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  1. Book: The endocannabinoid system in metabolic control

    Di Marzo, Vincenzo

    (Best practice & research : Clinical endocrinology & metabolism ; 23,1)

    2009  

    Author's details V. di Marzo, guest ed
    Series title Best practice & research : Clinical endocrinology & metabolism ; 23,1
    Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Collection Best practice & research
    Best practice & research ; Clinical endocrinology & metabolism
    Language English
    Size IX, 145 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015896683
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1075 -23,1- verfügbar in Königswinter Königswinter

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  2. Article ; Online: The Gut Microbiome-Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior.

    Silvestri, Cristoforo / Di Marzo, Vincenzo

    Function (Oxford, England)

    2023  Volume 4, Issue 2, Page(s) zqad003

    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Inflammation/metabolism ; Endocannabinoids/metabolism
    Chemical Substances Endocannabinoids
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqad003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Cannabinoids

    Di Marzo, Vincenzo

    (Neuroscience intelligence unit)

    2004  

    Author's details Vincenzo Di Marzo
    Series title Neuroscience intelligence unit
    Keywords Cannabinoids / pharmacokinetics ; Cannabinoids / therapeutic use ; Cannabinoids / adverse effects ; Marijuana Smoking / adverse effects ; Receptors, Cannabinoid
    Language English
    Size 216 S.
    Publisher Landes Bioscience/Eurekah.com u.a.
    Publishing place Georgetown, Tex
    Publishing country United States
    Document type Book
    HBZ-ID HT014047150
    ISBN 0-306-48228-2 ; 978-0-306-48228-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 3387 order for loan Magazin

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  4. Article ; Online: (Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders.

    Sihag, Jyoti / Di Marzo, Vincenzo

    Lipids in health and disease

    2022  Volume 21, Issue 1, Page(s) 9

    Abstract: The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. The diet modulates these bioactive lipids and the gut microbiome, both working in an entwined alliance. Mounting ... ...

    Abstract The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. The diet modulates these bioactive lipids and the gut microbiome, both working in an entwined alliance. Mounting evidence suggests that, in different ways and with a certain specialisation, lipid signalling mediators such as N-acylethanolamines (NAEs), 2-monoacylglycerols (2-MAGs), and N-acyl-amino acids (NAAs), along with endocannabinoids (eCBs), can modulate physiological mechanisms underpinning appetite, food intake, macronutrient metabolism, pain sensation, blood pressure, mood, cognition, and immunity. This knowledge has been primarily utilised in pharmacology and medicine to develop many drugs targeting the fine and specific molecular pathways orchestrating eCB and eCBome activity. Conversely, the contribution of dietary NAEs, 2-MAGs and eCBs to the biological functions of these molecules has been little studied. In this review, we discuss the importance of (Wh) olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N) utrition (WHEN), in the management of obesity and related disorders.
    MeSH term(s) Animals ; Endocannabinoids/metabolism ; Endocannabinoids/physiology ; Gastrointestinal Microbiome/physiology ; Humans ; Nutritional Physiological Phenomena/physiology ; Obesity/diet therapy ; Obesity/etiology ; Obesity/metabolism ; Receptors, Cannabinoid/metabolism
    Chemical Substances Endocannabinoids ; Receptors, Cannabinoid
    Language English
    Publishing date 2022-01-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2091381-3
    ISSN 1476-511X ; 1476-511X
    ISSN (online) 1476-511X
    ISSN 1476-511X
    DOI 10.1186/s12944-021-01609-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The endocannabinoidome as a substrate for noneuphoric phytocannabinoid action and gut microbiome dysfunction in neuropsychiatric disorders
.

    Di Marzo, Vincenzo

    Dialogues in clinical neuroscience

    2020  Volume 22, Issue 3, Page(s) 259–269

    Abstract: The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid ... ...

    Abstract The endocannabinoid (eCB) system encompasses the eCBs anandamide and 2-arachidonoylglycerol, their anabolic/catabolic enzymes, and the cannabinoid CB
    MeSH term(s) Animals ; Cannabidiol/pharmacology ; Cannabidiol/therapeutic use ; Cannabinoids/pharmacology ; Cannabinoids/therapeutic use ; Endocannabinoids/physiology ; Gastrointestinal Microbiome/drug effects ; Humans ; Mental Disorders/drug therapy ; Mental Disorders/microbiology ; Mood Disorders/drug therapy ; Mood Disorders/microbiology ; Signal Transduction
    Chemical Substances Cannabinoids ; Endocannabinoids ; Cannabidiol (19GBJ60SN5)
    Language English
    Publishing date 2020-10-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2188781-0
    ISSN 1958-5969 ; 1294-8322
    ISSN (online) 1958-5969
    ISSN 1294-8322
    DOI 10.31887/DCNS.2020.22.3/vdimarzo
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6188: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The emerging role of the endocannabinoidome-gut microbiome axis in eating disorders.

    Mir, Hayatte-Dounia / Giorgini, Giada / Di Marzo, Vincenzo

    Psychoneuroendocrinology

    2023  Volume 154, Page(s) 106295

    Abstract: Among the sources of chemical signals regulating food intake, energy metabolism and body weight, few have attracted recently as much attention as the expanded endocannabinoid system, or endocannabinoidome (eCBome), and the gut microbiome, the two systems ...

    Abstract Among the sources of chemical signals regulating food intake, energy metabolism and body weight, few have attracted recently as much attention as the expanded endocannabinoid system, or endocannabinoidome (eCBome), and the gut microbiome, the two systems on which this review article is focussed. Therefore, it is legitimate to expect that these two systems also play a major role in the etiopathology of eating disorders (EDs), in particular of anorexia nervosa, bulimia nervosa and binge-eating disorder. The major mechanisms through which, also via interactions with other endogenous signaling systems, the eCBome, with its several lipid mediators and receptors, and the gut microbiome, via its variety of microbial kingdoms, phyla and species, and armamentarium of metabolites, intervene in these disorders, are described here, based on several published studies in either experimental models or patients. Additionally, in view of the emerging multi-faceted cross-talk mechanisms between these two complex systems, we discuss the possibility that the eCBome-gut microbiome axis is also involved in EDs.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Feeding and Eating Disorders ; Bulimia Nervosa ; Anorexia Nervosa ; Endocannabinoids/physiology
    Chemical Substances Endocannabinoids
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2023.106295
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples.

    Falascina, Gianna / Bindels, Laure B / Di Marzo, Vincenzo / Cutignano, Adele

    Journal of pharmaceutical and biomedical analysis

    2023  Volume 226, Page(s) 115252

    Abstract: The recent discovery of N-acyl taurines (NATs) as a class of endogenous bioactive lipids and the perspective of their possible pharmacological applications stimulated the development of mass spectrometry-based methods for their quantitative measurements ... ...

    Abstract The recent discovery of N-acyl taurines (NATs) as a class of endogenous bioactive lipids and the perspective of their possible pharmacological applications stimulated the development of mass spectrometry-based methods for their quantitative measurements in biological tissues and fluids. We report here for the first time a procedure validated both in liver surrogate matrix and neat solvent (MeOH) based on UPLC-ESI-QqQ analysis for the identification and quantification of NATs in biological tissue extracts. The LC-MS method was based on five representative lipid analogues, including saturated, monounsaturated and polyunsaturated species, namely N-palmitoyl taurine (C16:0 NAT), N-oleoyl taurine (C18:1 NAT), N-arachidonoyl taurine (C20:4 NAT), N-docosanoyl taurine (C22:0 NAT) and N-nervonoyl taurine (C24:1 NAT), and evaluated for specificity, linearity, matrix effect, recovery, repeatability and intermediate precision and accuracy. The method validated in MeOH by internal standard approach (d
    MeSH term(s) Mice ; Animals ; Tandem Mass Spectrometry/methods ; Chromatography, Liquid ; Chromatography, High Pressure Liquid/methods ; Taurine ; Reference Standards ; Reproducibility of Results
    Chemical Substances Taurine (1EQV5MLY3D)
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Facile and Sustainable Synthesis of Commendamide and its Analogues.

    Villano, Rosaria / Tinto, Francesco / Di Marzo, Vincenzo

    Frontiers in chemistry

    2022  Volume 10, Page(s) 858854

    Abstract: Commendamide, or N-(3-hydroxypalmitoyl)- ... ...

    Abstract Commendamide, or N-(3-hydroxypalmitoyl)-glycine
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.858854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Obesity: The Fat Tissue Disease Version of Cancer.

    Boubertakh, Besma / Silvestri, Cristoforo / Di Marzo, Vincenzo

    Cells

    2022  Volume 11, Issue 12

    Abstract: Obesity is a disease with high potential for fatality. It perfectly fits the disease definition, as cancer does. This is because it damages body structure and functions, both mechanically and biologically, and alters physical, mental, and social health. ... ...

    Abstract Obesity is a disease with high potential for fatality. It perfectly fits the disease definition, as cancer does. This is because it damages body structure and functions, both mechanically and biologically, and alters physical, mental, and social health. In addition, it shares many common morbid characteristics with the most feared disease, cancer. For example, it is influenced by a sophisticated interaction between a person's genetics, the environment, and an increasing number of other backgrounds. Furthermore, it displays abnormal cell growth and proliferation events, only limited to white fat, resulting in adipose tissue taking up an increasing amount of space within the body. This occurs through fat "metastases" and via altered signaling that further aggravates the pathology of obesity by inducing ubiquitous dishomeostasis. These metastases can be made graver by angiogenesis, which might boost diseased tissue growth. More common features with cancer include its progressive escalation through different levels of severity and its possibility of re-onset after recovery. Despite all these similarities with cancer, obesity is substantially less agitating for most people. Thus, the ideas proposed herein could have utility to sensitize the public opinion about the hard reality of obesity. This is increasingly needed, as the obesity pandemic has waged a fierce war against our bodies and society in general, while there is still doubt about whether it is a real disease or not. Hence, raising public consciousness to properly face health issues is crucial to improving our health instead of gaining weight unhealthily. It is obviously illogical to fight cancer extremely seriously on the one hand and to consider dying with obesity as self-inflicted on the other. In fact, obesity merits a top position among the most lethal diseases besides cancer.
    MeSH term(s) Adipose Tissue ; Humans ; Neoplasms ; Obesity ; Weight Gain
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11121872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint.

    Schiano Moriello, Aniello / Di Marzo, Vincenzo / Petrosino, Stefania

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 3

    Abstract: There is growing evidence that perturbation of the gut microbiome, known as "dysbiosis", is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract. In this regard, recent studies have ... ...

    Abstract There is growing evidence that perturbation of the gut microbiome, known as "dysbiosis", is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract. In this regard, recent studies have demonstrated that dysbiosis is linked to the pathogenesis of central neuroinflammatory disorders, supporting the existence of the so-called microbiome-gut-brain axis. The endocannabinoid system is a recently recognized lipid signaling system and termed endocannabinoidome monitoring a variety of body responses. Accumulating evidence demonstrates that a profound link exists between the gut microbiome and the endocannabinoidome, with mutual interactions controlling intestinal homeostasis, energy metabolism and neuroinflammatory responses during physiological conditions. In the present review, we summarize the latest data on the microbiome-endocannabinoidome mutual link in health and disease, focalizing the attention on gut dysbiosis and/or altered endocannabinoidome tone that may distort the bidirectional crosstalk between these two complex systems, thus leading to gastrointestinal and metabolic diseases (e.g., idiopathic inflammation, chronic enteropathies and obesity) as well as neuroinflammatory disorders (e.g., neuropathic pain and depression). We also briefly discuss the novel possible dietary interventions based not only on probiotics and/or prebiotics, but also, and most importantly, on endocannabinoid-like modulators (e.g., palmitoylethanolamide) for intestinal health and beyond.
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12030348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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