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  1. Article ; Online: The effect of dielectrophoresis on living cells: crossover frequencies and deregulation in gene expression.

    Nerguizian, Vahé / Stiharu, Ion / Al-Azzam, Nosayba / Yassine-Diab, Bader / Alazzam, Anas

    The Analyst

    2019  Volume 144, Issue 12, Page(s) 3853–3860

    Abstract: This article documents the effect of dielectrophoresis on living cells. Given the longer duration procedures performed on microfluidic platforms, the influence of electric fields of high intensity may be of interest in manipulations other than ... ...

    Abstract This article documents the effect of dielectrophoresis on living cells. Given the longer duration procedures performed on microfluidic platforms, the influence of electric fields of high intensity may be of interest in manipulations other than dielectrophoresis. The crossover frequencies of several cell lines were experimentally determined using a microfluidic device. The crossover frequencies are investigated at different medium conductivities for red blood cells, white blood cells-Jurkat, 92.1 and OCM melanoma, and MDA-MB-231 breast cancer cell lines. The effect of dielectrophoresis on the cells at the gene level was also investigated by studying the alteration in gene expressions using microarray analysis. The alterations in genes due to the manipulation of cells at 10 kHz and 100 kHz with a sinusoidal 10 V peak signal for 60 minutes are explored. The two frequencies correspond to negative and positive dielectrophoresis, respectively. The cell line MDA-MB-231 is used as a model for studying the genes in this work. The dielectrophoresis was found to alter genes related to apoptosis, rRNA transcription, cellular respiration, energy production, cellular transcriptional activity, and other cellular functions.
    MeSH term(s) Cell Line, Tumor ; Electric Conductivity ; Electricity ; Electrophoresis ; Gene Expression/physiology ; Humans ; Lab-On-A-Chip Devices
    Language English
    Publishing date 2019-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 210747-8
    ISSN 1364-5528 ; 0003-2654
    ISSN (online) 1364-5528
    ISSN 0003-2654
    DOI 10.1039/c9an00320g
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  2. Article: [No title information]

    Aubert, Clémentine / Diab, Bahia / Joy, Luster / Papachan, Binsha C / Schäublin, Marie-Pauline

    Revue medicale suisse

    2019  Volume 15, Issue 673, Page(s) 2216–2217

    Title translation Prévention de la consommation d’alcool chez les adolescents à Mangalore.
    MeSH term(s) Adolescent ; Adolescent Behavior ; Alcohol Drinking ; Humans
    Language French
    Publishing date 2019-11-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
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    Zs.A 5998: Show issues Location:
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  3. Article ; Online: Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults.

    Pillet, Stéphane / Couillard, Julie / Trépanier, Sonia / Poulin, Jean-François / Yassine-Diab, Bader / Guy, Bruno / Ward, Brian J / Landry, Nathalie

    PloS one

    2019  Volume 14, Issue 6, Page(s) e0216533

    Abstract: Background: New influenza vaccines eliciting more effective protection are needed, particularly for the elderly who paid a large and disproportional toll of hospitalization and dead during seasonal influenza epidemics. Low (≤15 μg/strain) doses of a new ...

    Abstract Background: New influenza vaccines eliciting more effective protection are needed, particularly for the elderly who paid a large and disproportional toll of hospitalization and dead during seasonal influenza epidemics. Low (≤15 μg/strain) doses of a new plant-derived virus-like-particle (VLP) vaccine candidate have been shown to induce humoral and cellular responses against both homologous and heterologous strains in healthy adults 18-64 years of age. The two clinical trials reported here addressed the safety and immunogenicity of higher doses (≥15 μg/strain) of quadrivalent VLP candidate vaccine on 18-49 years old and ≥50 years old subjects. We also investigated the impact of alum on the immunogenicity induced by lower doses of the vaccine candidate.
    Method: In the first Phase II trial reported here (NCT02233816), 18-49 year old subjects received 15, 30 or 60 μg/strain of a hemagglutinin-bearing quadrivalent virus-like particle (QVLP) vaccine or placebo. In the second trial (NCT02236052), ≥50 years old subjects received QVLP as above or placebo with additional groups receiving 7.5 or 15 μg/strain with alum. Along with safety recording, the humoral and cell-mediated immune responses were analyzed.
    Results: Local and systemic side-effects were similar to those reported previously. The QVLP vaccine induced significant homologous and heterologous antibody responses at the two higher doses, the addition of alum having little-to-no effect. Serologic outcomes tended to be lower in ≥50 years old subjects previously vaccinated. The candidate vaccine also consistently elicited both homologous and heterologous antigen-specific CD4+ T cells characterized by their production of interferon-gamma (IFN-γ), interleukine-2 (IL-2) and/or tumor-necrosis factor alpha (TNF-α) upon ex vivo antigenic restimulation.
    Conclusion: Overall, the 30 μg dose produced the most consistent humoral and cellular responses in both 18-49 and ≥50 years old subjects, strongly supporting the clinical development of this candidate vaccine. That particular dose was chosen to test in the ongoing Phase III clinical trial.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Dose-Response Relationship, Immunologic ; Female ; Humans ; Immunity, Cellular/immunology ; Immunity, Humoral/immunology ; Influenza Vaccines/adverse effects ; Influenza Vaccines/immunology ; Male ; Middle Aged ; Plants ; Safety ; Vaccines, Virus-Like Particle/adverse effects ; Vaccines, Virus-Like Particle/immunology ; Young Adult
    Chemical Substances Antibodies, Viral ; Influenza Vaccines ; Vaccines, Virus-Like Particle
    Language English
    Publishing date 2019-06-05
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0216533
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  4. Article ; Online: Use of safety-engineered devices by healthcare workers for intravenous and/or phlebotomy procedures in healthcare settings: a systematic review and meta-analysis.

    Ballout, Rami A / Diab, Batoul / Harb, Alain C / Tarabay, Rami / Khamassi, Selma / Akl, Elie A

    BMC health services research

    2016  Volume 16, Page(s) 458

    Abstract: Background: The acquisition of needle-stick injuries (NSI) in a healthcare setting poses an occupational hazard of transmitting blood-borne pathogens from patients to healthcare workers (HCWs). The objective of this study was to systematically review ... ...

    Abstract Background: The acquisition of needle-stick injuries (NSI) in a healthcare setting poses an occupational hazard of transmitting blood-borne pathogens from patients to healthcare workers (HCWs). The objective of this study was to systematically review the evidence about the efficacy and safety of using safety-engineered intravenous devices and safety-engineered phlebotomy devices by HCWs.
    Methods: We included randomized and non-randomized studies comparing safety-engineered devices to conventional/standard devices that lack safety features for delivering intravenous injections and/or for blood-withdrawal procedures (phlebotomy). The outcomes of interest included NSI rates, and blood-borne infections rates among HCWs and patients. We conducted an extensive literature search strategy using the OVID interface in October 2013. We followed the standard methods for study selection and data abstraction. When possible, we conducted meta-analyses using a random-effects model. We used the GRADE methodology to assess the quality of evidence by outcome.
    Results: We identified twenty-two eligible studies: Twelve assessed safety-engineered devices for intravenous procedures, five for phlebotomy procedures, and five for both. Twenty-one of those studies were observational while one was a randomized trial. All studies assessed the reduction in NSIs among HCWs. For safety-engineered intravenous devices, the pooled relative risk for NSI per HCW was 0.28 [0.13, 0.59] (moderate quality evidence). The pooled relative risk for NSI per device used or procedure performed was 0.34 [0.08,1.49] (low quality evidence). For safety-engineered phlebotomy devices, the pooled relative risk for NSI per HCW was 0.57 [0.38, 0.84] (moderate quality evidence). The pooled relative risk for NSI per device used or procedure performed was 0.53 [0.43,0.65] (moderate quality evidence). We identified no studies assessing the outcome of blood-borne infections among healthcare workers or patients.
    Conclusion: There is moderate-quality evidence that the use of safety-engineered devices in intravenous injections and infusions, and phlebotomy (blood-drawing) procedures reduces NSI rates of HCWs.
    MeSH term(s) Blood-Borne Pathogens ; Equipment Design ; Health Personnel ; Humans ; Injections, Intramuscular/instrumentation ; Injections, Intravenous/instrumentation ; Injections, Subcutaneous/instrumentation ; Needlestick Injuries/prevention & control ; Phlebotomy/instrumentation ; Protective Devices ; Randomized Controlled Trials as Topic ; Safety
    Language English
    Publishing date 2016-09-01
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-016-1705-y
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  5. Article ; Online: Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial.

    Pillet, Stéphane / Aubin, Éric / Trépanier, Sonia / Poulin, Jean-François / Yassine-Diab, Bader / Ter Meulen, Jan / Ward, Brian J / Landry, Nathalie

    NPJ vaccines

    2018  Volume 3, Page(s) 3

    Abstract: The hemagglutinination inhibition (HI) response remains the gold standard used for the licensure of influenza vaccines. However, cell-mediated immunity (CMI) deserves more attention, especially when evaluating H5N1 influenza vaccines that tend to induce ... ...

    Abstract The hemagglutinination inhibition (HI) response remains the gold standard used for the licensure of influenza vaccines. However, cell-mediated immunity (CMI) deserves more attention, especially when evaluating H5N1 influenza vaccines that tend to induce poor HI response. In this study, we measured the humoral response (HI) and CMI (flow cytometry) during a Phase II dose-ranging clinical trial (NCT01991561). Subjects received two intramuscular doses, 21 days apart, of plant-derived virus-like particles (VLP) presenting the A/Indonesia/05/2005 H5N1 influenza hemagglutinin protein (H5) at the surface of the VLP (H5VLP). The vaccine was co-administrated with Alhydrogel
    Language English
    Publishing date 2018-01-23
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-017-0043-3
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  6. Article: Safety engineered injection devices for intramuscular, subcutaneous and intradermal injections in healthcare delivery settings: a systematic review and meta-analysis.

    Harb, Alain C / Tarabay, Rami / Diab, Batoul / Ballout, Rami A / Khamassi, Selma / Akl, Elie A

    BMC nursing

    2015  Volume 14, Page(s) 71

    Abstract: Background: Occupational sharps injuries are associated with transmission of bloodborne viruses to healthcare workers, including hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Similarly reuse of syringes in ... ...

    Abstract Background: Occupational sharps injuries are associated with transmission of bloodborne viruses to healthcare workers, including hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV). Similarly reuse of syringes in healthcare settings might transmit these infections between patients. The objective of this study was to systematically review the evidence about the effects of the use by health care workers of two types of safety engineered injection devices, when delivering intramuscular, subcutaneous, or intradermal injectable medications: sharps injury protection syringes and reuse prevention syringes.
    Methods: We included both randomized and non-randomized studies comparing safety syringes to syringes without safety features. Outcomes of interest included needlestick injuries, and HIV, HBV and HCV infections amongst HCWs (for sharps injury prevention syringes) and patients (for reuse prevention syringes). When possible, we conducted meta-analyses using a random-effects model. We tested results for heterogeneity across studies using the I statistic. We assessed the quality of evidence by outcome using the GRADE methodology.
    Results: We included nine eligible studies: six assessed devices that qualify as sharps injury prevention devices, and three assessed devices that qualify as both injury prevention devices and reuse prevention devices. Eight studies were observational while one was randomized. All studies assessed a single outcome: needle stick injuries among healthcare workers. For sharp injury prevention syringes, the meta-analysis of five studies resulted in a pooled relative risk of 0.54 [0.41, 0.71] for the effect on needlestick injuries per healthcare worker. The associated quality of evidence was rated as moderate. For reuse prevention syringes, data from one study provided a relative risk of 0.40 [0.27, 0.59] for the effect on needlestick injuries per healthcare worker. The associated quality of evidence was rated as moderate. We identified no studies reporting on the effect on the reuse of syringes.
    Conclusions: We identified moderate quality evidence that syringes with sharps injury prevention feature reduce the incidence of needlestick injuries per healthcare worker. We identified no studies reporting data for the remaining outcomes of interest for HCWs. Similarly we identified no studies reporting on the effect of syringes with a reuse prevention feature on the reuse of syringes or on the other outcomes of interest for patients.
    Language English
    Publishing date 2015-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091496-9
    ISSN 1472-6955
    ISSN 1472-6955
    DOI 10.1186/s12912-015-0119-1
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  7. Article: Meta-Analyses Proved Inconsistent in How Missing Data Were Handled Across Their Included Primary Trials: A Methodological Survey.

    Kahale, Lara A / Khamis, Assem M / Diab, Batoul / Chang, Yaping / Lopes, Luciane Cruz / Agarwal, Arnav / Li, Ling / Mustafa, Reem A / Koujanian, Serge / Waziry, Reem / Busse, Jason W / Dakik, Abeer / Hooft, Lotty / Guyatt, Gordon H / Scholten, Rob J P M / Akl, Elie A

    Clinical epidemiology

    2020  Volume 12, Page(s) 527–535

    Abstract: Background: How systematic review authors address missing data among eligible primary studies remains uncertain.: Objective: To assess whether systematic review authors are consistent in the way they handle missing data, both across trials included ... ...

    Abstract Background: How systematic review authors address missing data among eligible primary studies remains uncertain.
    Objective: To assess whether systematic review authors are consistent in the way they handle missing data, both across trials included in the same meta-analysis, and with their reported methods.
    Methods: We first identified 100 eligible systematic reviews that included a statistically significant meta-analysis of a patient-important dichotomous efficacy outcome. Then, we successfully retrieved 638 of the 653 trials included in these systematic reviews' meta-analyses. From each trial report, we extracted statistical data used in the analysis of the outcome of interest to compare with the data used in the meta-analysis. First, we used these comparisons to classify the "analytical method actually used" for handling missing data by the systematic review authors for each included trial. Second, we assessed whether systematic reviews explicitly reported their analytical method of handling missing data. Third, we calculated the proportion of systematic reviews that were consistent in their "analytical method actually used" across trials included in the same meta-analysis. Fourth, among systematic reviews that were consistent in the "analytical method actually used" across trials and explicitly reported on a method for handling missing data, we assessed whether the "analytical method actually used" and the reported methods were consistent.
    Results: We were unable to determine the "analytical method reviews actually used" for handling missing outcome data among 397 trials. Among the remaining 241, systematic review authors most commonly conducted "complete case analysis" (n=128, 53%) or assumed "none of the participants with missing data had the event of interest" (n=58, 24%). Only eight of 100 systematic reviews were consistent in their approach to handling missing data across included trials, but none of these reported methods for handling missing data. Among seven reviews that did explicitly report their analytical method of handling missing data, only one was consistent in their approach across included trials (using complete case analysis), and their approach was inconsistent with their reported methods (assumed all participants with missing data had the event).
    Conclusion: The majority of systematic review authors were inconsistent in their approach towards reporting and handling missing outcome data across eligible primary trials, and most did not explicitly report their methods to handle missing data. Systematic review authors should clearly identify missing outcome data among their eligible trials, specify an approach for handling missing data in their analyses, and apply their approach consistently across all primary trials.
    Language English
    Publishing date 2020-05-27
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S242080
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  8. Article ; Online: Potential impact of missing outcome data on treatment effects in systematic reviews: imputation study.

    Kahale, Lara A / Khamis, Assem M / Diab, Batoul / Chang, Yaping / Lopes, Luciane Cruz / Agarwal, Arnav / Li, Ling / Mustafa, Reem A / Koujanian, Serge / Waziry, Reem / Busse, Jason W / Dakik, Abeer / Schünemann, Holger J / Hooft, Lotty / Scholten, Rob Jpm / Guyatt, Gordon H / Akl, Elie A

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2898

    Abstract: Objective: To assess the risk of bias associated with missing outcome data in systematic reviews.: Design: Imputation study.: Setting: Systematic reviews.: Population: 100 systematic reviews that included a group level meta-analysis with a ... ...

    Abstract Objective: To assess the risk of bias associated with missing outcome data in systematic reviews.
    Design: Imputation study.
    Setting: Systematic reviews.
    Population: 100 systematic reviews that included a group level meta-analysis with a statistically significant effect on a patient important dichotomous efficacy outcome.
    Main outcome measures: Median percentage change in the relative effect estimate when applying each of the following assumption (four commonly discussed but implausible assumptions (best case scenario, none had the event, all had the event, and worst case scenario) and four plausible assumptions for missing data based on the informative missingness odds ratio (IMOR) approach (IMOR 1.5 (least stringent), IMOR 2, IMOR 3, IMOR 5 (most stringent)); percentage of meta-analyses that crossed the threshold of the null effect for each method; and percentage of meta-analyses that qualitatively changed direction of effect for each method. Sensitivity analyses based on the eight different methods of handling missing data were conducted.
    Results: 100 systematic reviews with 653 randomised controlled trials were included. When applying the implausible but commonly discussed assumptions, the median change in the relative effect estimate varied from 0% to 30.4%. The percentage of meta-analyses crossing the threshold of the null effect varied from 1% (best case scenario) to 60% (worst case scenario), and 26% changed direction with the worst case scenario. When applying the plausible assumptions, the median percentage change in relative effect estimate varied from 1.4% to 7.0%. The percentage of meta-analyses crossing the threshold of the null effect varied from 6% (IMOR 1.5) to 22% (IMOR 5) of meta-analyses, and 2% changed direction with the most stringent (IMOR 5).
    Conclusion: Even when applying plausible assumptions to the outcomes of participants with definite missing data, the average change in pooled relative effect estimate is substantive, and almost a quarter (22%) of meta-analyses crossed the threshold of the null effect. Systematic review authors should present the potential impact of missing outcome data on their effect estimates and use this to inform their overall GRADE (grading of recommendations assessment, development, and evaluation) ratings of risk of bias and their interpretation of the results.
    MeSH term(s) Bias ; Data Interpretation, Statistical ; Humans ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Research Design/standards ; Systematic Reviews as Topic
    Language English
    Publishing date 2020-08-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2898
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  9. Article ; Online: Knowledge, attitudes, beliefs, values, preferences, and feasibility in relation to the use of injection safety devices in healthcare settings: a systematic review.

    Tarabay, Rami / El Rassi, Rola / Dakik, Abeer / Harb, Alain / Ballout, Rami A / Diab, Batoul / Khamassi, Selma / Akl, Elie A

    Health and quality of life outcomes

    2016  Volume 14, Page(s) 102

    Abstract: Background: Adopting technologies such as injection safety devices in healthcare settings can enhance injection safety. Developing guidelines for appropriate adoption of such technologies need to consider factors beyond evidence for their health effects. ...

    Abstract Background: Adopting technologies such as injection safety devices in healthcare settings can enhance injection safety. Developing guidelines for appropriate adoption of such technologies need to consider factors beyond evidence for their health effects. The objective of this study is to systematically review the published literature for evidence among healthcare workers and patients about knowledge, attitudes, beliefs, values, preferences, and feasibility in relation to the use of injection safety devices in healthcare settings.
    Methods: We included both qualitative and quantitative studies conducted with the general public, patients, and healthcare workers, administrators, or policy makers. We searched MEDLINE, EMBASE, CINHAL and CENTRAL. We used a duplicate and independent approach to title and abstract screening, full text screening, data abstraction and risk of bias assessment.
    Results: Out of a total of 6568 identified citations, we judged fourteen studies as eligible for this systematic review. All these studies were surveys, conducted with healthcare workers in high-income countries. We did not identify any qualitative study, or a study of the general public, patients, healthcare administrators or policy makers. We did not identify any study assessing knowledge, or values assigned to outcomes relevant to injection safety devices. Each of the included studies suffered from methodological limitations, which lowers our confidence in their findings. Based on the findings of six studies, the injection safety devices were generally perceived as easy to use and as an improvement compared with conventional syringes. Some of these studies reported few technical problems while using the devices. In three studies assessing perceived safety, the majority of participants judged the devices as safe. Two studies reported positive perceptions of healthcare workers regarding patient tolerance of these injection safety devices. One study found that less than half the nurses felt comfortable using the insulin pens. Findings from four studies assessing preference and satisfaction were not consistent.
    Conclusions: This systematic review identified evidence that injection safety devices are generally perceived as easy to use, safe, and tolerated by patients. There were few reports of technical problems while using the devices and some discomfort by nurses using the insulin pens.
    MeSH term(s) Attitude of Health Personnel ; Feasibility Studies ; Health Knowledge, Attitudes, Practice ; Humans ; Injections ; Patient Preference ; Patient Satisfaction ; Protective Devices ; Qualitative Research
    Language English
    Publishing date 2016-07-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2098765-1
    ISSN 1477-7525 ; 1477-7525
    ISSN (online) 1477-7525
    ISSN 1477-7525
    DOI 10.1186/s12955-016-0505-8
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  10. Article ; Online: A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults.

    Pillet, Stéphane / Aubin, Éric / Trépanier, Sonia / Bussière, Diane / Dargis, Michèle / Poulin, Jean-François / Yassine-Diab, Bader / Ward, Brian J / Landry, Nathalie

    Clinical immunology (Orlando, Fla.)

    2016  Volume 168, Page(s) 72–87

    Abstract: Recent issues regarding efficacy of influenza vaccines have re-emphasized the need of new approaches to face this major public health issue. In a phase 1-2 clinical trial, healthy adults received one intramuscular dose of a seasonal influenza plant-based ...

    Abstract Recent issues regarding efficacy of influenza vaccines have re-emphasized the need of new approaches to face this major public health issue. In a phase 1-2 clinical trial, healthy adults received one intramuscular dose of a seasonal influenza plant-based quadrivalent virus-like particle (QVLP) vaccine or placebo. The hemagglutination inhibition (HI) titers met all the European licensure criteria for the type A influenza strains at the 3μg/strain dose and for all four strains at the higher dosages 21days after immunization. High HI titers were maintained for most of the strains 6months after vaccination. QVLP vaccine induced a substantial and sustained increase of hemagglutinin-specific polyfunctional CD4 T cells, mainly transitional memory and TEMRA effector IFN-γ(+) CD4 T cells. A T cells cross-reactive response was also observed against A/Hong-Kong/1/1968 H3N2 and B/Massachusetts/2/2012. Plant-based QVLP offers an attractive alternative manufacturing method for producing effective and HA-strain matching seasonal influenza vaccines.
    MeSH term(s) Adolescent ; Adult ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Cross Reactions/immunology ; Dose-Response Relationship, Drug ; Double-Blind Method ; Fatigue/etiology ; Female ; Flow Cytometry ; Humans ; Influenza A virus/immunology ; Influenza A virus/physiology ; Influenza Vaccines/administration & dosage ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Influenza, Human/blood ; Influenza, Human/immunology ; Influenza, Human/virology ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Male ; Middle Aged ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Nicotiana/genetics ; Treatment Outcome ; Vaccination/adverse effects ; Vaccination/methods ; Vaccines, Virus-Like Particle/administration & dosage ; Vaccines, Virus-Like Particle/genetics ; Vaccines, Virus-Like Particle/immunology ; Young Adult
    Chemical Substances Antibodies, Viral ; Influenza Vaccines ; Vaccines, Virus-Like Particle ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2016-03-14
    Publishing country United States
    Document type Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2016.03.008
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    ab Jg. 2022: Lesesaal (EG)

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