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  1. Article ; Online: Corticosteroids in Inflammatory Bowel Disease Patients: A Practical Guide for Physicians.

    Di Paolo, Maria Carla / Pagnini, Cristiano / Graziani, Maria Giovanna

    Current reviews in clinical and experimental pharmacology

    2020  Volume 16, Issue 3, Page(s) 210–218

    Abstract: Inflammatory Bowel Diseases (IBDs) are chronic conditions characterized by unknown etiology and pathogenesis with deregulation of mucosal immunity. Among possible treatments, corticosteroids, already available from the '50s, are still the mainstay of ... ...

    Abstract Inflammatory Bowel Diseases (IBDs) are chronic conditions characterized by unknown etiology and pathogenesis with deregulation of mucosal immunity. Among possible treatments, corticosteroids, already available from the '50s, are still the mainstay of treatment for moderate to severe disease. Nonetheless, the use of steroids is still largely empirical and solid evidence about therapeutic schemes are lacking. Moreover, due to the important side-effects and for the unsatisfactory impact on the long-term natural history of the disease, the steroid-sparing has become an important therapeutic goal in IBD management. Besides conventional steroids, the so-called "low bioavailability" steroids, which are steroids with high affinity for peripheral receptors and elevated hepatic first-pass metabolism, have demonstrated efficacy and a more favorable safety profile. In the present review of the literature evidence of efficacy and safety of conventional and low bioavailability steroids in IBD patients are evaluated, and practical suggestions for a correct use in clinical practice are presented according to the current clinical guidelines.
    MeSH term(s) Adrenal Cortex Hormones/adverse effects ; Chronic Disease ; Colitis ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Physicians
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2020-07-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-4336
    ISSN (online) 2772-4336
    DOI 10.2174/1574884715666200714114044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Safety and Potential Role of

    Pagnini, Cristiano / Di Paolo, Maria Carla / Urgesi, Riccardo / Pallotta, Lorella / Fanello, Gianfranco / Graziani, Maria Giovanna / Delle Fave, Gianfranco

    Microorganisms

    2023  Volume 11, Issue 6

    Abstract: Probiotics are microorganisms that confer benefits to the host, and, for this reason, they have been proposed in several pathologic states. Specifically, probiotic bacteria have been investigated as a therapeutic option in ulcerative colitis (UC) ... ...

    Abstract Probiotics are microorganisms that confer benefits to the host, and, for this reason, they have been proposed in several pathologic states. Specifically, probiotic bacteria have been investigated as a therapeutic option in ulcerative colitis (UC) patients, but clinical results are dishomogeneous. In particular, many probiotic species with different therapeutic schemes have been proposed, but no study has investigated probiotics in monotherapy in adequate trials for the induction of remission.
    Language English
    Publishing date 2023-05-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11061381
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  3. Article ; Online: Fighting the Battle against SARS-CoV-2 as Gastroenterologists in Italy.

    Pagnini, Cristiano / Urgesi, Riccardo / Di Paolo, Maria Carla / Graziani, Maria Giovanna

    Gastroenterology

    2020  Volume 159, Issue 4, Page(s) 1619

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Gastroenterologists ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.03.067
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  4. Article ; Online: Histologic disease activity control as a therapeutic target in Crohn's disease patients: A word of caution.

    Pagnini, Cristiano / Di Paolo, Maria Carla / Giordano, Marco / Graziani, Maria Giovanna

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2020  Volume 52, Issue 5, Page(s) 591–592

    MeSH term(s) Colitis, Ulcerative/pathology ; Colon/pathology ; Colonoscopy ; Crohn Disease/pathology ; Humans ; Reproducibility of Results ; Retrospective Studies
    Language English
    Publishing date 2020-02-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2020.01.003
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  5. Article: Probiotics and Vitamin D/Vitamin D Receptor Pathway Interaction: Potential Therapeutic Implications in Inflammatory Bowel Disease.

    Pagnini, Cristiano / Di Paolo, Maria Carla / Graziani, Maria Giovanna / Delle Fave, Gianfranco

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 747856

    Abstract: Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology and immunomediated pathogenesis. In the last years, the comprehension of the complex mechanisms involved in the intestinal mucosal homeostasis, and the analysis of the ... ...

    Abstract Inflammatory bowel diseases (IBD) are chronic conditions of unknown etiology and immunomediated pathogenesis. In the last years, the comprehension of the complex mechanisms involved in the intestinal mucosal homeostasis, and the analysis of the alterations potentially leading to inflammatory pathologic states, has consistently increased. Specifically, the extraordinary impulse in the field of research of the intestinal microbiome has opened the door to the investigation of possible novel approaches to the diagnosis, management and therapeutic applications in IBD. In line with that, administration of probiotic bacteria has been intensely evaluated, leading to much more exciting results in experimental models than in clinical practice. Considering the consistent heterogeneity of the available studies on probiotics, the increased knowledge of the properties of the single bacterial species would ideally lead to unravel potential mechanisms of action that may bring therapeutic applications in specific pathologic condition. Among the relevant molecular pathways for mucosal homeostasis maintenance, the vitamin D/vitamin D receptor (VDR) pathway has been intensely studied in the very last years. In fact, besides osteometabolic functions, the vitamin D exerts important homeostatic effects in the organism at multiple levels, such as immunomodulation, inflammation control, and microbiota regulation, which are likely to play a relevant role in intestinal mucosa protection. In the present review, recent findings about probiotic applications in IBD and mechanisms of action linking vitamin D/VDR pathway to IBD are reported. Available evidence for probiotic effect on vitamin D/VDR are reviewed and potential future application in IBD patients are discussed. At present, many aspects of IBD pathogenesis are still obscure, and current therapeutic options for IBD treatment are at best suboptimal. The increasing comprehension of the different pathways involved in IBD pathogenesis will lead to novel findings ideally leading to potential clinical applications. Microbiota manipulation and vitamin/VDR pathway appear a promising field for future research and therapeutic developments.
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.747856
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  6. Article ; Online: Application of validated bleeding risk scores for atrial fibrillation in obscure gastrointestinal bleeding patients increases videocapsule endoscopy's diagnostic yield: a retrospective monocentric study.

    Urgesi, Riccardo / Pagnini, Cristiano / De Angelis, Fernando / Di Paolo, Maria Carla / Pallotta, Lorella / Fanello, Gianfranco / Villotti, Giuseppe / Vitale, Mario Alessandro / Battisti, Paola / Graziani, Maria Giovanna

    International journal of colorectal disease

    2023  Volume 38, Issue 1, Page(s) 120

    Abstract: Background: Videocapsule endoscopy (VCE) is considered the gold standard for overt and obscure gastrointestinal bleeding (OGIB), after negative upper and lower endoscopy. Nonetheless, VCE's diagnostic yield is suboptimal, and it represents a costly, ... ...

    Abstract Background: Videocapsule endoscopy (VCE) is considered the gold standard for overt and obscure gastrointestinal bleeding (OGIB), after negative upper and lower endoscopy. Nonetheless, VCE's diagnostic yield is suboptimal, and it represents a costly, time-consuming, and often not easily available technique. In order to evaluate bleeding risk in patients with atrial fibrillation, several scoring systems have been proposed, but their utilization outside the original clinical setting has rarely been explored. The aim of the study is to evaluate potential role of bleeding risk scoring systems in predicting the occurrence of positive findings at VCE examination, and therefore in increasing VCE diagnostic yield.
    Methods: Data from consecutive patients undergoing VCE between April 2015 and June 2020 were retrospectively retrieved, and clinical and demographic characteristics were collected. HAS-BLED, ATRIA, and ORBIT scores were calculated, and patients were considered at low or high risk of bleeding accordingly. Discriminative ability of the scores for positive VCE findings has been evaluated by area under receiver operator characteristic curve (AUC) calculation. Diagnostic yield of scores in high- and low-risk patients was calculated.
    Results: A total of 413 patients underwent VCE examination, among which 368 (89%) for OGIB. Positive findings were observed in 246 patients (67%), with angiodysplasias being the most frequent lesion (92%). The three scores displayed similar consistent discriminative ability for positive VCE findings (mean AUC = 0.69), and identified high-risk group of patients in which VCE has a higher diagnostic yield.
    Conclusions: In the present retrospective study, bleeding scores accurately discriminated patients with higher probability of positive findings at VCE examination. Bleeding scores utilization may help in the management of patients with OGIB, with a potential consistent resource optimization and cost-saving.
    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Retrospective Studies ; Risk Factors ; Capsule Endoscopy ; Gastrointestinal Hemorrhage/diagnosis ; Gastrointestinal Hemorrhage/etiology
    Language English
    Publishing date 2023-05-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84975-3
    ISSN 1432-1262 ; 0179-1958
    ISSN (online) 1432-1262
    ISSN 0179-1958
    DOI 10.1007/s00384-023-04412-x
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  8. Article ; Online: Fighting the Battle against SARS-CoV-2 as Gastroenterologists in Italy

    Pagnini, Cristiano / Urgesi, Riccardo / Di Paolo, Maria Carla / Graziani, Maria Giovanna

    Gastroenterology

    2020  Volume 159, Issue 4, Page(s) 1619

    Keywords Gastroenterology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.03.067
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  9. Article ; Online: Similar But Not Identical: Plaque Psoriasis Exacerbation in a Patient With Crohn's Disease After Switching From CT-P13 to SB2 Infliximab Biosimilar.

    Pagnini, Cristiano / Di Paolo, Maria Carla / De Angelis, Giulia / Torcolacci, Federica / Milano, Michele / Trinca, Daniela / Porciello, Roberto / Graziani, Maria Giovanna

    Inflammatory bowel diseases

    2020  Volume 26, Issue 8, Page(s) e83–e84

    MeSH term(s) Adult ; Antibodies, Monoclonal/administration & dosage ; Biosimilar Pharmaceuticals/administration & dosage ; Biosimilar Pharmaceuticals/adverse effects ; Crohn Disease/complications ; Crohn Disease/drug therapy ; Disease Progression ; Drug Substitution/adverse effects ; Humans ; Infliximab/administration & dosage ; Infliximab/adverse effects ; Male ; Medical Illustration ; Psoriasis/chemically induced ; Psoriasis/complications
    Chemical Substances Antibodies, Monoclonal ; Biosimilar Pharmaceuticals ; CT-P13 ; SB2 infliximab ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2020-05-26
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1093/ibd/izaa128
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  10. Article ; Online: Probiotics in COVID-19 pandemic: when evidence lacks, rationale can still ease the way.

    Pagnini, Cristiano / DI Paolo, Maria Carla / D'Alba, Lucia / Urgesi, Riccardo / Pallotta, Lorella / Villotti, Giuseppe / D'Ambra, Giancarlo / Delle Fave, Gianfranco / Graziani, Maria Giovanna

    Minerva gastroenterology

    2020  Volume 69, Issue 2, Page(s) 314–317

    MeSH term(s) Humans ; COVID-19 ; Pandemics ; Probiotics/therapeutic use ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062713-8
    ISSN 2724-5365
    ISSN (online) 2724-5365
    DOI 10.23736/S2724-5985.20.02760-9
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