RAVLT immediate test in Brodmann area (BA)37 and BA22 and with RCFT, copy in BA40, and BA7. We did not find any significant relationships with other tests. Conclusion: In the AD population, brain (18F)FDG uptake is moderately related to the neuropsychological assessment, suggesting a limited impact on statistical data analysis of glucose brain metabolism.
Language	English
Publishing date	2020-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm10020025
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Article ; Online: Crosstalk between YAP/TAZ and Notch Signaling.

Totaro, Antonio / Castellan, Martina / Di Biagio, Daniele / Piccolo, Stefano

Trends in cell biology

2018 Volume 28, Issue 7, Page(s) 560–573

Abstract: How the behavior of cells in living tissues is orchestrated according to tissue needs, size, and developmental stage is still poorly understood. Advances in these directions are essential to understand morphogenesis, 'self-organization' phenomena, to ... ...

Abstract	How the behavior of cells in living tissues is orchestrated according to tissue needs, size, and developmental stage is still poorly understood. Advances in these directions are essential to understand morphogenesis, 'self-organization' phenomena, to build new tissues for regenerative medicine or to reverse the changes in deranged organs, such as in cancer or in genetic disorders. This review outlines a new scenario by which the crosstalk between the Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ) transcription factors and Notch signaling influences cell self-renewal, stem cell differentiation, cell fate decisions, epithelial-stromal interactions, inflammation, morphogenesis, and large-scale gene oscillations.
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Phosphoproteins/metabolism ; Receptors, Notch/metabolism ; Signal Transduction ; Trans-Activators ; Transcription Factors ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; YAP-Signaling Proteins
Chemical Substances	Adaptor Proteins, Signal Transducing ; Intracellular Signaling Peptides and Proteins ; Phosphoproteins ; Receptors, Notch ; Trans-Activators ; Transcription Factors ; Transcriptional Coactivator with PDZ-Binding Motif Proteins ; WWTR1 protein, human ; YAP-Signaling Proteins ; YAP1 protein, human
Language	English
Publishing date	2018-04-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	30122-x
ISSN	1879-3088 ; 0962-8924
ISSN (online)	1879-3088
ISSN	0962-8924
DOI	10.1016/j.tcb.2018.03.001
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Article: De Novo generation of somatic stem cells by yap/taz

Panciera, Tito / Azzolin, Luca / Di Biagio, Daniele / Totaro, Antonio / Cordenonsi, Michelangelo / Piccolo, Stefano

Journal of visualized experiments. 2018 May 07, , no. 135

2018

Abstract: Here we present protocols to isolate primary differentiated cells and turn them into stem/progenitor cells (SCs) of the same lineage by transient expression of the transcription factor YAP. With this method, luminal differentiated (LD) cells of the mouse ...

Abstract	Here we present protocols to isolate primary differentiated cells and turn them into stem/progenitor cells (SCs) of the same lineage by transient expression of the transcription factor YAP. With this method, luminal differentiated (LD) cells of the mouse mammary gland are converted into cells that exhibit molecular and functional properties of mammary SCs. YAP also turns fully differentiated pancreatic exocrine cells into pancreatic duct-like progenitors. Similarly, to endogenous, natural SCs, YAP-induced stem-like cells ("ySCs") can be eventually expanded as organoid cultures long term in vitro, without further need of ectopic YAP/TAZ, as ySCs are endowed with a heritable self-renewing SC-like state. The reprogramming procedure presented here offers the possibility to generate and expand in vitro progenitor cells of various tissue sources starting from differentiated cells. The straightforward expansion of somatic cells ex vivo has implications for regenerative medicine, for understanding mechanisms of tumor initiation and, more in general, for cell and developmental biology studies.
Keywords	functional properties ; mammary glands ; medicine ; mice ; neoplasms ; somatic cells ; stem cells ; transcription factors
Language	English
Dates of publication	2018-0507
Size	p. e57462.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/57462
Database	NAL-Catalogue (AGRICOLA)

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Article: Lipomatous hypertrophy of the interatrial septum: A potential pitfall resolved on comparing previous PET/CT.

Chiocchi, Marcello / Luciano, Alessandra / De Stasio, Vincenzo / Pugliese, Luca / Di Donna, Carlo / Cerocchi, Martina / Mecchia, Daniele / Mancuso, Leonardo / Di Biagio, Daniele / Floris, Roberto / Garaci, Francesco

Radiology case reports

2022 Volume 18, Issue 1, Page(s) 222–225

Abstract: In this case report, we describe a rare case of inter-atrial septal lipomatosis occasionally found in a PET-CT scan performed in an 81-year-old patient with a history of periprosthetic endocarditis post aortic prosthesis implantation. The patient ... ...

Abstract	In this case report, we describe a rare case of inter-atrial septal lipomatosis occasionally found in a PET-CT scan performed in an 81-year-old patient with a history of periprosthetic endocarditis post aortic prosthesis implantation. The patient reappeared in 2022 in the emergency department complaining of symptomatology of worsening asthenia, fever, and elevated inflammatory indices. He was hospitalized in Cardiology department on suspect of recurrence of endocarditis and underwent PET-CT examination that showed an increased metabolic finding at the interatrial septum. On possible suspicion of recurrence of infective endocarditis or cardiac tumor pathology, further diagnostic investigation by cardio-RM examination was requested. However, after radiologic consultation, the previous performed FDG-PET/TC examinations were re-evaluated and a misdiagnosed uptake at this level was revealed, which was assumed to be due to the endocarditis condition because of widespread uptake throughout the perivalvular area.
Language	English
Publishing date	2022-11-02
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2406300-9
ISSN	1930-0433
ISSN	1930-0433
DOI	10.1016/j.radcr.2022.09.103
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Article ; Online: De Novo Generation of Somatic Stem Cells by YAP/TAZ.

Panciera, Tito / Azzolin, Luca / Di Biagio, Daniele / Totaro, Antonio / Cordenonsi, Michelangelo / Piccolo, Stefano

Journal of visualized experiments : JoVE

2018 , Issue 135

Abstract	Here we present protocols to isolate primary differentiated cells and turn them into stem/progenitor cells (SCs) of the same lineage by transient expression of the transcription factor YAP. With this method, luminal differentiated (LD) cells of the mouse mammary gland are converted into cells that exhibit molecular and functional properties of mammary SCs. YAP also turns fully differentiated pancreatic exocrine cells into pancreatic duct-like progenitors. Similarly, to endogenous, natural SCs, YAP-induced stem-like cells ("ySCs") can be eventually expanded as organoid cultures long term in vitro, without further need of ectopic YAP/TAZ, as ySCs are endowed with a heritable self-renewing SC-like state. The reprogramming procedure presented here offers the possibility to generate and expand in vitro progenitor cells of various tissue sources starting from differentiated cells. The straightforward expansion of somatic cells ex vivo has implications for regenerative medicine, for understanding mechanisms of tumor initiation and, more in general, for cell and developmental biology studies.
MeSH term(s)	Acyltransferases ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Adult Stem Cells/cytology ; Adult Stem Cells/metabolism ; Adult Stem Cells/physiology ; Animals ; Cell Cycle Proteins ; Cell Differentiation/physiology ; Islets of Langerhans/cytology ; Mice ; Pancreas/cytology ; Pancreas/metabolism ; Pancreas/physiology ; Pancreas, Exocrine/cytology ; Pancreatic Ducts/cytology ; Phosphoproteins/genetics ; Phosphoproteins/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; YAP-Signaling Proteins
Chemical Substances	Adaptor Proteins, Signal Transducing ; Cell Cycle Proteins ; Phosphoproteins ; Transcription Factors ; YAP-Signaling Proteins ; Yap1 protein, mouse ; Acyltransferases (EC 2.3.-) ; tafazzin protein, mouse (EC 2.3.-)
Language	English
Publishing date	2018-05-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/57462
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Article ; Online: PET/CT with (18)F-choline after radical prostatectomy in patients with PSA ≤2 ng/ml. Can PSA velocity and PSA doubling time help in patient selection?

Chiaravalloti, Agostino / Di Biagio, Daniele / Tavolozza, Mario / Calabria, Ferdinando / Schillaci, Orazio

European journal of nuclear medicine and molecular imaging

2016 Volume 43, Issue 8, Page(s) 1418–1424

Abstract: Purpose: To investigate the performance of (18)F-fluorocholine ((18)F-FCH) PET/CT in relation to the prostate-specific antigen (PSA) kinetic indexes, PSA doubling time (PSAdt) and PSA velocity (PSAve), in detecting recurrent prostate cancer (PC) in a ... ...

Abstract	Purpose: To investigate the performance of (18)F-fluorocholine ((18)F-FCH) PET/CT in relation to the prostate-specific antigen (PSA) kinetic indexes, PSA doubling time (PSAdt) and PSA velocity (PSAve), in detecting recurrent prostate cancer (PC) in a selected population of patients treated with radical prostatectomy and with PSA ≤2 ng/ml. Methods: The study group comprised 79 patients (mean age 70 ± 7 years, range 58 - 77 years) who had been treated with radical surgery 30 to 90 months previously and with biochemical failure (defined as a measurable serum PSA level) who were evaluated with (18)F-FCH PET/CT. In order to establish the optimal threshold for PSAdt and PSAve, the diagnostic performance of PSA, PSAdt and PSAve were compared by receiver operating characteristic analysis. Results: In the population examined, PSA (mean ± SD) was 1.37 ± 0.44 ng/ml (range 0.21 - 2 ng/ml) before PET/CT examination, PSAdt was 10.04 ± 16.67 months and PSAve was 2.75 ± 3.11 ng/ml per year. (18)F-FCH PET/CT was positive in 44 patients (55 %). PSAve and PSAdt were significantly different between patients with a positive and a negative (18)F-FCH PET/CT scan. Thresholds of 6 months for PSAdt and 1 ng/ml per year for PSAve were selected. For PSAdt ≤6 months the detection rate (DR) was 65 %, and for PSAve >1 ng/ml per year the DR was 67 %. PSA values were not significantly different between patients with a positive and a negative PET/CT scan. Conclusion: The results of our study suggest that (18)F-FCH PET/CT could be considered for the evaluation of patients with biochemical recurrence of PC and with low PSA levels. Fast PSA kinetics could be useful in the selection of these patients.
MeSH term(s)	Aged ; Choline/analogs & derivatives ; Humans ; Image Processing, Computer-Assisted ; Kinetics ; Male ; Middle Aged ; Patient Selection ; Positron Emission Tomography Computed Tomography ; Prostate-Specific Antigen/blood ; Prostate-Specific Antigen/metabolism ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/surgery
Chemical Substances	fluorocholine ; Prostate-Specific Antigen (EC 3.4.21.77) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2016-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-015-3306-0
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Article ; Online: GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery.

Albrecht, Lauren V / Tejeda-Muñoz, Nydia / Bui, Maggie H / Cicchetto, Andrew C / Di Biagio, Daniele / Colozza, Gabriele / Schmid, Ernst / Piccolo, Stefano / Christofk, Heather R / De Robertis, Edward M

Cell reports

2020 Volume 32, Issue 4, Page(s) 107973

Abstract: Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation of Axin1, a ... ...

Abstract	Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation of Axin1, a tumor suppressor and component of the destruction complex, results in the activation of macropinocytosis. Surprisingly, inhibition of GSK3 by lithium chloride (LiCl), CHIR99021, or dominant-negative GSK3 triggers macropinocytosis. GSK3 inhibition causes a rapid increase in acidic endolysosomes that is independent of new protein synthesis. GSK3 inhibition or Axin1 mutation increases lysosomal activity, which can be followed with tracers of active cathepsin D, β-glucosidase, and ovalbumin degradation. Microinjection of LiCl into the blastula cavity of Xenopus embryos causes a striking increase in dextran macropinocytosis. The effects of GSK3 inhibition on protein degradation in endolysosomes are blocked by the macropinocytosis inhibitors EIPA or IPA-3, suggesting that increases in membrane trafficking drive lysosomal activity.
MeSH term(s)	Animals ; Axin Protein/metabolism ; Cell Line, Tumor ; Endocytosis/physiology ; Endosomes/metabolism ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3/physiology ; Lysosomes/metabolism ; Phosphorylation ; Pinocytosis/physiology ; Wnt Proteins/metabolism ; Wnt Signaling Pathway/physiology ; Xenopus Proteins/metabolism ; Xenopus Proteins/physiology ; Xenopus laevis ; beta Catenin/metabolism
Chemical Substances	Axin Protein ; Wnt Proteins ; Xenopus Proteins ; axin1 protein, Xenopus ; beta Catenin ; GSK3B protein, Xenopus (EC 2.7.11.26) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
Keywords	covid19
Language	English
Publishing date	2020-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2020.107973
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Article ; Online: Detection of local recurrence of prostate cancer after radical prostatectomy: Is there a role for early ¹⁸F-FCH PET/CT?

Di Biagio, Daniele / Chiaravalloti, Agostino / Tavolozza, Mario / Abbatiello, Paolo / Schillaci, Orazio

Annals of nuclear medicine

2015 Volume 29, Issue 10, Page(s) 861–869

Abstract: Aim: To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of ¹⁸F-FCH PET/CT.: Materials and methods: 99 patients with radical prostatectomy (mean PSA ...

Abstract	Aim: To investigate the diagnostic performance of early acquisition compared to late imaging for the detection of local recurrence of prostate cancer by means of ¹⁸F-FCH PET/CT. Materials and methods: 99 patients with radical prostatectomy (mean PSA 3.9 ± 5.03) were subjected to early dynamic PET/CT acquisition of the pelvis and a whole body PET/CT in the same exam session. None of the patients examined was subjected to radiotherapy for local or distant recurrence. All the subjects were taken off hormonal therapy. Results: 58 subjects did not show local recurrence in both early and late acquisition, 22 were positive in both modalities, 10 showed a positive early and a negative late acquisition while 9 showed a negative early and a positive late acquisition (Cohen's k = 0.558). When the results of imaging modalities were considered separately, sensitivity, specificity, positive predictive value and negative predictive value resulted: 78.9, 96.7, 93.8 and 88.1 % for early acquisition and 73.7, 95.1, 90.3 and 85.3 % for late acquisition, respectively. When the results of early and late acquisition were considered together, results were 97.4, 93.4, 90.2 and 98.3 %, respectively. Conclusions: The combination of early acquisition with late acquisition lead to an increase of the diagnostic accuracy of ¹⁸F-FCH PET/CT for the diagnosis of local recurrence in prostate cancer.
MeSH term(s)	Aged ; Choline/analogs & derivatives ; Humans ; Male ; Multimodal Imaging ; Neoplasm Recurrence, Local/diagnostic imaging ; Positron-Emission Tomography/methods ; Prostate-Specific Antigen/metabolism ; Prostatectomy ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Time Factors ; Tomography, X-Ray Computed/methods
Chemical Substances	fluorocholine ; Prostate-Specific Antigen (EC 3.4.21.77) ; Choline (N91BDP6H0X)
Language	English
Publishing date	2015-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1146984-5
ISSN	1864-6433 ; 0914-7187
ISSN (online)	1864-6433
ISSN	0914-7187
DOI	10.1007/s12149-015-1015-1
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Article: GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

Cell Rep

Abstract: Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the ß-catenin destruction complex. We find that mutation of Axin1, a ... ...

Abstract	Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the ß-catenin destruction complex. We find that mutation of Axin1, a tumor suppressor and component of the destruction complex, results in the activation of macropinocytosis. Surprisingly, inhibition of GSK3 by lithium chloride (LiCl), CHIR99021, or dominant-negative GSK3 triggers macropinocytosis. GSK3 inhibition causes a rapid increase in acidic endolysosomes that is independent of new protein synthesis. GSK3 inhibition or Axin1 mutation increases lysosomal activity, which can be followed with tracers of active cathepsin D, ß-glucosidase, and ovalbumin degradation. Microinjection of LiCl into the blastula cavity of Xenopus embryos causes a striking increase in dextran macropinocytosis. The effects of GSK3 inhibition on protein degradation in endolysosomes are blocked by the macropinocytosis inhibitors EIPA or IPA-3, suggesting that increases in membrane trafficking drive lysosomal activity.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32726636
Database	COVID19

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