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  1. AU="Di Gangi, Iole Maria"
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  1. Artikel: New insights in the slow ligand exchange reaction between Cr(III)-EDTA and Fe(III), and direct analysis of free and complexed EDTA in tannery wastewaters by liquid chromatography - Tandem mass spectrometry

    Roverso, Marco / Di Marco, Valerio / Favaro, Gabriella / Di Gangi, Iole Maria / Badocco, Denis / Zerlottin, Mirco / Refosco, Daniele / Tapparo, Andrea / Bogialli, Sara / Pastore, Paolo

    Chemosphere. 2021 Feb., v. 264

    2021  

    Abstract: EDTA and soluble Cr(III) are usually both present in wastewaters coming from treatment plants handling tannery effluents. A well-established method to determine EDTA is based on the conversion of free and complexed EDTA into its Fe(III) complex. This ... ...

    Abstract EDTA and soluble Cr(III) are usually both present in wastewaters coming from treatment plants handling tannery effluents. A well-established method to determine EDTA is based on the conversion of free and complexed EDTA into its Fe(III) complex. This procedure gives inconsistent data when Cr(III)-EDTA is present. This fact was here demonstrated by studying the kinetics of the exchange reaction between Fe(III) and Cr(III)-EDTA at 90 °C and various pH values, from acidic to neutral. The reaction is very slow (several weeks); the slow kinetics of conversion of Cr(III)-EDTA to Fe(III)-EDTA is even more accentuated at room temperature and the low concentrations of reactants in wastewaters. The presence of EDTA complexes of Fe(III) and Cr(III) was demonstrated in industrial effluents and wastewaters by developing a selective method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), which was able to detect free and complexed EDTA at concentration levels <1 μM. A systematic underestimation of the EDTA expressed as Fe(III) complex was demonstrated in samples containing Cr(III)-EDTA. Cr(III)-EDTA was identified for the first time as a component of wastewater samples at a concentration level of about 2 μM and turned out to be an inert species that significantly contributes to the final soluble Cr amount. This study gives new insights into the inertness of Cr(III) toward metal exchange equilibria of EDTA complexes, resolves a bias in the analysis of total EDTA in samples containing Cr(III)-EDTA, allowing the direct determination of free and complexed EDTA by LC-MS.
    Schlagwörter EDTA (chelating agent) ; chromium ; iron ; ligands ; liquid chromatography ; pH ; reaction kinetics ; tandem mass spectrometry ; tannery effluents ; wastewater
    Sprache Englisch
    Erscheinungsverlauf 2021-02
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    Anmerkung golden set
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.128487
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  2. Artikel: Ecotoxicological risk assessment for the herbicide glyphosate to non-target aquatic species: A case study with the mussel Mytilus galloprovincialis

    Matozzo, Valerio / Fabrello, Jacopo / Masiero, Luciano / Ferraccioli, Federico / Finos, Livio / Pastore, Paolo / Di Gangi, Iole Maria / Bogialli, Sara

    Environmental pollution. 2018 Feb., v. 233

    2018  

    Abstract: Glyphosate (GLY) is one of the most used herbicide worldwide. Considering that information concerning the impact of GLY on bivalves is scarce, in this study we evaluated for the first time the effects of environmentally realistic concentrations of GLY ( ... ...

    Abstract Glyphosate (GLY) is one of the most used herbicide worldwide. Considering that information concerning the impact of GLY on bivalves is scarce, in this study we evaluated for the first time the effects of environmentally realistic concentrations of GLY (10, 100 and 1000 μg/L) to the mussel Mytilus galloprovincialis. Mussels were exposed for 7, 14 and 21 days and several biomarkers were measured in haemocytes/haemolymph (total haemocyte counts, haemocyte diameter and volume, haemolymph pH, haemolymph lactate dehydrogenase activity, haemocyte lysate lysozyme and acid phosphatase activities), as well as in gills and digestive gland (antioxidant enzyme and acetylcholinesterase activities). The concentrations of GLY and its main metabolite aminomethylphosphonic acid in the experimental tanks were also measured. The MANOVA analysis demonstrated that the experimental variables considered (exposure concentration, exposure duration, and their interaction) affected significantly biomarker responses. In addition, the two-way ANOVA analysis indicated that GLY was able to affect most of the cellular parameters measured, whereas antioxidant enzyme activities resulted to be influenced moderately. Interestingly, exposure to GLY reduced significantly acetylcholinesterase activity in gills. Although preliminary, the results of this study demonstrated that GLY can affect both cellular and biochemical parameters in mussels, highlighting a potential risk for aquatic invertebrates.
    Schlagwörter Mytilus galloprovincialis ; acetylcholinesterase ; acid phosphatase ; analysis of variance ; antioxidants ; aquatic invertebrates ; biomarkers ; case studies ; ecotoxicology ; enzyme activity ; exposure duration ; gills ; glyphosate ; hemocytes ; lactate dehydrogenase ; lysozyme ; metabolites ; mussels ; pH ; risk ; risk assessment ; tanks
    Sprache Englisch
    Erscheinungsverlauf 2018-02
    Umfang p. 623-632.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2017.10.100
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  3. Artikel: Use of a LC-DAD-QTOF system for the characterization of the phenolic profile of the argentinean plant Zuccagnia punctata and of the related propolis: New biomarkers

    Solorzano, Eliana Rita / Bogialli, Sara / Bortolini, Claudio / Di Gangi, Iole Maria / Favaro, Gabriella / Maldonado, Luis / Pastore, Paolo

    Journal of functional foods. 2017 June, v. 33

    2017  

    Abstract: Argentinean northwestern propolis were included into the national Food Code, some of that were sometimes associated with Zuccagnia punctata, an endemic plant with interesting biological properties. An analytical protocol for characterizing the phenolic ... ...

    Abstract Argentinean northwestern propolis were included into the national Food Code, some of that were sometimes associated with Zuccagnia punctata, an endemic plant with interesting biological properties. An analytical protocol for characterizing the phenolic profile of Z. punctata by LC coupled to DAD-QTOF detection systems was proposed.Mass spectrometric and chromatographic selectivity allowed to recognize various compounds including isomers. Eleven compounds never mentioned before for this shrub were highlighted. Among them, two uncommon dihydrochalcones, i.e. 4′-hydroxy-2′-methoxydihydrochalcone and 2′,4′-dihydroxydihydrochalcone, were described for the first time as major constituents of Z. punctata, suggesting a peculiar biosynthetic pathway.Only the two propolis collected in the “Del Monte” phytogeographical region showed large amounts of molecules present in Z. punctata, which were proposed as markers of propolis type Z. punctata. Since Z. punctata exhibits a very interesting bioactivity, propolis derived from this plant can be used as nutraceutical food.
    Schlagwörter bioactive properties ; biomarkers ; chemical elements ; chromatography ; food law ; functional foods ; indigenous species ; isomers ; mass spectrometry ; phenolic compounds ; phytogeography ; propolis ; shrubs ; Zuccagnia ; Argentina
    Sprache Englisch
    Erscheinungsverlauf 2017-06
    Umfang p. 425-435.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2017.04.003
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  4. Artikel ; Online: New insights in the slow ligand exchange reaction between Cr(III)-EDTA and Fe(III), and direct analysis of free and complexed EDTA in tannery wastewaters by liquid chromatography - Tandem mass spectrometry.

    Roverso, Marco / Di Marco, Valerio / Favaro, Gabriella / Di Gangi, Iole Maria / Badocco, Denis / Zerlottin, Mirco / Refosco, Daniele / Tapparo, Andrea / Bogialli, Sara / Pastore, Paolo

    Chemosphere

    2020  Band 264, Heft Pt 1, Seite(n) 128487

    Abstract: EDTA and soluble Cr(III) are usually both present in wastewaters coming from treatment plants handling tannery effluents. A well-established method to determine EDTA is based on the conversion of free and complexed EDTA into its Fe(III) complex. This ... ...

    Abstract EDTA and soluble Cr(III) are usually both present in wastewaters coming from treatment plants handling tannery effluents. A well-established method to determine EDTA is based on the conversion of free and complexed EDTA into its Fe(III) complex. This procedure gives inconsistent data when Cr(III)-EDTA is present. This fact was here demonstrated by studying the kinetics of the exchange reaction between Fe(III) and Cr(III)-EDTA at 90 °C and various pH values, from acidic to neutral. The reaction is very slow (several weeks); the slow kinetics of conversion of Cr(III)-EDTA to Fe(III)-EDTA is even more accentuated at room temperature and the low concentrations of reactants in wastewaters. The presence of EDTA complexes of Fe(III) and Cr(III) was demonstrated in industrial effluents and wastewaters by developing a selective method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), which was able to detect free and complexed EDTA at concentration levels <1 μM. A systematic underestimation of the EDTA expressed as Fe(III) complex was demonstrated in samples containing Cr(III)-EDTA. Cr(III)-EDTA was identified for the first time as a component of wastewater samples at a concentration level of about 2 μM and turned out to be an inert species that significantly contributes to the final soluble Cr amount. This study gives new insights into the inertness of Cr(III) toward metal exchange equilibria of EDTA complexes, resolves a bias in the analysis of total EDTA in samples containing Cr(III)-EDTA, allowing the direct determination of free and complexed EDTA by LC-MS.
    Mesh-Begriff(e) Chromatography, Liquid ; Chromium/analysis ; Edetic Acid ; Ferric Compounds ; Ligands ; Tandem Mass Spectrometry ; Waste Water
    Chemische Substanzen Ferric Compounds ; Ligands ; Waste Water ; Chromium (0R0008Q3JB) ; Edetic Acid (9G34HU7RV0)
    Sprache Englisch
    Erscheinungsdatum 2020-10-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.128487
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  5. Artikel: Analytical metabolomics-based approaches to pancreatic cancer

    Di Gangi, Iole Maria / Fulvio Mattivi / Urska Vrhovsek / Valerio Pazienza

    Trends in analytical chemistry. 2014 Mar., v. 55

    2014  

    Abstract: We provide a comprehensive review of the analytical technologies applied in pancreatic cancer (PC) research, investigating tumor-associated metabolites identified as possible new biomarkers for screening the population at risk and for potential early ... ...

    Abstract We provide a comprehensive review of the analytical technologies applied in pancreatic cancer (PC) research, investigating tumor-associated metabolites identified as possible new biomarkers for screening the population at risk and for potential early tumor diagnosis. We briefly introduce PC tumorigenesis, risk factors and some of the benefits of studying changes to the metabolome associated with PC. We focus on the different matrices used in the studies and sample preparation for the analytical methods applied to PC specimens. We then delineate the advantages and the disadvantages of each analytical platform, pointing out the importance of extraction techniques in metabolomics approaches employed in PC research. We cover a number of case studies, and then review identified metabolites associated with PC. In the final section, we discuss possible approaches to understanding the link between metabolic profile and the onset of PC, which may provide insights into the physiopathological mechanisms involved in PC pathogenesis.
    Schlagwörter analytical methods ; at-risk population ; biomarkers ; carcinogenesis ; case studies ; metabolites ; metabolome ; metabolomics ; pancreatic neoplasms ; risk factors ; screening
    Sprache Englisch
    Erscheinungsverlauf 2014-03
    Umfang p. 94-116.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2013.12.006
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  6. Artikel ; Online: Liquid chromatography-high resolution mass spectrometric methods for the surveillance monitoring of cyanotoxins in freshwaters.

    Bogialli, Sara / Bortolini, Claudio / Di Gangi, Iole Maria / Di Gregorio, Federica Nigro / Lucentini, Luca / Favaro, Gabriella / Pastore, Paolo

    Talanta

    2017  Band 170, Seite(n) 322–330

    Abstract: A comprehensive risk management on human exposure to cyanotoxins, whose production is actually unpredictable, is limited by reliable analytical tools for monitoring as many toxic algal metabolites as possible. Two analytical approaches based on a LC-QTOF ...

    Abstract A comprehensive risk management on human exposure to cyanotoxins, whose production is actually unpredictable, is limited by reliable analytical tools for monitoring as many toxic algal metabolites as possible. Two analytical approaches based on a LC-QTOF system for target analysis and suspect screening of cyanotoxins in freshwater were presented. A database with 369 compounds belonging to cyanobacterial metabolites was developed and used for a retrospective data analysis based on high resolution mass spectrometry (HRMS). HRMS fragmentation of the suspect cyanotoxin precursor ions was subsequently performed for correctly identifying the specific variants. Alternatively, an automatic tandem HRMS analysis tailored for cyanotoxins was performed in a single chromatographic run, using the developed database as a preferred precursor ions list. Twenty-five extracts of surface and drinking waters contaminated by cyanobacteria were processed. The identification of seven uncommon microcystins (M(O)R, MC-FR, MSer
    Mesh-Begriff(e) Bacterial Toxins/analysis ; Chromatography, Liquid/methods ; Cyanobacteria/chemistry ; Cyanobacteria/isolation & purification ; Drinking Water/analysis ; Drinking Water/microbiology ; Environmental Monitoring/methods ; Fresh Water/analysis ; Fresh Water/microbiology ; Tandem Mass Spectrometry/methods ; Water Pollutants, Chemical/analysis
    Chemische Substanzen Bacterial Toxins ; Drinking Water ; Water Pollutants, Chemical
    Sprache Englisch
    Erscheinungsdatum 2017-04-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2017.04.033
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  7. Artikel ; Online: Ecotoxicological risk assessment for the herbicide glyphosate to non-target aquatic species: A case study with the mussel Mytilus galloprovincialis.

    Matozzo, Valerio / Fabrello, Jacopo / Masiero, Luciano / Ferraccioli, Federico / Finos, Livio / Pastore, Paolo / Di Gangi, Iole Maria / Bogialli, Sara

    Environmental pollution (Barking, Essex : 1987)

    2017  Band 233, Seite(n) 623–632

    Abstract: Glyphosate (GLY) is one of the most used herbicide worldwide. Considering that information concerning the impact of GLY on bivalves is scarce, in this study we evaluated for the first time the effects of environmentally realistic concentrations of GLY ( ... ...

    Abstract Glyphosate (GLY) is one of the most used herbicide worldwide. Considering that information concerning the impact of GLY on bivalves is scarce, in this study we evaluated for the first time the effects of environmentally realistic concentrations of GLY (10, 100 and 1000 μg/L) to the mussel Mytilus galloprovincialis. Mussels were exposed for 7, 14 and 21 days and several biomarkers were measured in haemocytes/haemolymph (total haemocyte counts, haemocyte diameter and volume, haemolymph pH, haemolymph lactate dehydrogenase activity, haemocyte lysate lysozyme and acid phosphatase activities), as well as in gills and digestive gland (antioxidant enzyme and acetylcholinesterase activities). The concentrations of GLY and its main metabolite aminomethylphosphonic acid in the experimental tanks were also measured. The MANOVA analysis demonstrated that the experimental variables considered (exposure concentration, exposure duration, and their interaction) affected significantly biomarker responses. In addition, the two-way ANOVA analysis indicated that GLY was able to affect most of the cellular parameters measured, whereas antioxidant enzyme activities resulted to be influenced moderately. Interestingly, exposure to GLY reduced significantly acetylcholinesterase activity in gills. Although preliminary, the results of this study demonstrated that GLY can affect both cellular and biochemical parameters in mussels, highlighting a potential risk for aquatic invertebrates.
    Mesh-Begriff(e) Animals ; Antioxidants/metabolism ; Biomarkers/metabolism ; Ecotoxicology ; Gills/metabolism ; Glycine/analogs & derivatives ; Glycine/metabolism ; Glycine/toxicity ; Hemocytes/drug effects ; Hemolymph/metabolism ; Herbicides/metabolism ; Herbicides/toxicity ; Mytilus/metabolism ; Mytilus/physiology ; Risk Assessment ; Water Pollutants, Chemical/metabolism ; Water Pollutants, Chemical/toxicity ; Glyphosate
    Chemische Substanzen Antioxidants ; Biomarkers ; Herbicides ; Water Pollutants, Chemical ; Glycine (TE7660XO1C)
    Sprache Englisch
    Erscheinungsdatum 2017-11-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2017.10.100
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  8. Artikel ; Online: Quantification of underivatised amino acids on dry blood spot, plasma, and urine by HPLC-ESI-MS/MS.

    Giordano, Giuseppe / Di Gangi, Iole Maria / Gucciardi, Antonina / Naturale, Mauro

    Methods in molecular biology (Clifton, N.J.)

    2012  Band 828, Seite(n) 219–242

    Abstract: Enzyme deficiencies in amino acid (AA) metabolism affecting the levels of amino acids and their derivatives in physiological fluids may serve as diagnostically significant biomarkers for one or a group of metabolic disorders. Therefore, it is important ... ...

    Abstract Enzyme deficiencies in amino acid (AA) metabolism affecting the levels of amino acids and their derivatives in physiological fluids may serve as diagnostically significant biomarkers for one or a group of metabolic disorders. Therefore, it is important to monitor a wide range of free amino acids simultaneously and to quantify them. This is time consuming if we use the classical methods and more than ever now that many laboratories have introduced Newborn Screening Programs for the semiquantitative analysis, detection, and quantification of some amino acids needed to be performed in a short time to reduce the rate of false positives.We have modified the stable isotope dilution HPLC-electrospray ionization (ESI)-MS/MS method previously described by Qu et al. (Anal Chem 74: 2034-2040, 2002) for a more rapid, robust, sensitive, and specific detection and quantification of underivatised amino acids. The modified method reduces the time of analysis to 10 min with very good reproducibility of retention times and a better separation of the metabolites and their isomers.The omission of the derivatization step allowed us to achieve some important advantages: fast and simple sample preparation and exclusion of artefacts and interferences. The use of this technique is highly sensitive, specific, and allows monitoring of 40 underivatized amino acids, including the key isomers and quantification of some of them, in order to cover many diagnostically important intermediates of metabolic pathways.We propose this HPLC-ESI-MS/MS method for underivatized amino acids as a support for the Newborn Screening as secondary test using the same dried blood spots for a more accurate and specific examination in case of suspected metabolic diseases. In this way, we avoid plasma collection from the patient as it normally occurs, reducing anxiety for the parents and further costs for analysis.The same method was validated and applied also to plasma and urine samples with good reproducibility, accuracy, and precision. The fast run time, feasibility of high sample throughput, and small amount of sample required make this method very suitable for routine analysis in the clinical setting.
    Mesh-Begriff(e) Amino Acids/blood ; Amino Acids/urine ; Calibration ; Chromatography, High Pressure Liquid/methods ; Chromatography, High Pressure Liquid/standards ; Dried Blood Spot Testing ; Humans ; Maple Syrup Urine Disease/blood ; Phenylketonurias/blood ; Reference Standards ; Solutions ; Spectrometry, Mass, Electrospray Ionization/methods ; Spectrometry, Mass, Electrospray Ionization/standards ; Staining and Labeling
    Chemische Substanzen Amino Acids ; Solutions
    Sprache Englisch
    Erscheinungsdatum 2012
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-61779-445-2_18
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  9. Artikel ; Online: Characterization of lipopeptides produced by Bacillus licheniformis using liquid chromatography with accurate tandem mass spectrometry.

    Favaro, Gabriella / Bogialli, Sara / Di Gangi, Iole Maria / Nigris, Sebastiano / Baldan, Enrico / Squartini, Andrea / Pastore, Paolo / Baldan, Barbara

    Rapid communications in mass spectrometry : RCM

    2016  Band 30, Heft 20, Seite(n) 2237–2252

    Abstract: Rationale: The plant endophyte Bacillus licheniformis, isolated from leaves of Vitis vinifera, was studied to individuate and characterize the presence of bioactive lipopeptides having amino acidic structures.: Methods: Crude extracts of liquid ... ...

    Abstract Rationale: The plant endophyte Bacillus licheniformis, isolated from leaves of Vitis vinifera, was studied to individuate and characterize the presence of bioactive lipopeptides having amino acidic structures.
    Methods: Crude extracts of liquid cultures were analyzed by ultra-high-performance liquid chromatography (UHPLC) coupled to a quadrupole time-of-flight (QTOF) mass analyzer. Chromatographic conditions were optimized in order to obtain an efficient separation of the different isobaric lipopeptides, avoiding merged fragmentations of co-eluted isomeric compounds and reducing possible cross-talk phenomena. Composition of the amino acids was outlined through the interpretation of the fragmentation behavior in tandem high-resolution mass spectrometry (HRMS/MS) mode, which showed both common-class and peculiar fragment ions. Both [M + H](+) and [M + Na](+) precursor ions were fragmented in order to differentiate some isobaric amino acids, i.e. Leu/Ile. Neutral losses characteristic of the iso acyl chain were also evidenced.
    Results: More than 90 compounds belonging to the classes of surfactins and lichenysins, known as biosurfactant molecules, were detected. Sequential LC/HRMS/MS analysis was used to identify linear and cyclic lipopeptides, and to single out the presence of a large number of isomers not previously reported. Some critical issues related to the simultaneous selection of different compounds by the quadrupole filter were highlighted and partially solved, leading to tentative assignments of several structures. Linear lichenysins are described here for the first time.
    Conclusions: The approach was proved to be useful for the characterization of non-target lipopeptides, and proposes a rationale MS experimental scheme aimed to investigate the difference in amino acid sequence and/or in the acyl chain of the various congeners, when standards are not available. Results expanded the knowledge about production of linear and cyclic bioactive compounds from Bacillus licheniformis, clarifying the structures of isomeric forms, and enabling the use of selected endophytes to produce fungicides for eco-friendly biocontrol. Copyright © 2016 John Wiley & Sons, Ltd.
    Sprache Englisch
    Erscheinungsdatum 2016-10-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.7705
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  10. Artikel ; Online: Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.

    Ciciliot, Stefano / Albiero, Mattia / Campanaro, Stefano / Poncina, Nicol / Tedesco, Serena / Scattolini, Valentina / Dalla Costa, Francesca / Cignarella, Andrea / Vettore, Monica / Di Gangi, Iole Maria / Bogialli, Sara / Avogaro, Angelo / Fadini, Gian Paolo

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2018  Band 32, Heft 7, Seite(n) 4004–4015

    Abstract: The 66 kDa isoform of the mammalian Shc gene promotes adipogenesis, and ... ...

    Abstract The 66 kDa isoform of the mammalian Shc gene promotes adipogenesis, and p66Shc
    Mesh-Begriff(e) Animals ; Diet, High-Fat/adverse effects ; Female ; Gastrointestinal Microbiome ; Gene Deletion ; Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/etiology ; Obesity/genetics ; Obesity/metabolism ; Obesity/microbiology ; Pancreatitis-Associated Proteins/genetics ; Pancreatitis-Associated Proteins/metabolism ; Src Homology 2 Domain-Containing, Transforming Protein 1/genetics ; Src Homology 2 Domain-Containing, Transforming Protein 1/metabolism
    Chemische Substanzen Pancreatitis-Associated Proteins ; Reg3g protein, mouse ; Shc1 protein, mouse ; Src Homology 2 Domain-Containing, Transforming Protein 1
    Sprache Englisch
    Erscheinungsdatum 2018-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201701409R
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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