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  1. Article ; Online: Acute spontaneous non-hemorrhagic adrenal infarction in pregnancy: case-report and literature review.

    Ornaghi, Sara / Fernicola, Federica / Marelli, Elisabetta / Perotti, Mario / Di Gennaro, Filiberto / Cameroni, Irene / Mariani, Eloisa M / Pincelli, Angela I / Colciago, Elisabetta / Cetin, Irene / Vergani, Patrizia

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2023  Volume 39, Issue 1, Page(s) 2234492

    Abstract: Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely ... ...

    Abstract Unilateral non-hemorrhagic adrenal infarction (NHAI) is a very uncommon cause of acute abdomen in pregnancy. Diagnosis is highly challenging due to its rarity, heterogeneity of clinical presentation, and inconclusiveness of the initial workup. Timely recognition is pivotal to ensuring optimal outcomes. Here we describe a case of spontaneous unilateral NHAI diagnosed in a singleton pregnant woman at 32 weeks' gestation at our centre and provide the findings of an extensive literature review on the topic. We identified 22 articles describing 31 NHAI cases in 30 obstetric patients: NHAI occurs more frequently on the right side and in the third trimester, and diagnosis is formulated more than 24 h after clinical presentation in 50% of cases; second-level imaging is always necessary to reach a definitive diagnosis and start appropriate treatment. A high degree of clinical suspicion is needed to promptly recognize NHAI in pregnancy, thus allowing appropriate multidisciplinary management and timely treatment initiation. Promotion of knowledge and awareness of NHAI as a potential cause of acute abdomen in pregnancy is mandatory to improve clinical practice and, ultimately, perinatal outcomes.
    MeSH term(s) Pregnancy ; Female ; Humans ; Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; Adrenal Gland Diseases/diagnosis ; Pregnancy Trimester, Third ; Infarction/diagnostic imaging ; Infarction/etiology
    Language English
    Publishing date 2023-07-24
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2023.2234492
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  2. Article ; Online: Iron Overload Following Hematopoietic Stem Cell Transplantation: Prevalence, Severity, and Management in Children and Adolescents with Malignant and Nonmalignant Diseases.

    Cattoni, Alessandro / Capitoli, Giulia / Casagranda, Sara / Corti, Paola / Adavastro, Marta / Molinaro, Alessandro / Di Gennaro, Filiberto / Bonanomi, Sonia / Biondi, Andrea / Galimberti, Stefania / Balduzzi, Adriana

    Transplantation and cellular therapy

    2023  Volume 29, Issue 4, Page(s) 271.e1–271.e12

    Abstract: Iron overload (IOL) is a frequently reported complication following hematopoietic stem cell transplantation (HSCT) that has been investigated extensively in the field of hemoglobinopathies but has not been thoroughly characterized after HSCT in pediatric ...

    Abstract Iron overload (IOL) is a frequently reported complication following hematopoietic stem cell transplantation (HSCT) that has been investigated extensively in the field of hemoglobinopathies but has not been thoroughly characterized after HSCT in pediatric malignancies. Our aim was to assess prevalence, severity, risk factors, and management of IOL, as defined using biochemical (serum ferritin) and radiologic tools (T2*-weighted magnetic resonance imaging [MRI]), in a cohort of pediatric patients who underwent HSCT for either malignant or benign diseases. This monocentric, retrospective, observational study included all the 163 patients alive and in continuous remission at 24 months post-HSCT out of the 219 consecutive children and adolescents who underwent HSCT at our institution between 2012 and 2018, were included in the study. IOL was classified into 4 categories: absent, mild, moderate, and severe. Among the 163 patients, 73% had some degree of IOL (mild in 37%, moderate in 29%, and severe in 7%). Moderate/severe IOL was more frequent among patients diagnosed with a malignant disease versus those with a benign disease (43% versus 19%; P = .0065). Trend lines for serum ferritin showed a "bell-shaped" distribution, with the highest levels recorded during the first 6 months post-HSCT, followed by a spontaneous reduction. Both pre-HSCT (1659 ng/mL versus 617 ng/mL; P < .001) and maximum post-HSCT (2473 ng/mL versus 1591 ng/mL; P < .001) median ferritin levels were statistically higher in the patients with malignancies. Radiologic assessment of IOL confirmed a more severe degree in patients with malignant disorders compared to those with benign disorders (median T2*-MRI, 4.20 msec [interquartile range (IQR), 3.0 to 6.40 msec] versus 7.40 msec [IQR, 4.90 to 11.00 msec]; P = .008). T2* levels were associated with the number of transfusions performed (P = .0006), with a steeper drop in T2* values for the first 20 transfusions and a milder slope for subsequent transfusions. T2* and ferritin values showed a statistically significant negative exponential relationship (P < .0001), although a ferritin level ≥1000 ng/mL showed poor specificity (48%) and low positive predictive value (53%) for discriminating moderate-to-severe IOL from absent-mild IOL as assessed by T2*-MRI, but with high sensitivity (92%) and negative predictive value (91%). In a multivariable model, >20 transfusions (odds ratio [OR], 4.07; 95% confidence interval [CI], 1.61 to 10.68; P = .003) and higher pre-HSCT ferritin level (P < .001) were associated with the risk of developing moderate-to-severe IOL. Use of a sibling donor (OR, .29; 95% CI, .10 to .77; P = .015) and a nonmalignancy (OR, .27; 95% CI, .08 to .82; P = .026) were protective factors. Phlebotomy (66%), low-dose oral chelators (9%), or a combined approach (25%) were started at a median of 12 months after HSCT in 78% of the patients with IOL. Six percent of the patients treated exclusively with phlebotomy (median, 14, significantly higher in patients >40 kg) discontinued phlebotomy owing to poor venous access, lack of compliance, or hypotension, whereas 39% of patients treated with chelators developed mild renal or hepatic side effects that resolved after tapering or discontinuation. Patients with malignancies showed statistically higher pre-HSCT and post-HSCT ferritin levels and lower T2* values. High ferritin level recorded on T2*-MRI showed unsatisfactory diagnostic accuracy in predicting IOL; thus, T2*-MRI should be considered a key tool for confirming IOL after HSCT in patients with an elevated serum ferritin level. IOL treatment is feasible after HSCT.
    MeSH term(s) Humans ; Child ; Adolescent ; Retrospective Studies ; Prevalence ; Iron Overload/diagnosis ; Iron Overload/epidemiology ; Iron Overload/etiology ; Ferritins ; Precancerous Conditions/complications ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Chelating Agents
    Chemical Substances Ferritins (9007-73-2) ; Chelating Agents
    Language English
    Publishing date 2023-01-26
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2023.01.020
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  3. Article ; Online: Prolonged exposure to welding fumes as a novel cause of systemic iron overload.

    Mariani, Raffaella / Pelucchi, Sara / Paolini, Valentina / Belingheri, Michael / di Gennaro, Filiberto / Faverio, Paola / Riva, Michele / Pesci, Alberto / Piperno, Alberto

    Liver international : official journal of the International Association for the Study of the Liver

    2021  Volume 41, Issue 7, Page(s) 1600–1607

    Abstract: Background & aims: Inhalation of welding fume may cause pulmonary disease known as welder's lung. At our centre we came across a number of welders with systemic iron overload and prolonged occupational history and we aimed at characterizing this novel ... ...

    Abstract Background & aims: Inhalation of welding fume may cause pulmonary disease known as welder's lung. At our centre we came across a number of welders with systemic iron overload and prolonged occupational history and we aimed at characterizing this novel clinical form of iron overload.
    Methods: After exclusion of other known causes of iron overload, 20 welders were fully evaluated for working history, hepatic, metabolic and iron status. MRI iron assessment was performed in 19 patients and liver biopsy in 12. We included 40 HFE-HH patients and 24 healthy controls for comparison.
    Results: 75% of patients showed lung HRCT alterations; 90% had s-FERR > 1000 ng/mL and 60% had TSAT > 45%. Liver iron overload was mild in 8 and moderate-severe in 12. The median iron removed was 7.8 g. Welders showed significantly lower TSAT and higher SIS and SIS/TIS ratio than HFE-HH patients. Serum hepcidin was significantly higher in welders than in HFE-HH patients and healthy controls. At liver biopsy, 50% showed liver fibrosis that was mild in four, and moderate-severe in two. Liver staging correlated with liver iron overload.
    Conclusions: Welders with prolonged fume exposure can develop severe liver iron overload. The mechanism of liver iron accumulation is quite different to that of HFE-HH suggesting that reticuloendothelial cells may be the initial site of deposition. We recommend routine measurement of serum iron indices in welders to provide adequate diagnosis and therapy, and the inclusion of prolonged welding fume exposure in the list of acquired causes of hyperferritinemia and iron overload.
    MeSH term(s) Humans ; Iron ; Iron Overload ; Liver ; Lung/diagnostic imaging ; Welding
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.14874
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  4. Article ; Online: Endometriosis-related spontaneous hemoperitoneum in pregnancy: A case series.

    Bazzurini, Luca / Ornaghi, Sara / Colciago, Elisabetta / Penati, Cristina / di Gennaro, Filiberto / Passoni, Paolo / Buda, Alessandro / Locatelli, Anna / Landoni, Fabio / Vergani, Patrizia

    The journal of obstetrics and gynaecology research

    2022  Volume 49, Issue 2, Page(s) 744–752

    Abstract: Endometriosis can be associated with adverse pregnancy outcomes. We report six cases of endometriosis-related spontaneous hemoperitoneum diagnosed in pregnant and postpartum women over 13 years. Spontaneous hemoperitoneum in pregnancy mainly occurred in ... ...

    Abstract Endometriosis can be associated with adverse pregnancy outcomes. We report six cases of endometriosis-related spontaneous hemoperitoneum diagnosed in pregnant and postpartum women over 13 years. Spontaneous hemoperitoneum in pregnancy mainly occurred in the second half of gestation. All women presented with acute abdominal pain; four of them needed an emergent surgery, two were managed expectantly. The median estimated blood loss was 4250 ml, four women required massive transfusion. Three out of six women had a known history of endometriosis, all of them had histologically confirmed endometriosis after surgery. No maternal or perinatal deaths occurred. In one case, reticence to perform a computed tomography scan led to delayed diagnosis. Since delay can lead to lethal consequences, high levels of suspicion for spontaneous hemoperitoneum should be maintained in cases of severe abdominal pain, even with a woman's negative history of endometriosis. Improved knowledge and regular interdisciplinary meetings are pivotal to ameliorate outcomes.
    MeSH term(s) Pregnancy ; Female ; Humans ; Endometriosis/complications ; Endometriosis/diagnosis ; Endometriosis/surgery ; Hemoperitoneum/etiology ; Hemoperitoneum/surgery ; Pregnancy Outcome ; Abdominal Pain/etiology
    Language English
    Publishing date 2022-11-11
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1327307-3
    ISSN 1447-0756 ; 1341-8076
    ISSN (online) 1447-0756
    ISSN 1341-8076
    DOI 10.1111/jog.15498
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  5. Article ; Online: Diagnostic efficacy of model-based iterative reconstruction algorithm in an assessment of coronary artery in comparison with standard hybrid-Iterative reconstruction algorithm: dose reduction and image quality.

    Ippolito, Davide / Riva, Luca / Talei Franzesi, Cammillo R / Cangiotti, Cecilia / De Vito, Andrea / Di Gennaro, Filiberto / D'andrea, Gabriele / Crespi, Andrea / Sironi, Sandro

    La Radiologia medica

    2018  Volume 124, Issue 5, Page(s) 350–359

    Abstract: Purpose: To evaluate the image quality and radiation dose exposure of low-dose coronary CTA (cCTA) study, reconstructed with the new model-based iterative reconstruction algorithm (IMR), compared with standard hybrid-iterative reconstruction (iDose: ... ...

    Abstract Purpose: To evaluate the image quality and radiation dose exposure of low-dose coronary CTA (cCTA) study, reconstructed with the new model-based iterative reconstruction algorithm (IMR), compared with standard hybrid-iterative reconstruction (iDose
    Materials and methods: Ninety-eight patients with an indication for coronary CT study were prospectively enrolled. Fifty-two patients (study group) underwent 256-MDCT low-dose cCTA (80 kV; automated-mAs; 60 mL of CM, 350 mgL/mL) with prospective ECG-triggering acquisition and IMR. A control group of 46 patients underwent 256-MDCT standard prospective ECG-gated protocol (100 kV; automated-mAs; 70 mL of CM, 400 mgL/mL; iDose
    Results: Mean values of mAs were significantly lower for IMR-cCTA (167 ± 62 mAs) compared to iDose-cCTA (278 ± 55 mAs), p < 0.001. With a significant reduction of 38% in radiation dose exposure (DLP: IMR-cCTA 91.7 ± 26 mGy cm vs. iDose-cCTA 148.6 ± 35 mGy cm; p value < 0.001), despite the use of different CM, we found higher mean attenuation values of the coronary arteries in IMR group compared to iDose
    Conclusions: Low-dose cCTA study combined with IMR reconstruction allows to correctly evaluate coronary arteries disease, offering high-quality images and significant radiation dose exposure reduction (38%), as compared to standard cCTA protocol.
    MeSH term(s) Aged ; Aged, 80 and over ; Algorithms ; Cardiac-Gated Imaging Techniques ; Computed Tomography Angiography/methods ; Contrast Media ; Coronary Angiography/methods ; Coronary Artery Disease/diagnostic imaging ; Female ; Humans ; Iohexol/analogs & derivatives ; Male ; Middle Aged ; Prospective Studies ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted/methods ; Signal-To-Noise Ratio
    Chemical Substances Contrast Media ; iobitridol (182ECH14UH) ; Iohexol (4419T9MX03)
    Language English
    Publishing date 2018-12-11
    Publishing country Italy
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
    DOI 10.1007/s11547-018-0964-6
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  6. Article ; Online: G-CSF for Extensive STEMI.

    Achilli, Felice / Pontone, Gianluca / Bassetti, Beatrice / Squadroni, Lidia / Campodonico, Jeness / Corrada, Elena / Facchini, Camilla / Mircoli, Luca / Esposito, Giovanni / Scarpa, Daniele / Pidello, Stefano / Righetti, Stefano / Di Gennaro, Filiberto / Guglielmo, Marco / Muscogiuri, Giuseppe / Baggiano, Andrea / Limido, Alberto / Lenatti, Laura / Di Tano, Giuseppe /
    Malafronte, Cristina / Soffici, Federica / Ceseri, Martina / Maggiolini, Stefano / Colombo, Gualtiero I / Pompilio, Giulio

    Circulation research

    2019  Volume 125, Issue 3, Page(s) 295–306

    Abstract: Rationale: In the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation ... ...

    Abstract Rationale: In the exploratory Phase II STEM-AMI (Stem Cells Mobilization in Acute Myocardial Infarction) trial, we reported that early administration of G-CSF (granulocyte colony-stimulating factor), in patients with anterior ST-segment-elevation myocardial infarction and left ventricular (LV) dysfunction after successful percutaneous coronary intervention, had the potential to significantly attenuate LV adverse remodeling in the long-term.
    Objective: The STEM-AMI OUTCOME CMR (Stem Cells Mobilization in Acute Myocardial Infarction Outcome Cardiac Magnetic Resonance) Substudy was adequately powered to evaluate, in a population showing LV ejection fraction ≤45% after percutaneous coronary intervention for extensive ST-segment-elevation myocardial infarction, the effects of early administration of G-CSF in terms of LV remodeling and function, infarct size assessed by late gadolinium enhancement, and myocardial strain.
    Methods and results: Within the Italian, multicenter, prospective, randomized, Phase III STEM-AMI OUTCOME trial, 161 ST-segment-elevation myocardial infarction patients were enrolled in the CMR Substudy and assigned to standard of care (SOC) plus G-CSF or SOC alone. In 119 patients (61 G-CSF and 58 SOC, respectively), CMR was available at baseline and 6-month follow-up. Paired imaging data were independently analyzed by 2 blinded experts in a core CMR lab. The 2 groups were similar for clinical characteristics, cardiovascular risk factors, and pharmacological treatment, except for a trend towards a larger infarct size and longer symptom-to-balloon time in G-CSF patients. ANCOVA showed that the improvement of LV ejection fraction from baseline to 6 months was 5.1% higher in G-CSF patients versus SOC (P=0.01); concurrently, there was a significant between-group difference of 6.7 mL/m
    Conclusions: Early administration of G-CSF exerted a beneficial effect on top of SOC in patients with LV dysfunction after extensive ST-segment-elevation myocardial infarction in terms of global systolic function, adverse remodeling, scar size, and myocardial strain.
    Clinical trial registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01969890.
    MeSH term(s) Aged ; Female ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Heart Ventricles/drug effects ; Heart Ventricles/pathology ; Humans ; Male ; Middle Aged ; Myocardial Contraction/drug effects ; Organ Size ; Prospective Studies ; ST Elevation Myocardial Infarction/drug therapy ; ST Elevation Myocardial Infarction/pathology ; ST Elevation Myocardial Infarction/physiopathology ; Single-Blind Method ; Stroke Volume/drug effects ; Ventricular Remodeling/drug effects
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2019-05-29
    Publishing country United States
    Document type Clinical Trial, Phase III ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.118.314617
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  7. Article ; Online: Simultaneous liver iron and fat measures by magnetic resonance imaging in patients with hyperferritinemia.

    Galimberti, Stefania / Trombini, Paola / Bernasconi, Davide Paolo / Redaelli, Irene / Pelucchi, Sara / Bovo, Giorgio / Di Gennaro, Filiberto / Zucchini, Nicola / Paruccini, Nicoletta / Piperno, Alberto

    Scandinavian journal of gastroenterology

    2015  Volume 50, Issue 4, Page(s) 429–438

    Abstract: Objective: Hyperferritinemia is frequent in chronic liver diseases of any cause, but the extent to which ferritin truly reflects iron stores is variable. In these patients, both liver iron and fat are found in variable amount and association. Liver ... ...

    Abstract Objective: Hyperferritinemia is frequent in chronic liver diseases of any cause, but the extent to which ferritin truly reflects iron stores is variable. In these patients, both liver iron and fat are found in variable amount and association. Liver biopsy is often required to quantify liver fat and iron, but sampling variability and invasiveness limit its use. We aimed to assess single breath-hold multiecho magnetic resonance imaging (MRI) for the simultaneous lipid and iron quantification in patients with hyperferritinemia.
    Material and methods: We compared MRI results for both iron and fat with their respective gold standards - liver iron concentration and computer-assisted image analysis for steatosis on biopsy. We prospectively studied 67 patients with hyperferritinemia and other 10 consecutive patients were used for validation. We estimated two linear calibration equations for the prediction of iron and fat based on MRI. The agreement between MRI and biopsy was evaluated.
    Results: MRI showed good performances in both the training and validation samples. MRI information was almost completely in line with that obtained from liver biopsy.
    Conclusion: Single breath-hold multiecho MRI is an accurate method to obtain a valuable measure of both liver iron and steatosis in patients with hyperferritinemia.
    MeSH term(s) Adipose Tissue ; Biopsy ; Fatty Liver/pathology ; Female ; Humans ; Iron/analysis ; Iron/blood ; Liver/chemistry ; Liver/pathology ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Prospective Studies
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 82042-8
    ISSN 1502-7708 ; 0036-5521
    ISSN (online) 1502-7708
    ISSN 0036-5521
    DOI 10.3109/00365521.2014.940380
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  8. Article ; Online: G-CSF treatment for STEMI: final 3-year follow-up of the randomised placebo-controlled STEM-AMI trial.

    Achilli, Felice / Malafronte, Cristina / Maggiolini, Stefano / Lenatti, Laura / Squadroni, Lidia / Gibelli, Giuseppe / Capogrossi, Maurizio C / Dadone, Viola / Gentile, Francesco / Bassetti, Beatrice / Di Gennaro, Filiberto / Camisasca, Paola / Calchera, Ivan / Valagussa, Laura / Colombo, Gualtiero I / Pompilio, Giulio

    Heart (British Cardiac Society)

    2014  Volume 100, Issue 7, Page(s) 574–581

    Abstract: Objective: To assess whether granulocyte colony-stimulating factor (G-CSF) treatment induces a sustained benefit on adverse remodelling in patients with large anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction ... ...

    Abstract Objective: To assess whether granulocyte colony-stimulating factor (G-CSF) treatment induces a sustained benefit on adverse remodelling in patients with large anterior ST-elevation myocardial infarction (STEMI) and left ventricular (LV) dysfunction after successful reperfusion.
    Methods: The STEM-AMI Trial was a prospective, placebo-controlled, multicentre study. Sixty consecutive patients with a first anterior STEMI, who underwent primary percutaneous coronary intervention 2-12 h after symptom onset, with LV ejection fraction (LVEF) ≤45% measured by echocardiography within 12 h after successful revascularisation (TIMI flow score ≥2), were randomised 1:1 to G-CSF (5 µg/Kg body weight b.i.d.) or placebo. Clinical events and Major Adverse Cardiac and Cerebrovascular Event (MACCE) were monitored, and LVEF, LV end-diastolic (LVEDV) and end-systolic (LVESV) volumes, and infarct size were evaluated by MRI at the final 3-year follow-up.
    Results: Fifty-four patients completed the study, of whom 35 with MRI. No significant differences were found in mortality and MACCE between G-CSF and placebo-treated groups. The 3-year infarct size was not different between groups, whereas LVEDV was significantly lower in G-CSF (n=20) than in placebo (n=15) patients (170.1±8.1 vs 197.2±8.9 mL, respectively; p=0.033 at analysis of covariance). A significant inverse correlation was detected in G-CSF patients between the number of circulating CD34 cells at 30 days after reperfusion and the 3-year absolute and indexed LVEDV (ρ=-0.71, 95% CI -0.90 to -0.30, and ρ=-0.62, -0.86 to -0.14, respectively), or their change over time (r=-0.59, -0.85 to -0.11, and r=-0.55, -0.83 to -0.06, respectively).
    Conclusions: G-CSF therapy may be beneficial in attenuating ventricular remodelling subsequent to a large anterior STEMI in the long term. No differences have been detected in clinical outcome.
    MeSH term(s) Female ; Follow-Up Studies ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Male ; Middle Aged ; Myocardial Infarction/complications ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Prospective Studies ; Time Factors ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/prevention & control ; Ventricular Remodeling
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2013-304955
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