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  1. Book: The Rose and Mackay Textbook of Autoimmune Diseases

    Gershwin, Eric / Tsokos, George / Diamond, Betty / Mackay, Charles

    2024  

    Abstract: In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive ... ...

    Abstract In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases.The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients.The new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.
    Keywords autoimmune disease; cancer; COVID; autoinflammation; T-cells; B-cells ; Immunologie ; Immunology ; Life Sciences ; Single-item retail product ; Rheumatologie, Muskelerkrankungen
    Language English
    Dates of publication 2024-2024
    Size 276 mm.
    Publisher Elsevier Science & Technology
    Publishing country United States
    Document type Book
    HBZ-ID HT030071462
    ISBN 9780443186479 ; 9780443186486 ; 0443186472 ; 0443186480
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Autoimmune diseases / 1

    Diamond, Betty

    2014  

    Author's details Betty Diamond ... ed
    Collection Autoimmune diseases
    Language English
    Size XLIII, 628 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018444088
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4407 available for loan (reading room) Lesesaal EG

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  3. Book: Autoimmune diseases / 2

    Diamond, Betty

    2014  

    Author's details Betty Diamond ... ed
    Collection Autoimmune diseases
    Language English
    Size XLIII S., S. 630 - 1296 : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018444099
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  4. Book ; Collection: Autoimmune diseases

    Diamond, Betty

    (Encyclopedia of medical immunology ; <2> ; Springer reference)

    2014  

    Author's details Betty Diamond ... ed
    Series title Encyclopedia of medical immunology ; <2>
    Springer reference
    Collection
    Language English
    Dates of publication 2014-9999
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book ; Collection (display volumes)
    HBZ-ID HT018430770
    ISBN 978-0-387-84827-3 ; 978-0-387-84829-7 ; 9780387848280 ; 0-387-84827-4 ; 0-387-84829-0 ; 0387848282
    Database Catalogue ZB MED Medicine, Health

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  5. Book ; Online ; E-Book: Autoimmune diseases

    Diamond, Betty

    (Encyclopedia of medical immunology ; <2>)

    2014  

    Author's details Betty Diamond ... ed
    Series title Encyclopedia of medical immunology ; <2>
    Collection
    Language English
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT018430719
    ISBN 978-0-387-84828-0 ; 978-0-387-84829-7 ; 9780387848273 ; 0-387-84828-2 ; 0-387-84829-0 ; 0387848274
    DOI 10.1007/978-0-387-84828-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Online: The Role of HMGB1 in Immunity

    Shin, Jeon-Soo / Diamond, Betty / Son, Myoungsun

    2020  

    Keywords Medicine ; Immunology ; HMGB1 ; secretion ; inflammation ; sepsis ; cancer ; immune function ; potential therapeutics
    Size 1 electronic resource (112 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231581
    ISBN 9782889661343 ; 2889661342
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article ; Online: Not Dead Yet.

    Diamond, Betty

    Annual review of immunology

    2023  Volume 41, Page(s) 1–15

    Abstract: I have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies you care about ... ...

    Abstract I have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies you care about with colleagues and trainees leads to strong and lasting bonds. Science isn't easy; being a woman in science presents challenges, but the drive to understand a disease remains strong.
    MeSH term(s) Female ; Humans ; Career Choice ; Lupus Erythematosus, Systemic ; Biomedical Research
    Language English
    Publishing date 2023-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604953-9
    ISSN 1545-3278 ; 0732-0582
    ISSN (online) 1545-3278
    ISSN 0732-0582
    DOI 10.1146/annurev-immunol-101721-065214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of microglia isolation and culture methodology on transcriptional profile and function.

    Mizrachi, Mark / Diamond, Betty

    Journal of neuroinflammation

    2024  Volume 21, Issue 1, Page(s) 87

    Abstract: Background: Microglial isolation and culturing methods continue to be explored to maximize cellular yield, purity, responsiveness to stimulation and similarity to in vivo microglia. This study aims to evaluate five different microglia isolation methods- ... ...

    Abstract Background: Microglial isolation and culturing methods continue to be explored to maximize cellular yield, purity, responsiveness to stimulation and similarity to in vivo microglia. This study aims to evaluate five different microglia isolation methods-three variants of microglia isolation from neonatal mice and two variants of microglia isolation from adult mice-on transcriptional profile and response to HMGB1.
    Methods: Microglia from neonatal mice, age 0-3 days (P0-P3) were isolated from mixed glial cultures (MGC). We included three variations of this protocol that differed by use of GM-CSF in culture (No GM-CSF or 500 pg/mL GM-CSF), and days of culture in MGC before microglial separation (10 or 21). Protocols for studying microglia from adult mice age 6-8 weeks included isolation by adherence properties followed by 7 days of culture with 100 ng/mL GM-CSF and 100 ng/mL M-CSF (Vijaya et al. in Front Cell Neurosci 17:1082180, 2023), or acute isolation using CD11b beads (Bordt et al. in STAR Protoc 1:100035, 2020. https://doi.org/10.1016/j.xpro.2020.100035 ). Purity, yield, and RNA quality of the isolated microglia were assessed by flow cytometry, hemocytometer counting, and Bioanalyzer, respectively. Microglial responsiveness to an inflammatory stimulus, HMGB1, was evaluated by measuring TNFα, IL1β, and IFNβ concentration in supernatant by ELISA and assessing gene expression patterns using bulk mRNA sequencing.
    Results: All five methods demonstrated greater than 90% purity. Microglia from all cultures increased transcription and secretion of TNFα, IL1β, and IFNβ in response to HMGB1. RNA sequencing showed a larger number of differentially expressed genes in response to HMGB1 treatment in microglia cultured from neonates than from adult mice, with sparse changes among the three MGC culturing conditions. Additionally, cultured microglia derived from adult and microglia derived from MGCs from neonates display transcriptional signatures corresponding to an earlier developmental stage.
    Conclusion: These findings suggest that while all methods provided high purity, the choice of protocol may significantly influence yield, RNA quality, baseline transcriptional profile and response to stimulation. This comparative study provides valuable insights to inform the choice of microglial isolation and culture method.
    MeSH term(s) Animals ; Mice ; Microglia/metabolism ; Granulocyte-Macrophage Colony-Stimulating Factor ; HMGB1 Protein/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Cells, Cultured ; RNA/metabolism
    Chemical Substances Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; HMGB1 Protein ; Tumor Necrosis Factor-alpha ; RNA (63231-63-0)
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-024-03076-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The renin-angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications.

    Diamond, Betty

    The Journal of experimental medicine

    2020  Volume 217, Issue 8

    Abstract: The renin-angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use ... ...

    Abstract The renin-angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19.
    MeSH term(s) Angiotensin I/metabolism ; Angiotensin-Converting Enzyme 2 ; Animals ; Blood Coagulation Disorders/virology ; COVID-19 ; Coronavirus Infections/etiology ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Cytokines/metabolism ; Humans ; Hypertension/physiopathology ; Lung/metabolism ; Lung/physiopathology ; Lung/virology ; Lung Diseases/metabolism ; Lung Diseases/physiopathology ; Lung Diseases/virology ; Obesity/physiopathology ; Pandemics ; Peptide Fragments/metabolism ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/etiology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/physiopathology ; Receptor, Angiotensin, Type 1/metabolism ; Severity of Illness Index
    Chemical Substances Cytokines ; Peptide Fragments ; Receptor, Angiotensin, Type 1 ; Angiotensin I (9041-90-1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; angiotensin I (1-7) (IJ3FUK8MOF)
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20201000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial overview: Autoimmunity 2022.

    Diamond, Betty / Kaplan, Mariana

    Current opinion in immunology

    2023  Volume 81, Page(s) 102287

    MeSH term(s) Humans ; Autoimmunity ; Autoimmune Diseases
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Editorial
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2023.102287
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