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Article: Adverse Drug Reactions to Antiretroviral Therapy: Frequency, Type, and Risk Factors in Children in Mali.

Oumar, Aboubacar Alassane / Seydou, Alassane / Fofana, Souleymane / Diarra, Zoumana / Mariko, Djeneba / Diallo, Abdallah / Coulibaly, Sanata / Sidibe, Lala N / Togo, Boubacar / Dao, Sounkalo / Doumbia, Seydou / Tulkens, Paul M

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2023 Volume 28, Issue 3, Page(s) 197–203

Abstract: Objective: The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People ... ...

Abstract	Objective: The aim of our study was to evaluate the frequency, type, and risk factors associated with adverse drug reactions (ADRs) in HIV-positive children with adherence to antiretroviral therapy (ART) at the Unit of Care and Accompaniment for People Living With HIV (USAC) of Bamako. Methods: A cross-sectional study was conducted at USAC of Bamako from May 1, 2014, to July 31, 2015. We included children aged 1 to 14 years with at least 6 months of ARV treatment initiated at USAC, with or without ADRs. Data collection was based on information collected from parents and clinical/biological assessments. Results: Median age of participants was 36 months and female sex was predominant (54.8%). Poor adherence during the study was observed in 15% of cases. Of patients in the study, 52% had a CD4 count less than 350 cells/mm Conclusions: In this study we found that ADRs were frequent in HIV-positive patients but less frequent in ART-adherent HIV-positive children. Therefore, it is essential to regularly monitor children receiving ARVs to detect and treat the complications associated with these therapies according to ART adherence.
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-28.3.197
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Article: Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population

Kassogue, Yaya / Diakite, Brehima / Kassogue, Oumar / Konate, Issa / Tamboura, Kadidiatou / Diarra, Zoumana / Dehbi, Hind / Nadifi, Sellama / Traore, Cheick Bougadari / Dao, Sounkalo / Doumbia, Seydou / Dolo, Guimogo

Molecular biology reports. 2020 Jan., v. 47, no. 1

2020

Abstract: Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual ... ...

Abstract	Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies. We performed the present study to establish the frequencies of the GSTM1, GSTT1, and GSTP1 c. 313A > G (rs1695) polymorphisms in 206 individuals of the Malian healthy population. GSTM1 and GSTT1 were genotyped by using multiplex polymerase chain reaction, whereas genotypes of GSTP1 were identified by polymerase chain reaction followed by restriction fragment length polymorphism. The frequencies of GSTM1-null and GSTT1-null genotypes were respectively 24.3 and 41.3%. The observed genotype frequencies for GSTP1 were 25.73% homozygous wild-type AA, 49.03% heterozygous AG and 25.24% homozygous mutant GG. The frequency of GSTP1-A allele was 50.24% versus 49.76% for the GSTP1-G allele. The distribution of these three genes was homogeneous between men and women (p > 0.05). We found no statistical association between the presence of a particular profile of GSTM1 or GSTT1 with the genotypes of GSTP1 (p > 0.05). Nevertheless, we noticed that the majority of the individuals harboring the GSTM1-present or the GSTT1-present harbor also the GSTP1-AG genotype. In addition, the triple genotype GSTM1-present/GSTT1-present/AG was the most frequent with 25.2%. Our findings will facilitate future studies regarding genetic associations of multifactorial diseases and pharmacogenetic, thus opening the way to personalized medicine in our population.
Keywords	alleles ; genotyping ; glutathione transferase ; heterozygosity ; homozygosity ; molecular biology ; mutants ; pharmacokinetics ; polymerase chain reaction ; precision medicine ; restriction fragment length polymorphism ; xenobiotics
Language	English
Dates of publication	2020-01
Size	p. 393-400.
Publishing place	Springer Netherlands
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-019-05143-5
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Article ; Online: Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics.

Kassogue, Yaya / Diakite, Brehima / Kassogue, Oumar / Konate, Issa / Tamboura, Kadidiatou / Diarra, Zoumana / Maiga, Mamoudou / Dehbi, Hind / Nadifi, Sellama / Traore, Cheick Bougadari / Kamate, Bakarou / Dao, Sounkalo / Doumbia, Seydou / Dolo, Guimogo

Medicine

2021 Volume 100, Issue 29, Page(s) e26614

Abstract: Abstract: Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is noteworthy that these enzymes are highly polymorphic and, depending ... ...

Abstract	Abstract: Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is noteworthy that these enzymes are highly polymorphic and, depending on the genetic makeup, an individual may have impaired enzymatic activity. Therefore, the identification of genetic variants in these genes could facilitate the implementation of pharmacogenetic studies and genetic predisposition to multifactorial diseases. We have established the frequencies of CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) alleles and genotypes in 209 healthy Malian subjects using TaqMan drug metabolism genotyping assays for allelic discrimination. Allele frequencies were 37% for CYP2B6 rs3745274; 38% for CYP2B6 rs2279343; and 75% for CYP3A4 rs2740574 respectively. Overall, the frequencies observed in Mali are statistically comparable to those reported across Africa except North Africa. The major haplotypes in CYP2B6 rs3745274 and CYP2B6 rs2279343 were represented by GA (60.24%) followed by TG (35.36%). We noted a strong linkage disequilibrium between CYP2B6 rs3745274 and CYP2B6 rs2279343 with D' = 0.91 and r2 = 0.9. The frequencies of the genotypic combinations were 43.5% (GT/AG), 37.3% (GG/AA) and 11.5% (TT/GG) in the combination of CYP2B6-rs3745274 and CYP2B6-rs2279343; 26.8% (GT/CC), 25.4%, (GT/CT), 17.2% and GG/CT in the combination CYP2B6-rs3745274-CYP3A4-rs2740574; 26.8% (AG/CC), 23.9% (AA/CC), 19.1% (AG/CT), and 11% (AA/CT) in the combination CYP2B6-rs2279343-CYP3A4-rs2740574, respectively. The most common triple genotype was GT/AG/CC with 24.9%, followed by GG/AA/CC with 23.9%, GT/AG/CT with 16.7%, and GG/AA/CT with 10%. Our results provide new insights into the distribution of these pharmacogenetically relevant genes in the Malian population. Moreover, these data will be useful for studies of individual genetic variability to drugs and genetic predisposition to diseases.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alleles ; Cytochrome P-450 CYP2B6/genetics ; Cytochrome P-450 CYP3A/genetics ; Female ; Genotype ; Haplotypes/genetics ; Humans ; Malaysia/ethnology ; Male ; Middle Aged ; Pharmacogenetics/methods
Chemical Substances	Cytochrome P-450 CYP2B6 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026614
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Article ; Online: Descriptive study of cases of schizophrenia in the Malian population.

Coulibaly, Souleymane Dit Papa / Ba, Baba / Mounkoro, Pakuy Pierre / Diakite, Brehima / Kassogue, Yaya / Maiga, Mamoudou / Dara, Aperou Eloi / Traoré, Joseph / Kamaté, Zoua / Traoré, Kadiatou / Koné, Mahamadou / Maiga, Boubacar / Diarra, Zoumana / Coulibaly, Souleymane / Togora, Arouna / Maiga, Youssoufa / Koumaré, Baba

BMC psychiatry

2021 Volume 21, Issue 1, Page(s) 413

Abstract: Background: Schizophrenia is a relatively common disease worldwide with a point prevalence of around 5/1000 in the population. The aim of this present work was to assess the demographic, clinical, familial, and environmental factors associated with ... ...

Abstract	Background: Schizophrenia is a relatively common disease worldwide with a point prevalence of around 5/1000 in the population. The aim of this present work was to assess the demographic, clinical, familial, and environmental factors associated with schizophrenia in Mali. Methods: This was a prospective descriptive study on a series of 164 patients aged at least 12 years who came for a follow-up consultation at the psychiatry department of the University Hospital Center (CHU) Point G in Mali between February 2019 and January 2020 for schizophrenia spectrum disorder as defined by DSM-5 diagnostic criteria. Results: Our results revealed that the male sex was predominant (80.5%). The 25-34 age group was more represented with 44.5%. The place of birth for the majority of our patients was the urban area (52.4%), which also represented the place of the first year of life for the majority of our patients (56.1%). We noted that the unemployed and single people accounted for 56.1 and 61% respectively. More than half of our patients 58.5% reported having reached secondary school level. With the exception of education level, there was a statistically significant difference in the distribution of demographic parameters. Familial schizophrenia cases accounted for 51.7% versus 49.3% for non-familial cases. The different clinical forms were represented by the paranoid form, followed by the undifferentiated form, and the hebephrenic form with respectively 34, 28 and 17.1%. We noted that almost half (48.8%) of patients were born during the cold season. Cannabis use history was not observed in 68.7% of the patients. The proportions of patients with an out-of-school father or an out-of-school mother were 51.2 and 64.2%, respectively. Conclusion: The onset of schizophrenia in the Malian population has been associated with socio-demographic, clinical, genetic and environmental characteristics.
MeSH term(s)	Diagnostic and Statistical Manual of Mental Disorders ; Educational Status ; Humans ; Male ; Prospective Studies ; Schizophrenia/epidemiology ; Seasons
Language	English
Publishing date	2021-08-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-021-03422-9
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Article ; Online: Influence of CYP2B6 and CYP3A4 polymorphisms on the virologic and immunologic responses of patients treated with efavirenz-containing regimen.

Pharmacogenetics and genomics

2022 Volume 32, Issue 6, Page(s) 219–225

Abstract: Objectives: The main objective of this study was to evaluate the effect of CYP2B6 and CYP3A4 polymorphisms on the virological and immunologic responses of HIV patients. A total of 153 HIV-positive patients were enlisted for the study.: Patients and ... ...

Abstract	Objectives: The main objective of this study was to evaluate the effect of CYP2B6 and CYP3A4 polymorphisms on the virological and immunologic responses of HIV patients. A total of 153 HIV-positive patients were enlisted for the study. Patients and methods: Viral load and median CD4 T cell counts were evaluated at baseline and month 6 (M6). Samples were identified using TaqMan genotyping assays. Results: The AG in CYP2B6 rs2279343 was associated with VLS compared to homozygous AA. In the dominant model, the AG/GG genotypes were associated with VLS compared to the AA genotype. Moreover, in overdominant model, the AG genotype was associated with VLS compared to AA/GG. Regarding immunological response, only the AG in SNP rs2279343 CYP2B6 was associated with an increase in CD4 cell count between baseline and M6. In CYP2B6 rs3745274, the CD4 cell count at M6 was higher than that of baseline for GG carriers and for GT carriers. In CYP3A4 rs2740574, the TC carriers showed a higher median CD4 count at M6 compared to that of the baseline count, as well as for CC carriers. The best genotypes combination associated with CD4 cell count improvement were AA/AG in SNP rs2279343 and GG/GT in SNP rs3745274. Conclusion: Our findings support the fact that CYP2B6 rs2279343 could help in the prediction of VLS and both SNPs rs3745274 and rs2279343 in CYP2B6 and CYP3A4 rs2740574 were associated with immune recovery in Malian HIV-positive patients.
MeSH term(s)	Alkynes ; Anti-HIV Agents/pharmacology ; Benzoxazines/pharmacology ; Cyclopropanes/pharmacology ; Cytochrome P-450 CYP2B6/genetics ; Cytochrome P-450 CYP2B6 Inhibitors/pharmacology ; Cytochrome P-450 CYP3A/genetics ; Genotype ; HIV Infections/drug therapy ; HIV Infections/enzymology ; HIV Infections/genetics ; Humans ; Polymorphism, Single Nucleotide
Chemical Substances	Alkynes ; Anti-HIV Agents ; Benzoxazines ; Cyclopropanes ; Cytochrome P-450 CYP2B6 Inhibitors ; CYP2B6 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2B6 (EC 1.14.14.1) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A4 protein, human (EC 1.14.14.55) ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175826-8
ISSN	1744-6880 ; 0960-314X ; 1744-6872
ISSN (online)	1744-6880
ISSN	0960-314X ; 1744-6872
DOI	10.1097/FPC.0000000000000477
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Article ; Online: Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population.

Molecular biology reports

2019 Volume 47, Issue 1, Page(s) 393–400

Abstract	Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies. We performed the present study to establish the frequencies of the GSTM1, GSTT1, and GSTP1 c. 313A > G (rs1695) polymorphisms in 206 individuals of the Malian healthy population. GSTM1 and GSTT1 were genotyped by using multiplex polymerase chain reaction, whereas genotypes of GSTP1 were identified by polymerase chain reaction followed by restriction fragment length polymorphism. The frequencies of GSTM1-null and GSTT1-null genotypes were respectively 24.3 and 41.3%. The observed genotype frequencies for GSTP1 were 25.73% homozygous wild-type AA, 49.03% heterozygous AG and 25.24% homozygous mutant GG. The frequency of GSTP1-A allele was 50.24% versus 49.76% for the GSTP1-G allele. The distribution of these three genes was homogeneous between men and women (p > 0.05). We found no statistical association between the presence of a particular profile of GSTM1 or GSTT1 with the genotypes of GSTP1 (p > 0.05). Nevertheless, we noticed that the majority of the individuals harboring the GSTM1-present or the GSTT1-present harbor also the GSTP1-AG genotype. In addition, the triple genotype GSTM1-present/GSTT1-present/AG was the most frequent with 25.2%. Our findings will facilitate future studies regarding genetic associations of multifactorial diseases and pharmacogenetic, thus opening the way to personalized medicine in our population.
MeSH term(s)	Adolescent ; Adult ; Aged ; Alleles ; Female ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genotype ; Glutathione S-Transferase pi/genetics ; Glutathione S-Transferase pi/metabolism ; Glutathione Transferase/genetics ; Glutathione Transferase/metabolism ; Healthy Volunteers ; Humans ; Male ; Mali ; Metabolic Detoxication, Phase II/genetics ; Metabolic Detoxication, Phase II/physiology ; Middle Aged ; Polymorphism, Genetic/genetics ; Risk Factors
Chemical Substances	glutathione S-transferase T1 (EC 2.5.1.-) ; GSTP1 protein, human (EC 2.5.1.18) ; Glutathione S-Transferase pi (EC 2.5.1.18) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18)
Language	English
Publishing date	2019-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-019-05143-5
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Article ; Online: Efavirenz and Lopinavir Levels in HIV-Infected Women and Their Nursing Infants, in Mali.

Oumar, Aboubacar Alassane / Bagayoko-Maiga, Kadiatou / Bahachimi, Aliou / Maiga, Mamoudou / Cere, Marie-Christine / Diarra, Zoumana / Chatelut, Etienne / Sylla, Mariam / Murphy, Robert Leo / Dao, Sounkalo / Gandia, Peggy

The Journal of pharmacology and experimental therapeutics

2018 Volume 366, Issue 3, Page(s) 479–484

Abstract: Limited data are currently available on antiretroviral pharmacokinetics in breast milk (BM) and in breastfed infants' blood. To explore these parameters in patients in Mali, we measured plasma antiretroviral levels in human immunodeficiency virus (HIV)- ... ...

Abstract	Limited data are currently available on antiretroviral pharmacokinetics in breast milk (BM) and in breastfed infants' blood. To explore these parameters in patients in Mali, we measured plasma antiretroviral levels in human immunodeficiency virus (HIV)-infected mothers and their breastfed infants over 6 months. We specifically analyzed the concentrations of efavirenz (EFV) and lopinavir (LPV) in the plasma of mothers living with HIV and their breastfed infants. Blood samples were collected at delivery and at month 1, 3, and 6 postpartum. EFV and LPV concentrations were measured by liquid chromatography-tandem mass spectrometry. HIV-1 RNA load was measured by Abbott M2000RT RealTime System at delivery and 6 months postpartum for mothers, and at 3 and 6 months postbirth for infants. The median duration of antiretroviral therapy at study inclusion was 57 months [interquartile range (IQR), 0-168 months]. The median EFV ratios of infant plasma/maternal plasma (MP) were 0.057 at month 1, 0.072 at month 3, and 0.048 at month 6. During the study period, the median BM/MP ratio of EFV was 1.16 (IQR, 0.96-20.62), which corresponds to a relative infant dose of 2.46% of the recommended weight-adjusted pediatric EFV dose at month 6. The apparent infant clearance of EFV was 0.146 l/h per kilogram at month 6. The LPV concentrations in the plasma of all infants were undetectable. No drug-related adverse reaction or toxicity was observed in any of the infants. The two women who presented a viral load of >50 copies/ml at month 6 had undetectable plasma drug concentrations at the same period. This study showed that breastfed infants received a low level of EFV but not LPV from their treated mothers.
MeSH term(s)	Adolescent ; Adult ; Alkynes ; Anti-HIV Agents/adverse effects ; Anti-HIV Agents/blood ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/therapeutic use ; Benzoxazines/adverse effects ; Benzoxazines/blood ; Benzoxazines/pharmacokinetics ; Benzoxazines/therapeutic use ; Breast Feeding ; Cyclopropanes ; Female ; HIV Infections/drug therapy ; Humans ; Infant ; Lopinavir/adverse effects ; Lopinavir/blood ; Lopinavir/pharmacokinetics ; Lopinavir/therapeutic use ; Male ; Mali ; Mothers ; Safety ; Tissue Distribution ; Young Adult
Chemical Substances	Alkynes ; Anti-HIV Agents ; Benzoxazines ; Cyclopropanes ; Lopinavir (2494G1JF75) ; efavirenz (JE6H2O27P8)
Language	English
Publishing date	2018-07-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.118.249938
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Article: Performance Comparison of Xpert HIV-1 Viral Load Assay and Roche Taqman and Abbott M2000 RT in Bamako, Mali.

Kone, Bourahima / Goita, Drissa / Dolo, Oumar / Traore, Daouda / Sogoba, Dramane / Somboro, Amadou / Sanogo, Moumine / Somboro, Anou M / Coulibaly, Nadie / Sanogo, Alou / Diarra, Zoumana / Traore, Madou / Maiga, Almoustapha I / Baya, Bocar / Sarro, Yeya Dit Sadio / Diarra, Bassirou / Kone, Amadou / Diallo, Dramane / Dabitao, Djeneba /

Holl, Jane L / Belson, Michael / Dao, Sounkalo / Murphy, Robert L / Diakite, Mahamadou / Diallo, Souleymane / Doumbia, Seydou / Maiga, Mamoudou

Journal of AIDS & clinical research

2020 Volume 11, Issue 7

Abstract: Background: Routine monitoring of HIV-1 Viral Load (VL) is important in patients on Antiretroviral Therapy (ART) management. Access to HIV VL remains a challenge in resource-limited settings, especially in rural areas. Universal access to VL requires ... ...

Abstract	Background: Routine monitoring of HIV-1 Viral Load (VL) is important in patients on Antiretroviral Therapy (ART) management. Access to HIV VL remains a challenge in resource-limited settings, especially in rural areas. Universal access to VL requires more simplified and less restrictive alternatives to current conventional VL methods. The objective of this study was to evaluate the performance of the new rapid (2-hour turnaround time) Xpert HIV-1VL technique compared to Roche TaqMan and Abbott RT m2000 for HIV-1 RNA quantification in HIV- infected patients. Study design: We conducted a cross-sectional study in patients seen for routine VL monitoring between August and November 2018 in a HIV care site in Bamako. The performance of the Xpert HIV-1 VL assay was evaluated against the Roche TaqMan assay and Abbott m2000 RT assay. Performance, utility and reliability/reproducibility were verified using accuracy, sensitivity, specificity, positive and negative predictive values, Diagnostic Odds Ratio (DOR), Kappa coefficient, Pearson correlation coefficient, and Bland-Altman analysis. Results: The Xpert assay compared well with the two current referral assays (Roche TaqMan and Abbott m2000 RT assays). Compared to Roche TaqMan assay the sensitivity was 93.10%, specificity (97.01%) and accuracy (95.20%), the correlation coefficient of Pearson (r) was 0.98 (p <0.01). Bland-Altman analysis showed a mean difference of 0.18 log10 cp/mL; (Standard Deviation) SD=0.33. Compared to the Abbott m2000 RT, the sensitivity, the specificity and the accuracy were respectively 93.44%; 92% and 92.65%. The Xpert HIV-1 VL assay showed a good correlation with a correlation coefficient of Pearson, r=0.99 (p <0.001). The overall mean difference in the HIV-1 VL values obtained by Xpert HIV-1 VL and Abbott m2000 RT assays was 0.08 log10 cp/mL; SD=0.30. Conclusion: Xpert HIV-1 VL showed a good performance compared to Roche TaqMan and Abbott m2000 RT. With the rapid test results (less than 2 h) and ease of testing individual specimens, the Xpert HIV-1 VL assay could be an effective alternative for HIV VL monitoring in resource-limited settings.
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2601227-3
ISSN	2155-6113
ISSN	2155-6113
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Article: Prevalence of schistomasiasis lesions detected by ultrasonography in children in Molodo, Mali.

Kéita, Adama Diaman / Sangho, Hamadoun / Sacko, Moussa / Diarra, Zoumana / Simaga, Sidi Yaya / Traore, Issa

Gastroenterologie clinique et biologique

2005 Volume 29, Issue 6-7, Page(s) 652–655

Abstract: Aim: To study schistomasiasis infection in school children in Molodo, an irrigated rice growing region of Mali, by determining the prevalence of schistomasiasis and lesions identified by ultrasonography among children living in this region.: Methods: ...

Abstract	Aim: To study schistomasiasis infection in school children in Molodo, an irrigated rice growing region of Mali, by determining the prevalence of schistomasiasis and lesions identified by ultrasonography among children living in this region. Methods: This cross sectional study included 346 children aged 7 to 14 years selected at random from five schools in Molodo. We tested for hematuria using urine dipsticks and searched for Schistosoma haematobium eggs in urine and S. mansoni eggs in stools. Ultrasonography of the liver, spleen and urinary tract was performed. Results: The prevalences of Schistosoma haematobium and S. mansoni infection were 72% (range: 66.9-76.6%) and 68.2% (range: 60.9-71.2%) respectively; 55.1% of the children had co-infection. Ultrasonography of the urinary tract revealed an irregular bladder wall as the most frequent abnormality (3.4% of children). Abdominal ultrasonography demonstrated type B hepatic fibrosis in four children (1.1%), type C in one (0.3%) and type D in one (0.3%). Conclusion: Few schistosomiasis lesions were detected by ultrasonography compared with the prevalence of S. haematobium and S. mansoni infections. This observation is probably related to mass treatment programs conducted during a national anti-schistosomiasis program.
MeSH term(s)	Adolescent ; Animals ; Child ; Cross-Sectional Studies ; Feces/parasitology ; Female ; Hematuria/etiology ; Humans ; Male ; Prevalence ; Schistosoma haematobium/isolation & purification ; Schistosoma haematobium/pathogenicity ; Schistosoma mansoni/isolation & purification ; Schistosoma mansoni/pathogenicity ; Schistosomiasis haematobia/diagnostic imaging ; Schistosomiasis haematobia/epidemiology ; Schistosomiasis japonica/diagnostic imaging ; Schistosomiasis japonica/epidemiology ; Ultrasonography ; Urinary Tract/diagnostic imaging ; Urinary Tract/parasitology
Language	English
Publishing date	2005-06
Publishing country	France
Document type	Journal Article
ZDB-ID	752002-5
ISSN	0399-8320
ISSN	0399-8320
DOI	10.1016/s0399-8320(05)82151-7
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