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  1. Article: Hemosiderin-Laden Macrophages in Canine Mammary Carcinomas.

    Giambrone, Giada / Vullo, Cecilia / Puleio, Roberto / Rifici, Claudia / Di Giorgio, Stefania / Sfacteria, Alessandra

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 23

    Abstract: Macrophages are among the main actors in cancer immunoediting, with several functions, including recycling iron and packaging it in hemosiderin. Even though TAMs are widely studied in breast cancer and canine mammary tumors, hemosiderin-laden macrophages ...

    Abstract Macrophages are among the main actors in cancer immunoediting, with several functions, including recycling iron and packaging it in hemosiderin. Even though TAMs are widely studied in breast cancer and canine mammary tumors, hemosiderin-laden macrophages (HLMs) have not received as much attention. Considering the growing interest in iron metabolism in cancer, this study aims to evaluate the presence of HLMs in canine mammary tumors. Fifty cases of canine mammary carcinomas presenting aggregates of pigmented macrophages were chosen. Prussian blue and Meguro staining were performed to assess the presence of iron. Immunohistochemistry was carried out to try to identify macrophagic phenotypes and hypothesize their role. Evaluation of the H&E sections showed that pigmented macrophages were variously localized in peritumoral and stromal areas. These pigmented cells were variably stained with Prussian blue and reacted strongly with DAB in the Meguro staining method, thus confirming the presence of iron within them. In their immunohistochemistry, the HLMs were negative for the MAC387 but positive for CD 204 and VEGF. Considering their positivity for CD 204, HLMs could be M2 macrophages that supply iron to both the neoplastic cells and the tumor inflammatory microenvironment, promoting angiogenesis and protecting cancer cells from hypoxia.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13233634
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prenatal Diagnosis of Canine and Feline Twins Using Ultrasound: A Retrospective Study.

    Pecchia, Fabiana / Di Giorgio, Stefania / Sfacteria, Alessandra / Monti, Salvatore / Vullo, Cecilia / Catone, Giuseppe / Marino, Gabriele

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 21

    Abstract: Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing ... ...

    Abstract Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing interest is emerging for the preterm ultrasound morphological screening of embryos and foetuses, aimed at assessing the integrity and viability of the conceptus, as well as the early diagnosis of anomalies which can cause complications. This study is a retrospective study of the ultrasonographic findings of twins in the authors' clinical activity from 2016 to 2022. Only seven cases of monochorionic twins were recorded, out of the whole number of evaluations performed on 3120 foetuses, with a prevalence of 0.6% and 0.2% in feline and canine foetuses. All the twins had their own amniotic sac and umbilical cord but presented a single placenta and a single allantoic sac. Unfortunately, the three feline cases were not more recognizable at term. In the four canine cases, three were of opposite sex and then necessarily dizygotic. Twins may have an impact on the success of a pregnancy due to the risk of dystocia, as observed in some of the reported cases. Prenatal ultrasound allows early recognition of twins in dogs and cats.
    Language English
    Publishing date 2023-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13213309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas.

    Giambrone, Giada / Di Giorgio, Stefania / Vullo, Cecilia / Marino, Gabriele / Puleio, Roberto / Mariotti, Francesca / Mazzullo, Giuseppe / Sfacteria, Alessandra

    Veterinary sciences

    2022  Volume 9, Issue 11

    Abstract: Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the tumour ... ...

    Abstract Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the tumour through organized cellular aggregates that are called tertiary lymphoid structures (TLSs). However, their occurrence has different meanings in different tumour types. For example, the presence of TLSs in breast cancer is associated with the most aggressive subtypes. This paper aimed to study TLSs in canine mammary simple carcinomas. A morphological assessment of the inflammatory infiltrate was performed on H&E sections of fifty cases. Immunohistochemistry was then carried out to typify the inflammatory cells in the tumour microenvironment. Results showed that, sometimes, inflammatory infiltrates were organized in follicles close to high-grade carcinomas, simulating a lymphoid organization, as in breast cancer. Therefore, we can assume that even in canine mammary tumours, TLSs exist and they are entities to consider due to their presence in the most aggressive histotypes or tumours with a high degree of malignancy.
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci9110628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Conservative treatments for feline fibroadenomatous changes of the mammary gland.

    Marino, Gabriele / Pugliese, Michela / Pecchia, Fabiana / Garufi, Giuseppe / Lupo, Vincenzo / Di Giorgio, Stefania / Sfacteria, Alessandra

    Open veterinary journal

    2021  Volume 11, Issue 4, Page(s) 680–685

    Abstract: Background: Fibroadenomatous changes (FAC) of the mammary gland in cats represents a benign, progesterone-associated fibroglandular proliferation of one or more mammary glands that may occur in intact female cats at the time of puberty, during pregnancy ...

    Abstract Background: Fibroadenomatous changes (FAC) of the mammary gland in cats represents a benign, progesterone-associated fibroglandular proliferation of one or more mammary glands that may occur in intact female cats at the time of puberty, during pregnancy or pseudopregnancy, or in female and male cats of any age under progestin treatment. Nowadays, the elective treatment of FAC is based on the progesterone antagonist aglepristone. This study aimed to report the treatment of FAC with a combination of drugs designed to preserve mammary gland integrity, even in pregnant cats.
    Case description: Eight sexually intact female cats with FAC showed mammary glands that were symmetrically enlarged and inflamed in all cases, and the skin was ulcerated in six cats. Four cats were on days 25-32 of pregnancy at presentation. Non-pregnant cats were treated with aglepristone and with a dietary supplement containing maltodextrin and bromelain. The mammary glands were massaged daily with an
    Conclusion: This case series encourages adjuvant therapy in the course of FAC to preserve mammary gland integrity and functionality. Exploiting the natural decline of progesterone at the end of pregnancy (or pseudopregnancy), the therapy may also be used without aglepristone, when its use has other limitations.
    MeSH term(s) Animals ; Cats ; Conservative Treatment/veterinary ; Female ; Male ; Pregnancy ; Progesterone ; Uterus
    Chemical Substances Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2021-11-21
    Publishing country Libya
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2651664-0
    ISSN 2218-6050 ; 2218-6050
    ISSN (online) 2218-6050
    ISSN 2218-6050
    DOI 10.5455/OVJ.2021.v11.i4.19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Bovine besnoitiosis in a cattle herd in Sicily: an isolated outbreak or the acknowledgment of an endemicity?

    Napoli, Ettore / Remesar, Susana / Mendoza-Roldan, Jairo / De Benedetto, Giovanni / Di Giorgio, Stefania / Sfacteria, Alessandra / Marino, Gabriele / Arfuso, Francesca / Catone, Giuseppe / Brianti, Emanuele

    Parasitology research. 2021 Oct., v. 120, no. 10

    2021  

    Abstract: Bovine besnoitiosis is a debilitating infectious disease caused by Besnoitia besnoiti (Apicomplexa; Sarcocystidae). The disease is mainly characterized by cutaneous and systemic signs, infertility in bulls, and abortion in cows. The current study ... ...

    Abstract Bovine besnoitiosis is a debilitating infectious disease caused by Besnoitia besnoiti (Apicomplexa; Sarcocystidae). The disease is mainly characterized by cutaneous and systemic signs, infertility in bulls, and abortion in cows. The current study describes an autochthonous outbreak of bovine besnoitiosis in Sicily, Southern Italy, being the first report of B. besnoiti infection in the island so far. In a cattle farm located in Syracuse province, a 4-year-old Belgian blue bull born in Sicily displayed typical clinical signs of the sub-acute/chronic disease phase with thickening of the skin of the scrotum and testicular degeneration. Histological examination of scrotal biopsies revealed the presence of several tissue cysts of B. besnoiti. The serological analysis of the herd using a commercial ELISA revealed a high seroprevalence (45 out of 55; 82%) of antibodies against B. besnoiti. Few seropositive animals (5 out of 45; 11%) showed clinical signs, cysts in vestibulum vaginae (1 out of 31; 3.2%), and testicular degeneration (4 out of 14; 28.6%) assessed by ultrasonographic investigations. The paucity of clinical signs associated with the high seroprevalence in the farm led to hypothesize that bovine besnoitiosis is endemic in the area though further studies are needed. Local practitioners should be more aware of the disease to facilitate the early detection of cases, prevent the spread of infection, and avoid economic losses and animal health problem.
    Keywords Belgian Blue ; Besnoitia besnoiti ; animal health ; bulls ; coccidiosis ; farms ; herds ; histology ; indigenous species ; infectious diseases ; parasitology ; research ; scrotum ; serodiagnosis ; seroprevalence ; testes ; ultrasonography ; Italy ; Sicily
    Language English
    Dates of publication 2021-10
    Size p. 3547-3553.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-021-07298-2
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 75/710: Show issues

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  6. Article ; Online: Bovine besnoitiosis in a cattle herd in Sicily: an isolated outbreak or the acknowledgment of an endemicity?

    Napoli, Ettore / Remesar, Susana / Mendoza-Roldan, Jairo / De Benedetto, Giovanni / Di Giorgio, Stefania / Sfacteria, Alessandra / Marino, Gabriele / Arfuso, Francesca / Catone, Giuseppe / Brianti, Emanuele

    Parasitology research

    2021  Volume 120, Issue 10, Page(s) 3547–3553

    Abstract: Bovine besnoitiosis is a debilitating infectious disease caused by Besnoitia besnoiti (Apicomplexa; Sarcocystidae). The disease is mainly characterized by cutaneous and systemic signs, infertility in bulls, and abortion in cows. The current study ... ...

    Abstract Bovine besnoitiosis is a debilitating infectious disease caused by Besnoitia besnoiti (Apicomplexa; Sarcocystidae). The disease is mainly characterized by cutaneous and systemic signs, infertility in bulls, and abortion in cows. The current study describes an autochthonous outbreak of bovine besnoitiosis in Sicily, Southern Italy, being the first report of B. besnoiti infection in the island so far. In a cattle farm located in Syracuse province, a 4-year-old Belgian blue bull born in Sicily displayed typical clinical signs of the sub-acute/chronic disease phase with thickening of the skin of the scrotum and testicular degeneration. Histological examination of scrotal biopsies revealed the presence of several tissue cysts of B. besnoiti. The serological analysis of the herd using a commercial ELISA revealed a high seroprevalence (45 out of 55; 82%) of antibodies against B. besnoiti. Few seropositive animals (5 out of 45; 11%) showed clinical signs, cysts in vestibulum vaginae (1 out of 31; 3.2%), and testicular degeneration (4 out of 14; 28.6%) assessed by ultrasonographic investigations. The paucity of clinical signs associated with the high seroprevalence in the farm led to hypothesize that bovine besnoitiosis is endemic in the area though further studies are needed. Local practitioners should be more aware of the disease to facilitate the early detection of cases, prevent the spread of infection, and avoid economic losses and animal health problem.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases/epidemiology ; Coccidiosis/epidemiology ; Coccidiosis/veterinary ; Disease Outbreaks/veterinary ; Female ; Male ; Sarcocystidae ; Seroepidemiologic Studies ; Sicily/epidemiology
    Language English
    Publishing date 2021-09-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-021-07298-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.124: Show issues Location:
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