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  1. Article ; Online: Panniculitis in a patient with metastatic renal cell carcinoma on a tyrosine kinase inhibitor.

    Nafissi, Nellie N / Karlin, Nina / Pittelkow, Mark R / Dicaudo, David J / Mangold, Aaron R

    Anti-cancer drugs

    2020  Volume 32, Issue 4, Page(s) 474–475

    Abstract: A 71-year-old female was diagnosed with localized renal cell carcinoma in July 2008 with subsequent metastasis in 2012 to the right adrenal gland, lungs, and brain. Due to disease progression, she was started on pazopanib 800 mg daily in October 2012. In ...

    Abstract A 71-year-old female was diagnosed with localized renal cell carcinoma in July 2008 with subsequent metastasis in 2012 to the right adrenal gland, lungs, and brain. Due to disease progression, she was started on pazopanib 800 mg daily in October 2012. In November 2016, the patient developed an ill-defined, red, 10 × 15 cm indurated plaque on the left lateral upper thigh with a discrete 3 cm firm tender tumor without ulceration. An incisional biopsy was performed and showed panniculitis with features resembling sclerosing lipogranuloma. Alternative causes including rheumatologic disease and trauma were ruled out. We report the first case of pazopanib-induced panniculitis. Key clinical and histopathological features include tender subcutaneous nodules, exclusion of other causes, and fatty microcysts within a densely sclerotic background on pathology. As targeted therapies are becoming increasingly common in the field of oncology, prompt identification and reporting of adverse reactions is critical for proper management.
    MeSH term(s) Aged ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Indazoles/administration & dosage ; Indazoles/adverse effects ; Kidney Neoplasms/drug therapy ; Panniculitis/chemically induced ; Pyrimidines/administration & dosage ; Pyrimidines/adverse effects ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects
    Chemical Substances Angiogenesis Inhibitors ; Indazoles ; Pyrimidines ; Sulfonamides ; pazopanib (7RN5DR86CK)
    Language English
    Publishing date 2020-12-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1065301-6
    ISSN 1473-5741 ; 0959-4973
    ISSN (online) 1473-5741
    ISSN 0959-4973
    DOI 10.1097/CAD.0000000000000999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3125: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dermoscopic features of cutaneous Langerhans cell histiocytosis.

    Mangold, Aaron R / Costello, Collin M / Nelson, Steven A / Dicaudo, David J / Pittelkow, Mark R / Swanson, David L

    European journal of dermatology : EJD

    2017  Volume 28, Issue 1, Page(s) 88–89

    MeSH term(s) Adult ; Biopsy ; Dermoscopy ; Histiocytosis, Langerhans-Cell/diagnostic imaging ; Histiocytosis, Langerhans-Cell/pathology ; Humans ; Male ; Skin Diseases/diagnostic imaging ; Skin Diseases/pathology
    Language English
    Publishing date 2017-11-21
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2017.3153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3484: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Review of contemporaneous mycosis fungoides and B-cell malignancy at Mayo Clinic.

    Herro, Elise / Dicaudo, David J / Davis, Mark D P / Weaver, Amy L / Swanson, David L

    Journal of the American Academy of Dermatology

    2009  Volume 61, Issue 2, Page(s) 271–275

    Abstract: Background: Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other.: Objective: We sought to determine whether the contemporaneous occurrence of the two malignancies is greater than chance and to investigate possible ...

    Abstract Background: Having either mycosis fungoides or B-cell lymphoma may predispose a patient to the other.
    Objective: We sought to determine whether the contemporaneous occurrence of the two malignancies is greater than chance and to investigate possible risk factors for the second malignancy.
    Methods: We retrospectively reviewed the records of patients with contemporaneous mycosis fungoides and B-cell lymphoma seen between 1990 and 2007 at Mayo Clinic, Rochester, MN, or at Mayo Clinic, Scottsdale, AZ.
    Results: In all, 23 patients had contemporaneous mycosis fungoides and B-cell malignancy. The first diagnosis was mycosis fungoides in 10 patients and B-cell lymphoma in 7; in 6 patients, the diseases were diagnosed simultaneously. No therapeutic factors could account for a predisposition to a second malignancy.
    Limitations: Retrospective design, referral center, and small sample size are limitations.
    Conclusion: Mycosis fungoides and B-cell lymphoma are unlikely to occur contemporaneously by chance, but no factor obviously predisposes a patient with one malignancy to development of the second.
    MeSH term(s) Academic Medical Centers ; Adult ; Age Distribution ; Age of Onset ; Aged ; Biopsy, Needle ; Cohort Studies ; Comorbidity ; Female ; Humans ; Immunohistochemistry ; Incidence ; Lymphoma, B-Cell/epidemiology ; Lymphoma, B-Cell/pathology ; Lymphoma, B-Cell/therapy ; Lymphoma, T-Cell, Cutaneous/epidemiology ; Lymphoma, T-Cell, Cutaneous/pathology ; Lymphoma, T-Cell, Cutaneous/therapy ; Male ; Middle Aged ; Mycosis Fungoides/epidemiology ; Mycosis Fungoides/pathology ; Mycosis Fungoides/therapy ; Neoplasm Staging ; Prognosis ; Registries ; Retrospective Studies ; Sex Distribution ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Survival Rate
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2009.03.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Specificity of IRF4 translocations for primary cutaneous anaplastic large cell lymphoma: a multicenter study of 204 skin biopsies.

    Wada, David A / Law, Mark E / Hsi, Eric D / Dicaudo, David J / Ma, Linglei / Lim, Megan S / Souza, Aieska de / Comfere, Nneka I / Weenig, Roger H / Macon, William R / Erickson, Lori A / Ozsan, Nazan / Ansell, Stephen M / Dogan, Ahmet / Feldman, Andrew L

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2010  Volume 24, Issue 4, Page(s) 596–605

    Abstract: Current pathologic criteria cannot reliably distinguish cutaneous anaplastic large cell lymphoma from other CD30-positive T-cell lymphoproliferative disorders (lymphomatoid papulosis, systemic anaplastic large cell lymphoma with skin involvement, and ... ...

    Abstract Current pathologic criteria cannot reliably distinguish cutaneous anaplastic large cell lymphoma from other CD30-positive T-cell lymphoproliferative disorders (lymphomatoid papulosis, systemic anaplastic large cell lymphoma with skin involvement, and transformed mycosis fungoides). We previously reported IRF4 (interferon regulatory factor-4) translocations in cutaneous anaplastic large cell lymphomas. Here, we investigated the clinical utility of detecting IRF4 translocations in skin biopsies. We performed fluorescence in situ hybridization (FISH) for IRF4 in 204 biopsies involved by T-cell lymphoproliferative disorders from 182 patients at three institutions. In all, 9 of 45 (20%) cutaneous anaplastic large cell lymphomas and 1 of 32 (3%) cases of lymphomatoid papulosis with informative results demonstrated an IRF4 translocation. Remaining informative cases were negative for a translocation (7 systemic anaplastic large cell lymphomas; 44 cases of mycosis fungoides/Sézary syndrome (13 transformed); 24 peripheral T-cell lymphomas, not otherwise specified; 12 CD4-positive small/medium-sized pleomorphic T-cell lymphomas; 5 extranodal NK/T-cell lymphomas, nasal type; 4 gamma-delta T-cell lymphomas; and 5 other uncommon T-cell lymphoproliferative disorders). Among all cutaneous T-cell lymphoproliferative disorders, FISH for IRF4 had a specificity and positive predictive value for cutaneous anaplastic large cell lymphoma of 99 and 90%, respectively (P=0.00002, Fisher's exact test). Among anaplastic large cell lymphomas, lymphomatoid papulosis, and transformed mycosis fungoides, specificity and positive predictive value were 98 and 90%, respectively (P=0.005). FISH abnormalities other than translocations and IRF4 protein expression were seen in 13 and 65% of cases, respectively, but were nonspecific with regard to T-cell lymphoproliferative disorder subtype. Our findings support the clinical utility of FISH for IRF4 in the differential diagnosis of T-cell lymphoproliferative disorders in skin biopsies, with detection of a translocation favoring cutaneous anaplastic large cell lymphoma. Like all FISH studies, IRF4 testing must be interpreted in the context of morphology, phenotype, and clinical features.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biopsy ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Interferon Regulatory Factors/genetics ; Lymphoma, Large-Cell, Anaplastic/genetics ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/chemistry ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/genetics ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/pathology ; Lymphomatoid Papulosis/genetics ; Lymphoproliferative Disorders/genetics ; Lymphoproliferative Disorders/metabolism ; Lymphoproliferative Disorders/pathology ; Male ; Middle Aged ; Mycosis Fungoides/genetics ; Predictive Value of Tests ; Sensitivity and Specificity ; Skin Neoplasms/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Translocation, Genetic ; United States ; Young Adult
    Chemical Substances Biomarkers, Tumor ; Interferon Regulatory Factors ; interferon regulatory factor-4
    Language English
    Publishing date 2010-12-17
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1038/modpathol.2010.225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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