LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 343

Search options

  1. Article ; Online: La televisita per l’assistenza cardiologica: un piccolo passo per il cardiologo, un grande passo per la cardiologia.

    Casolo, Giancarlo / Di Lenarda, Andrea

    Giornale italiano di cardiologia (2006)

    2021  Volume 22, Issue 11, Page(s) 942–943

    Title translation Virtual visit and cardiology care: a small step for the cardiologist, a quantum leap for cardiology.
    MeSH term(s) Cardiologists ; Cardiology ; Cardiovascular System ; Humans
    Language Italian
    Publishing date 2021-11-29
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3689.36753
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Training e mini-Delphi per implementare il trattamento dell’insufficienza cardiaca con gli antagonisti dei recettori dei mineralcorticoidi.

    Iacoviello, Massimo / Pulignano, Giovanni / Di Lenarda, Andrea

    Giornale italiano di cardiologia (2006)

    2022  Volume 23, Issue 6, Page(s) 469–476

    Abstract: Background: Mineralocorticoid receptor antagonists (MRAs) are a class of drugs still underused in heart failure with reduced ejection fraction. Hyperkalemia, worsening of renal function and gynecomastia are the main causes of the MRA missed prescription ...

    Title translation Medical training and mini-Delphi approach to implement heart failure treatment with mineralocorticoid receptor antagonists.
    Abstract Background: Mineralocorticoid receptor antagonists (MRAs) are a class of drugs still underused in heart failure with reduced ejection fraction. Hyperkalemia, worsening of renal function and gynecomastia are the main causes of the MRA missed prescription but also an inadequate knowledge of this class of drugs may represent a reason for their underuse. The aim of this project was to evaluate the possible usefulness of a unique and innovative web-based platform in order to identify the main issues related to the underuse of MRAs and to discuss shared strategies of interventions to overcome the obstacles to MRA prescription.
    Methods: The "HF Clinical Practice project" enrolled 55 hospital cardiologists. It was based on the development and production of the eCaseTrack platform which was capable of activating a content-sharing system between professionals and specialists, using a mixed-methods study consisting of a survey, shared clinical experiences, training and consensus mini-Delphi method.
    Results: The results of the survey showed that the respondents substantially agreed about the criteria for MRA prescription (NYHA class, left ventricular ejection fraction, glomerular filtration rate and serum potassium). This agreement was confirmed by mini-Delphi, by which the use of MRAs in patients with hypotension, hyperkalemia and gynecomastia emerged as the most controversial issue.
    Conclusions: A web-based system of sharing clinical experiences and discussing controversial issues, is useful to implement the introduction of a proven efficacious therapeutic strategy which is still underused in current clinical practice.
    MeSH term(s) Gynecomastia/drug therapy ; Heart Failure/drug therapy ; Humans ; Hyperkalemia/drug therapy ; Male ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Stroke Volume ; Ventricular Function, Left
    Chemical Substances Mineralocorticoid Receptor Antagonists
    Language Italian
    Publishing date 2022-06-08
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3810.37944
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Ruolo del cardiologo come consulente nei reparti non cardiologici: sono necessarie nuove competenze, nuove mansioni, nuove modalità organizzative.

    Santangelo, Gloria / Di Lenarda, Andrea / Faggiano, Pompilio

    Giornale italiano di cardiologia (2006)

    2022  Volume 23, Issue 8, Page(s) 645–648

    Title translation Role of the cardiologist as a consultant in non-cardiological wards: new skills and new tasks are needed.
    MeSH term(s) Cardiologists ; Cardiology ; Consultants ; Hospitals ; Humans
    Language Italian
    Publishing date 2022-10-13
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3856.38395
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Rapidità, simultaneità, sinergia e personalizzazione nella terapia iniziale dello scompenso cardiaco con frazione di eiezione ridotta: quattro regole per i quattro farmaci raccomandati.

    Di Tano, Giuseppe / Di Lenarda, Andrea

    Giornale italiano di cardiologia (2006)

    2022  Volume 23, Issue 9, Page(s) 663–667

    Title translation Speed, simultaneity, synergy and personalization in the first-line therapy for heart failure with reduced ejection fraction: four rules for the four recommended drugs.
    MeSH term(s) Heart Failure/drug therapy ; Humans ; Stroke Volume ; Ventricular Function, Left
    Language Italian
    Publishing date 2022-07-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/3860.38448
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Predicting left ventricular functional recovery in ischaemic cardiomyopathy: needs and challenges.

    Radesich, Cinzia / Cappelletto, Chiara / Indennidate, Carla / Perotto, Maria / Di Lenarda, Andrea

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl B, Page(s) B69–B74

    Abstract: Left ventricular (LV) systolic function is an essential parameter for the evaluation of patients with ischaemic heart disease, and therapeutic choices are significantly driven by LV ejection fraction (LVEF) in the early stage of the disease and during ... ...

    Abstract Left ventricular (LV) systolic function is an essential parameter for the evaluation of patients with ischaemic heart disease, and therapeutic choices are significantly driven by LV ejection fraction (LVEF) in the early stage of the disease and during follow-up. After an acute coronary syndrome, ventricular dysfunction may be reversible when caused by transient myocardial stunning. Therefore, the identification of clinical, laboratory, and instrumental predictors of improvement in LV systolic function (in addition to LVEF) is essential for an adequate prognostic stratification. In the setting of chronic ischaemic heart disease, there is no evidence that an improvement in LV systolic function is invariably associated with a better prognosis and LVEF is only one of many parameters that should be considered for the risk stratification. This state-of-the-art review will critically analyse the scientific evidence regarding known predictors of LVEF recovery, trying to elucidate their pathophysiological principles and clinical value.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad071
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Is L-PRF an effective hemostatic agent in single tooth extractions? A cohort study on VKA and DOAC patients.

    Berton, Federico / Costantinides, Fulvia / Stacchi, Claudio / Corradini, Ambra / Di Lenarda, Andrea / Di Lenarda, Roberto

    Clinical oral investigations

    2023  Volume 27, Issue 6, Page(s) 2865–2874

    Abstract: Objectives: The aim of this clinical observational study was to assess the efficacy of L-PRF as a hemostatic agent in patients under treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs).: Materials and methods: Patients ... ...

    Abstract Objectives: The aim of this clinical observational study was to assess the efficacy of L-PRF as a hemostatic agent in patients under treatment with vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs).
    Materials and methods: Patients under oral anticoagulant therapy (VKA or DOACs) who needed a single simple tooth extraction were enrolled. L-PRF plug was positioned inside the alveolus and secured with non-absorbable sutures. Surgical time, pain-VAS, paracetamol intake, intra-operative, post-operative biological complications, and bleeding events have been registered.
    Results: A total of 112 patients (59 patients for DOAC and 53 for VKA group) were enrolled. Post-operative bleeding was recorded in nine patients (17%) for VKA group and nine patients (15.3%) for DOACs group. None of the patients needed a medical support for managing of bleeding. Seven days after surgery, no cases of post-extractive complications occurred.
    Conclusions: The use of L-PRF resulted in limited mild late post-operative bleedings without the need of medical intervention.
    Clinical relevance: The use of L-PRF can be adopted for an uneventful post-operative curse in anticoagulated patients without chasing their therapy for single tooth extraction.
    MeSH term(s) Humans ; Cohort Studies ; Platelet-Rich Fibrin ; Vitamin K ; Administration, Oral ; Postoperative Hemorrhage/chemically induced ; Anticoagulants ; Postoperative Complications/etiology ; Hemostatics/therapeutic use ; Tooth Extraction/adverse effects
    Chemical Substances Vitamin K (12001-79-5) ; Anticoagulants ; Hemostatics
    Language English
    Publishing date 2023-01-28
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-023-04880-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Simple scores to predict 1-year mortality in atrial fibrillation.

    Cemin, Roberto / Maggioni, Aldo Pietro / Gonzini, Lucio / Di Pasquale, Giuseppe / Boriani, Giuseppe / Di Lenarda, Andrea / Nardi, Federico / Gulizia, Michele Massimo

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2024  Volume 25, Issue 4, Page(s) 271–279

    Abstract: Background: Traditional scores as CHADS2 and CHA2DS2-Vasc are suitable for predicting stroke and systemic embolism in patients with atrial fibrillation (AF) and have shown to be also associated with mortality. Other more complex scores have been ... ...

    Abstract Background: Traditional scores as CHADS2 and CHA2DS2-Vasc are suitable for predicting stroke and systemic embolism in patients with atrial fibrillation (AF) and have shown to be also associated with mortality. Other more complex scores have been recommended for survival prediction. The purpose of our analysis was to test the performance of different clinical scores in predicting 1-year mortality in AF patients.
    Material and methods: CHADS2 and CHA2DS2-Vasc scores were calculated for AF patients of the BLITZ-AF register and compared to R2-CHADS2, R2-CHA2DS2-Vasc and CHA2DS2VASc-RAF scores in predicting 1-year survival. Scores including renal function were calculated both with glomerular filtration rate (GFR) and creatinine clearance.
    Results: One-year vital status (1960 alive and 199 dead) was available in 2159 patients. Receiver-operating characteristic curves displayed an association of each score to all-cause mortality, with R2(ClCrea)-CHADS2 being the best [area under the curve (AUC) 0.734]. Differences among the AUCs of the eight scores were not so evident, and a significant difference was found only between R2(ClCrea)-CHADS2 and CHADS2, CHA2DS2VASc, (ClCrea)-CHA2DS2-VASC-RAF.All the scores showed a similar performance for cardiovascular (CV) mortality, with CHA2DS2VASc-RAF being the best (AUC 0.757), with a significant difference with respect to CHADS2, CHA2DS2VASc, and (ClCrea)CHA2DS2Vasc-RAF.
    Conclusions: More complex scores, even if with better statistical performance, do not show a clinically relevant higher capability to discriminate alive or dead patients at 12 months. The classical and well known CHA2DS2VASc score, which is routinely used all around the world, has a high sensitivity in predicting all-cause mortality (AUC 0.695; Sensit. 80.4%) and CV mortality (AUC 0.691; Sensit. 80.0%).
    Graphical abstract: http://links.lww.com/JCM/A632.
    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Risk Assessment/methods ; Risk Factors ; Fendiline ; Stroke/diagnosis ; Stroke/etiology ; Predictive Value of Tests
    Chemical Substances Fendiline (S253D559A8)
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001602
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Indirect comparison between ferric carboxymaltose and oral iron replacement in heart failure with reduced ejection fraction: a network meta-analysis.

    Sciatti, Edoardo / Nesti, Ugo / Di Lenarda, Andrea

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2021  Volume 91, Issue 3

    Abstract: Treatment of iron deficiency (ID) in patients with heart failure (HF) has improved symptoms, quality of life, exercise capacity and has reduced hospitalizations in randomized controlled trials (RCTs) and meta-analyses. Intravenous ferric carboxymaltose ( ... ...

    Abstract Treatment of iron deficiency (ID) in patients with heart failure (HF) has improved symptoms, quality of life, exercise capacity and has reduced hospitalizations in randomized controlled trials (RCTs) and meta-analyses. Intravenous ferric carboxymaltose (FCM) provided convincing results in this field, while oral iron supplementation failed. However, FCM and oral iron were compared to placebo, and a comparison between the two strategies is still lacking. We aimed to fill this gap of knowledge with an indirect comparison between them by means of a network meta-analysis of RCTs. Five studies measuring exercise capacity (i.e. 6-minute walking test) and quality of life (i.e. Kansas City Cardiomyopathy Questionnaire) were eligible to be included in our review. Given the limitations of a network meta-analysis, our findings support the better efficacy of FCM than oral iron as regards exercise capacity, with a trend towards an improvement in quality of life, suggesting that FCM seems to be strategy of choice to correct ID in HF patients.
    MeSH term(s) Anemia, Iron-Deficiency/drug therapy ; Ferric Compounds ; Heart Failure/drug therapy ; Humans ; Iron ; Maltose/analogs & derivatives ; Network Meta-Analysis
    Chemical Substances Ferric Compounds ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2021-03-31
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2021.1703
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Flexible Approaches Based on Multistate Models and Microsimulation to Perform Real-World Cost-Effectiveness Analyses: An Application to Proprotein Convertase Subtilisin-Kexin Type 9 Inhibitors.

    Gregorio, Caterina / Rea, Federico / Ieva, Francesca / Scagnetto, Arjuna / Indennidate, Carla / Cappelletto, Chiara / Di Lenarda, Andrea / Barbati, Giulia

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

    2024  

    Abstract: Objectives: This study aims to show the application of flexible statistical methods in real-world cost-effectiveness analyses applied in the cardiovascular field, focusing specifically on the use of proprotein convertase subtilisin-kexin type 9 ... ...

    Abstract Objectives: This study aims to show the application of flexible statistical methods in real-world cost-effectiveness analyses applied in the cardiovascular field, focusing specifically on the use of proprotein convertase subtilisin-kexin type 9 inhibitors for hyperlipidemia.
    Methods: The proposed method allowed us to use an electronic health database to emulate a target trial for cost-effectiveness analysis using multistate modeling and microsimulation. We formally established the study design and provided precise definitions of the causal measures of interest while also outlining the assumptions necessary for accurately estimating these measures using the available data. Additionally, we thoroughly considered goodness-of-fit assessments and sensitivity analyses of the decision model, which are crucial to capture the complexity of individuals' healthcare pathway and to enhance the validity of this type of health economic models.
    Results: In the disease model, the Markov assumption was found to be inadequate, and a "time-reset" timescale was implemented together with the use of a time-dependent variable to incorporate past hospitalization history. Furthermore, the microsimulation decision model demonstrated a satisfying goodness of fit, as evidenced by the consistent results obtained in the short-term horizon compared with a nonmodel-based approach. Notably, proprotein convertase subtilisin-kexin type 9 inhibitors revealed their favorable cost-effectiveness only in the long-term follow-up, with a minimum willingness to pay of 39 000 Euro/life years gained.
    Conclusions: The approach demonstrated its significant utility in several ways. Unlike nonmodel-based or alternative model-based methods, it enabled to (1) investigate long-term cost-effectiveness comprehensively, (2) use an appropriate disease model that aligns with the specific problem under study, and (3) conduct subgroup-specific cost-effectiveness analyses to gain more targeted insights.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1471745-1
    ISSN 1524-4733 ; 1098-3015
    ISSN (online) 1524-4733
    ISSN 1098-3015
    DOI 10.1016/j.jval.2024.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Una campagna nazionale per promuovere un utilizzo appropriato dei peptidi natriuretici nello scompenso cardiaco.

    Di Lenarda, Andrea

    Giornale italiano di cardiologia (2006)

    2016  Volume 17, Issue 1, Page(s) 48–50

    Title translation A national campaign for the promotion of the appropriate use of natriuretic peptide assays in heart failure patients.
    MeSH term(s) Biomarkers/blood ; Guidelines as Topic ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/economics ; Humans ; Italy ; Natriuretic Agents/blood ; Natriuretic Peptide, Brain/blood ; Natriuretic Peptides/blood ; Natriuretic Peptides/economics ; Predictive Value of Tests ; Prognosis ; Sensitivity and Specificity ; Severity of Illness Index
    Chemical Substances Biomarkers ; Natriuretic Agents ; Natriuretic Peptides ; Natriuretic Peptide, Brain (114471-18-0)
    Language Italian
    Publishing date 2016-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/2140.23190
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top