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  1. Article: Multiple sclerosis--new treatment modalities.

    Totaro, Rocco / Di Carmine, Caterina / Marini, Carmine / Carolei, Antonio

    The Indian journal of medical research

    2016  Volume 142, Issue 6, Page(s) 647–654

    Abstract: Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate ...

    Abstract Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate treatment to the right patient at the right time. The purpose of this review is to describe novel agents recently approved for multiple sclerosis treatment, namely teriflunomide, alemtuzumab and dimethylfumarate, focusing on mechanism of action, efficacy data in experimental setting, safety and tolerability. The place in therapy of newer treatment implies careful balancing of risk-benefit profile as well as accurate patient selection. Hence the widening of therapeutic arsenal provides greater opportunity for personalized therapy but also entails a complex trade-off between efficacy, tolerability, safety and eventually patient preference.
    MeSH term(s) Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal/therapeutic use ; Clinical Trials as Topic ; Humans ; Multiple Sclerosis/drug therapy
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2016-02-01
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/0971-5916.174543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Distribution and Temporal Trends From 1993 to 2015 of Ischemic Stroke Subtypes: A Systematic Review and Meta-Analysis.

    Ornello, Raffaele / Degan, Diana / Tiseo, Cindy / Di Carmine, Caterina / Perciballi, Laura / Pistoia, Francesca / Carolei, Antonio / Sacco, Simona

    Stroke

    2018  Volume 49, Issue 4, Page(s) 814–819

    Abstract: Background and purpose: Preventive strategies, together with demographic and socioeconomic changes, might have modified the worldwide distribution of ischemic stroke (IS) subtypes. We investigated those changes by means of a systematic review and meta- ... ...

    Abstract Background and purpose: Preventive strategies, together with demographic and socioeconomic changes, might have modified the worldwide distribution of ischemic stroke (IS) subtypes. We investigated those changes by means of a systematic review and meta-analysis.
    Methods: We evaluated all population- and hospital-based studies reporting the distribution of IS etiologic subtypes according to the TOAST criteria (Trial of ORG 10172 in Acute Stroke Treatment). Studies were identified by searching articles indexed on PubMed and Scopus from January 1, 1993, to June 30, 2017. Two independent investigators extracted data and checked them for accuracy. Proportions of each etiologic subtype were pooled according to a random effect meta-analytic model weighted by study size; temporal trends were assessed using a mixed-effect meta-regression model.
    Results: Sixty-five studies including patients from 1993 to 2015 were finally included. Overall, ISs were attributed to cardioembolism (22%; 95% confidence interval [CI], 20-23); large artery atherosclerosis (23%; 95% CI, 21-25); small artery occlusion (22%; 95% CI, 21-24); other determined cause (3%; 95% CI, 3-3); and undetermined cause (26%; 95% CI, 24-28). Cardioembolism was the leading IS etiologic subtype in whites (28%; 95% CI, 26-29) and large artery atherosclerosis in Asians (33%; 95% CI, 31-36). Meta-regression showed an increasing temporal trend for cardioembolism in whites (2.4% annually,
    Conclusions: According to our systematic review and meta-analysis, cardioembolism in whites and large artery atherosclerosis in Asians are the leading causes of IS. The heterogeneous distribution of etiologic subtypes of IS may depend on the demographic and socioeconomic characteristics of the different populations. More extensive protocols should be adopted to reduce the persistently relevant proportion of undetermined cause IS.
    MeSH term(s) African Continental Ancestry Group ; Arterial Occlusive Diseases/epidemiology ; Arterial Occlusive Diseases/ethnology ; Asian Continental Ancestry Group ; Brain Ischemia/epidemiology ; Brain Ischemia/ethnology ; Cerebral Small Vessel Diseases/epidemiology ; Cerebral Small Vessel Diseases/ethnology ; European Continental Ancestry Group ; Humans ; Intracranial Arteriosclerosis/epidemiology ; Intracranial Arteriosclerosis/ethnology ; Intracranial Embolism/epidemiology ; Intracranial Embolism/ethnology ; Population Growth ; Regression Analysis ; Stroke/epidemiology ; Stroke/ethnology
    Language English
    Publishing date 2018-03-13
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.117.020031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 448: Show issues Location:
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  3. Article ; Online: Is size an essential criterion to define tumefactive plaque? MR features and clinical correlation in multiple sclerosis.

    Patriarca, Lucia / Torlone, Silvia / Ferrari, Fabiana / Di Carmine, Caterina / Totaro, Rocco / di Cesare, Ernesto / Splendiani, Alessandra

    The neuroradiology journal

    2016  Volume 29, Issue 5, Page(s) 384–389

    Abstract: Tumefactive multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. It has recently been described as a rare subtype of multiple sclerosis (MS) characterised by the appearance of solitary or multiple space-occupying ... ...

    Abstract Tumefactive multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. It has recently been described as a rare subtype of multiple sclerosis (MS) characterised by the appearance of solitary or multiple space-occupying lesions associated with imaging characteristics mimicking neoplasm. Atypical features include plaque size >2 cm with mass effect, oedema, and/or ring enhancement on magnetic resonance (MR) images.This study is a retrospective review designed to evaluate the prevalence of tumefactive plaques in a selected population of 440 MS patients referred to our MS centre in Southern Italy between 2005 and 2014. We analysed the radiographic features of lesions ranging in size from 0.5 to 2 cm to establish whether smaller plaques with MR characteristics similar to tumefactive plaques present different symptoms, disease evolution and prognosis. We also aimed to ascertain if MR features suggestive of biological aggressiveness could be useful prognostic criteria for a correct diagnosis of the disease and subsequent treatment. Our data suggest that lesions 0.5-2 cm and >2 cm have similar MR features and clinical evolution.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis/diagnostic imaging ; Multiple Sclerosis/pathology ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400916665385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2823: Show issues Location:
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  4. Article: Fingolimod Treatment in Relapsing-Remitting Multiple Sclerosis Patients: A Prospective Observational Multicenter Postmarketing Study.

    Totaro, Rocco / Di Carmine, Caterina / Costantino, Gianfranco / Fantozzi, Roberta / Bellantonio, Paolo / Fuiani, Aurora / Mundi, Ciro / Ruggieri, Stefano / Marini, Carmine / Carolei, Antonio

    Multiple sclerosis international

    2015  Volume 2015, Page(s) 763418

    Abstract: Objective. The aim of this prospective observational multicenter postmarketing study was to evaluate fingolimod efficacy in a real world clinical setting. Methods. One hundred forty-two subjects with relapsing-remitting multiple sclerosis (RRMS) were ... ...

    Abstract Objective. The aim of this prospective observational multicenter postmarketing study was to evaluate fingolimod efficacy in a real world clinical setting. Methods. One hundred forty-two subjects with relapsing-remitting multiple sclerosis (RRMS) were enrolled in three multiple sclerosis centers throughout Central and Southern Italy between January 2011 and September 2013. After enrollment, regular visits and EDSS assessment were scheduled every 3 months, and MRI scan was obtained every 12 months. Patients were followed up from 1 to 33 months (mean 14.95 ± 9.15 months). The main efficacy endpoints included the proportion of patients free from clinical relapses, from disability progression, from magnetic resonance imaging activity, and from any disease activity. Results. Out of 142 patients enrolled in the study, 88.1% were free from clinical relapse and 69.0% were free from disability progression; 68.5% of patients remained free from new or newly enlarging T2 lesions and 81.7% of patients were free from gadolinium enhancing lesions. Overall the proportion of patients free from any disease activity was 41.9%. Conclusions. Our data in a real world cohort are consistent with previous findings that yield convincing evidence for the efficacy of fingolimod in patients with RRMS.
    Language English
    Publishing date 2015-07-22
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2603577-7
    ISSN 2090-2662 ; 2090-2654
    ISSN (online) 2090-2662
    ISSN 2090-2654
    DOI 10.1155/2015/763418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Defining the course of tumefactive multiple sclerosis: A large retrospective multicentre study.

    Di Gregorio, Maria / Torri Clerici, Valentina Liliana Adriana / Fenu, Giuseppe / Gaetani, Lorenzo / Gallo, Antonio / Cavalla, Paola / Ragonese, Paolo / Annovazzi, Pietro / Gajofatto, Alberto / Prosperini, Luca / Landi, Doriana / Nicoletti, Carolina Gabri / Di Carmine, Caterina / Totaro, Rocco / Nociti, Viviana / De Fino, Chiara / Ferraro, Diana / Tomassini, Valentina / Tortorella, Carla /
    Righini, Isabella / Amato, Maria Pia / Manni, Alessia / Paolicelli, Damiano / Iaffaldano, Pietro / Lanzillo, Roberta / Moccia, Marcello / Buttari, Fabio / Fantozzi, Roberta / Cerqua, Raffaella / Zagaglia, Sara / Farina, Deborah / De Luca, Giovanna / Buscarinu, Maria Chiara / Pinardi, Federica / Cocco, Eleonora / Gasperini, Claudio / Solaro, Claudio Marcello / Di Filippo, Massimiliano

    European journal of neurology

    2021  Volume 28, Issue 4, Page(s) 1299–1307

    Abstract: Background and purpose: Tumefactive multiple sclerosis (TuMS) (i.e., MS onset presenting with tumefactive demyelinating lesions [TDLs]) is a diagnostic and therapeutic challenge. We performed a multicentre retrospective study to describe the clinical ... ...

    Abstract Background and purpose: Tumefactive multiple sclerosis (TuMS) (i.e., MS onset presenting with tumefactive demyelinating lesions [TDLs]) is a diagnostic and therapeutic challenge. We performed a multicentre retrospective study to describe the clinical characteristics and the prognostic factors of TuMS.
    Methods: One hundred two TuMS patients were included in this retrospective study. Demographic, clinical, magnetic resonance imaging (MRI), laboratory data and treatment choices were collected.
    Results: TuMS was found to affect women more than men (female:male: 2.4), with a young adulthood onset (median age: 29.5 years, range: 11-68 years, interquartile range [IQR]: 38 years). At onset, 52% of TuMS patients presented with the involvement of more than one functional system and 24.5% of them with multiple TDLs. TDLs most frequently presented with an infiltrative MRI pattern (38.7%). Cerebrospinal fluid immunoglobulin G oligoclonal bands were often demonstrated (76.6%). In 25.3% of the cases, more than one acute-phase treatment was administered, and almost one-half of the patients (46.6%) were treated with high-efficacy treatments. After a median follow-up of 2.3 years (range: 0.1-10.7 years, IQR: 3.4 years), the median Expanded Disability Status Scale (EDSS) score was 1.5 (range: 0-7, IQR: 2). Independent risk factors for reaching an EDSS score ≥3 were a higher age at onset (odds ratio [OR]: 1.08, 95% confidence interval [CI]: 1.03-1.14, p < 0.01), a higher number of TDLs (OR: 1.67, 95% CI: 1.02-2.74, p < 0.05) and the presence of infiltrative TDLs (OR: 3.34, 95% CI: 1.18-9.5, p < 0.001) at baseline.
    Conclusions: The management of TuMS might be challenging because of its peculiar characteristics. Large prospective studies could help to define the clinical characteristics and the best treatment algorithms for people with TuMS.
    MeSH term(s) Adolescent ; Adult ; Aged ; Child ; Demyelinating Diseases ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multiple Sclerosis/diagnostic imaging ; Oligoclonal Bands ; Prospective Studies ; Retrospective Studies ; Young Adult
    Chemical Substances Oligoclonal Bands
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.14672
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    Zs.A 4738: Show issues Location:
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  6. Article ; Online: Updates on Somatoform Disorders (SFMD) in Parkinson's Disease and Dementia with Lewy Bodies and discussion of phenomenology.

    Onofrj, Marco / Thomas, Astrid / Tiraboschi, Pietro / Wenning, Gregor / Gambi, Francesco / Sepede, Gianna / Di Giannantonio, Massimo / Di Carmine, Caterina / Monaco, Daniela / Maruotti, Valerio / Ciccocioppo, Fausta / D'Amico, Maria Chiara / Bonanni, Laura

    Journal of the neurological sciences

    2011  Volume 310, Issue 1-2, Page(s) 166–171

    Abstract: Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients ... ...

    Abstract Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had neurodegenerative diseases and 1718 psychiatric disorders. After 2-9 years of follow up, 488 patients were labelled as PD, 415 as Alzheimer Disease, 162 as DLB, 48 as Progressive Supranuclear Palsy, 48 as Multiple System Atrophy and 49 as Fronto-Temporal Dementia. The frequency of SFMD (DSM-IV-TR criteria) was determined in each diagnostic category by direct observation of SFMD symptoms, psychiatric interviews, SCL 90Rss, collection of previous general practitioners and hospital charts. The frequency of SFMD was considerably higher in DLB (29 patients, 18%) and PD (37 patients, 7.5%) than in any other group (0-2%). The frequency of SFMD in psychiatric patients was 2%. SFMD in PD and DLB were characterised by motor and non-motor patterns and were often accompanied by catatonic signs consisting of posturing stereotypies and negativism (55%). SFMD symptoms preceded PD motor signs by 6 months-5 years in 92% of the 29 DLB and 37 PD patients and in 70% SFMD were recurrent at follow-up. In 93% of these patients, hypochondria was a preceding or concomitant background.
    MeSH term(s) Aged ; Aged, 80 and over ; Consciousness ; Female ; Humans ; Lewy Body Disease/complications ; Lewy Body Disease/epidemiology ; Male ; Parkinson Disease/complications ; Parkinson Disease/epidemiology ; Psychiatric Status Rating Scales ; Retrospective Studies ; Somatoform Disorders/diagnosis ; Somatoform Disorders/epidemiology ; Somatoform Disorders/etiology ; Somatoform Disorders/psychology
    Language English
    Publishing date 2011-11-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2011.07.010
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