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  1. Article ; Online: Reproducibility of retinal vessel density among three different OCTA devices in ADOA patients.

    Lombardo, Marco / Di Marco, Ernesto / Nucci, Carlo / Cesareo, Massimo

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 261, Issue 1, Page(s) 277–279

    MeSH term(s) Humans ; Reproducibility of Results ; Retinal Vessels ; Fluorescein Angiography ; Tomography, Optical Coherence
    Language English
    Publishing date 2022-08-08
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05788-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ul I Zs.15: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The Retinal Posterior Pole in Early Parkinson's Disease: A Fundus Perimetry and SD-OCT Study.

    Cesareo, Massimo / Di Marco, Ernesto / Giannini, Clarissa / Di Marino, Matteo / Aiello, Francesco / Pisani, Antonio / Pierantozzi, Mariangela / Mercuri, Nicola Biagio / Nucci, Carlo / Mancino, Raffaele

    Clinical ophthalmology (Auckland, N.Z.)

    2021  Volume 15, Page(s) 4005–4014

    Abstract: Purpose: To assess the structure and function of the retinal posterior pole in patients with early Parkinson's disease (PD) and to identify possible biomarkers correlated with clinical features.: Patients and methods: A cross-sectional case-control ... ...

    Abstract Purpose: To assess the structure and function of the retinal posterior pole in patients with early Parkinson's disease (PD) and to identify possible biomarkers correlated with clinical features.
    Patients and methods: A cross-sectional case-control study of 21 patients with PD and 22 age-matched healthy controls (HC) was conducted. All subjects underwent full ophthalmological examinations, fundus perimetry (FP) and spectral domain-OCT (SD-OCT) of the entire retinal posterior pole and peripapillary retinal nerve fiber layer (pRNFL).
    Results: We analyzed 41 eyes from 21 patients (14 males and 7 females) with early PD (Hoehn and Yahr scale (H&Y) equal to or less than stage 2) and 41 eyes from 22 HC (12 males and 10 females). We found no significant difference in the pRNFL thickness between patients with PD and HC. The statistical analysis of the SD-OCT posterior pole area, consisting of 64 values for each retinal layer, revealed a decrease in the outer nuclear layer (ONL) thickness in patients with PD (p < 0.0001). On the contrary, a significant increase in the thickness of the outer plexiform layer (OPL) (p < 0.0001) and of the retinal pigmented epithelium (RPE) (p= 0.002) compared to healthy controls was detected. Other retinal layers showed no significant statistical differences. The differential light sensitivity (DLS) values measured by FP were significantly lower in patients than the healthy controls (15 [13-16.2] vs 17.95 [16.08-18.96] p<0.0001).
    Conclusion: Our results showed that DLS and retinal structure differed in the posterior pole between patients with early PD and controls. Thickening of the OPL may represent accumulation of α-synuclein in the OPL of patients with PD.
    Language English
    Publishing date 2021-10-04
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S323944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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