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Article ; Online: Optimizing the Endoscopic Transorbital Approach: MacCarty Keyhole for Enhanced Surgical Exposure in the Opticocarotid Region.

Plata-Bello, Julio / Mosteiro-Cadaval, Alejandra / Torné, Ramón / Di Somma, Alberto / Enseñat, Joaquim / Prats-Galino, Alberto

World neurosurgery

2024 Volume 185, Page(s) 290–296

Abstract: Background: In recent years, the endoscopic transorbital (TO) approach has gained increasing interest for the treatment of middle cranial fossa lesions. We propose a technical refinement to the conventional superior eyelid TO approach, which improves ... ...

Abstract	Background: In recent years, the endoscopic transorbital (TO) approach has gained increasing interest for the treatment of middle cranial fossa lesions. We propose a technical refinement to the conventional superior eyelid TO approach, which improves the surgical exposure and augments the working angles when targeting the opticocarotid region. Methods: Four embalmed adult cadaveric specimens (8 sides) were dissected at the Laboratory of Surgical Neuroanatomy of our institution. A TO approach was performed, with removal of the anterior clinoid process and the lateral orbital rim. Subsequently, the MacCarty keyhole was drilled in the superolateral orbital wall. Given that the lesser sphenoid wing was already drilled in the conventional TO craniectomy, the opening of the keyhole was essentially a lateral extension of the craniectomy. Results: The procedure was successfully conducted in all 4 orbits. Clinoidectomy was performed either before or after extending the craniectomy to the MacCarty point. Extending the craniectomy made anterior clinoidectomy easier, by increasing the surgical exposure, and allowing a more lateral entrance for the endoscope. The extension also facilitated frontal lobe retraction, and it facilitated the optic nerve and carotid artery manipulation. Postoperative computed tomography scans showed a minimal 10-mm craniectomy extension, which remained covered by the temporal muscle after reconstruction. Conclusions: The modified endoscopic TO approach with the extension of the craniectomy to MacCarty point improves surgical access and visualization of the opticocarotid region. This facilitates anterior clinoidectomy and optic nerve decompression. Although it implies judicious instrument manipulation and a larger incision size, further studies can define its potential benefits.
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.03.006
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Article ; Online: Superior eyelid transorbital approaches: a modular classification system.

de Notaris, Matteo / Kong, Doo-Sik / Di Somma, Alberto / Enseñat, Joaquim / Hong, Chang-Ki / Moe, Kris / Schwartz, Theodore H

Journal of neurosurgery

2024 , Page(s) 1–6

Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2024.1.JNS232465
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Article ; Online: A Comparative Study of the Inhibitory Action of Berberine Derivatives on the Recombinant Protein FtsZ of

Di Somma, Angela / Canè, Carolina / Rotondo, Natalie Paola / Cavalluzzi, Maria Maddalena / Lentini, Giovanni / Duilio, Angela

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Medicinal plants belonging to the ... ...

Abstract	Medicinal plants belonging to the genus
MeSH term(s)	Cytoskeletal Proteins/metabolism ; Molecular Docking Simulation ; Berberine/chemistry ; Escherichia coli/metabolism ; Bacterial Proteins/metabolism ; Recombinant Proteins/metabolism ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Cytoskeletal Proteins ; Berberine (0I8Y3P32UF) ; Bacterial Proteins ; Recombinant Proteins ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065674
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Article: Interaction of Temporin-L Analogues with the

Di Somma, Angela / Canè, Carolina / Moretta, Antonio / Duilio, Angela

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 6

Abstract: The research of new therapeutic agents to fight bacterial infections has recently focused on the investigation of antimicrobial peptides (AMPs), the most common weapon that all organisms produce to prevent invasion by external pathogens. Among AMPs, the ... ...

Abstract	The research of new therapeutic agents to fight bacterial infections has recently focused on the investigation of antimicrobial peptides (AMPs), the most common weapon that all organisms produce to prevent invasion by external pathogens. Among AMPs, the amphibian Temporins constitute a well-known family with high antibacterial properties against Gram-positive and Gram-negative bacteria. In particular, Temporin-L was shown to affect bacterial cell division by inhibiting FtsZ, a tubulin-like protein involved in the crucial step of Z-ring formation at the beginning of the division process. As FtsZ represents a leading target for new antibacterial compounds, in this paper we investigated in detail the interaction of Temporin L with
Language	English
Publishing date	2021-06-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10060704
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Article ; Online: Endoscopic superior eyelid transorbital approach: how I do it.

Di Somma, Alberto / Sanchez España, Juan Carlos / Alobid, Isam / Enseñat, Joaquim

Acta neurochirurgica

2022 Volume 164, Issue 7, Page(s) 1953–1959

Abstract: Background: The endoscopic transorbital approach to the skull base is currently growing in popularity, and it is nowadays progressively used as a skull base approach. Clinical experience, along with detailed anatomical knowledge, makes this technique ... ...

Abstract	Background: The endoscopic transorbital approach to the skull base is currently growing in popularity, and it is nowadays progressively used as a skull base approach. Clinical experience, along with detailed anatomical knowledge, makes this technique safe and effective. Method: We present a step by step description of our technique based on the most recent anatomic references, and clinical experience. In order to better understand every phase of the procedure, we propose to keep on the following scheme, that is (1) skin phase; (2) working space; (3) lesion removal; (4) reconstruction. Hence, alone or in combination with the well-known endonasal pathway, the transorbital avenue seems to be a useful approach for selected skull base lesions. We present our technique, along with an anatomic analysis on cadaveric specimens. Conclusions: Detailed knowledge of surgical anatomy, and a specific stepwise analysis of each part of the surgical procedure, is notably useful in order to safely and effectively perform a superior eyelid endoscopic transorbital surgery to the skull base.
MeSH term(s)	Cadaver ; Endoscopy/methods ; Eyelids/surgery ; Humans ; Neurosurgical Procedures/methods ; Orbit/anatomy & histology ; Orbit/surgery ; Skull Base/anatomy & histology ; Skull Base/surgery
Language	English
Publishing date	2022-03-11
Publishing country	Austria
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-022-05177-y
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Article: A new and efficient procedure to load bioactive molecules within the human heavy-chain ferritin nanocage.

Lucignano, Rosanna / Stanzione, Ilaria / Ferraro, Giarita / Di Girolamo, Rocco / Cané, Carolina / Di Somma, Angela / Duilio, Angela / Merlino, Antonello / Picone, Delia

Frontiers in molecular biosciences

2023 Volume 10, Page(s) 1008985

Abstract: For their easy and high-yield recombinant production, their high stability in a wide range of physico-chemical conditions and their characteristic hollow structure, ferritins (Fts) are considered useful scaffolds to encapsulate bioactive molecules. ... ...

Abstract	For their easy and high-yield recombinant production, their high stability in a wide range of physico-chemical conditions and their characteristic hollow structure, ferritins (Fts) are considered useful scaffolds to encapsulate bioactive molecules. Notably, for the absence of immunogenicity and the selective interaction with tumor cells, the nanocages constituted by the heavy chain of the human variant of ferritin (hHFt) are optimal candidates for the delivery of anti-cancer drugs. hHFt nanocages can be disassembled and reassembled
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2023.1008985
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Article ; Online: Release of a novel peptide from ferritin nanocages: A new tool for therapeutic applications.

Canè, Carolina / Lucignano, Rosanna / Di Somma, Angela / Liccardo, Maria / Iannuzzi, Clara / Duilio, Angela / Picone, Delia

Biochimica et biophysica acta. General subjects

2023 Volume 1868, Issue 2, Page(s) 130525

Abstract: The development of new drug delivery systems for targeted chemotherapy release in cancer cells represents a very promising tool. In this contest, protein-based nanocages have considerable potential as drug delivery devices. Notably, ferritin has emerged ... ...

Abstract	The development of new drug delivery systems for targeted chemotherapy release in cancer cells represents a very promising tool. In this contest, protein-based nanocages have considerable potential as drug delivery devices. Notably, ferritin has emerged as an excellent candidate due to its unique architecture, surface properties and high biocompatibility. A promising strategy might then involve ferritin cargos for specifical release of AntiMicrobial Peptides endowed with anticancer activity to cancer cells. In this paper, we encapsulated the TRIL analogue of Temporin-L peptide within a ferritin nanocage and evaluated the cargo biological properties. The results demonstrated a reduced haemolytic activity of the peptide and a selective cytotoxicity activity on cancer cells likely mediated by oxidative stress while having no effects on non-tumoral cells. The combination of the properties of ferritin with TRIL, might open up the way to the development of novel peptide delivery systems for future pharmaceutical applications.
MeSH term(s)	Ferritins/chemistry ; Peptides/pharmacology ; Peptides/chemistry ; Drug Delivery Systems/methods
Chemical Substances	Ferritins (9007-73-2) ; Peptides
Language	English
Publishing date	2023-12-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbagen.2023.130525
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Article ; Online: Endonasal versus supraorbital approach for anterior skull base meningiomas: Results and quality of life assessment from a single-surgeon cohort.

Torales, Jorge / Di Somma, Alberto / Alobid, Isam / Lopez, Mauricio / Hoyos, Jhon / Ferres, Abel / Morillas, Ruben / Reyes, Luis / Roldan, Pedro / Valero, Ricard / Enseñat, Joaquim

Neurocirugia (English Edition)

2024

Abstract: Objective: In this prospective non-randomized study we reported our experience related to planum sphenoidale (PS) and tuberculum sellae (TS) meningiomas in a similar cohort of patients operated via the endonasal or the supraorbital route. A ... ...

Abstract	Objective: In this prospective non-randomized study we reported our experience related to planum sphenoidale (PS) and tuberculum sellae (TS) meningiomas in a similar cohort of patients operated via the endonasal or the supraorbital route. A comprehensive quality of life analysis has been performed. Methods: Being comparable in general features, between November 2017 to January 2020, a total of 20 patients with anterior skull base meningioma were included. Hence, 10 patients were treated using the supraorbital keyhole procedure (SO) while 10 patients received an endoscopic endonasal approach (EEA). Both surgical techniques were analyzed and compared. Quality of life has been analyzed with the SF-36 questionnaire. Results: Twenty patients were identified who underwent either EEA (n=10) or SO (n=10). The average extent of resection achieved was not significantly different between the 2 groups. Post-operatively, the EEA group demonstrated a longer hospital stay and bed days compared with SO patients as well as a longer surgical time. There was a significant rate of more CSF leakage after EEA then after SO (20% vs 0%, p=0,0491). The follow-up period resulted shorter in the SO group, with a slight increased recurrence rate. Overall, no differences in visual outcome were detected. There were no differences in terms of quality of life between the two groups in all the explored items. Conclusions: In this single-center single-surgeon study of similarly sized and located PS and TS meningiomas, EEA showed longer hospital stays with higher degree of CSF leak compared with the SO group. Supraorbital craniotomy via eyebrow incision reported a comparable quality of life results, even if with a slightly higher percentage of recurrence and less follow-up.
Language	English
Publishing date	2024-01-05
Publishing country	Spain
Document type	Journal Article
ISSN	2529-8496
ISSN (online)	2529-8496
DOI	10.1016/j.neucie.2023.12.001
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Article ; Online: Endoscopic transorbital approach bone pillars: a comprehensive stepwise anatomical appraisal.

Codes, Marta / Mosteiro, Alejandra / Tafuto, Roberto / Gomez, Lorena / Matas, Jessica / Alobid, Isam / Lopez, Mauricio / Prats-Galino, Alberto / Enseñat, Joaquim / Di Somma, Alberto

Neurosurgical focus

2024 Volume 56, Issue 4, Page(s) E5

Abstract: Objective: The endoscopic superior eyelid transorbital approach has garnered significant consideration and gained popularity in recent years. Detailed anatomical knowledge along with clinical experience has allowed refinement of the technique as well as ...

Abstract	Objective: The endoscopic superior eyelid transorbital approach has garnered significant consideration and gained popularity in recent years. Detailed anatomical knowledge along with clinical experience has allowed refinement of the technique as well as expansion of its indications. Using bone as a consistent reference, the authors identified five main bone pillars that offer access to the different intracranial targeted areas for different pathologies of the skull base, with the aim of enhancing the understanding of the intracranial areas accessible through this corridor. Methods: The authors present a bone-oriented review of the anatomy of the transorbital approach in which they conducted a 3D analysis using Brainlab software and performed dry skull and subsequent cadaveric dissections. Results: Five bone pillars of the transorbital approach were identified: the lesser sphenoid wing, the sagittal crest (medial aspect of the greater sphenoid wing), the anterior clinoid, the middle cranial fossa, and the petrous apex. The associations of these bone targets with their respective intracranial areas are reported in detail. Conclusions: Identification of consistent bone references after the skin incision has been made and the working space is determined allows a comprehensive understanding of the anatomy of the approach in order to safely and effectively perform transorbital endoscopic surgery in the skull base.
MeSH term(s)	Humans ; Neurosurgical Procedures/methods ; Endoscopy/methods ; Skull Base/surgery ; Skull Base/anatomy & histology ; Sphenoid Bone/surgery ; Cranial Fossa, Middle
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/2024.1.FOCUS23846
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Article ; Online: Neurophysiologic Monitoring of Oculomotor Nerves During Transorbital Surgery: Proof of Concept and Anatomic Demonstration.

Ferres, Abel / Tercero-Uribe, Ana Isabel / Matas, Jessica / Alcubierre, Rafel / Codes, Marta / Tafuto, Roberto / Camós-Carreras, Anna / Muñoz-Lopetegi, Amaia / Tercero, Javier / Alobid, Isam / Sanchez-Dalmau, Bernardo / Di Somma, Alberto / Enseñat, Joaquim

Operative neurosurgery (Hagerstown, Md.)

2024

Abstract: Background and objectives: Transorbital neuroendoscopic surgery (TONES) is continuously evolving and gaining terrain in approaching different skull base pathologies. The objective of this study was to present our methodology for introducing recording ... ...

Abstract	Background and objectives: Transorbital neuroendoscopic surgery (TONES) is continuously evolving and gaining terrain in approaching different skull base pathologies. The objective of this study was to present our methodology for introducing recording electrodes, which includes a new transconjunctival pathway, to monitor the extraocular muscle function during TONES. Methods: A translational observational study was performed from an anatomic demonstration focused on the transconjunctival electrode placement technique to a descriptive analysis in our series of 6 patients operated using TONES in association with intraoperative neurophysiologic monitoring of the oculomotor nerves from 2017 to 2023. The stepwise anatomic demonstration for the electrode placement and correct positioning in the target muscle was realized through cadaveric dissection. The descriptive analysis evaluated viability (obtention of the electromyography in each cranial nerve [CN] monitored), security (complications), and compatibility (interference with TONES). Results: In our series of 6 patients, 16 CNs were correctly monitored: 6 (100%) CNs III, 5 (83.3%) CNs VI, and 5 (83.3%) CNs IV. Spontaneous electromyography was registered correctly, and compound muscle action potential using triggered electromyography was obtained for anatomic confirmation of structures (1 CN III and VI). No complications nor interference with the surgical procedure were detected. Conclusion: The methodology for introducing the recording electrodes was viable, secure, and compatible with TONES.
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000001139
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