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Article ; Online: A case of bilateral humerus varus from the late antiquity Catacomb of Santa Mustiola (Chiusi, Italy).

Sperduti, Alessandra / Braconi, Matteo / Di Biasi, Claudio / Facchin, Giulia / Ferri, Giovanna / Interlando, Stella / Spanò, Ferdinando / Candilio, Francesca

International journal of paleopathology

2022 Volume 39, Page(s) 14–19

Abstract: Objective: To report a case of bilateral humerus varus from a late antiquity archeological context in central Italy.: Materials: The individual is a 25-40-year-old female, dated to the 4th cent. CE, from the catacomb of Santa Mustiola in Chiusi, ... ...

Abstract	Objective: To report a case of bilateral humerus varus from a late antiquity archeological context in central Italy. Materials: The individual is a 25-40-year-old female, dated to the 4th cent. CE, from the catacomb of Santa Mustiola in Chiusi, Italy. Methods: The bones were examined macroscopically and through CT scan imaging. Results: Both humeri show evident alterations in shape, including elongated, flattened and distally dislocated humeral heads, shortened anatomical necks, angulated upper diaphyseal shafts, and reduced overall lengths. The scapulae appear to have been mildly affected by this condition and show some bone loss and slight retroversion of the glenoid cavity. Conclusions: Observations are consistent with a diagnosis of humerus varus deformity likely caused by a traumatic event early in the individual's life. Significance: Varus deformity of the proximal humerus is seldom reported in bioarcheological literature. The case presented provides insight into the etiology and effects of this condition and may serve as comparison for future studies. Limitations: Even though the absence of other skeletal deformities renders a systemic condition improbable, the traumatic etiology of the condition cannot be confirmed with certainty. Suggestions for further research: Future publications of new cases may give a broader perspective of the etiology of this condition in the past.
MeSH term(s)	Humans ; Female ; Adult ; Humerus/diagnostic imaging ; Scapula ; Glenoid Cavity ; Diaphyses ; Italy
Language	English
Publishing date	2022-08-24
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2606330-X
ISSN	1879-9825 ; 1879-9817
ISSN (online)	1879-9825
ISSN	1879-9817
DOI	10.1016/j.ijpp.2022.08.001
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Article ; Online: Correction: Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study.

Puliani, Giulia / Sbardella, Emilia / Cozzolino, Alessia / Sada, Valentina / Tozzi, Rossella / Andreoli, Chiara / Fiorelli, Marco / Di Biasi, Claudio / Corallino, Diletta / Balla, Andrea / Paganini, Alessandro M / Venneri, Mary Anna / Lenzi, Andrea / Lubrano, Carla / Isidori, Andrea M

International journal of obesity (2005)

2023 Volume 47, Issue 10, Page(s) 1027

Language	English
Publishing date	2023-08-28
Publishing country	England
Document type	Published Erratum
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01363-9
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Article ; Online: Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study.

International journal of obesity (2005)

2023 Volume 47, Issue 10, Page(s) 948–955

Abstract: Background: Despite obesity being well known to be associated with several pituitary hormone imbalances, pituitary appearance in magnetic resonance imaging (MRI) in patients with obesity is understudied.: Objective: To evaluate the pituitary volume ... ...

Abstract	Background: Despite obesity being well known to be associated with several pituitary hormone imbalances, pituitary appearance in magnetic resonance imaging (MRI) in patients with obesity is understudied. Objective: To evaluate the pituitary volume and signal intensity at MRI in patients with obesity. Methods: This is a prospective study performed in an endocrine Italian referral center (ClinicalTrial.gov Identifier: NCT03458533). Sixty-nine patients with obesity (BMI > 30 kg/m Results: At baseline, no difference in pituitary volume was observed between the obese and non-obese cohorts. At the 3-year follow-up, pituitary volume was significantly reduced (p = 0.011) only in participants with stable-increased body weight. Furthermore, a significant difference was noted in the mean pituitary intensity of T1-weighted plain and contrast-enhanced sequences between the obese and non-obese cohorts at baseline (p = 0.006; p = 0.002), and a significant decrease in signal intensity was observed in the subgroup of participants who had not lost weight (p = 0.012; p = 0.017). Insulin-like growth factor-1 levels, following correction for BMI, were correlated with pituitary volume (p = 0.001) and intensity (p = 0.049), whereas morning cortisol levels were correlated with pituitary intensity (p = 0.007). The T1-weighted pituitary intensity was negatively correlated with truncal fat (p = 0.006) and fibrinogen (p = 0.018). Conclusions: The CHIASM study describes a quantitative reduction in pituitary intensity in T1-weighted sequences in patients with obesity. These alterations could be explained by changes in the pituitary stromal tissue, correlated with low-grade inflammation.
MeSH term(s)	Humans ; Prospective Studies ; Obesity/diagnostic imaging ; Weight Gain ; Fibrinogen ; Inflammation
Chemical Substances	Fibrinogen (9001-32-5)
Language	English
Publishing date	2023-07-21
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01338-w
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Article ; Online: A transient magnetic resonance spectroscopy peri-ischemic peak: a possible radiological biomarker of post-stroke neurogenesis.

De Michele, Manuela / Iacobucci, Marta / Letteri, Federica / Andreoli, Chiara / Lorenzano, Svetlana / Canese, Rossella / Petraglia, Luca / Berto, Irene / Schiavo, Oscar Gaetano / Di Biasi, Claudio / Toni, Danilo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Volume 44, Issue 3, Page(s) 967–978

Abstract: Background and aims: In adult human brain, neurogenesis seems to persist throughout life and ischemic stroke was proved to stimulate this process. Using magnetic resonance spectroscopy (MRS), a 1.28-ppm peak, putative biomarker of neural progenitor ... ...

Abstract	Background and aims: In adult human brain, neurogenesis seems to persist throughout life and ischemic stroke was proved to stimulate this process. Using magnetic resonance spectroscopy (MRS), a 1.28-ppm peak, putative biomarker of neural progenitor cells (NPCs), was identified both in vitro and in vivo, i.e., in normal rat and healthy human brain. The aim of our study was to identify a 1.28-ppm peak in adult human ischemic brain by using 3.0 T multivoxel MRS. Methods: We studied 10 patients, six males, and four females, with a mean (± SD) age of 59.3 (± 17.3), at three different time points from ischemic stroke onset (T0: < 5 days; T14: 14 ± 2 days; T30: 30 ± 2 days). Results: In all patients except one, a 1.28-ppm peak at T14 was detected at the ischemic boundary (all p values < 0.05). MRS performed on six voluntary age-matched healthy subjects did not detect any 1.28-ppm peak. Conclusions: The nature of this 1.28-pm peak is uncertain; however, our data support the hypothesis that it might represent a marker of NPCs in post-stroke human brain.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Rats ; Animals ; Stroke/diagnosis ; Magnetic Resonance Spectroscopy/methods ; Neurogenesis/physiology ; Biomarkers ; Ischemic Stroke
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-11-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06479-w
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Zs.A 1877: Show issues

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Article ; Online: Metastatic cancer and endentulism: Exploring comorbidity to assist with differential diagnosis in a case from Vico nel Lazio (Fr, Italy), 13th-15th century CE.

Rubini, Mauro / Gozzi, Alessandro / Libianchi, Nunzia / Dellù, Elena / Spanò, Ferdinando / Di Biasi, Claudio / Pendenza, Matteo / Sala, Paola / Filannino, Floriana / Zaio, Paola

International journal of paleopathology

2022 Volume 38, Page(s) 1–12

Abstract: Objective: To differentially diagnose cranial lesions noted on a medieval skeleton and explore the importance of comorbidity.: Materials: A skull of an adult female with osteolytic and osteoblastic lesions, edentulism, and an ectopic tooth from an ... ...

Abstract	Objective: To differentially diagnose cranial lesions noted on a medieval skeleton and explore the importance of comorbidity. Materials: A skull of an adult female with osteolytic and osteoblastic lesions, edentulism, and an ectopic tooth from an ossuary of the Church of Santa Maria in Vico del Lazio, Frosinone Italy, dating to the Middle Ages. Methods: Macroscopic observations of the remains, CT scan, and differential diagnosis was undertaken. Results: A diagnosis of metastatic cancer (potentially breast cancer) or metastatic neuroblastoma (NBL) is offered. Conclusions: Considering the noted comorbidities, this case might represent a rare case of metastatic neuroblastoma. Significance: The exploration of comorbidity, in this case the presence of metastatic carcinoma and edentulism, has tremendous potential to expand our knowledge about cancer in the past. Limitations: Lack of postcranial elements. Suggestions for further research: Clinical and paleopathological investigation of comorbidity in modern and archeological populations to develop an evolutionary perspective on the presence of cancer in the past.
MeSH term(s)	Adult ; Carcinoma ; Comorbidity ; Diagnosis, Differential ; Female ; Humans ; Italy ; Middle Aged ; Neuroblastoma/pathology ; Skull/pathology
Language	English
Publishing date	2022-06-06
Publishing country	Netherlands
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606330-X
ISSN	1879-9825 ; 1879-9817
ISSN (online)	1879-9825
ISSN	1879-9817
DOI	10.1016/j.ijpp.2022.05.005
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Article ; Online: Bevacizumab-containing regimen in relapsed/progressed brain tumors: a single-institution experience.

Schiavetti, Amalia / Varrasso, Giulia / Mollace, Maria Giovanna / Dominici, Carlo / Ferrara, Eva / Papoff, Paola / Di Biasi, Claudio

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2019 Volume 35, Issue 6, Page(s) 1007–1012

Abstract: Aim: The aim of the study is to assess tumor response, treatment-related toxicities, progression-free survival (PFS), and overall survival (OS) in patients with relapsed/refractory brain tumors treated with bevacizumab-containing regimen.: Methods: ... ...

Abstract	Aim: The aim of the study is to assess tumor response, treatment-related toxicities, progression-free survival (PFS), and overall survival (OS) in patients with relapsed/refractory brain tumors treated with bevacizumab-containing regimen. Methods: Patients that had received I and II line treatments with or without megatherapy were included. Doses and schedule were as follows: bevacizumab (BVZ) 10 mg/kg i.v. with irinotecan (IRI) 150 mg/m Results: Between 2013 and 2018, 12 patients (3F/9M), median age 161 months (range 66-348), affected with medulloblastoma (n 7), or low-grade glioma (n 2), or high-grade glioma (n 3), received BVZ/IRI association (median courses 20, range 4-67); 3 of them continued single-agent BVZ (median courses 23, range 8-39). TMZ (median courses 8, range 2-26) was administered in eight patients and then stopped in three of them because of myelotoxicity or lack of compliance. Treatment was well tolerated. After 3 months, two complete responses, two partial responses, seven stable diseases, and one progressive disease were observed. Nine cases experienced an improvement in neurological symptoms. Median time to progression was 11 months (95% confidence interval, 4-18 months). Six-month and 2-year PFS were 75% and 42%, respectively. The OS is 33%; interestingly, two cases (one medulloblastoma and one high-grade glioma) are progression-free off-therapy since 30 and 48 months, respectively. Conclusions: BVZ/IRI association ± TMZ showed encouraging therapeutic activity and low toxicity in this series of relapsed/refractory brain tumors.
MeSH term(s)	Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bevacizumab/administration & dosage ; Bevacizumab/adverse effects ; Brain Neoplasms/drug therapy ; Brain Neoplasms/mortality ; Cerebellar Neoplasms/drug therapy ; Cerebellar Neoplasms/mortality ; Child ; Child, Preschool ; Female ; Glioma/drug therapy ; Glioma/mortality ; Humans ; Irinotecan/administration & dosage ; Irinotecan/adverse effects ; Male ; Medulloblastoma/drug therapy ; Medulloblastoma/mortality ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/mortality ; Salvage Therapy/methods ; Temozolomide/administration & dosage ; Temozolomide/adverse effects ; Young Adult
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; Irinotecan (7673326042) ; Temozolomide (YF1K15M17Y)
Language	English
Publishing date	2019-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-019-04117-z
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Zs.A 2036: Show issues

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Article ; Online: Peri-procedural brain lesions prevention in CAS (3PCAS): Randomized trial comparing CGuard™ stent vs. Wallstent™.

Capoccia, Laura / Sirignano, Pasqualino / Mansour, Wassim / d'Adamo, Alessandro / Sbarigia, Enrico / Mariani, Paola / Di Biasi, Claudio / Speziale, Francesco

International journal of cardiology

2018 Volume 279, Page(s) 148–153

Abstract: Background: Aim of this study was to evaluate peri-procedural incidence of new diffusion-weighted-magnetic-resonance-imaging (DWMRI) brain lesions in CAS patients treated by carotid mesh stent (CGuard™) or closed-cell stent (Wallstent™).: Methods: ... ...

Abstract	Background: Aim of this study was to evaluate peri-procedural incidence of new diffusion-weighted-magnetic-resonance-imaging (DWMRI) brain lesions in CAS patients treated by carotid mesh stent (CGuard™) or closed-cell stent (Wallstent™). Methods: Consecutive patients with asymptomatic carotid stenosis ≥ 70% were submitted to preoperative DW-MRI scan, to exclude the presence of preoperative silent cerebral lesions. Patients were randomized to CGuard or Wallstent. DWMRI was performed immediately after the intervention and at 72-hour postoperatively. Moreover, pre and postoperative Mini-Mental-State-Examination Test (MMSE) and a Montreal-Cognitive-Assessment (MoCA) test were conducted, and S100β and NSE neurobiomarkers were measured at 5-time points (preoperatively, 2, 12, 24, and 48 h postoperatively). Results: From January 2015 to October 2016, sixty-one consecutive eligible patients were submitted to preoperative DWMRI scan. Three patients were excluded because of preoperative silent cerebral lesions. In 29 CGuard patients, 1 developed a minor stroke and 8 silent new lesions were observed in the 72 h-DWMRI (31%): 4 lesions were ipsilateral, and 4 lesions were contra or bilateral. In 29 Wallstent patients, 7 clinically-silent new lesions were found in the 72 h-DWMRI (24.1%; p = 0.38). In 4 cases lesions were ipsilateral and in 3 cases contra or bilateral. S100B values doubled at 48 h in 24 patients, and among them 12 presented new DWMRI lesions. 48-h S100B increase was significantly related to 72-h DWMRI lesions (p = 0.012). Conclusions: In our experience both stents showed an acceptable rate of subclinical neurological events with no significant differences at 72-hour DWMRI between groups. Bilateral/contralateral lesions suggest that periprocedural neurological damage may have extra-carotid sources.
MeSH term(s)	Aged ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/surgery ; Diffusion Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/standards ; Female ; Humans ; Male ; Preoperative Care/methods ; Preoperative Care/standards ; Stents/standards
Language	English
Publishing date	2018-09-21
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2018.09.066
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Zs.A 1673: Show issues

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Article ; Online: In normal aging ventricular system never attains pathological values of Evans' index.

Missori, Paolo / Rughetti, Aurelia / Peschillo, Simone / Gualdi, Gianfranco / Di Biasi, Claudio / Nofroni, Italo / Marinelli, Lucio / Fattapposta, Francesco / Currà, Antonio

Oncotarget

2016 Volume 7, Issue 11, Page(s) 11860–11863

Abstract: Ventricular enlargement in normal aging frequently forces the radiological diagnosis of hydrocephalus, but the reliability of Evans' index as a radiological marker of abnormal ventricular enlargement (values > 0.30) during aging is not assessed. Here we ... ...

Abstract	Ventricular enlargement in normal aging frequently forces the radiological diagnosis of hydrocephalus, but the reliability of Evans' index as a radiological marker of abnormal ventricular enlargement (values > 0.30) during aging is not assessed. Here we analyze ventricular size during aging and the reliability of Evans' index as a radiological marker of abnormal ventricular enlargement. We calculated Evans' index in the axial Computed Tomography scans of 1221 consecutive individuals (aged 45-101 years) from an emergency department. Stratified analysis of one-year cohorts showed that the mean Evans' index value per class was invariably < 0.30. Roughly one out five Computed Tomography scans was associated with Evans' index values > 0.30 and Evans' index values increased with age. The risk of having an Evans' index value > 0.30 increased by 7.8% per year of age (p < 0.001) and males were at 83.9% greater risk than females (p < 0.001). Overall, this study shows that normal aging enlarges the ventricular system, but never causes abnormal ventricular enlargement. Evans' index values > 0.30 should reflect an underlying neurological condition in every individual.
Language	English
Publishing date	2016-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.7644
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Article ; Online: The outcome of white matter abnormalities in early treated phenylketonuric patients: A retrospective longitudinal long-term study.

Mastrangelo, Mario / Chiarotti, Flavia / Berillo, Luana / Caputi, Caterina / Carducci, Claudia / Di Biasi, Claudio / Manti, Filippo / Nardecchia, Francesca / Leuzzi, Vincenzo

Molecular genetics and metabolism

2015 Volume 116, Issue 3, Page(s) 171–177

Abstract: Background: Pathogenesis and clinical consequences of white matter abnormalities on magnetic resonance imaging (MRI) in phenylketonuric (PKU) patients are incompletely known.: Objective: To study white matter alterations progression and outcome and ... ...

Abstract	Background: Pathogenesis and clinical consequences of white matter abnormalities on magnetic resonance imaging (MRI) in phenylketonuric (PKU) patients are incompletely known. Objective: To study white matter alterations progression and outcome and its relationships with phenylalanine levels and intelligence quotient (IQ) in early treated PKU subjects who underwent serial MRIs during a prolonged follow-up. Methods: 47 early treated PKU patients (mean age 25.1 ± 5.6 years; range 12-37 years) have been enrolled when two or more consecutive brain MRIs, a complete biochemical history, and MRI-concurrent blood phenylalanine levels were available. The severity and extension of white matter abnormalities were expressed in a computed score. Consecutive IQ assessments were available in 24 patients. We analyzed intra- and interindividual white matter alterations variations and their relationship with quality of biochemical control and cognitive outcome. Results: Early treated PKU patients showed a high rate of white matter alterations with a relevant increase in frequency/severity from the second decade of life onwards. Age and quality of dietary control before or between subsequent examinations showed an independent cumulative effect on white matter alterations outcome. No significant association was found between white matter alterations and cognitive outcome. A remarkable interindividual variability was found and several patients disclosed incongruity between the trajectory of white matter alterations and biochemical control. About 30% of white matter alterations variability remains unexplained by the disease-associated determinants. Conclusions: The evolution of white matter alterations is not significantly affected by intellectual outcome and is affected by aging, chronic exposure to phenylalanine, and unknown individual factors.
MeSH term(s)	Adolescent ; Adult ; Aging ; Child ; Female ; Follow-Up Studies ; Humans ; Intelligence Tests ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Phenylalanine/blood ; Phenylketonurias/blood ; Phenylketonurias/pathology ; Phenylketonurias/therapy ; Retrospective Studies ; White Matter/pathology ; Young Adult
Chemical Substances	Phenylalanine (47E5O17Y3R)
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1418518-0
ISSN	1096-7206 ; 1096-7192
ISSN (online)	1096-7206
ISSN	1096-7192
DOI	10.1016/j.ymgme.2015.08.005
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Article ; Online: Immunological diagnosis as an adjunctive tool for an early diagnosis of tuberculous meningitis of an immune competent child in a low tuberculosis endemic country: a case report.

Vita, Serena / Ajassa, Camilla / Caraffa, Emanuela / Lichtner, Miriam / Mascia, Claudia / Mengoni, Fabio / Paglia, Maria Grazia / Mancarella, Cristina / Colistra, Davide / Di Biasi, Claudio / Ciardi, Rosa Maria / Mastroianni, Claudio Maria / Vullo, Vincenzo

BMC research notes

2017 Volume 10, Issue 1, Page(s) 123

Abstract: Background: Pediatric tuberculous meningitis is a highly morbid, often fatal disease. Its prompt diagnosis and treatment saves lives, in fact delays in the initiation of therapy have been associated with high mortality rates.: Case presentation: This ...

Abstract	Background: Pediatric tuberculous meningitis is a highly morbid, often fatal disease. Its prompt diagnosis and treatment saves lives, in fact delays in the initiation of therapy have been associated with high mortality rates. Case presentation: This is a case of an Italian child who was diagnosed with tuberculous meningitis after a history of a month of headache, fatigue and weight loss. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis with predominance and decreased glucose concentration. Microscopy and conventional diagnostic tests to identify Mycobacterium tuberculosis were negative, while a non classical method based on intracellular cytokine flow cytometry response of CD4 cells in cerebral spinal fluid helped us to address the diagnosis, that was subsequently confirmed by a nested polymerase chain reaction amplifying a 123 base pair fragment of the M. tuberculosis DNA. Conclusions: We diagnosed tuberculous meningitis at an early stage through an innovative immunological approach, supported by a nested polymerase chain reaction for detection of M. tuberculosis DNA. An early diagnosis is required in order to promptly initiate a therapy and to increase the patient's survival.
MeSH term(s)	Child ; Female ; Flow Cytometry ; Humans ; Italy/epidemiology ; Leukocytosis ; Tuberculosis, Meningeal/diagnosis ; Tuberculosis, Meningeal/epidemiology ; Tuberculosis, Meningeal/immunology
Language	English
Publishing date	2017-03-13
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-017-2444-9
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