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  1. AU="Diane M. Pascoe"
  2. AU="Hartner, G"
  3. AU="Özgür Akgül"
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Artikel ; Online: Correlation of positron emission tomography ventilation-perfusion matching with CT densitometry in severe emphysema

Asha Bonney / Carrie-Anne Wagner / Shankar Siva / Jason Callahan / Pierre-Yves Le Roux / Diane M. Pascoe / Louis Irving / Michael S. Hofman / Daniel P. Steinfort

EJNMMI Research, Vol 10, Iss 1, Pp 1-

2020  Band 7

Abstract: Abstract Background Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of ventilation or perfusion varies widely, and no prior study has evaluated correlation between ... ...

Abstract Abstract Background Emphysema severity is frequently measured on CT via densitometry. Correlation with scintigraphic and spirometric functional measures of ventilation or perfusion varies widely, and no prior study has evaluated correlation between densitometry and lobar ventilation/perfusion in patients with severe emphysema. The aim of this study was to evaluate the utility and findings of gallium-68 (68Ga) ventilation/perfusion positron emission tomography-CT (68Ga-VQ/PET-CT) in severe emphysema assessment. Methods Fourteen consecutive patients undergoing evaluation for bronchoscopic lung volume reduction between March 2015 and March 2018 underwent 68Ga-VQ/PET-CT assessment for lobar functional lung mapping, in addition to CT densitometry. Correlations between CT densitometry and 68Ga-VQ/PET-CT parameters for individual lobar lung function were sought. Results CT densitometry assessment of emphysema correlated only weakly (R 2 = 0.13) with lobar perfusion and was not correlated with ventilation (R 2 = 0.04). Densitometry was moderately (R 2 = 0.67) correlated with V/Q units in upper lobes, though poorly reflected physiological function in lower lobes (R 2 = 0.19). Emphysema severity, as measured by CT densitometry, was moderately correlated with proportion of normal V/Q units and matched V/Q defects in individual lobes. Conclusions Assessment of lobar pulmonary function by 68Ga-VQ/PET-CT provides physiologic information not evident on CT densitometry such as ventilation and perfusion specifics and matched defects. Further research is needed to see if the discordant findings on 68Ga-VQ/PET-CT provide prognostic information or can be used to modify patient management and improve outcomes.
Schlagwörter Ventilation ; Perfusion ; PET ; Emphysema ; Bronchoscopy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Thema/Rubrik (Code) 610
Sprache Englisch
Erscheinungsdatum 2020-07-01T00:00:00Z
Verlag SpringerOpen
Dokumenttyp Artikel ; Online
Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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