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  1. Article ; Online: Guardians of the barrier: Microbiota engage AHR in keratinocytes to mantain skin homeostasis.

    Alwan, Wisam / Di Meglio, Paola

    Cell host & microbe

    2021  Volume 29, Issue 8, Page(s) 1213–1216

    Abstract: The skin barrier is critical in ensuring homeostasis, yet factors influencing its development, repair, and maintenance are ill-defined. In this issue of Cell Host & Microbe, Uberoi et al. demonstrate the skin microbiota's role in maintaining barrier ... ...

    Abstract The skin barrier is critical in ensuring homeostasis, yet factors influencing its development, repair, and maintenance are ill-defined. In this issue of Cell Host & Microbe, Uberoi et al. demonstrate the skin microbiota's role in maintaining barrier integrity via AHR signaling in keratinocytes, which has implications for skin disease management.
    MeSH term(s) Homeostasis ; Humans ; Keratinocytes ; Microbiota ; Signal Transduction ; Skin
    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2021.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation.

    Alangari, Abdullah A / Ashoori, Matin D / Alwan, Wisam / Dawe, Hannah R / Stockinger, Brigitta / Barker, Jonathan N / Wincent, Emma / Di Meglio, Paola

    Pharmacological research

    2023  Volume 194, Page(s) 106848

    Abstract: Manuka honey (MH) is a complex nutritional material with antimicrobial, antioxidant and anti-inflammatory activity. We have previously shown that MH down regulates IL-4-induced CCL26 expression in immortalized keratinocytes. As MH contains potential ... ...

    Abstract Manuka honey (MH) is a complex nutritional material with antimicrobial, antioxidant and anti-inflammatory activity. We have previously shown that MH down regulates IL-4-induced CCL26 expression in immortalized keratinocytes. As MH contains potential ligands of the Aryl Hydrocarbon Receptor (AHR), a key regulator of skin homeostasis, we hypothesize that this effect is mediated via AHR activation. Here, we treated HaCaT cell lines, either stable transfected with an empty vector (EV-HaCaT) or in which AHR had been stable silenced (AHR-silenced HaCaT); or primary normal human epithelial keratinocytes (NHEK) with 2% MH for 24 h. This induced a 15.4-fold upregulation of CYP1A1 in EV-HaCaTs, which was significantly reduced in AHR-silenced cells. Pre-treatment with the AHR antagonist CH223191 completely abrogated this effect. Similar findings were observed in NHEK. In vivo treatment of the Cyp1a1
    MeSH term(s) Animals ; Humans ; Mice ; Cytochrome P-450 CYP1A1/genetics ; Cytochrome P-450 CYP1A1/metabolism ; Dermatitis ; Honey ; Inflammation ; Interleukin-4/immunology ; Receptors, Aryl Hydrocarbon/metabolism
    Chemical Substances 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide ; Cytochrome P-450 CYP1A1 (EC 1.14.14.1) ; Interleukin-4 (207137-56-2) ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106848
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 721: Show issues Location:
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  3. Article ; Online: Human skin CD141

    Lui, Prudence PokWai / Ainali, Chrysanthi / Chu, Chung-Ching / Terranova-Barberio, Manuela / Karagiannis, Panagiotis / Tewari, Angela / Safinia, Niloufar / Sharif-Paghaleh, Ehsan / Tsoka, Sophia / Woszczek, Grzegorz / Di Meglio, Paola / Lombardi, Giovanna / Young, Antony R / Nestle, Frank O / Ali, Niwa

    iScience

    2023  Volume 26, Issue 10, Page(s) 108029

    Abstract: Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified ... ...

    Abstract Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108029
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  4. Article ; Online: Psoriasis.

    Di Meglio, Paola / Villanova, Federica / Nestle, Frank O

    Cold Spring Harbor perspectives in medicine

    2014  Volume 4, Issue 8

    Abstract: Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated ... ...

    Abstract Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Biological Factors/therapeutic use ; Biomarkers/metabolism ; Dermatologic Agents/therapeutic use ; Environment ; Forecasting ; Genetic Predisposition to Disease/genetics ; Humans ; Immune System/physiology ; Proteins/genetics ; Psoriasis/classification ; Psoriasis/etiology ; Psoriasis/therapy
    Chemical Substances Antibodies, Monoclonal ; Biological Factors ; Biomarkers ; Dermatologic Agents ; PSORS1C1 protein, human ; Proteins
    Language English
    Publishing date 2014-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a015354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study.

    Mondelli, Valeria / Cattaneo, Annamaria / Nikkheslat, Naghmeh / Souza, Laila / Walsh, Annabel / Zajkowska, Zuzanna / Zonca, Valentina / Marizzoni, Moira / Fisher, Helen L / Kohrt, Brandon A / Kieling, Christian / Di Meglio, Paola

    Brain, behavior, & immunity - health

    2021  Volume 18, Page(s) 100396

    Abstract: Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which ... ...

    Abstract Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which provides only a limited understanding of the immune pathways involved in the development of depression. The IDEA-FLAME study aims to identify immune phenotypes underlying increased risk of developing depression in adolescence in a middle-income country. To this end, we will perform deep-immunophenotyping of peripheral blood mononuclear cells and RNA genome-wide gene expression analyses in a longitudinal cohort of Brazilian adolescents stratified for depression risk. The project will involve the 3-year follow-up of an already recruited cohort of 150 Brazilian adolescents selected for risk/presence of depression on the basis of a composite risk score we developed using sociodemographic characteristics (50 adolescents with low-risk and 50 with high-risk of developing depression, and 50 adolescents with a current major depressive disorder). We will 1) test whether the risk group classification at baseline is associated with differences in immune cell frequency, phenotype and functional status, 2) test whether baseline immune markers (cytokines and immune cell markers) are associated with severity of depression at 3-year follow-up, and 3) identify changes in gene expression of immune pathways over the 3-year follow-up in adolescents with increased risk and presence of depression. Because of the exploratory nature of the study, the findings would need to be replicated in a separate and larger sample. Ultimately, this research will contribute to elucidating key immune therapeutic targets and inform the development of interventions to prevent onset of depression among adolescents.
    Language English
    Publishing date 2021-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2021.100396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Biomarkers in psoriasis and psoriatic arthritis.

    Villanova, Federica / Di Meglio, Paola / Nestle, Frank O

    Annals of the rheumatic diseases

    2013  Volume 72 Suppl 2, Page(s) ii104–10

    Abstract: Psoriasis is a common immune-mediated disease of the skin, which associates in 20-30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between ... ...

    Abstract Psoriasis is a common immune-mediated disease of the skin, which associates in 20-30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery.
    MeSH term(s) Arthritis, Psoriatic/blood ; Arthritis, Psoriatic/genetics ; Arthritis, Psoriatic/metabolism ; Biomarkers/blood ; Biomarkers/metabolism ; Genetic Markers ; Humans ; Psoriasis/blood ; Psoriasis/genetics ; Psoriasis/metabolism
    Chemical Substances Biomarkers ; Genetic Markers
    Language English
    Publishing date 2013-03-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2012-203037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.114: Show issues Location:
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    Zs.MO 167: Show issues

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  7. Article ; Online: Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase.

    Yiu, Zenas Z N / Barker, Jonathan N W N / Barnes, Michael R / Di Meglio, Paola / Emsley, Richard / Reynolds, Nick J / Smith, Catherine H / Warren, Richard B / Griffiths, Christopher E M

    The Journal of investigative dermatology

    2021  Volume 141, Issue 8, Page(s) 1872–1878

    Abstract: A stratified medicine approach for the treatment of psoriasis promises greater certainty of clinical decision making through prediction of response on the basis of clinical, pharmacological, and -omics data from an individual patient. As yet, there is no ...

    Abstract A stratified medicine approach for the treatment of psoriasis promises greater certainty of clinical decision making through prediction of response on the basis of clinical, pharmacological, and -omics data from an individual patient. As yet, there is no predictive model for treatment response in routine clinical use for psoriasis. The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) Consortium is a United Kingdom Medical Research Council‒funded, academic‒industrial stratified medicine consortium established with the objective of discovering the predictors and stratifiers of response of psoriasis to biologic therapies. A showcase meeting was convened and attended by 80 stakeholders at the Royal College of Physicians, London, United Kingdom on 18 November 2019. The purpose was to disseminate the research findings from the PSORT consortium discovered thus far. This report summarizes the presentations made on the day and the significant advances made by PSORT toward a stratified medicine approach to the management of psoriasis.
    MeSH term(s) Biological Products/pharmacokinetics ; Biological Products/therapeutic use ; Biomarkers/analysis ; Congresses as Topic ; Dermatology/methods ; Dermatology/organization & administration ; Humans ; Intersectoral Collaboration ; Pharmacogenomic Testing ; Precision Medicine/methods ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/immunology ; Skin/immunology ; Skin/pathology ; Treatment Outcome ; United Kingdom
    Chemical Substances Biological Products ; Biomarkers
    Language English
    Publishing date 2021-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.02.746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CD8 T Cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation.

    Di Meglio, Paola / Duarte, João H

    The Journal of investigative dermatology

    2013  Volume 133, Issue 4, Page(s) 871–874

    Abstract: A pathogenic crosstalk between epithelial and immune cells underpins the aberrant immune and epidermal responses seen in psoriasis. Data from a novel mouse model of psoriasiform skin inflammation not only highlight the importance of the interplay between ...

    Abstract A pathogenic crosstalk between epithelial and immune cells underpins the aberrant immune and epidermal responses seen in psoriasis. Data from a novel mouse model of psoriasiform skin inflammation not only highlight the importance of the interplay between keratinocytes, targets of genetic manipulation, and T cells as the major effector cells, but also reveal a critical role for CD8 T cells and IFN-γ in disease initiation.
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/pathology ; Female ; Interferon-gamma/immunology ; Male ; Proto-Oncogene Proteins p21(ras)/immunology ; Psoriasis/immunology ; Psoriasis/pathology ; Signal Transduction/immunology
    Chemical Substances Interferon-gamma (82115-62-6) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1038/jid.2012.426
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  9. Article ; Online: Psoriasis.

    Perera, Gayathri K / Di Meglio, Paola / Nestle, Frank O

    Annual review of pathology

    2012  Volume 7, Page(s) 385–422

    Abstract: Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to ... ...

    Abstract Psoriasis is a common relapsing and remitting immune-mediated inflammatory disease that affects the skin and joints. This review focuses on current immunogenetic concepts, key cellular players, and axes of cytokines that are thought to contribute to disease pathogenesis. We highlight potential therapeutic targets and give an overview of the currently used immune-targeted therapies.
    MeSH term(s) Cytokines/antagonists & inhibitors ; Cytokines/immunology ; Humans ; Psoriasis/drug therapy ; Psoriasis/genetics ; Psoriasis/immunology ; Psoriasis/pathology ; Skin/pathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2012
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2227429-7
    ISSN 1553-4014 ; 1553-4006
    ISSN (online) 1553-4014
    ISSN 1553-4006
    DOI 10.1146/annurev-pathol-011811-132448
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  10. Article ; Online: The aryl hydrocarbon receptor: multitasking in the immune system.

    Stockinger, Brigitta / Di Meglio, Paola / Gialitakis, Manolis / Duarte, João H

    Annual review of immunology

    2014  Volume 32, Page(s) 403–432

    Abstract: The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the ... ...

    Abstract The aryl hydrocarbon receptor (AhR), for many years almost exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity of xenobiotics such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has more recently attracted the attention of immunologists. The evolutionary conservation of this transcription factor and its widespread expression in the immune system point to important physiological functions that are slowly being unraveled. In particular, the emphasis is now shifting from the role of AhR in the xenobiotic pathway toward its mode of action in response to physiological ligands. In this article, we review the current understanding of the molecular interactions and functions of AhR in the immune system in steady state and in the presence of infection and inflammation, with a focus on barrier organs such as the skin, the gut, and the lung.
    MeSH term(s) Animals ; Gene Expression Regulation ; Humans ; Immune System/physiology ; Ligands ; Organ Specificity/genetics ; Protein Binding ; Receptors, Aryl Hydrocarbon/chemistry ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism ; Signal Transduction
    Chemical Substances Ligands ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2014-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-032713-120245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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