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Book ; Online: Giovani a tempo indeterminato. Valori e atteggiamenti dei giovani romani

Di Franco, Giovanni

2017

Abstract: Being young in Italy in times of crisis means living with a mood that oscillates between depression and euphoria. Rather than thinking about the future, which is not known in any way, it is useful to look for some satisfaction in an eternal present time. ...

Abstract	Being young in Italy in times of crisis means living with a mood that oscillates between depression and euphoria. Rather than thinking about the future, which is not known in any way, it is useful to look for some satisfaction in an eternal present time. The Italian young peoples lives are suspended, invisible, lost, delayed, resized. They are those of an indefinite youth
Keywords	Sociology (General) ; Social sciences (General)
Size	1 electronic resource ( p.)
Publisher	FrancoAngeli
Document type	Book ; Online
Note	Italian ; Open Access
HBZ-ID	HT020097904
ISBN	9788891756404 ; 8891756407
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Establishment of Zebrafish Patient-derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing.

Usai, Alice / Di Franco, Gregorio / Gabellini, Chiara / Morelli, Luca / Raffa, Vittoria

Journal of visualized experiments : JoVE

2023 , Issue 195

Abstract: Cancer is one of the main causes of death worldwide, and the incidence of many types of cancer continues to increase. Much progress has been made in terms of screening, prevention, and treatment; however, preclinical models that predict the ... ...

Abstract	Cancer is one of the main causes of death worldwide, and the incidence of many types of cancer continues to increase. Much progress has been made in terms of screening, prevention, and treatment; however, preclinical models that predict the chemosensitivity profile of cancer patients are still lacking. To fill this gap, an in vivo patient-derived xenograft model was developed and validated. The model was based on zebrafish (Danio rerio) embryos at 2 days post fertilization, which were used as recipients of xenograft fragments of tumor tissue taken from a patient's surgical specimen. It is also worth noting that bioptic samples were not digested or disaggregated, in order to maintain the tumor microenvironment, which is crucial in terms of analyzing tumor behavior and the response to therapy. The protocol details a method for establishing zebrafish-based patient-derived xenografts (zPDXs) from primary solid tumor surgical resection. After screening by an anatomopathologist, the specimen is dissected using a scalpel blade. Necrotic tissue, vessels, or fatty tissue are removed and then chopped into 0.3 mm x 0.3 mm x 0.3 mm pieces. The pieces are then fluorescently labeled and xenotransplanted into the perivitelline space of zebrafish embryos. A large number of embryos can be processed at a low cost, enabling high-throughput in vivo analyses of the chemosensitivity of zPDXs to multiple anticancer drugs. Confocal images are routinely acquired to detect and quantify the apoptotic levels induced by chemotherapy treatment compared to the control group. The xenograft procedure has a significant time advantage, since it can be completed in a single day, providing a reasonable time window to carry out a therapeutic screening for co-clinical trials.
MeSH term(s)	Humans ; Animals ; Zebrafish ; Heterografts ; Pancreatic Neoplasms/drug therapy ; Adipose Tissue ; Disease Models, Animal ; Tumor Microenvironment ; Pancreatic Neoplasms
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/63744
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Article ; Online: Minimally Invasive Surgery for the Treatment of Moderate to Critical Acute Pancreatitis: A Case-matched Comparison With the Traditional Open Approach Over 10 years.

Morelli, Luca / Guadagni, Simone / Palmeri, Matteo / Bechini, Bianca / Gianardi, Desirée / Furbetta, Niccolò / Di Franco, Gregorio / Di Candio, Giulio

Surgical laparoscopy, endoscopy & percutaneous techniques

2023 Volume 33, Issue 2, Page(s) 191–197

Abstract: Purpose: The purpose of this study is to compare short-term and midterm outcomes between patients with acute pancreatitis (AP) treated with minimally invasive surgery (MIS) and patients treated with open necrosectomy (ON).: Materials and methods: We ... ...

Abstract	Purpose: The purpose of this study is to compare short-term and midterm outcomes between patients with acute pancreatitis (AP) treated with minimally invasive surgery (MIS) and patients treated with open necrosectomy (ON). Materials and methods: We compared data of all patients who had undergone MIS for AP with a similar group of patients with ON patients between January 2012 and June 2021 using a case-matched methodology based on AP severity and patient characteristics. Inhospital and midterm follow-up variables, including quality-of-life assessment, were evaluated. Results: Starting from a whole series of 79 patients with moderate to critical AP admitted to our referral center, the final study sample consisted of 24 patients (12 MIS and 12 ON). Postoperative (18.7±10.9 vs. 30.3±21.7 d; P =0.05) and overall hospitalization (56.3±17.4 vs. 76.9±39.4 d; P =0.05) were lower in the MIS group. Moreover, the Short-Form 36 scores in the ON group were statistically significantly lower in role limitations because of emotional problems ( P =0.002) and health changes ( P =0.03) at 3 and 6 months and because of emotional problems ( P =0.05), emotional well-being ( P =0.02), and general health ( P =0.007) at 1 year. Conclusions: MIS for the surgical management of moderate to critical AP seems to be a good option, as it could provide more chances for a better midterm quality of life compared with ON. Further studies are needed to confirm our findings.
MeSH term(s)	Humans ; Treatment Outcome ; Quality of Life ; Acute Disease ; Pancreatitis/surgery ; Minimally Invasive Surgical Procedures/methods ; Retrospective Studies
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1475108-2
ISSN	1534-4908 ; 1530-4515 ; 1051-7200
ISSN (online)	1534-4908
ISSN	1530-4515 ; 1051-7200
DOI	10.1097/SLE.0000000000001157
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Article ; Online: Use of 3D models for planning, simulation, and training in vascular surgery.

Moglia, Andrea / Di Franco, Gregorio / Morelli, Luca

Updates in surgery

2019 Volume 71, Issue 1, Page(s) 185–186

MeSH term(s)	Imaging, Three-Dimensional ; Printing, Three-Dimensional ; Vascular Surgical Procedures
Language	English
Publishing date	2019-02-25
Publishing country	Italy
Document type	Letter ; Comment
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-019-00636-1
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Article ; Online: Alternative uses of virtual simulators for laparoscopy and robot-assisted surgery for medical students.

Di Franco, Gregorio / Gianardi, Desirée / Berchiolli, Raffaella

Updates in surgery

2019 Volume 71, Issue 2, Page(s) 397–398

MeSH term(s)	Clinical Competence ; Computer Simulation ; Education, Medical/methods ; Humans ; Laparoscopy/education ; Robotic Surgical Procedures/education ; Students, Medical ; Virtual Reality
Language	English
Publishing date	2019-01-08
Publishing country	Italy
Document type	Letter
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-018-00621-0
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Article ; Online: Technical details for a robot-assisted hand-sewn esophago-gastric anastomosis during minimally invasive Ivor Lewis esophagectomy.

Peri, A / Furbetta, N / Viganò, J / Pugliese, L / Di Franco, G / Latteri, F S / Mineo, N / Bruno, F C / Gallo, V / Morelli, L / Pietrabissa, A

Surgical endoscopy

2021 Volume 36, Issue 2, Page(s) 1675–1682

Abstract: Background: Minimally invasive Ivor Lewis esophagectomy (MIILE) provides better outcomes than open techniques, particularly in terms of post-operative recovery and pulmonary complications. However, in addition to requiring advanced technical skills, ... ...

Abstract	Background: Minimally invasive Ivor Lewis esophagectomy (MIILE) provides better outcomes than open techniques, particularly in terms of post-operative recovery and pulmonary complications. However, in addition to requiring advanced technical skills, thoracoscopic access makes it hard to perform esophagogastric anastomosis safely, and the reported rates of anastomotic leak vary from 5 to 16%. Several minimally invasive esophago-gastric anastomotic techniques have been described, but to date strong evidence to support one technique over the others is still lacking. We herein report the technical details and preliminary results of a new robot-assisted hand-sewn esophago-gastric anastomosis technique. Methods: From January 2018 to December 2020, 12 cases of laparoscopic/thoracoscopic Ivor Lewis esophagectomy with robot-assisted hand-sewn esophago-gastric anastomosis were performed. The gastric conduit was prepared and tailored taking care of vascularization with a complete resection of the gastric fundus. The anastomosis consisted of a robot-assisted, hand-sewn four layers of absorbable monofilament running barbed suture (V-lock). The posterior outer layer incorporated the gastric and esophageal staple lines. Results: The post-operative course was uneventful in nine cases. Two patients developed chyloperitoneum, one patient a Sars-Cov-2 infection, and one patient a late anastomotic stricture. In all cases, there were no anastomotic leaks or delayed gastric conduit emptying. The median post-operative stay was 13 days (min 7, max 37 days); the longest in-hospital stay was recorded in patients who developed chyloperitoneum. Conclusion: Despite the small series, we believe that our technique looks to be promising, safe, and reproducible. Some key points may be useful to guarantee a low complications rate after MIILE, particularly regarding anastomotic leaks and delayed emptying: the resection of the gastric fundus, the use of robot assistance, the incorporation of the staple lines in the posterior aspect of the anastomosis, and the use of barbed suture. Further cases are needed to validate the preliminary, but very encouraging, results.
MeSH term(s)	Anastomosis, Surgical ; Anastomotic Leak/etiology ; COVID-19 ; Esophageal Neoplasms/surgery ; Esophagectomy ; Humans ; Retrospective Studies ; Robotics ; SARS-CoV-2
Language	English
Publishing date	2021-09-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08715-4
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Article ; Online: Should we use virtual simulators for surgical resident selection?

Morelli, Luca / Di Franco, Gregorio / Moglia, Andrea / Cuschieri, Alfred

Journal of robotic surgery

2019 Volume 13, Issue 4, Page(s) 605–606

MeSH term(s)	Clinical Competence ; Computer Simulation ; Humans ; Internship and Residency ; Robotic Surgical Procedures
Language	English
Publishing date	2019-01-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2268283-1
ISSN	1863-2491 ; 1863-2483
ISSN (online)	1863-2491
ISSN	1863-2483
DOI	10.1007/s11701-018-00918-7
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Article: Robotic Hepatectomy plus Biliary Reconstruction for Bismuth Type III and Type IV Hilar Cholangiocarcinoma: State of the Art and Literature Review.

Guadagni, Simone / Comandatore, Annalisa / Furbetta, Niccolò / Di Franco, Gregorio / Carpenito, Cristina / Bechini, Bianca / Vagelli, Filippo / Ramacciotti, Niccolò / Palmeri, Matteo / Di Candio, Giulio / Morelli, Luca

Journal of personalized medicine

2023 Volume 14, Issue 1

Abstract: Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this ... ...

Abstract	Background: In Bismuth type III and IV Hilar Cholangiocarcinoma (III-IV HC), surgical resection is the only chance for long-term survival. As the surgical procedure is complex and Robotic-Assisted Surgery (RAS) may be particularly suitable in this setting, the aim of this study is to evaluate the potential benefits of RAS in III-IV HC in terms of post-operative outcomes. Methods: We conducted a systematic review using the PRISMA checklist for article selection. We searched the PubMed database and included only studies with clinical data about the treatment of III-IV HC using RAS. Results: A total of 12 papers involving 50 patients were included. All cases were Bismuth IIIa ( Conclusions: RAS for III-IV HC is safe and feasible, at least if performed by experienced surgeons on selected cases. The oncological outcomes appear acceptable, given the aggressiveness of this pathology, but further studies are needed to fully elucidate the exact role of robotics in this setting.
Language	English
Publishing date	2023-12-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010012
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Article ; Online: Initial 50 consecutive full-robotic pancreatoduodenectomies without conversion by a single surgeon: a learning curve analysis from a tertiary referral high-volume center.

Morelli, Luca / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Di Franco, Gregorio / Gianardi, Desirée / Cervelli, Rosa / Lorenzoni, Valentina / Comandatore, Annalisa / Carpenito, Cristina / Di Candio, Giulio / Cuschieri, Alfred

Surgical endoscopy

2023 Volume 37, Issue 5, Page(s) 3531–3539

Abstract: Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic ... ...

Abstract	Background: Several studies report on a learning curve for robotic pancreatoduodenectomy (R-PD) ranging between 20 and 80 operations, with conversion rates varying between 1.1 and 35%. However, as these publications mostly refer to initial robotic experiences and do not take into account the previous surgical background in pancreatic surgery (PS) and in robotic-assisted surgery (RAS), the center's volume, as well as the platform used, we aimed to perform a surgical outcomes analysis with a particular view to these aspects. Methods: Intraoperative and perioperative outcomes of the first 50 consecutive R-PD performed with the da Vinci Xi by the same surgeon, within a tertiary referral high-volume center, between January 2018 and March 2022, were analyzed. The surgeon was previously experienced in both PS and RAS. Shewhart control chart and cumulative sum (CUSUM) analysis were used to evaluate the learning curve of R-PD. Results: All the operations were performed with a full-robotic technique, without any conversion to open surgery. Twenty of 50 patients (40%) had a BMI ≥ 25 kg/m Conclusions: An extensive prior experience in both PS and RAS, within a tertiary referral high-volume center with availability of the da Vinci Xi platform, can significantly flatten the learning curve and, therefore, enable safe performance of challenging operations, i.e., pancreatoduodenectomies with a minimally invasive approach, with very low risk of conversion to open surgery, even in the first 50 operations.
MeSH term(s)	Humans ; Learning Curve ; Pancreaticoduodenectomy ; Referral and Consultation ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Surgeons/education
Language	English
Publishing date	2023-01-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-022-09784-9
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Article ; Online: Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy: Comparison between traditional open surgery and full-robotic approach with da Vinci Xi.

Morelli, Luca / Di Franco, Gregorio / Furbetta, Niccolò / Palmeri, Matteo / Guadagni, Simone / Gianardi, Desirée / Carpenito, Cristina / Comandatore, Annalisa / Giovannetti, Elisa / Di Candio, Giulio / Cuschieri, Alfred

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 , Page(s) e2571

Abstract: Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD.: Methods: Open ... ...

Abstract	Introduction: Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy, especially after pylorus preservation (Pp). We evaluated the effect of a fully robotic approach with da Vinci Xi on DGE after PpPD. Methods: Open and robotic PDs were performed in 353 and 50 cases, respectively, from January 2009 to March 2022. We compared the clinical outcomes and incidence of clinically relevant DGE between robotic PpPD (R-PpPD) and open PpPD after one-to-one case-control matching. Results: Each group consisted of 30 patients. Clinically relevant DGE was less common after R-PpPD (3/30 [10%] vs. 10/30 cases [33.3%], p = 0.028). The median length of hospital stay (LoS) was significantly lower in the R-PpPD group (10 vs. 15 days, p = 0.013). Conclusion: The reduced tissue trauma by the minimally invasive robotic approach is associated with a lower incidence of DGE, reducing the LoS and encouraging PpPD performed using the fully robotic approach.
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2571
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