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  1. AU="Di Salvo, Jessica"
  2. AU="Chugani, Carla"
  3. AU="Ford, Kory"
  4. AU=Sankar Krishana S
  5. AU="Harry Cridge"
  6. AU="Ameriso, Sebastián"
  7. AU="Candice Czech"
  8. AU="Pargent, Florian"
  9. AU=Fausther Michel
  10. AU="Arrate, Clara"
  11. AU="Tarrach, Klaus"
  12. AU="Coburn, Bryan A"
  13. AU="Fieke Mooren"
  14. AU=Lubitz Steven A.
  15. AU=Chattopadhyay Sanchari
  16. AU=Ghanbari Behzad
  17. AU="Desmecht, Daniel"
  18. AU="Juškov, A. N"
  19. AU="Bach, Francis"
  20. AU="Afşin, Emine"
  21. AU="McLeod, Jonathan"
  22. AU=Srensen Morten Drby
  23. AU=de Noronha Lucia
  24. AU=Robinson Jennifer G
  25. AU=CHIACO JOHN MICHAEL S. CHUA
  26. AU="Simon, Benedikt"
  27. AU="Zhao, Andong"
  28. AU="Zhao, Tianshi"
  29. AU="Morris, Helen"

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  1. Artikel ; Online: Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options.

    Galiero, Raffaele / Caturano, Alfredo / Vetrano, Erica / Beccia, Domenico / Brin, Chiara / Alfano, Maria / Di Salvo, Jessica / Epifani, Raffaella / Piacevole, Alessia / Tagliaferri, Giuseppina / Rocco, Maria / Iadicicco, Ilaria / Docimo, Giovanni / Rinaldi, Luca / Sardu, Celestino / Salvatore, Teresa / Marfella, Raffaele / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2023  Band 24, Heft 4

    Abstract: Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with ... ...

    Abstract Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis for type 2 diabetes mellitus (T2DM), while it appears in subjects with type 1 diabetes mellitus (T1DM) almost 10 years after the onset of the disease. The impairment can involve both somatic fibers of the peripheral nervous system, with sensory-motor manifestations, as well as the autonomic system, with neurovegetative multiorgan manifestations through an impairment of sympathetic/parasympathetic conduction. It seems that, both indirectly and directly, the hyperglycemic state and oxygen delivery reduction through the vasa nervorum can determine inflammatory damage, which in turn is responsible for the alteration of the activity of the nerves. The symptoms and signs are therefore various, although symmetrical painful somatic neuropathy at the level of the lower limbs seems the most frequent manifestation. The pathophysiological aspects underlying the onset and progression of DN are not entirely clear. The purpose of this review is to shed light on the most recent discoveries in the pathophysiological and diagnostic fields concerning this complex and frequent complication of diabetes mellitus.
    Mesh-Begriff(e) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetic Neuropathies ; Autonomic Nervous System ; Pain/complications
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043554
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: An Overview of the Cardiorenal Protective Mechanisms of SGLT2 Inhibitors.

    Salvatore, Teresa / Galiero, Raffaele / Caturano, Alfredo / Rinaldi, Luca / Di Martino, Anna / Albanese, Gaetana / Di Salvo, Jessica / Epifani, Raffaella / Marfella, Raffaele / Docimo, Giovanni / Lettieri, Miriam / Sardu, Celestino / Sasso, Ferdinando Carlo

    International journal of molecular sciences

    2022  Band 23, Heft 7

    Abstract: Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, ... ...

    Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors block glucose reabsorption in the renal proximal tubule, an insulin-independent mechanism that plays a critical role in glycemic regulation in diabetes. In addition to their glucose-lowering effects, SGLT2 inhibitors prevent both renal damage and the onset of chronic kidney disease and cardiovascular events, in particular heart failure with both reduced and preserved ejection fraction. These unexpected benefits prompted changes in treatment guidelines and scientific interest in the underlying mechanisms. Aside from the target effects of SGLT2 inhibition, a wide spectrum of beneficial actions is described for the kidney and the heart, even though the cardiac tissue does not express SGLT2 channels. Correction of cardiorenal risk factors, metabolic adjustments ameliorating myocardial substrate utilization, and optimization of ventricular loading conditions through effects on diuresis, natriuresis, and vascular function appear to be the main underlying mechanisms for the observed cardiorenal protection. Additional clinical advantages associated with using SGLT2 inhibitors are antifibrotic effects due to correction of inflammation and oxidative stress, modulation of mitochondrial function, and autophagy. Much research is required to understand the numerous and complex pathways involved in SGLT2 inhibition. This review summarizes the current known mechanisms of SGLT2-mediated cardiorenal protection.
    Mesh-Begriff(e) Blood Glucose ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Sodium-Glucose Transporter 2/metabolism ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Stroke Volume
    Chemische Substanzen Blood Glucose ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-03-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073651
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Impact of Acute Kidney Injury on the COVID-19 In-Hospital Mortality in Octogenarian Patients: Insights from the COVOCA Study.

    Caturano, Alfredo / Galiero, Raffaele / Vetrano, Erica / Medicamento, Giulia / Alfano, Maria / Beccia, Domenico / Brin, Chiara / Colantuoni, Sara / Di Salvo, Jessica / Epifani, Raffaella / Nevola, Riccardo / Marfella, Raffaele / Sardu, Celestino / Coppola, Carmine / Scarano, Ferdinando / Maggi, Paolo / Calabrese, Cecilia / De Lucia Sposito, Pellegrino / Rescigno, Carolina /
    Sbreglia, Costanza / Fraganza, Fiorentino / Parrella, Roberto / Romano, Annamaria / Calabria, Giosuele / Polverino, Benedetto / Pagano, Antonio / Numis, Fabio Giuliano / Bologna, Carolina / Nunziata, Mariagrazia / Esposito, Vincenzo / Coppola, Nicola / Maturo, Nicola / Nasti, Rodolfo / Di Micco, Pierpaolo / Perrella, Alessandro / Adinolfi, Luigi Elio / Di Domenico, Marina / Monda, Marcellino / Russo, Vincenzo / Ruggiero, Roberto / Docimo, Giovanni / Rinaldi, Luca / Sasso, Ferdinando Carlo

    Life (Basel, Switzerland)

    2024  Band 14, Heft 1

    Abstract: Background and aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to ... ...

    Abstract Background and aims: The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has fundamentally reshaped the landscape of global public health, with some people suffering more adverse clinical outcomes than others. The aim of this study is to deepen our understanding of the specific impact of acute kidney injury (AKI) on the in-hospital mortality in octogenarian patients with COVID-19.
    Methods: This is a prospective observational cohort study, which involved 23 COVID-19 hospital units in the Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. Only patients aged ≥80 years were deemed eligible for the study.
    Results: 197 patients were included in the study (median age 83.0 [82.0-87.0] years; 51.5% men), with a median duration of hospitalization of 15.0 [8.0-25.0] days. From the multivariable Cox regression analysis, after the application of Šidák correction, only the respiratory rate (HR 1.09, 95% CI: 1.04 to 1.14;
    Conclusions: In our investigation, we identified a significant association between AKI and mortality rates among octogenarian patients admitted for COVID-19. These findings raise notable concerns and emphasize the imperative for vigilant monitoring of this demographic cohort.
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14010086
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Impact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy.

    Galiero, Raffaele / Loffredo, Giuseppe / Simeon, Vittorio / Caturano, Alfredo / Vetrano, Erica / Medicamento, Giulia / Alfano, Maria / Beccia, Domenico / Brin, Chiara / Colantuoni, Sara / Di Salvo, Jessica / Epifani, Raffaella / Nevola, Riccardo / Marfella, Raffaele / Sardu, Celestino / Coppola, Carmine / Scarano, Ferdinando / Maggi, Paolo / Calabrese, Cecilia /
    De Lucia Sposito, Pellegrino / Rescigno, Carolina / Sbreglia, Costanza / Fraganza, Fiorentino / Parrella, Roberto / Romano, Annamaria / Calabria, Giosuele / Polverino, Benedetto / Pagano, Antonio / Numis, Fabio / Bologna, Carolina / Nunziata, Mariagrazia / Esposito, Vincenzo / Coppola, Nicola / Maturo, Nicola / Nasti, Rodolfo / Di Micco, Pierpaolo / Perrella, Alessandro / Adinolfi, Luigi Elio / Chiodini, Paolo / Di Domenico, Marina / Rinaldi, Luca / Sasso, Ferdinando Carlo

    PloS one

    2024  Band 19, Heft 5, Seite(n) e0296495

    Abstract: Background & aims: SARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver ... ...

    Abstract Background & aims: SARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver fibrosis assessed by FIB-4 and liver impairment, assessed by cytolysis indices, on intrahospital mortality in COVID-19 subjects.
    Methods: This is a retrospective observational cohort study, which involved 23 COVID Hospital Units in Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. According to FIB-4 values, we subdivided the overall population in three groups (FIB-4<1.45; 1.45<FIB-4<3.25; FIB-4>3.25), respectively group 1,2,3.
    Results: At the end of the study, 938 individuals had complete discharged/dead data. At admission, 428 patients were in group 1 (45.6%), 387 in group 2 (41.3%) and 123 in group 3 (13.1%). Among them, 758 (81%) subjects were discharged, while the remaining 180 (19%) individuals died. Multivariable Cox's regression model showed a significant association between mortality risk and severity of FIB-4 stages (group 3 vs group 1, HR 2.12, 95%CI 1.38-3.28, p<0.001). Moreover, Kaplan-Meier analysis described a progressive and statistically significant difference (p<0.001 Log-rank test) in mortality according to FIB-4 groups. Among discharged subjects, 507 showed a FIB-4<1.45 (66.9%, group 1), 182 a value 1.45<FIB-4<3.25 (24.1%, group 2) and 69 a FIB-4>3.25 (9.0%, group 3). Among dead subjects, 42 showed a FIB-4<1.45 (23.3%, group 1), 62 a value 1.45<FIB-4<3.25 (34.4%, group 2) and 76 a FIB-4>3.25 (42.3%, group 3).
    Conclusions: FIB-4 value is significantly associated with intrahospital mortality of COVID-19 patients. During hospitalization, particularly in patients with worse outcomes, COVID-19 seems to increase the risk of acute progression of liver damage.
    Mesh-Begriff(e) Humans ; COVID-19/mortality ; COVID-19/epidemiology ; COVID-19/pathology ; Italy/epidemiology ; Liver Cirrhosis/mortality ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Female ; Male ; Hospital Mortality ; Middle Aged ; Retrospective Studies ; Aged ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Aged, 80 and over ; Hospitalization/statistics & numerical data ; Adult
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296495
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Association between Renal Function at Admission and COVID-19 in-Hospital Mortality in Southern Italy: Findings from the Prospective Multicenter Italian COVOCA Study.

    Galiero, Raffaele / Simeon, Vittorio / Loffredo, Giuseppe / Caturano, Alfredo / Rinaldi, Luca / Vetrano, Erica / Medicamento, Giulia / Alfano, Maria / Beccia, Domenico / Brin, Chiara / Colantuoni, Sara / Di Salvo, Jessica / Epifani, Raffaella / Nevola, Riccardo / Marfella, Raffaele / Sardu, Celestino / Coppola, Carmine / Scarano, Ferdinando / Maggi, Paolo /
    Calabrese, Cecilia / De Lucia Sposito, Pellegrino / Rescigno, Carolina / Sbreglia, Costanza / Fraganza, Fiorentino / Parrella, Roberto / Romano, Annamaria / Calabria, Giosuele / Polverino, Benedetto / Pagano, Antonio / Numis, Fabio Giuliano / Bologna, Carolina / Nunziata, Mariagrazia / Esposito, Vincenzo / Coppola, Nicola / Maturo, Nicola / Nasti, Rodolfo / Di Micco, Pierpaolo / Perrella, Alessandro / Lettieri, Miriam / Adinolfi, Luigi Elio / Chiodini, Paolo / Sasso, Ferdinando Carlo / On Behalf Of Covoca Study Group

    Journal of clinical medicine

    2022  Band 11, Heft 20

    Abstract: Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the ...

    Abstract Background. Evidence has shown a close association between COVID-19 infection and renal complications in both individuals with previously normal renal function and those with chronic kidney disease (CKD). Methods. The aim of this study is to evaluate the in-hospital mortality of SARS-CoV-2 patients according to their clinical history of CKD or estimated glomerular filtration rate (eGFR). This is a prospective multicenter observational cohort study which involved adult patients (≥18 years old) who tested positive with SARS-CoV-2 infection and completed their hospitalization in the period between November 2020 and June 2021. Results. 1246 patients were included in the study, with a mean age of 64 years (SD 14.6) and a median duration of hospitalization of 15 days (IQR 9−22 days). Cox’s multivariable regression model revealed that mortality risk was strongly associated with the stage of renal impairment and the Kaplan−Meier survival analysis showed a progressive and statistically significant difference (p < 0.0001) in mortality according to the stage of CKD. Conclusion. This study further validates the association between CKD stage at admission and mortality in patients hospitalized for COVID-19. The risk stratification based on eGFR allows clinicians to identify the subjects with the highest risk of intra-hospital mortality despite the duration of hospitalization.
    Sprache Englisch
    Erscheinungsdatum 2022-10-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11206121
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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