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Article: Vaccines Administration in the Perspective of Patient Safety and Quality of Healthcare: Lesson from the Experience of an Italian Teaching Hospital for Pandemic Preparedness.

De Micco, Francesco / De Benedictis, Anna / Sommella, Lorenzo / Di Mattia, Andrea / Campanozzi, Laura Leondina / Alloni, Rossana / Tambone, Vittoradolfo

Vaccines

2022 Volume 10, Issue 9

Abstract: The development and administration of vaccines against COVID-19 was a key element in the fight against the pandemic, as it protected health systems and helped restore global economies. National implementation plans and vaccination strategies for COVID-19 ...

Abstract	The development and administration of vaccines against COVID-19 was a key element in the fight against the pandemic, as it protected health systems and helped restore global economies. National implementation plans and vaccination strategies for COVID-19 vaccines ensured the immunization of large segments of the population in the shortest time. However, even before the start of the vaccination campaign, it was clear to decision-makers that the usual methods of vaccination were not suitable. The aim of this report is to share the experience of an Italian teaching hospital in the organisation of spaces and activities of healthcare workers to realise a safe vaccination campaign. An in-depth analysis of how the vaccination campaign was organised could be useful to understand strengths and weaknesses learnt from this experience and plan an effective, efficient, and resilient response to future pandemics right away. The adoption of a systemic clinical risk management (SCRM) could guarantee healthcare organizations a more adequate and resilient response in an ethics of a job well done perspective, allowing them to maintain high patient safety standards regardless of the contingent situation for which safety first should be the motto of a disaster response plan.
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10091495
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Article ; Online: Queueing Theory and COVID-19 Prevention: Model Proposal to Maximize Safety and Performance of Vaccination Sites.

Di Pumpo, Marcello / Ianni, Andrea / Miccoli, Ginevra Azzurra / Di Mattia, Andrea / Gualandi, Raffaella / Pascucci, Domenico / Ricciardi, Walter / Damiani, Gianfranco / Sommella, Lorenzo / Laurenti, Patrizia

Frontiers in public health

2022 Volume 10, Page(s) 840677

Abstract: Introduction: COVID-19 (Coronavirus Disease 19) has rapidly spread all around the world. Vaccination represents one of the most promising counter-pandemic measures. There is still little specific evidence in literature on how to safely and effectively ... ...

Abstract	Introduction: COVID-19 (Coronavirus Disease 19) has rapidly spread all around the world. Vaccination represents one of the most promising counter-pandemic measures. There is still little specific evidence in literature on how to safely and effectively program access and flow through specific healthcare settings to avoid overcrowding in order to prevent SARS-CoV-2 transmission. Literature regarding appointment scheduling in healthcare is vast. Unpunctuality however, especially when targeting healthcare workers during working hours, is always possible. Therefore, when determining how many subjects to book, using a linear method assuming perfect adhesion to scheduled time could lead to organizational problems. Methods: This study proposes a "Queuing theory" based approach. A COVID-19 vaccination site targeting healthcare workers based in a teaching hospital in Rome was studied to determine real-life arrival rate variability. Three simulations using Queueing theory were performed. Results: Queueing theory application reduced subjects queueing over maximum safety requirements by 112 in a real-life based vaccination setting, by 483 in a double-sized setting and by 750 in a mass vaccination model compared with a linear approach. In the 3 settings, respectively, the percentage of station's time utilization was 98.6, 99.4 and 99.8%, while the average waiting time was 27.2, 33.84, and 33.84 min. Conclusions: Queueing theory has already been applied in healthcare. This study, in line with recent literature developments, proposes the adoption of a Queueing theory base approach to vaccination sites modeling, during the COVID-19 pandemic, as this tool enables to quantify ahead of time the outcome of organizational choices on both safety and performance of vaccination sites.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.840677
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Article: Cisti spleniche primitive. Presentazione di cinque casi di cui quattro inediti e revisione della letteratura.

Bisceglia, M / Nirchio, V / Di Mattia, A / Scaramuzzi, G / Tardio, B

Pathologica

1994 Volume 86, Issue 6, Page(s) 638–644

Abstract: After a complete review of the literature with an amount of 280 previously reported cases, the authors report on five total cases of primary (true) cysts of the spleen one of which already published. All these cases occurred in pediatric age and were ... ...

Title translation	Primary splenic cysts. Report of 5 cases, 4 of which unpublished and review of the literature.
Abstract	After a complete review of the literature with an amount of 280 previously reported cases, the authors report on five total cases of primary (true) cysts of the spleen one of which already published. All these cases occurred in pediatric age and were treated by total splenectomy. All were large solitary cysts (size ranged from 4.5 up to 15 cm) but one, the largest of which in addition to the main cavity exhibited some more microscopic cysts of the same type few mm sized. Three of them were lined on their inner surface by a multilayered squamous epithelium, which in one case was also keratinized. The other two cysts showed a single layered epithelium which appeared flattened in one case, cubic in the other one. The discussion concerns the pathogenetic mechanisms which can lead to cyst formation, the imaging diagnosis of these rare lesions prior to surgical intervention, their treatment, and the correct histological recognition of these true cysts versus secondary (false) cysts or pseudocysts which commonly occur following trauma. One of the cases herein presented qualifies as a "pseudo-pseudocysts" due to the fact that a history of trauma was on record and to the fact that almost the entire epithelium was mechanically lost due to hemorrhage which filled the cyst cavity.
MeSH term(s)	Adolescent ; Adult ; Child ; Cysts/pathology ; Female ; Humans ; Male ; Splenic Diseases/pathology
Language	Italian
Publishing date	1994-12
Publishing country	Italy
Document type	Case Reports ; English Abstract ; Journal Article ; Review
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
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Article: Leukocytoclastic vasculitis of the colon.

Bisceglia, M / Germani, G / Tardio, B / Di Mattia, A / Li Bergoli, M

The Italian journal of surgical sciences

1989 Volume 19, Issue 3, Page(s) 269–272

Abstract: Two cases of young patients with an acute abdomen caused by a necrotizing angiitis of the cecum and ascending colon are reported. The absence of any systemic disease and a history of medical treatment in both cases led to the diagnosis of ... ...

Abstract	Two cases of young patients with an acute abdomen caused by a necrotizing angiitis of the cecum and ascending colon are reported. The absence of any systemic disease and a history of medical treatment in both cases led to the diagnosis of hypersensitivity vasculitis by a serum sickness-like reaction. An extensive review of the literature is also presented.
MeSH term(s)	Adolescent ; Adult ; Arteritis/pathology ; Cecum/blood supply ; Cecum/pathology ; Colon/blood supply ; Colon/pathology ; Female ; Humans ; Leukocytosis/pathology ; Male ; Necrosis ; Neutrophils/pathology
Language	English
Publishing date	1989
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	604847-x
ISSN	0392-3525
ISSN	0392-3525
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Zs.A 1139: Show issues

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Article: Gonorrhoea and condyloma acuminata in a male transsexual.

Fiumara, N J / Di Mattia, A

The British journal of venereal diseases

1973 Volume 49, Issue 5, Page(s) 478–479

MeSH term(s)	Adult ; Condylomata Acuminata/complications ; Condylomata Acuminata/drug therapy ; Disorders of Sex Development ; Gonorrhea/complications ; Gonorrhea/drug therapy ; Humans ; Male ; Podophyllin/therapeutic use ; Spectinomycin/therapeutic use ; Transsexualism/complications ; Transsexualism/surgery
Chemical Substances	Podophyllin (9000-55-9) ; Spectinomycin (93AKI1U6QF)
Language	English
Publishing date	1973-10
Publishing country	England
Document type	Journal Article
ZDB-ID	80086-7
ISSN	0007-134X
ISSN	0007-134X
DOI	10.1136/sti.49.5.478
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Article: Adrenocortical oncocytic tumors: report of 10 cases and review of the literature.

Bisceglia, Michele / Ludovico, Ornella / Di Mattia, Antonio / Ben-Dor, David / Sandbank, Judith / Pasquinelli, Gianandrea / Lau, Sean K / Weiss, Lawrence M

International journal of surgical pathology

2004 Volume 12, Issue 3, Page(s) 231–243

Abstract: Ten additional adrenocortical oncocytic tumors are presented: 2 benign oncocytomas, 4 borderline oncocytomas of uncertain malignant potential, and 4 oncocytic carcinomas. Histologically all tumors were entirely or predominantly composed of oncocytes. ... ...

Abstract	Ten additional adrenocortical oncocytic tumors are presented: 2 benign oncocytomas, 4 borderline oncocytomas of uncertain malignant potential, and 4 oncocytic carcinomas. Histologically all tumors were entirely or predominantly composed of oncocytes. Immunohistochemically all tumors were immunoreactive for mitochondrial antigen mES-13. Electron microscopy was performed in 8 cases and was confirmatory of the oncocytic cell change. The morphologic parameters of the Weiss system, considered to be predictive of the biologic behavior of conventional (nononcocytic) adrenocortical tumors, are reviewed in the context of their possible application to the oncocytic tumor variant. Proposed major criteria (high mitotic rate, atypical mitoses, venous invasion) and minor criteria (large size and huge weight, necrosis, capsular invasion, sinusoidal invasion) in distinguishing malignant tumors are discussed, and definitional criteria (predominantly cells with eosinophilic and granular cytoplasm, high nuclear grade, diffuse architectural pattern) in common with all types of oncocytic tumors are outlined. The authors' proposed working rules for diagnostic categorization of oncocytic adrenocortical tumors are defined, with the presence of 1 major criterion indicating malignancy, 1 to 4 minor criteria indicating uncertain malignant potential (borderline), and the absence of all major and minor criteria indicative of benignancy. Using these criteria, the diagnosis of malignancy was straightforward in 3 of the 4 cases designated as oncocytic carcinoma (presence of at least 2 major criteria and all the minor criteria), while in 1 case the original diagnosis of benign oncocytoma was reversed to malignant following critical review of the original pathologic material after local tumor recurrence. Tumor recurrence occurred in 2 carcinomas at 8 and 20 months, respectively, and was followed in 1 case by the patient's death. The third patient expired at 6 months from unrelated causes, and the fourth patient is free of disease at the relatively short follow-up interval of 6 months. Regarding the 4 patients with borderline tumors, all are alive with no evidence of disease, with follow-up ranging from 10 to 61 months (mean 38.7 months). The 2 benign tumors have a follow-up of 25 and 30 months, respectively. Diagnostic difficulties are delineated and a complete review of the literature on this topic has also been performed.
MeSH term(s)	Adenoma, Oxyphilic/metabolism ; Adenoma, Oxyphilic/pathology ; Adenoma, Oxyphilic/ultrastructure ; Adrenal Cortex Neoplasms/metabolism ; Adrenal Cortex Neoplasms/pathology ; Adrenal Cortex Neoplasms/ultrastructure ; Adult ; Aged ; Biomarkers, Tumor/analysis ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; Male ; Microscopy, Electron, Transmission ; Middle Aged ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2004-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1336393-1
ISSN	1066-8969
ISSN	1066-8969
DOI	10.1177/106689690401200304
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Article: Gigantic cutaneous horns of the scalp: lesions with a gross similarity to the horns of animals: a report of four cases.

Michal, Michal / Bisceglia, Michele / Di Mattia, Antonio / Requena, Luis / Fanburg-Smith, Julie C / Mukensnabl, Petr / Hes, Ondrej / Cada, Frantisek

The American journal of surgical pathology

2002 Volume 26, Issue 6, Page(s) 789–794

Abstract: Gigantic cutaneous horns, grossly similar to the horns seen in animals, are exceedingly rare in humans. After finding one case in practice, we searched our departmental files for similar cases and examined them grossly and microscopically. Four cases ... ...

Abstract	Gigantic cutaneous horns, grossly similar to the horns seen in animals, are exceedingly rare in humans. After finding one case in practice, we searched our departmental files for similar cases and examined them grossly and microscopically. Four cases were identified. All occurred as solitary lesions in older women on the parietal-occipital region of the scalp. They had a growth history of up to 30 years; the women hid these horns in their hair. Grossly, the horns were yellow-grey, and there were shallow furrows running along the length of the horns. The length ranged from 17 to 25 cm, and the width was up to 2.5 cm. All four lesions showed similar histologic changes. Microscopically, the gigantic horns consisted of a mixture of squamous epithelial cells and tricholemmal keratinized debris. In one case the base of the horn was directly connected with a mass composed of benign tricholemmal cysts of the scalp. Mitoses were common, but atypical mitoses were not observed. The nuclei of the squamous cells were bland without pleomorphism, hyperchromasia, or atypia. Follow-up of all patients was uneventful: all patients were well and without signs of recurrence or metastasis 2-15 years after the surgical excision. Gigantic cutaneous horns are rare and benign. We think that they represent an extremely well-differentiated variant of proliferating tricholemmal tumor with an unusual and remarkable gross pattern.
MeSH term(s)	Aged ; Aged, 80 and over ; Animals ; Cattle ; Cysts/pathology ; Cysts/surgery ; Female ; Horns/anatomy & histology ; Humans ; Middle Aged ; Scalp/pathology ; Scalp Dermatoses/pathology ; Scalp Dermatoses/surgery ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
Language	English
Publishing date	2002-08-16
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/00000478-200206000-00014
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Article: Malignant melanoma developing from intradermal nevi.

Okun, M R / Di Mattia, A / Thompson, J / Pearson, S H

Archives of dermatology

1974 Volume 110, Issue 4, Page(s) 599–601

MeSH term(s)	Breast Neoplasms ; Female ; Humans ; Male ; Melanoma/etiology ; Melanoma/pathology ; Middle Aged ; Neoplasm Metastasis ; Nevus, Pigmented/complications ; Nevus, Pigmented/pathology ; Scalp ; Skin Neoplasms/complications ; Skin Neoplasms/pathology
Language	English
Publishing date	1974-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	212139-6
ISSN	1538-3652 ; 0003-987X
ISSN (online)	1538-3652
ISSN	0003-987X
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Article: Lesioni mesenchimali benigne tumorali e simil-tumorali della mammella.

Bisceglia, M / Nirchio, V / Carosi, I / Cappucci, U / Decata, A / Paragone, T / Di Mattia, A L

Pathologica

1995 Volume 87, Issue 1, Page(s) 20–41

Abstract: All the spectrum is encompassed of those miscellaneous pathologic entities occurring in the mammary stroma which are on record up to date other than "mixed fibroepithelial" tumors (fibroadenomas and phyllodes tumors) and tumors both "pure" and "mixed" ... ...

Title translation	Tumor and tumor-like benign mesenchymal lesions of the breast.
Abstract	All the spectrum is encompassed of those miscellaneous pathologic entities occurring in the mammary stroma which are on record up to date other than "mixed fibroepithelial" tumors (fibroadenomas and phyllodes tumors) and tumors both "pure" and "mixed" originating from myoepithelium (adenomyoepitheliomas and pleomorphic adenomas). Also they were excluded those dysreactive-autoimmune diseases (sarcoidosis, sclerosing lymphocytic lobulitis, lobular granulomatous mastitis) and those inflammatory-infectious conditions (tuberculosis, actinomycosis, foreign body reactions, Mondor's disease) which can mimick breast tumors clinically or on image analysis, but on the contrary not evoking the idea of a tumor on histology. Specifically, inflammatory pseudotumor, myofibroblastoma, leiomyoma, neurinoma/neurofibroma, benign fibrous histiocytoma, hemangiopericytoma, fibromatosis, nodular fascitis, variants of lipoma, mesenchymoma, amartoma and its variants, hemangiomas, pseudoangiomatous hyperplasia of stroma, amyloid tumor, granular cell tumor, are consecutively described and discussed, with a large list of references enclosed to each rubric. Most of the pictures are taken from personally observed lesions of the breast. Only few pictures referred to are from their analogue lesions which occurred in soft parts of other locations, with specific mention of that when it was the case. Of note after reviewing the literature the fact that no glomus tumor, nor Kaposi's sarcoma either sporadic or in the context of any immunodeficiency, nor myelolipoma has been recorded yet.
MeSH term(s)	Breast Neoplasms/pathology ; Humans ; Mesoderm
Language	Italian
Publishing date	1995-02
Publishing country	Italy
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	418229-7
ISSN	1591-951X ; 0031-2983
ISSN (online)	1591-951X
ISSN	0031-2983
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Article: Improved earphone enclosure for communication in noise.

Bauer, B B / DiMattia, A L

The Journal of the Acoustical Society of America

1972 Volume 51, Issue 5, Page(s) 1388–1393

MeSH term(s)	Acoustics ; Communication ; Methods ; Noise
Language	English
Publishing date	1972-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	219231-7
ISSN	1520-8524 ; 0001-4966
ISSN (online)	1520-8524
ISSN	0001-4966
DOI	10.1121/1.1912989
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