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  1. Article ; Online: Antifungal Peptides.

    Diamond, Gill

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 6

    Abstract: Fungal infections represent an increasing public health crisis [ ... ]. ...

    Abstract Fungal infections represent an increasing public health crisis [...].
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7060437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial: Cellular Mechanisms of Aging and Longevity in Oral Health and Disease.

    Cutler, Christopher W / Diamond, Gill

    Frontiers in oral health

    2022  Volume 3, Page(s) 971191

    Language English
    Publishing date 2022-07-12
    Publishing country Switzerland
    Document type Editorial
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2022.971191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antiviral Activities of Human Host Defense Peptides.

    Brice, David C / Diamond, Gill

    Current medicinal chemistry

    2019  Volume 27, Issue 9, Page(s) 1420–1443

    Abstract: Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common ... ...

    Abstract Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout nature. As they participate in a number of different aspects of innate immunity in mammals, they have been termed Host Defense Peptides (HDPs). Due to their common structural features, including an amphipathic structure and cationic charge, they have been widely shown to interact with and disrupt microbial membranes. Thus, it is not surprising that human HDPs have activity against enveloped viruses as well as bacteria and fungi. However, these peptides also exhibit activity against a wide range of non-enveloped viruses as well, acting at a number of different steps in viral infection. This review focuses on the activity of human host defense peptides, including alpha- and beta-defensins and the sole human cathelicidin, LL-37, against both enveloped and non-enveloped viruses. The broad spectrum of antiviral activity of these peptides, both in vitro and in vivo suggest that they play an important role in the innate antiviral defense against viral infections. Furthermore, the literature suggests that they may be developed into antiviral therapeutic agents.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Bacteria ; Fungi ; Humans ; Immunity, Innate ; Peptides ; Virus Diseases
    Chemical Substances Antiviral Agents ; Peptides
    Language English
    Publishing date 2019-08-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867326666190805151654
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Enhancement of innate immunity in gingival epithelial cells by vitamin D and HDAC inhibitors.

    Figgins, Erika L / Arora, Payal / Gao, Denny / Porcelli, Emily / Ahmed, Rabab / Daep, Carlo Amorin / Keele, Garrett / Ryan, Lisa K / Diamond, Gill

    Frontiers in oral health

    2024  Volume 5, Page(s) 1378566

    Abstract: Introduction: The human host defense peptide LL-37 is a component of the innate immune defense mechanisms of the oral cavity against colonization by microbes associated with periodontal disease. We have previously shown that the active form of vitamin D, ...

    Abstract Introduction: The human host defense peptide LL-37 is a component of the innate immune defense mechanisms of the oral cavity against colonization by microbes associated with periodontal disease. We have previously shown that the active form of vitamin D, 1,25(OH)
    Methods: We treated 3-dimensional primary cultures of GEC topically with the inactive form of vitamin D, in the presence and absence of selected histone deacetylase (HDAC) inhibitors. LL-37 mRNA levels were quantified by quantitative RT-PCR, and inhibition of invasion of bacteria was measured by fluorescence microscopy.
    Results: Vitamin D treatment led to an induction of LL-37 mRNA levels, as well as an inhibition of pro-inflammatory cytokine secretion. This effect was further enhanced by HDAC inhibitors, most strongly when the HDAC inhibitor, phenyl butyrate (PBA) was combined with Vitamin D
    Conclusions: Our results demonstrate that a combination of inactive vitamin D and sodium butyrate could be developed as a safe treatment for periodontal disease.
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-4842
    ISSN (online) 2673-4842
    DOI 10.3389/froh.2024.1378566
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  5. Article ; Online: Peptidomimetic Oligomers Targeting Membrane Phosphatidylserine Exhibit Broad Antiviral Activity.

    Tate, Patrick M / Mastrodomenico, Vincent / Cunha, Christina / McClure, Joshua / Barron, Annelise E / Diamond, Gill / Mounce, Bryan C / Kirshenbaum, Kent

    ACS infectious diseases

    2023  Volume 9, Issue 8, Page(s) 1508–1522

    Abstract: The development of durable new antiviral therapies is challenging, as viruses can evolve rapidly to establish resistance and attenuate therapeutic efficacy. New compounds that selectively target conserved viral features are attractive therapeutic ... ...

    Abstract The development of durable new antiviral therapies is challenging, as viruses can evolve rapidly to establish resistance and attenuate therapeutic efficacy. New compounds that selectively target conserved viral features are attractive therapeutic candidates, particularly for combating newly emergent viral threats. The innate immune system features a sustained capability to combat pathogens through production of antimicrobial peptides (AMPs); however, these AMPs have shortcomings that can preclude clinical use. The essential functional features of AMPs have been recapitulated by peptidomimetic oligomers, yielding effective antibacterial and antifungal agents. Here, we show that a family of AMP mimetics, called peptoids, exhibit direct antiviral activity against an array of enveloped viruses, including the key human pathogens Zika, Rift Valley fever, and chikungunya viruses. These data suggest that the activities of peptoids include engagement and disruption of viral membrane constituents. To investigate how these peptoids target lipid membranes, we used liposome leakage assays to measure membrane disruption. We found that liposomes containing phosphatidylserine (PS) were markedly sensitive to peptoid treatment; in contrast, liposomes formed exclusively with phosphatidylcholine (PC) showed no sensitivity. In addition, chikungunya virus containing elevated envelope PS was more susceptible to peptoid-mediated inactivation. These results indicate that peptoids mimicking the physicochemical characteristics of AMPs act through a membrane-specific mechanism, most likely through preferential interactions with PS. We provide the first evidence for the engagement of distinct viral envelope lipid constituents, establishing an avenue for specificity that may enable the development of a new family of therapeutics capable of averting the rapid development of resistance.
    MeSH term(s) Animals ; Humans ; Antiviral Agents/pharmacology ; Peptidomimetics/pharmacology ; Phosphatidylserines ; Liposomes ; Peptoids/pharmacology ; Peptoids/chemistry ; Zika Virus ; Zika Virus Infection
    Chemical Substances Antiviral Agents ; Peptidomimetics ; Phosphatidylserines ; Liposomes ; Peptoids
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.3c00063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modulation of Human β-Defensin-1 Production by Viruses.

    Ryan, Lisa Kathleen / Diamond, Gill

    Viruses

    2017  Volume 9, Issue 6

    Abstract: While initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of expression of its gene, ...

    Abstract While initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of expression of its gene,
    Language English
    Publishing date 2017-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v9060153
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  7. Article ; Online: LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells.

    Brice, David C / Toth, Zsolt / Diamond, Gill

    Antiviral research

    2018  Volume 158, Page(s) 25–33

    Abstract: Oral epithelial cells (OECs) represent the first line of defense against viruses that are spread via saliva, including Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of humans by KSHV and viral pathogenesis begins by infecting OECs. One method ...

    Abstract Oral epithelial cells (OECs) represent the first line of defense against viruses that are spread via saliva, including Kaposi's sarcoma-associated herpesvirus (KSHV). Infection of humans by KSHV and viral pathogenesis begins by infecting OECs. One method OECs use to limit viral infections in the oral cavity is the production of antimicrobial peptides (AMPs), or host defense peptides (HDPs). However, no studies have investigated the antiviral activities of any HDP against KSHV. The goal of this study was to determine the antiviral activity of one HDP, LL-37, against KSHV in the context of infecting OECs. Our results show that LL-37 significantly decreased KSHV's ability to infect OECs in both a structure- and dose-dependent manner. However, this activity does not stem from affecting OECs, but instead the virions themselves. We found that LL-37 exerts its antiviral activity against KSHV by disrupting the viral envelope, which can inhibit viral entry into OECs. Our data suggest that LL-37 exhibits a marked antiviral activity against KSHV during infection of oral epithelial cells, which can play an important role in host defense against oral KSHV infection. Thus, we propose that inducing LL-37 expression endogenously in oral epithelial cells, or potentially introducing as a therapy, may help restrict oral KSHV infection and ultimately KSHV-associated diseases.
    MeSH term(s) Antimicrobial Cationic Peptides/pharmacology ; Antiviral Agents/pharmacology ; Cell Line ; Epithelial Cells/virology ; Herpesviridae Infections/drug therapy ; Herpesvirus 8, Human/drug effects ; Herpesvirus 8, Human/pathogenicity ; Humans ; Keratinocytes ; Mouth/virology ; Virion/drug effects ; Virion/metabolism ; Virus Internalization/drug effects
    Chemical Substances Antimicrobial Cationic Peptides ; Antiviral Agents ; ropocamptide (3DD771JO2H)
    Language English
    Publishing date 2018-08-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2018.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Self-Assembly of Antimicrobial Peptoids Impacts Their Biological Effects on

    Nielsen, Josefine Eilsø / Alford, Morgan Ashley / Yung, Deborah Bow Yue / Molchanova, Natalia / Fortkort, John A / Lin, Jennifer S / Diamond, Gill / Hancock, Robert E W / Jenssen, Håvard / Pletzer, Daniel / Lund, Reidar / Barron, Annelise E

    ACS infectious diseases

    2022  Volume 8, Issue 3, Page(s) 533–545

    Abstract: Antimicrobial peptides (AMPs) are promising pharmaceutical candidates for the prevention and treatment of infections caused by multidrug- ... ...

    Abstract Antimicrobial peptides (AMPs) are promising pharmaceutical candidates for the prevention and treatment of infections caused by multidrug-resistant
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/pharmacology ; Bacteria ; Peptoids/chemistry ; Peptoids/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Antimicrobial Cationic Peptides ; Peptoids
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Anti-persister and Anti-biofilm Activity of Self-Assembled Antimicrobial Peptoid Ellipsoidal Micelles.

    Lin, Jennifer S / Bekale, Laurent A / Molchanova, Natalia / Nielsen, Josefine Eilsø / Wright, Megan / Bacacao, Brian / Diamond, Gill / Jenssen, Håvard / Santa Maria, Peter L / Barron, Annelise E

    ACS infectious diseases

    2022  Volume 8, Issue 9, Page(s) 1823–1830

    Abstract: Although persister cells are the root cause of resistance development and relapse of chronic infections, more attention has been focused on developing antimicrobial agents against resistant bacterial strains than on developing anti-persister agents. ... ...

    Abstract Although persister cells are the root cause of resistance development and relapse of chronic infections, more attention has been focused on developing antimicrobial agents against resistant bacterial strains than on developing anti-persister agents. Frustratingly, the global preclinical antibacterial pipeline does not include any anti-persister drug. Therefore, the central point of this work is to explore antimicrobial peptidomimetics called peptoids (sequence-specific oligo-
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Humans ; Micelles ; Microbial Sensitivity Tests ; Peptoids/pharmacology ; Recurrence
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Micelles ; Peptoids
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.2c00288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: β-Defensins Coordinate In Vivo to Inhibit Bacterial Infections of the Trachea.

    Ryan, Lisa Kathleen / Wu, Jichuan / Schwartz, Kyell / Yim, Sunghan / Diamond, Gill

    Vaccines

    2018  Volume 6, Issue 3

    Abstract: β-defensins are predicted to play an important role in innate immunity against bacterial infections in the airway. We previously observed that a type III-secretion product ... ...

    Abstract β-defensins are predicted to play an important role in innate immunity against bacterial infections in the airway. We previously observed that a type III-secretion product of
    Language English
    Publishing date 2018-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines6030057
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