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  1. Article ; Online: Suprapubic single-port approach for complicated diverticulitis.

    Spinelli, A / Di Candido, F / Carvello, M

    Techniques in coloproctology

    2018  Volume 22, Issue 9, Page(s) 657–662

    Abstract: Background: Laparoscopic sigmoidectomy is the gold standard for elective surgical treatment of diverticulitis. A periumbilical single-port technique reduces the size of the access wound, usually to 3-4 cm. However, in the presence of large phlegmon or ... ...

    Abstract Background: Laparoscopic sigmoidectomy is the gold standard for elective surgical treatment of diverticulitis. A periumbilical single-port technique reduces the size of the access wound, usually to 3-4 cm. However, in the presence of large phlegmon or fistulae, the risk of conversion is higher and the extraction site might be enlarged. A suprapubic Pfannenstiel incision reduces the risk of incisional hernia compared to umbilical access and might provide the possibility to perform sigmoidectomy with a hybrid technique. The aim of the present study was to investigate the feasibility of laparoscopic sigmoidectomy through a single suprapubic transverse access for large diverticular phlegmon.
    Methods: Consecutive patients with a diverticular inflammatory mass ≥ 5 cm, with or without sigmoid-vesical fistula, were considered candidates for laparoscopic sigmoidectomy through a 5-cm single-port suprapubic (SPSP) access, extended (if required) to match the size of the inflammatory mass.
    Results: Twenty patients underwent SPSP sigmoidectomy at our institution in April 2014-April 2017. All procedures were completed by SPSP access, with no intraoperative complications or need for additional trocar placement. Eight patients had a sigmoid-vesical fistula (bladder sutured in three patients). The splenic flexure was mobilized in nine patients. Median operative time was 178 min and median hospital stay was 5.5 days (iqr 4-6). Postoperative complications occurred in four patients and included one subcutaneous hematoma, one urinary tract infection, and two superficial wound infections. After a median follow-up time of 25 months (interquartile range 15-38), all patients experienced complete resolution of symptoms, with no incisional hernias reported.
    Conclusions: SPSP sigmoidectomy for diverticulitis is feasible and effective, minimizing the size of the access wound and avoiding increased risk of hernia. This approach might be especially valuable for the management of large diverticular phlegmon and sigmoid-vesical fistula.
    MeSH term(s) Aged ; Cellulitis/etiology ; Cellulitis/surgery ; Colon, Sigmoid/surgery ; Diverticulitis, Colonic/complications ; Diverticulitis, Colonic/surgery ; Female ; Humans ; Intestinal Fistula/etiology ; Intestinal Fistula/surgery ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Urinary Bladder Fistula/etiology ; Urinary Bladder Fistula/surgery
    Keywords covid19
    Language English
    Publishing date 2018-09-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-018-1843-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Technical variations and feasibility of transanal ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified across continents.

    Zaghiyan, K / Warusavitarne, J / Spinelli, A / Chandrasinghe, P / Di Candido, F / Fleshner, P

    Techniques in coloproctology

    2018  Volume 22, Issue 11, Page(s) 867–873

    Abstract: Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers ... ...

    Abstract Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers performing taIPAA across two continents.
    Methods: Prospective IPAA registries from three institutions in the US and Europe were queried for patients undergoing taIPAA. Demographic, preoperative, intraoperative, and postoperative data were compiled into a single database and evaluated.
    Results: Sixty-two patients (median age 38 years; range 16-68 years, 43 (69%) male) underwent taIPAA in the three centers (USA 24, UK 23, Italy 15). Most patients had had a subtotal colectomy before taIPAA [n = 55 (89%)]. Median surgical time was 266 min (range 180-576 min) and blood loss 100 ml (range 10-500 ml). Technical variations across the three institutions included proctectomy plane of dissection (intramesorectal or total mesorectal excision plane), specimen extraction site (future ileostomy site vs. anus), ileo-anal anastomosis technique (stapled vs. hand sewn) and use of fluorescence angiography. Despite technical differences, anastomotic leak rates (5/62; 8%) and overall complications (18/62; 29%) were acceptable across the three centers.
    Conclusions: This is the first collaborative report showing safety and feasibility of taIPAA. Despite technical variations, outcomes are similar across centers. A large multi-institutional, international IPAA collaborative is needed to compare technical factors and outcomes.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anastomotic Leak/epidemiology ; Anastomotic Leak/etiology ; Colitis, Ulcerative/surgery ; Feasibility Studies ; Female ; Humans ; Inflammatory Bowel Diseases/surgery ; Italy/epidemiology ; Male ; Middle Aged ; Operative Time ; Proctocolectomy, Restorative/methods ; Prospective Studies ; Registries ; Transanal Endoscopic Surgery/methods ; Treatment Outcome ; United Kingdom/epidemiology ; United States/epidemiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2018-12-11
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-018-1889-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Restorative proctocolectomy and ileal pouch-anal anastomosis for right-sided colonic adenocarcinoma in familial adenomatous polyposis: an abdominal laparoscopic approach combined with transanal total mesorectal excision - a video vignette.

    Carvello, M / David, G / Sacchi, M / Di Candido, F / Spinelli, A

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2018  Volume 20, Issue 4, Page(s) 355–356

    MeSH term(s) Abdomen/surgery ; Adenocarcinoma/surgery ; Adenomatous Polyposis Coli/surgery ; Colonic Neoplasms/surgery ; Female ; Humans ; Laparoscopy/methods ; Middle Aged ; Proctocolectomy, Restorative/methods ; Transanal Endoscopic Surgery/methods
    Keywords covid19
    Language English
    Publishing date 2018-02-19
    Publishing country England
    Document type Case Reports ; Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Factors associated with stoma formation in ileocolic resection for Crohn's disease and the development of a predictive scoring system.

    Wickramasinghe, Dakshitha / Carvello, Michele / Di Candido, Francesca / Maroli, Annalisa / Adegbola, Samuel / Sahnan, Kapil / Morar, Pritesh / Spinelli, Antonino / Warusavitarne, Janindra

    Langenbeck's archives of surgery

    2022  Volume 407, Issue 7, Page(s) 2997–3003

    Abstract: Purpose: The likelihood of a stoma following ileocolic resection (ICR) for Crohn's disease (CD) is an important consideration. This study aims to identify the factors associated with an increased likelihood of a stoma and develop a predictive scoring ... ...

    Abstract Purpose: The likelihood of a stoma following ileocolic resection (ICR) for Crohn's disease (CD) is an important consideration. This study aims to identify the factors associated with an increased likelihood of a stoma and develop a predictive scoring system (SS).
    Methods: Patient data were collected from St. Marks Hospital, London, UK and Humanitas Clinical and Research Center, Milan, Italy, on all patients who underwent an ICR for CD from 2005 to 2017. A logistic regression analysis was used for multivariate analysis. The SS was developed from the logistic regression model. The performance of the SS was evaluated using receiver operating characteristics area under the curve (AUROC).
    Results: A total of 628 surgeries were included in the analysis. Sixty-nine surgeries were excluded due to missing data. The remaining 559 were divided into two cohorts for the scoring system's development (n = 434) and validation (n = 125). The regression model was statistically significant (p < 0.0001). The statistically significant independent variables included sex, preoperative albumin and haemoglobin levels, surgical access and simultaneous colonic resection. The AUROC for the development and validation cohorts were 0.803 and 0.905, respectively (p < 0.0001). Youden's index suggested the cut-off score of - 95.9, with a sensitivity of 87.6% and a specificity of 62.9%.
    Conclusions: Male sex, low preoperative albumin, anaemia, laparoscopic conversion and simultaneous colonic resection were associated with an increased likelihood of requiring a stoma and were used to develop an SS. The calculator is available online at https://rebrand.ly/CrohnsStoma .
    MeSH term(s) Humans ; Male ; Crohn Disease/surgery ; Colectomy ; Anastomosis, Surgical ; Colon/surgery ; Albumins ; Retrospective Studies
    Chemical Substances Albumins
    Language English
    Publishing date 2022-07-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02626-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Right sided diverticulitis in western countries: A review.

    Epifani, Angelo Gabriele / Cassini, Diletta / Cirocchi, Roberto / Accardo, Caterina / Di Candido, Francesca / Ardu, Massimiliano / Baldazzi, Gianandrea

    World journal of gastrointestinal surgery

    2022  Volume 13, Issue 12, Page(s) 1721–1735

    Abstract: Background: Although the treatment guidelines for left sided diverticulitis are clear, the management of right colonic diverticulitis is not well established. This disease can no longer be ignored due to significant spread throughout Asia.: Aim: To ... ...

    Abstract Background: Although the treatment guidelines for left sided diverticulitis are clear, the management of right colonic diverticulitis is not well established. This disease can no longer be ignored due to significant spread throughout Asia.
    Aim: To analyse epidemiology, diagnosis and treatment of right-sided diverticulitis in western countries.
    Methods: MEDLINE and PubMed searches were performed using the key words "right-sided diverticulitis'', ''right colon diverticulitis'', ''caecal diverticulitis'', ''ascending colon diverticulitis'' and ''caecum diverticula'' in order to find relevant articles published until 2021.
    Results: A total of 18 studies with 422 patients were found. Correct diagnosis was made only in 32.2%, mostly intraoperatively or
    Conclusion: The management of right- sided diverticulitis is not well clarified in the western world and no selective guidelines have been considered even if principles are similar to those with left- sided diverticulitis. Wrong diagnosis is one of the most important problems and CT scan seems to be the best imaging modality. NOM offers a safe and effective treatment; surgery should be considered only in cases of complicated diverticulitis or if malignancy cannot be excluded. Further studies are needed to clarify the correct treatment.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v13.i12.1721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Fistula Between a Primary Sigmoid Large B-Cell Lymphoma and an Ovarian Teratoma.

    Accardo, Caterina / Ardu, Massimiliano / Di Candido, Francesca / Epifani, Gabriele / Cassini, Diletta / Bono, Francesca / Baldazzi, Gianandrea

    ACG case reports journal

    2022  Volume 9, Issue 6, Page(s) e00794

    Abstract: Primary colorectal lymphoma is a rare neoplasm. We report the case of a fistula between a diffuse large B-cell lymphoma of the sigmoid colon and an ovarian teratoma. An emergent laparotomy for an acute abdomen in a 90-year-old woman was performed. A ... ...

    Abstract Primary colorectal lymphoma is a rare neoplasm. We report the case of a fistula between a diffuse large B-cell lymphoma of the sigmoid colon and an ovarian teratoma. An emergent laparotomy for an acute abdomen in a 90-year-old woman was performed. A pelvic mass of 12 × 9 cm fistulized in the left colon was found with the presence of gas and free liquid within the abdomen. This is an extremely rare condition, and as far as we know, no cases of a fistula between a large B-cell colonic lymphoma and an ovarian teratoma are present in the literature.
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000794
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Darvadstrocel for the treatment of patients with perianal fistulas in Crohn's disease.

    Kotze, P G / Spinelli, A / Warusavitarne, J / Di Candido, F / Sahnan, K / Adegbola, S O / Danese, S

    Drugs of today (Barcelona, Spain : 1998)

    2019  Volume 55, Issue 2, Page(s) 95–105

    Abstract: Despite significant advances in medical and surgical therapy for perianal fistulas in Crohn's disease (CD), treatment results are still modest, and a specific need for more effective therapies is a reality. Darvadstrocel is composed of expanded human ... ...

    Abstract Despite significant advances in medical and surgical therapy for perianal fistulas in Crohn's disease (CD), treatment results are still modest, and a specific need for more effective therapies is a reality. Darvadstrocel is composed of expanded human allogeneic mesenchymal adult stem cells extracted from adipose tissue and constitutes the first stem cell therapy for perianal fistulizing CD to receive approval from the European Medicines Agency (EMA). This therapy is injected in both internal and external openings, as well as inside the fistula tracks, to induce fistula healing. In this monograph, the authors review the preclinical pharmacology of darvadstrocel, as well as pharmacokinetics and metabolism, and cover the main indications and detailed information on the efficacy and safety profile of the agent. Possible interactions with other agents used to treat CD are also explored. Darvadstrocel is a safe and effective therapy for perianal complex fistulas in CD, and represents the beginning of a new era of mesenchymal stem cell therapy in this difficult phenotype of the disease.
    MeSH term(s) Adipose Tissue/cytology ; Adult ; Crohn Disease/complications ; Crohn Disease/therapy ; Humans ; Rectal Fistula/etiology ; Rectal Fistula/therapy ; Stem Cell Transplantation ; Treatment Outcome
    Language English
    Publishing date 2019-04-10
    Publishing country Spain
    Document type Journal Article ; Review
    ISSN 1699-3993
    ISSN 1699-3993
    DOI 10.1358/dot.2019.55.2.2914336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Patient-reported functional and quality-of-life outcomes after transanal total mesorectal excision.

    Keller, D S / Reali, C / Spinelli, A / Penna, M / Di Candido, F / Cunningham, C / Hompes, R

    The British journal of surgery

    2019  Volume 106, Issue 4, Page(s) 364–366

    Abstract: Follow-up of more than 1 year after transanal total mesorectal excision for rectal cancer demonstrated improved quality of life and stable or improved functional outcomes. Continued experience and operative efficiency hold promise for improved overall ... ...

    Abstract Follow-up of more than 1 year after transanal total mesorectal excision for rectal cancer demonstrated improved quality of life and stable or improved functional outcomes. Continued experience and operative efficiency hold promise for improved overall outcomes with this emerging technology. Key patient-reported outcomes.
    MeSH term(s) Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Aged ; Analysis of Variance ; Disease-Free Survival ; Endoscopic Mucosal Resection/methods ; Endoscopic Mucosal Resection/mortality ; Female ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Quality of Life ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery ; Registries ; Risk Assessment ; Statistics, Nonparametric ; Survival Analysis ; Transanal Endoscopic Surgery/methods ; Transanal Endoscopic Surgery/mortality ; Treatment Outcome
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.11069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction to: Transanal irrigation in functional bowel disorders and LARS: short‑term results from an Italian national study.

    Falletto, E / Martellucci, J / Rossitti, P / Bondurri, A / Zaffaroni, G / Ascanelli, S / Chimisso, L / Lauretta, A / Mirafiori, M / Clementi, I / Ripetti, V / Luffarelli, P / Cestaro, G / Bottini, C / Bellini, M / Lambiase, C / Di Candido, F / Zattoni, D / Cornaglia, S /
    Tonello, P / Zucchi, E

    Techniques in coloproctology

    2023  Volume 27, Issue 12, Page(s) 1413–1414

    Language English
    Publishing date 2023-10-23
    Publishing country Italy
    Document type Published Erratum
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-023-02871-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Transanal irrigation in functional bowel disorders and LARS: short-term results from an Italian national study.

    Falletto, E / Martellucci, J / Rossitti, P / Bondurri, A / Zaffaroni, G / Ascanelli, S / Chimisso, L / Lauretta, A / Mirafiori, M / Clementi, I / Ripetti, V / Lufarelli, P / Cestaro, G / Bottini, C / Bellini, M / Lambiase, C / Di Candido, F / Zattoni, D / Cornaglia, S /
    Tonello, P / Zucchi, E

    Techniques in coloproctology

    2023  Volume 27, Issue 6, Page(s) 481–490

    Abstract: Purpose: To evaluate the potential benefits associated with the short-term (6 months) treatment with transanal irrigation (TAI) in patients suffering from functional constipation (FC), functional fecal incontinence (FI), and low anterior resection ... ...

    Abstract Purpose: To evaluate the potential benefits associated with the short-term (6 months) treatment with transanal irrigation (TAI) in patients suffering from functional constipation (FC), functional fecal incontinence (FI), and low anterior resection syndrome (LARS).
    Methods: A multicenter observational study (12 centers; 369 patients) was conducted to assess the following primary and secondary objectives: to evaluate the level of satisfaction regarding bowel control and quality of life (QoL); to evaluate bowel symptoms severity and dropout frequency and reason. To this aim, validated questionnaires were provided to the patients at baseline (T0) and after 6 months of TAI treatment (T6) performed with the medical device Peristeen
    Results: A 6-month treatment with TAI enabled a statistically significant (p < 0.05) improvement of QoL scores, satisfaction scores regarding bowel control, and severity indexes of disorder-related symptoms in patients suffering from FC, FI, and LARS. Globally, 8.0% of patients discontinued the treatment after 6 months as a result of occurrence of symptoms (2.4%) or other justifications (3.8%) such as personal reasons. None of the dropouts were due to treatment inefficacy.
    Conclusion: Results of the present study suggest that short-term TAI treatment is beneficial for patients suffering from functional bowel disorders and LARS. Future analysis of prospective data will focus on the clinical outcomes associated with the long-term use (up to 24 months) of TAI when dealing with these types of medical conditions.
    MeSH term(s) Humans ; Quality of Life ; Postoperative Complications ; Prospective Studies ; Rectal Neoplasms ; Irritable Bowel Syndrome/therapy ; Low Anterior Resection Syndrome
    Language English
    Publishing date 2023-04-25
    Publishing country Italy
    Document type Multicenter Study ; Observational Study ; Journal Article
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-023-02800-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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