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  1. Article ; Online: Optimal Timing of Cholecystectomy for Severe Acute Pancreatitis and Understanding Complications and Comorbidities-Reply.

    Di Martino, Marcello / Ielpo, Benedetto / Podda, Mauro

    JAMA surgery

    2024  Volume 159, Issue 4, Page(s) 466–467

    MeSH term(s) Humans ; Pancreatitis/surgery ; Pancreatitis/etiology ; Acute Disease ; Cholecystectomy/adverse effects ; Cholecystectomy, Laparoscopic/adverse effects ; Retrospective Studies
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2023.6932
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    Uk I Zs.72: Show issues Location:
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  2. Article ; Online: ASO Author Reflections: Peri-operative Chemotherapy for Resectable Colorectal Liver Metastases.

    Di Martino, Marcello / Primavesi, Florian

    Annals of surgical oncology

    2022  Volume 29, Issue 11, Page(s) 6843–6844

    MeSH term(s) Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Hepatectomy ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-022-12176-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
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  3. Article ; Online: Pancreatic cancer surgery.

    Di Martino, Marcello / El Boghdady, Michael

    BMC surgery

    2023  Volume 23, Issue 1, Page(s) 196

    MeSH term(s) Humans ; Pancreatic Neoplasms/surgery ; Pancreas/surgery ; Pancreatectomy ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-023-02091-7
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  4. Article ; Online: Metodologia e regole per misurare l’aderenza: oltre il binomio medico-paziente.

    Alagna, Michela / Di Martino, Mirko

    Recenti progressi in medicina

    2021  Volume 112, Issue 9, Page(s) 557–560

    Abstract: Observational studies report low adherence to chronic polytherapy indicated by the international guidelines for the secondary prevention of acute myocardial infarction. However, current scientific evidence does not allow to quantify how much of the ... ...

    Title translation Methodology and rules for measuring adherence: beyond the doctor-patient combination.
    Abstract Observational studies report low adherence to chronic polytherapy indicated by the international guidelines for the secondary prevention of acute myocardial infarction. However, current scientific evidence does not allow to quantify how much of the distance from the guidelines is attributable to the patient's behavior, to the providers of local care (general practitioners, district, Local Health Authority) or to the hospital of discharge. A cohort of about 17,600 patients with incident myocardial infarction, discharged from hospitals of Lazio region was selected, with the aim to measure the adherence in real clinical practice. Pharmaceutical prescriptions recorded in the two years following discharge were collected and analyzed. Results show low adherence to polytherapy and substantial intra-regional variability and identify in the hospital of discharge the care setting most responsible for the variability found in adherence levels, even after two years from acute episode.
    MeSH term(s) General Practitioners ; Guideline Adherence ; Humans ; Medication Adherence ; Myocardial Infarction/drug therapy ; Patient Discharge ; Secondary Prevention
    Language Italian
    Publishing date 2021-07-09
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 138266-4
    ISSN 2038-1840 ; 0034-1193
    ISSN (online) 2038-1840
    ISSN 0034-1193
    DOI 10.1701/3658.36416
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    Zs.B 193: Show issues Location:
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  5. Article ; Online: Percutaneous cholecystostomy in elderly patients with acute cholecystitis: a systematic review and meta-analysis.

    Terrone, Alfonso / Di Martino, Marcello / Saeidi, Sara / Ranucci, Chiara / Di Saverio, Salomone / Giuliani, Antonio

    Updates in surgery

    2024  Volume 76, Issue 2, Page(s) 363–373

    Abstract: Percutaneous cholecystostomy (PC) is often preferred over early cholecystectomy (EC) for elderly patients presenting with acute cholecystitis (AC). However, there is a lack of solid data on this issue. Following the PRISMA guidelines, we searched the ... ...

    Abstract Percutaneous cholecystostomy (PC) is often preferred over early cholecystectomy (EC) for elderly patients presenting with acute cholecystitis (AC). However, there is a lack of solid data on this issue. Following the PRISMA guidelines, we searched the Medline and Web of Science databases for reports published before December 2022. Studies that assessed elderly patients (aged 65 years and older) with AC treated using PC, in comparison with those treated with EC, were included. Outcomes analyzed were perioperative outcomes and readmissions. The literature search yielded 3279 records, from which 7 papers (1208 patients) met the inclusion criteria. No clinical trials were identified. Patients undergoing PC comprised a higher percentage of cases with ASA III or IV status (OR 3.49, 95%CI 1.59-7.69, p = 0.009) and individuals with moderate to severe AC (OR 1.78, 95%CI 1.00-3.16, p = 0.05). No significant differences were observed in terms of mortality and morbidity. However, patients in the PC groups exhibited a higher rate of readmissions (OR 3.77, 95%CI 2.35-6.05, p < 0.001) and a greater incidence of persistent or recurrent gallstone disease (OR 12.60, 95%CI 3.09-51.38, p < 0.001). Elderly patients selected for PC, displayed greater frailty and more severe AC, but did not exhibit increased post-interventional morbidity and mortality compared to those undergoing EC. Despite their inferior life expectancy, they still presented a greater likelihood of persistent or recurrent disease compared to the control group.
    MeSH term(s) Aged ; Humans ; Cholecystostomy/adverse effects ; Treatment Outcome ; Cholecystitis, Acute/surgery ; Cholecystitis, Acute/etiology ; Cholecystectomy/adverse effects ; Gallstones/surgery ; Retrospective Studies
    Language English
    Publishing date 2024-02-19
    Publishing country Italy
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-023-01736-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 101: Show issues Location:
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  6. Article: A Neural Network Based Superstructure Optimization Approach to Reverse Osmosis Desalination Plants.

    Di Martino, Marcello / Avraamidou, Styliani / Pistikopoulos, Efstratios N

    Membranes

    2022  Volume 12, Issue 2

    Abstract: An ever-growing population together with globally depleting water resources pose immense stresses for water supply systems. Desalination technologies can reduce these stresses by generating fresh water from saline water sources. Reverse osmosis (RO), as ... ...

    Abstract An ever-growing population together with globally depleting water resources pose immense stresses for water supply systems. Desalination technologies can reduce these stresses by generating fresh water from saline water sources. Reverse osmosis (RO), as the industry leading desalination technology, typically involves a complex network of membrane modules that separate unwanted particles from water. The optimal design and operation of these complex RO systems can be computationally expensive. In this work, we present a modeling and optimization strategy for addressing the optimal operation of an industrial-scale RO plant. We employ a feed-forward artificial neural network (ANN) surrogate modeling representation with rectified linear units as activation functions to capture the membrane behavior accurately. Several ANN set-ups and surrogate models are presented and evaluated, based on collected data from the H2Oaks RO desalination plant in South-Central Texas. The developed ANN is then transformed into a mixed-integer linear programming formulation for the purpose of minimizing energy consumption while maximizing water utilization. Trade-offs between the two competing objectives are visualized in a Pareto front, where indirect savings can be uncovered by comparing energy consumption for an array of water recoveries and feed flows.
    Language English
    Publishing date 2022-02-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12020199
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  7. Book ; Online: Computation of a possible Tunguska's strewn field

    Carbognani, Albino / Di Martino, Mario / Stirpe, Giovanna

    2023  

    Abstract: On June 30, 1908, at about 0h 14.5m UTC, the Tunguska Event (TE) occurred, most likely caused by the fall of a small stony asteroid of about 50-80 meters in diameter over the basin of the Tunguska River (Central Siberia). This paper will establish ... ...

    Abstract On June 30, 1908, at about 0h 14.5m UTC, the Tunguska Event (TE) occurred, most likely caused by the fall of a small stony asteroid of about 50-80 meters in diameter over the basin of the Tunguska River (Central Siberia). This paper will establish whether stony macroscopic fragments could have survived the TCB's airburst (Tunguska Cosmic Body) and where they might have fallen. For this purpose, we have implemented a fall model to describe the mass ablation, pancake expansion, airburst and fragments's dark flight. In our scenario, the fragments have a higher mean strength than the main body due to Weibull's law. The results, for a TCB with a kinetic energy of 15 Mt, atmospheric speed in the range of 11-20 km/s, trajectory inclination of $35^\circ$ and average strength in the range of 3-70 MPa, tell us that for a macroscopic fragment with a mean strength between 14-85 MPa would be possible to survive the high pressure and temperature airburst to reach the ground. The falling speed of the fragments is in the range of 0.8-0.5 km/s, favouring their burial in the permafrost. The range of mean strength values for the TCB's macroscopic fragment appears physically plausible if we consider the falls of Carancas in 2007, with an estimated strength in the range of 20-40 MPa. So our possible strewn field, computed for a typical fall speed of $10 \pm 3 $ km/s, is located about 11 km northwest from the epicentre, with an area of about $140~\textrm{km}^2$. Finally, Cheko Lake, which by some authors is considered an impact crater, falls about 3.5 km outside the strewn fields at 3 sigma level and it is unlikely that it could be a real impact crater: only if the TCB's trajectory had an azimuth in the range $150^\circ - 180^\circ$ would be in the strewn field area, but this is not consistent with the most likely trajectory azimuth.

    Comment: 19 pages, 7 figures, draft of a work in progress, version 7
    Keywords Astrophysics - Earth and Planetary Astrophysics ; Physics - Geophysics
    Subject code 333
    Publishing date 2023-02-27
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Polynucleotides and Hyaluronic Acid (PN-HA) Mixture With or Without Deproteinized Bovine Bone Mineral as a Novel Approach for the Treatment of Deep Infra-Bony Defects: A Retrospective Case-Series.

    Cairo, Francesco / Cavalcanti, Raffaele / Barbato, Luigi / Nieri, Michele / Castelluzzo, Walter / di Martino, Maria / Pilloni, Andrea

    The International journal of periodontics & restorative dentistry

    2024  , Page(s) 1–24

    Abstract: Polynucleotides and Hyaluronic Acid (PN-HA) mixture showed several effects in modulation of healing process. The aim of this study was to assess the safety and clinical performance of PN-HA alone or in association with Deproteinized Bovine Bone Mineral ( ... ...

    Abstract Polynucleotides and Hyaluronic Acid (PN-HA) mixture showed several effects in modulation of healing process. The aim of this study was to assess the safety and clinical performance of PN-HA alone or in association with Deproteinized Bovine Bone Mineral (DBBM) with papillary preservation flaps (PPF) in the treatment of residual pockets. A total of 43 patients with 55 infra-bony defects were recruited; 30% were smokers. The mean baseline Probing Depth (PD) was 7.7 ±1.9 mm with a corresponding mean recession (Rec) of 1.9± 1.3 mm. The depth of infra-bony defect at the surgical measurement was 5.2±2.1 mm. DBBM was applied at 56% of the defects considered as not-containing based on clinical judgment. Healing was uneventful at all sites. After one year, PD reduction was 4.4±1.8 mm with a Rec increase of 1.0 ±0.8 mm. Detected bone fill at x-ray was 3.5 ± 1.9mm. The multilevel analysis showed that absence of smoking habits was associated with improved PD reduction (P =0.026) and bone gain (P= 0.039). PN-HA mixture is a safe product for periodontal surgery and seems to promote clinical benefit in the treatment of residual pockets associated to infra-bony defects.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ISSN 1945-3388
    ISSN (online) 1945-3388
    DOI 10.11607/prd.7065
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  9. Article ; Online: Recent Progress in Photoresponsive Biomaterials.

    Di Martino, Miriam / Sessa, Lucia / Diana, Rosita / Piotto, Stefano / Concilio, Simona

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 9

    Abstract: Photoresponsive biomaterials have garnered increasing attention recently due to their ability to dynamically regulate biological interactions and cellular behaviors in response to light. This review provides an overview of recent advances in the design, ... ...

    Abstract Photoresponsive biomaterials have garnered increasing attention recently due to their ability to dynamically regulate biological interactions and cellular behaviors in response to light. This review provides an overview of recent advances in the design, synthesis, and applications of photoresponsive biomaterials, including photochromic molecules, photocleavable linkers, and photoreactive polymers. We highlight the various approaches used to control the photoresponsive behavior of these materials, including modulation of light intensity, wavelength, and duration. Additionally, we discuss the applications of photoresponsive biomaterials in various fields, including drug delivery, tissue engineering, biosensing, and optical storage. A selection of significant cutting-edge articles collected in recent years has been discussed based on the structural pattern and light-responsive performance, focusing mainly on the photoactivity of azobenzene, hydrazone, diarylethenes, and spiropyrans, and the design of smart materials as the most targeted and desirable application. Overall, this review highlights the potential of photoresponsive biomaterials to enable spatiotemporal control of biological processes and opens up exciting opportunities for developing advanced biomaterials with enhanced functionality.
    MeSH term(s) Biocompatible Materials ; Polymers/chemistry ; Drug Delivery Systems ; Hydrazones ; Light
    Chemical Substances Biocompatible Materials ; Polymers ; Hydrazones
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28093712
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    Zs.MO 81: Show issues

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  10. Article ; Online: Systemic therapy with lenvatinib in advanced hepatocellular carcinoma: what to do in the case of a complete radiologic response?

    Pirozzi, Raffaele Emmanuele Maria / Di Martino, Marcello / Ferraro, Daniele / Pisaniello, Donatella / Vennarecci, Giovanni

    Journal of gastrointestinal and liver diseases : JGLD

    2023  Volume 32, Issue 1, Page(s) 118–119

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/drug therapy ; Phenylurea Compounds/therapeutic use ; Quinolines/therapeutic use
    Chemical Substances lenvatinib (EE083865G2) ; Phenylurea Compounds ; Quinolines
    Language English
    Publishing date 2023-04-01
    Publishing country Romania
    Document type Letter ; Comment
    ZDB-ID 2427021-0
    ISSN 1842-1121 ; 1841-8724
    ISSN (online) 1842-1121
    ISSN 1841-8724
    DOI 10.15403/jgld-4811
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