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Article ; Online: Endiandra macrocarpa (Lauraceae), a new tree species from south-western China

Zou, Dian-yang / Cao, Guan-long / Zhang, Jin-guo / Li, Lang / Li, Jie

PhytoKeys. 2023 Apr. 07, v. 224 p.183-192

2023

Abstract: AbstractEndiandra macrocarpa, a new species of Endiandra (Lauraceae) from Yunnan Province of south-western China, is here described and illustrated, based on morphological evidence. Compared to other Endiandra species occurring in south China and the ... ...

Abstract	AbstractEndiandra macrocarpa, a new species of Endiandra (Lauraceae) from Yunnan Province of south-western China, is here described and illustrated, based on morphological evidence. Compared to other Endiandra species occurring in south China and the adjacent regions in Indochina, this species is mainly characterised by its much larger ellipsoidal fruits (up to 11 × 6 cm), as well as glabrous branchlets and puberulent inflorescences.
Keywords	Endiandra ; new species ; trees ; China ; Indochina ; morphology ; taxonomy ; tropical montane forest ; Yunnan Province
Language	English
Dates of publication	2023-0407
Size	p. 183-192.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.224.102752
Database	NAL-Catalogue (AGRICOLA)

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Article:

Zou, Dian-Yang / Cao, Guan-Long / Zhang, Jin-Guo / Li, Lang / Li, Jie

PhytoKeys

2023 Volume 224, Page(s) 183–192

Abstract: ... ...

Abstract	Endiandramacrocarpa
Language	English
Publishing date	2023-04-07
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2579891-1
ISSN	1314-2003 ; 1314-2011
ISSN (online)	1314-2003
ISSN	1314-2011
DOI	10.3897/phytokeys.224.102752
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficient exon skipping by base-editor-mediated abrogation of exonic splicing enhancers

Han Qiu / Geng Li / Juanjuan Yuan / Dian Yang / Yunqing Ma / Feng Wang / Yi Dai / Xing Chang

Cell Reports, Vol 42, Iss 11, Pp 113340- (2023)

2023

Abstract: Summary: Duchenne muscular dystrophy (DMD) is a severe genetic disease caused by the loss of the dystrophin protein. Exon skipping is a promising strategy to treat DMD by restoring truncated dystrophin. Here, we demonstrate that base editors (e.g., ... ...

Abstract	Summary: Duchenne muscular dystrophy (DMD) is a severe genetic disease caused by the loss of the dystrophin protein. Exon skipping is a promising strategy to treat DMD by restoring truncated dystrophin. Here, we demonstrate that base editors (e.g., targeted AID-mediated mutagenesis [TAM]) are able to efficiently induce exon skipping by disrupting functional redundant exonic splicing enhancers (ESEs). By developing an unbiased and high-throughput screening to interrogate exonic sequences, we successfully identify novel ESEs in DMD exons 51 and 53. TAM-CBE (cytidine base editor) induces near-complete skipping of the respective exons by targeting these ESEs in patients’ induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Combined with strategies to disrupt splice sites, we identify suitable single guide RNAs (sgRNAs) with TAM-CBE to efficiently skip most DMD hotspot exons without substantial double-stranded breaks. Our study thus expands the repertoire of potential targets for CBE-mediated exon skipping in treating DMD and other RNA mis-splicing diseases.
Keywords	CP: Genomics ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The ubiquitin-specific protease 8 antagonizes melatonin-induced endocytic degradation of MT1 receptor to promote lung adenocarcinoma growth

Qianhui Sun / Jinrui Zhang / Xiaoxi Li / Guoheng Yang / Shaoxuan Cheng / Dong Guo / Qingqing Zhang / Feng Sun / Feng Zhao / Dian Yang / Shanshan Wang / Taishu Wang / Shuyan Liu / Lijuan Zou / Yingqiu Zhang / Han Liu

Journal of Advanced Research, Vol 41, Iss , Pp 1-

2022 Volume 12

Abstract: Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well- ... ...

Abstract	Introduction: The human genome encodes two melatonin receptors (MT1 and MT2) that relay melatonin signals to cellular interior. Accumulating evidence has linked melatonin to multiple health benefits, among which its anticancer effects have become well-established. However, the implications of its receptors in lung adenocarcinoma have so far remained incompletely understood. Objectives: This study aims to investigate the response of the MT1 receptor to melatonin treatment and its dynamic regulation by ubiquitin-specific protease 8 (USP8) in lung adenocarcinoma. Methods: The mRNA levels of MT1 and MT2 receptors were analyzed with sequencing data. The expression and localization of the MT1 receptor with melatonin treatment were investigated by immunoblotting, immunofluorescence and confocal microscopy assays. Endocytic deubiquitylases were screened to identify MT1 association. The effects of USP8 were assessed with shRNA-mediated knockdown and small molecule inhibitor. The combined efficacy of melatonin and USP8 suppression was also evaluated using xenograft animal models. Results: Bioinformatic analysis revealed increased expression of the MT1 receptor in lung adenocarcinoma tissues. Melatonin treatment leads to the downregulation of the MT1 receptor in lung adenocarcinoma cells, which is attributed to receptor endocytosis and lysosomal degradation via the canonical endo-lysosomal route. USP8 negatively regulates the endocytic degradation of the MT1 receptor incurred by melatonin exposure and thus protects lung adenocarcinoma cell growth. USP8 suppression by knockdown or pharmacological inhibition effectively deters cancer cell proliferation and sensitizes lung adenocarcinoma cells to melatonin in vitro. Furthermore, USP8 silencing significantly potentiates the anticancer effects of melatonin in xenograft tumor models. Conclusion: The MT1 receptor responds to melatonin treatment and is endocytosed for lysosomal degradation that is counteracted by USP8. The inhibition of USP8 demonstrates tumor-suppressive effects ...
Keywords	Melatonin ; MT1 ; USP8 ; Lung adenocarcinoma ; Endocytosis ; DUB ; Medicine (General) ; R5-920 ; Science (General) ; Q1-390
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Collection and disinfection of forensic biological specimens in five cases concerning COVID-19 in Guangzhou, China

Xingyi Yang / Quyi Xu / Hong Liu / Jichao Xu / Dian Yang / Cheng xiao / Huiying Hu / Yunyun Liu / Chao Liu

Forensic Science International: Synergy, Vol 2, Iss , Pp 210-

2020 Volume 214

Abstract: There have been many cases of pneumonia caused by novel coronavirus infections in China and around the world. This will inevitably lead to a rise in the number of patients. At the present time, clinical and forensic autopsies have given guidance and ... ...

Abstract	There have been many cases of pneumonia caused by novel coronavirus infections in China and around the world. This will inevitably lead to a rise in the number of patients. At the present time, clinical and forensic autopsies have given guidance and explanations in relation to the problem of COVID-19 transmission and defense. However, less attention is paid to the handling of COVID-19 biological samples in forensic practice. Particularly, COVID-19 can survive on some surfaces for days. Since there were many cases involving COVID-19 during the epidemic, this article shares the methods and strategies for handling such inspection materials and the biological samples related specifically to COVID-19 cases.
Keywords	Forensic biology ; Biological specimens ; COVID-19 ; Biosecurity ; Criminal law and procedure ; K5000-5582 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Bilayer hydrogel mixed composites that respond to multiple stimuli for environmental sensing and underwater actuation

Cheng, Yu / Chao Huang / Dian Yang / Kai Ren / Jie Wei

Journal of materials chemistry B. 2018 Dec. 12, v. 6, no. 48

2018

Abstract: Bilayer-type hydrogel composites that respond to multiple stimuli provide a useful approach for manufacturing soft actuators and intelligent sensors. In this study, we propose two types of bilayer hydrogel composites (referred to as “N” type and “D” type) ...

Abstract	Bilayer-type hydrogel composites that respond to multiple stimuli provide a useful approach for manufacturing soft actuators and intelligent sensors. In this study, we propose two types of bilayer hydrogel composites (referred to as “N” type and “D” type). The “N” type and the “D” type separately consist of poly(N-isopropylacrylamide) (PNIPAM) and poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) bilayer hydrogels, with acrylamide (AM) as the co-monomer. The “N” type hydrogel composite exhibits oriented bending as temperature increases or as environmental salt concentration increases. The “D” type also presents oriented bending as temperature increases. Additionally, it demonstrates bending and changes color based on the pH of the surrounding solution, since it is doped with an acid-based pH-indicator. In a demonstration, we present several straight rods composed of a mixture of “N” and “D” type hydrogel composites that are able to morph into the letters “SOS” under environmental changes (temperature or pH). This can be used as a visual environmental indicator, or as an alarm. Furthermore, we show structures composed of a mixture of “N” and “D” composites imitating the flexible motions of a ballet dancer or a Tai Chi master. These mixed bilayer polymer composites may be used for applications in soft robotics, biomimetic devices, and environmental sensors.
Keywords	acrylamides ; actuators ; biomimetic materials ; color ; environmental indicators ; hydrogels ; manufacturing ; pH ; robots ; salt concentration ; temperature
Language	English
Dates of publication	2018-1212
Size	p. 8170-8179.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c8tb02242a
Database	NAL-Catalogue (AGRICOLA)

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Article: Differential Transcription and Alternative Splicing in Cotton Underly Specialized Defense Responses Against Pests.

Chen, Dian-Yang / Chen, Qiu-Yi / Wang, Dan-Dan / Mu, Yu-Pei / Wang, Mu-Yang / Huang, Ji-Rong / Mao, Ying-Bo

Frontiers in plant science

2020 Volume 11, Page(s) 573131

Abstract: The green mirid bug ( ...

Abstract	The green mirid bug (
Language	English
Publishing date	2020-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.573131
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spatiotemporal trends and ecological determinants in maternal mortality ratios in 2,205 Chinese counties, 2010-2013

Junming Li / Juan Liang / Jinfeng Wang / Zhoupeng Ren / Dian Yang / Yanping Wang / Yi Mu / Xiaohong Li / Mingrong Li / Yuming Guo / Jun Zhu

PLoS Medicine, Vol 17, Iss 5, p e

A Bayesian modelling analysis.

2020 Volume 1003114

Abstract: BACKGROUND:As one of its Millennium Development Goals (MDGs), China has achieved a dramatic reduction in the maternal mortality ratio (MMR), although a distinct spatial heterogeneity still persists. Evidence of the quantitative effects of determinants on ...

Abstract	BACKGROUND:As one of its Millennium Development Goals (MDGs), China has achieved a dramatic reduction in the maternal mortality ratio (MMR), although a distinct spatial heterogeneity still persists. Evidence of the quantitative effects of determinants on MMR in China is limited. A better understanding of the spatiotemporal heterogeneity and quantifying determinants of the MMR would support evidence-based policymaking to sustainably reduce the MMR in China and other developing areas worldwide. METHODS AND FINDINGS:We used data on MMR collected by the National Maternal and Child Health Surveillance System (NMCHSS) at the county level in China from 2010 to 2013. We employed a Bayesian space-time model to investigate the spatiotemporal trends in the MMR from 2010 to 2013. We used Bayesian multivariable regression and GeoDetector models to address 3 main ecological determinants of the MMR, including per capita income (PCI), the proportion of pregnant women who delivered in hospitals (PPWDH), and the proportion of pregnant women who had at least 5 check-ups (PPWFC). Among the 2,205 counties, there were 925 (42.0%) hotspot counties, located mostly in China's western and southwestern regions, with a higher MMR, and 764 (34.6%) coldspot counties with a lower MMR than the national level. China's westernmost regions, including Tibet and western Xinjiang, experienced a weak downward trend over the study period. Nationwide, medical intervention was the major determinant of the change in MMR. The MMR decreased by 1.787 (95% confidence interval [CI]: 1.424-2.142, p < 0.001) per 100,000 live births when PPWDH increased by 1% and decreased by 0.623 (95% CI 0.436-0.798, p < 0.001) per 100,000 live births when PPWFC increased by 1%. The major determinants for the MMR in China's western and southwestern regions were PCI and PPWFC, while that in China's eastern and southern coastlands was PCI. The MMR in western and southwestern regions decreased nonsignificantly by 1.111 (95% CI -1.485-3.655, p = 0.20) per 100,000 live births ...
Keywords	Medicine ; R
Subject code	950
Language	English
Publishing date	2020-05-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer

Rui Hu / Minxue Zheng / Jinchang Wu / Cheng Li / Danqing Shen / Dian Yang / Li Li / Mingfeng Ge / Zhimin Chang / Wenfei Dong

Nanomaterials, Vol 7, Iss 5, p

2017 Volume 111

Abstract: The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor ... ...

Abstract	The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe3O4@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe3O4@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency. For the in vitro tests, a low concentration of Fe3O4@Au NPs after a short period of near-infrared irradiation lead to the time-dependent death of cervical cancer cells. Further, the combination of RT and PTT induced synergistic anti-cancer effects in vitro. More importantly, an external magnetic field could significantly enhance the synergistic efficacy of Fe3O4@Au NPs by improving their internalization. Hence, the reported Fe3O4@Au NPs have the potential to be good nanoagents with excellent magnetic targeting ability for cervical cancer radio-photothermal treatment.
Keywords	cervical cancer ; magnetic gold nanoparticles ; synergetic ; radio-photothermal therapy ; magnetic field ; Chemistry ; QD1-999
Language	English
Publishing date	2017-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Arabidopsis Transcription Factors SPL1 and SPL12 Confer Plant Thermotolerance at Reproductive Stage

Chao, Lu-Men / Dian-Yang Chen / Xiao-Ya Chen / Xue-Yi Xue / Yao-Qian Liu / Ying-Bo Mao

Molecular plant. 2017 May 01, v. 10, no. 5

2017

Abstract: Plant reproductive organs are vulnerable to heat, but regulation of heat-shock responses in inflorescence is largely uncharacterized. Here, we report that two of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcriptional factors in Arabidopsis, ... ...

Abstract	Plant reproductive organs are vulnerable to heat, but regulation of heat-shock responses in inflorescence is largely uncharacterized. Here, we report that two of the SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcriptional factors in Arabidopsis, SPL1 and SPL12, act redundantly in thermotolerance at the reproductive stage. The spl1-1 spl12-1 inflorescences displayed hypersensitivity to heat stress, whereas overexpression of SPL1 or SPL12 enhanced the thermotolerance in both Arabidopsis and tobacco. RNA sequencing revealed 1939 upregulated and 1479 downregulated genes in wild-type inflorescence upon heat stress, among which one-quarter (1,040) was misregulated in spl1-1 spl12-1, indicating that SPL1 and SPL12 contribute greatly to the heat-triggered transcriptional reprogramming in inflorescence. Notably, heat stress induced a large number of abscisic acid (ABA) responsive genes, of which ∼39% were disturbed in heat induction in spl1-1 spl12-1 inflorescence. Preapplication of ABA and overexpression of SPL1 restored the inflorescence thermotolerance in spl1-1 spl12-1 and in the ABA biosynthesis mutant aba2-1, but not in the pyl sextuple mutant defective in ABA receptors PYR1/PYL1/PYL2/PYL4/PYL5/PYL8. Thus, inflorescence thermotolerance conferred by SPL1 and SPL2 involves PYL-mediated ABA signaling. The molecular network consisting of SPL1 and SPL12 illustrated here shed new light on the mechanisms of plant thermotolerance at the reproductive stage.
Keywords	abscisic acid ; Arabidopsis ; biosynthesis ; gene expression regulation ; gene overexpression ; genes ; heat ; heat shock response ; heat stress ; heat tolerance ; hypersensitivity ; inflorescences ; mutants ; receptors ; sequence analysis ; tobacco ; transcription (genetics) ; transcription factors
Language	English
Dates of publication	2017-0501
Size	p. 735-748.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2393618-6
ISSN	1752-9867 ; 1674-2052
ISSN (online)	1752-9867
ISSN	1674-2052
DOI	10.1016/j.molp.2017.03.010
Database	NAL-Catalogue (AGRICOLA)

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