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Article ; Online: Regional differences in the quality of maternal and neonatal care during the COVID-19 pandemic in Portugal: Results from the IMAgiNE EURO study.

Costa, Raquel / Barata, Catarina / Dias, Heloísa / Rodrigues, Carina / Santos, Teresa / Mariani, Ilaria / Covi, Benedetta / Valente, Emanuelle Pessa / Lazzerini, Marzia

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2022 Volume 159 Suppl 1, Page(s) 137–153

Abstract: Objective: To compare women's perspectives on the quality of maternal and newborn care (QMNC) around the time of childbirth across Nomenclature of Territorial Units for Statistics 2 (NUTS-II) regions in Portugal during the COVID-19 pandemic.: Methods!# ...

Abstract	Objective: To compare women's perspectives on the quality of maternal and newborn care (QMNC) around the time of childbirth across Nomenclature of Territorial Units for Statistics 2 (NUTS-II) regions in Portugal during the COVID-19 pandemic. Methods: Women participating in the cross-sectional IMAgiNE EURO study who gave birth in Portugal from March 1, 2020, to October 28, 2021, completed a structured questionnaire with 40 key WHO standards-based quality measures. Four domains of QMNC were assessed: (1) provision of care; (2) experience of care; (3) availability of human and physical resources; and (4) reorganizational changes due to the COVID-19 pandemic. Frequencies for each quality measure within each QMNC domain were computed overall and by region. Results: Out of 1845 participants, one-third (33.7%) had a cesarean. Examples of high-quality care included: low frequencies of lack of early breastfeeding and rooming-in (8.0% and 7.7%, respectively) and informal payment (0.7%); adequate staff professionalism (94.6%); adequate room comfort and equipment (95.2%). However, substandard practices with large heterogeneity across regions were also reported. Among women who experienced labor, the percentage of instrumental vaginal births ranged from 22.3% in the Algarve to 33.5% in Center; among these, fundal pressure ranged from 34.8% in Lisbon to 66.7% in Center. Episiotomy was performed in 39.3% of noninstrumental vaginal births with variations between 31.8% in the North to 59.8% in Center. One in four women reported inadequate breastfeeding support (26.1%, ranging from 19.4% in Algarve to 31.5% in Lisbon). One in five reported no exclusive breastfeeding at discharge (22.1%; 19.5% in Lisbon to 28.2% in Algarve). Conclusion: Urgent actions are needed to harmonize QMNC and reduce inequities across regions in Portugal.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics ; Portugal/epidemiology ; Quality of Health Care ; Geography ; Maternal-Child Health Services
Language	English
Publishing date	2022-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.14507
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Article: Hypertriglyceridemic waist phenotype and associated factors in individuals with arterial hypertension and/or diabetes mellitus

Borges, Luiza Delazari / Comini, Luma de Oliveira / Oliveira, Laura Camargo de / Dias, Heloísa Helena / Ferreira, Emily de Souza / Batistelli, Clara Regina Santos / da Costa, Glauce Dias / Moreira, Tiago Ricardo / da Silva, Rodrigo Gomes / Cotta, Rosângela Minardi Mitre

Journal of nutritional science. , v. 10

2021

Abstract: Cardiovascular diseases are among the main causes of death in Brazil and worldwide. The literature indicates the hypertriglyceridemic waist phenotype (HTWP) as an accessible alternative for the identification of cardiovascular and metabolic risk. The ... ...

Abstract	Cardiovascular diseases are among the main causes of death in Brazil and worldwide. The literature indicates the hypertriglyceridemic waist phenotype (HTWP) as an accessible alternative for the identification of cardiovascular and metabolic risk. The present study aimed to identify the prevalence and factors associated with HTWP in individuals diagnosed with arterial hypertension (AH) and/or diabetes mellitus type 2 (DM2). A cross-sectional study was conducted with individuals diagnosed with AH and/or DM2. The study data were collected through semi-structured interviews containing socio-demographic information, lifestyle, health care, in addition to anthropometric assessment, blood pressure measurement and biochemical blood tests. The prevalence of HTWP was estimated and bivariate and multivariate logistic regression was used to assess the factors associated with HTWP. Of the 788 individuals analysed, 21⋅5 % had the HTWP. In the adjusted model, the following variables remained associated with a greater chance of presenting HTWP: sex, age, body mass index (BMI) and very-low-density lipoprotein (VLDL). Being female increased the chance of HTWP by 7⋅7 times (OR 7⋅7; 95 % CI 3⋅9, 15⋅2). The one-year increase in age increased the chance of HTWP by 4 % (OR 1⋅04; 95 % CI 1⋅02, 1⋅06). The addition of 1 mg/dl of VLDL-c increased the chance of HTWP by 15 % (odds ratio (OR) 1⋅15; 95 % confidence interval (CI) 1⋅12, 1⋅18), as well as the increase of 1 kg/m² in the BMI increased the chance of this condition by 20 % (OR 1⋅20; 95 % CI 1⋅15, 1⋅27). The prevalence of HTWP was associated with females, older age, higher BMI, higher VLDL-c and risk waist/height ratio.
Keywords	blood ; blood pressure ; body mass index ; confidence interval ; cross-sectional studies ; death ; diabetes mellitus ; females ; health services ; hypertension ; lifestyle ; models ; odds ratio ; phenotype ; regression analysis ; risk ; very low density lipoprotein ; waist ; Brazil
Language	English
Publishing place	Cambridge University Press
Document type	Article
ZDB-ID	2656288-1
ISSN	2048-6790
ISSN	2048-6790
DOI	10.1017/jns.2021.71
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Article ; Online: Applying best practices to pregnant women in the obstetric center.

Vieira, Bianca da Costa / Backes, Marli Terezinha Stein / Costa, Lediana Dalla / Fernandes, Vanessa Martinhago Borges / Dias, Heloísa Helena Zimmer Ribas / Backes, Dirce Stein

Revista brasileira de enfermagem

2019 Volume 72, Issue suppl 3, Page(s) 191–196

Abstract: Objective: To identify the meaning attributed by nursing technicians to good care practices based on scientific evidence used with the pregnant women during the dilation stage of labor.: Method: A qualitative study, based on Grounded Theory ... ...

Abstract	Objective: To identify the meaning attributed by nursing technicians to good care practices based on scientific evidence used with the pregnant women during the dilation stage of labor. Method: A qualitative study, based on Grounded Theory principles. Twelve interviews with nursing technicians attending labor in the obstetric center of two public hospitals, in Florianópolis/SC, were performed, from August of 2016 to March of 2017. Data were analyzed using open, axial coding. Results: The implementation of good practices, for nursing technicians, means adequately performing their activities, providing humanized care to the pregnant woman, respecting her autonomy, promoting pain relief, and a peaceful labor. Final considerations: An adequate number of technicians must be determined to maintain quality of care, and to complete nursing records in a more detailed and systematized manner.
MeSH term(s)	Adult ; Birthing Centers/organization & administration ; Birthing Centers/statistics & numerical data ; Female ; Grounded Theory ; Humans ; Labor, Obstetric/psychology ; Practice Guidelines as Topic ; Pregnancy ; Pregnant Women/psychology ; Qualitative Research
Language	Portuguese
Publishing date	2019-10-28
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731983-6
ISSN	1984-0446 ; 0034-7167
ISSN (online)	1984-0446
ISSN	0034-7167
DOI	10.1590/0034-7167-2018-0422
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Article ; Online: Hypertriglyceridemic waist phenotype and associated factors in individuals with arterial hypertension and/or diabetes mellitus.

Borges, Luiza Delazari / Comini, Luma de Oliveira / de Oliveira, Laura Camargo / Dias, Heloísa Helena / Ferreira, Emily de Souza / Batistelli, Clara Regina Santos / da Costa, Glauce Dias / Moreira, Tiago Ricardo / da Silva, Rodrigo Gomes / Cotta, Rosângela Minardi Mitre

Journal of nutritional science

2021 Volume 10, Page(s) e74

Abstract	Cardiovascular diseases are among the main causes of death in Brazil and worldwide. The literature indicates the hypertriglyceridemic waist phenotype (HTWP) as an accessible alternative for the identification of cardiovascular and metabolic risk. The present study aimed to identify the prevalence and factors associated with HTWP in individuals diagnosed with arterial hypertension (AH) and/or diabetes mellitus type 2 (DM2). A cross-sectional study was conducted with individuals diagnosed with AH and/or DM2. The study data were collected through semi-structured interviews containing socio-demographic information, lifestyle, health care, in addition to anthropometric assessment, blood pressure measurement and biochemical blood tests. The prevalence of HTWP was estimated and bivariate and multivariate logistic regression was used to assess the factors associated with HTWP. Of the 788 individuals analysed, 21⋅5 % had the HTWP. In the adjusted model, the following variables remained associated with a greater chance of presenting HTWP: sex, age, body mass index (BMI) and very-low-density lipoprotein (VLDL). Being female increased the chance of HTWP by 7⋅7 times (OR 7⋅7; 95 % CI 3⋅9, 15⋅2). The one-year increase in age increased the chance of HTWP by 4 % (OR 1⋅04; 95 % CI 1⋅02, 1⋅06). The addition of 1 mg/dl of VLDL-c increased the chance of HTWP by 15 % (odds ratio (OR) 1⋅15; 95 % confidence interval (CI) 1⋅12, 1⋅18), as well as the increase of 1 kg/m
MeSH term(s)	Aged ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Hypertension/epidemiology ; Hypertriglyceridemic Waist/epidemiology ; Male ; Middle Aged ; Phenotype ; Risk Factors
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2656288-1
ISSN	2048-6790 ; 2048-6790
ISSN (online)	2048-6790
ISSN	2048-6790
DOI	10.1017/jns.2021.71
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Article: Individual and Combined Components of Metabolic Syndrome with Chronic Kidney Disease in Individuals with Hypertension and/or Diabetes Mellitus Accompanied by Primary Health Care.

Comini, Luma de O / de Oliveira, Laura C / Borges, Luiza D / Dias, Heloísa H / Batistelli, Clara R S / da Silva, Luciana S / Moreira, Tiago R / da Silva, Rodrigo G / Cotta, Rosângela M M

Diabetes, metabolic syndrome and obesity : targets and therapy

2020 Volume 13, Page(s) 71–80

Abstract: Purpose: To identify the associations between MetS and its components and chronic kidney disease (CKD) in a population with arterial hypertension (AH), or diabetes mellitus (DM) accompanied by the Primary Health Care (PHC).: Patients and methods: A ... ...

Abstract	Purpose: To identify the associations between MetS and its components and chronic kidney disease (CKD) in a population with arterial hypertension (AH), or diabetes mellitus (DM) accompanied by the Primary Health Care (PHC). Patients and methods: A cross-sectional study with 788 individuals diagnosed with AH and/or DM followed by PHC of Viçosa, Brazil. Anthropometric, biochemical and clinical measures were performed for the diagnosis of MetS and CKD. MetS was identified using the NCEP-ATPIII criteria. CKD was identified by estimating the glomerular filtration rate using the CKD-EPI equation. Logistic regression models were used to estimate the chances of CKD associated with MetS and its components and specific combinations of components. Results: The prevalence of MetS reported in the population was 65.4%, that of hidden CKD was 15.4%. The prevalence of CKD among participants with MetS was 75.2%. The most prevalent component of MetS in the population was AH (96.7%). Elevated fasting blood glucose, central obesity, and reduced HDL-c were significantly associated with an increased chance of CKD (OR = 2.80, 95% CI 1.76-4.45, OR = 1.68, 95% CI, 05-2.71, OR = 1.61, CI 95% 1.03-2.50, respectively). For the multivariate adjustment, the participants with MetS were 2 times more likely to have CKD than those without MetS (OR = 2.07; 95% CI, 1.25-3.44). The combination of three components of MetS high blood pressure, abdominal obesity and elevated fasting blood glucose and the combination of four components of MetS high blood pressure, reduced HDL-c, high fasting blood glucose and abdominal obesity were associated with increased odds of CKD (OR = 2.67, CI 95% 1.70-4.20, OR = 2.50, CI 95% 1.55-4.02, respectively). Conclusion: MetS, as well as its individual or combined components were independently associated with CKD in the population with AH and/or DM accompanied by PHC.
Language	English
Publishing date	2020-01-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S223929
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Article ; Online: Low-grade albuminuria in adult and elderly individuals with diabetes mellitus and arterial hypertension accompanied by Primary Health Care.

de Resende, Matheus Augusto Soares / Ferreira, Emily de Souza / Dias, Heloísa Helena / Santos, Daniel Souza / Batistelli, Clara Regina Santos / Borges, Luiza Delazari / Comini, Luma de Oliveira / Moreira, Tiago Ricardo / da Costa, Glauce Dias / da Silva, Eunice Ferreira / da Silva, Rodrigo Gomes / Cotta, Rosângela Minardi Mitre

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17565

Abstract: Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the ... ...

Abstract	Diabetes mellitus (DM) and arterial hypertension (AH) are the two main clinical conditions related to Chronic Kidney Disease (CKD); disease also identify by the levels of low-grade albuminuria (LGA). Few studies have simultaneously investigated the associations of glycated hemoglobin (HbA1c) and fasting plasma glucose (FPG) with LGA. Our study aimed to investigate and compare the association of HbA1c and FPG with the probability of LGA in adult and elderly individuals with DM and AH, within the scope of Primary Health Care (PHC). Cross-sectional study involving 737 Brazilians individuals previously diagnosed with hypertension and/or diabetes. Tests for HbA1c, FPG and LGA were performed. LGA was defined as the highest quartile of albumin urinary (≥ 13 mg/g) among individuals with urinary LGA < 30 mg / g. A significant increase in the prevalence of LGA was found with increasing levels of HbA1c (p < 0.001). There was a significant association of HbA1c with LGA (p < 0.001) and increased probability of LGA for participants with HbA1c ≥ 6.5% compared to those with Hba1c < 5.7% (OR [95% CI]: 2.43 [1.32-4.46], p < 0.05), after adjusting for confounding factors, except when adjusted for FPG (p = 0.379 and p = 0.359, respectively). HbA1c and FPG were significantly associated in a collinear manner with an increased probability of LGA in adult and elderly individuals with DM and AH.
MeSH term(s)	Adult ; Aged ; Albuminuria/epidemiology ; Albuminuria/pathology ; Blood Glucose/metabolism ; Brazil/epidemiology ; Cross-Sectional Studies ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Fasting ; Glycated Hemoglobin A/metabolism ; Humans ; Hypertension/blood ; Hypertension/epidemiology ; Male ; Middle Aged ; Prevalence ; Primary Health Care/statistics & numerical data
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; hemoglobin A1c protein, human
Language	English
Publishing date	2021-09-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-96652-6
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Article ; Online: WHO Standards-based questionnaire to measure health workers' perspective on the quality of care around the time of childbirth in the WHO European region: development and mixed-methods validation in six countries.

BMJ open

2022 Volume 12, Issue 4, Page(s) e056753

Abstract: Objectives: Develop and validate a WHO Standards-based online questionnaire to measure the quality of maternal and newborn care (QMNC) around the time of childbirth from the health workers' perspective.: Design: Mixed-methods study.: Setting: Six ... ...

Abstract	Objectives: Develop and validate a WHO Standards-based online questionnaire to measure the quality of maternal and newborn care (QMNC) around the time of childbirth from the health workers' perspective. Design: Mixed-methods study. Setting: Six countries of the WHO European Region. Participants and methods: The questionnaire is based on lessons learnt in previous studies, and was developed in three sequential phases: (1) WHO Quality Measures were prioritised and content, construct and face validity were assessed through a Delphi involving a multidisciplinary board of experts from 11 countries of the WHO European Region; (2) translation/back translation of the English version was conducted following The Professional Society for Health Economics and Outcomes Research guidelines; (3) internal consistency, intrarater reliability and acceptability were assessed among 600 health workers in six countries. Results: The questionnaire included 40 items based on WHO Standards Quality Measures, equally divided into four domains: provision of care, experience of care, availability of human and physical resources, organisational changes due to COVID-19; and its organised in six sections. It was translated/back translated in 12 languages: Bosnian, Croatian, French, German, Italian, Norwegian, Portuguese, Romanian, Russian, Slovenian, Spanish and Swedish. The Cronbach's alpha values were ≥0.70 for each questionnaire section where questions were hypothesised to be interrelated, indicating good internal consistence. Cohen K or Gwet's AC1 values were ≥0.60, suggesting good intrarater reliability, except for one question. Acceptability was good with only 1.70% of health workers requesting minimal changes in question wording. Conclusions: Findings suggest that the questionnaire has good content, construct, face validity, internal consistency, intrarater reliability and acceptability in six countries of the WHO European Region. Future studies may further explore the questionnaire's use in other countries, and how to translate evidence generated by this tool into policies to improve the QMNC. Trail registration number: NCT04847336.
MeSH term(s)	COVID-19 ; Female ; Humans ; Infant, Newborn ; Pregnancy ; Psychometrics ; Quality of Health Care ; Reproducibility of Results ; Surveys and Questionnaires ; World Health Organization
Language	English
Publishing date	2022-04-08
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-056753
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Article ; Online: Survival and analysis of predictors of mortality in patients undergoing replacement renal therapy: a 20-year cohort.

Ferreira, Emily de Souza / Moreira, Tiago Ricardo / da Silva, Rodrigo Gomes / da Costa, Glauce Dias / da Silva, Luciana Saraiva / Cavalier, Samantha Bicalho de Oliveira / Silva, Beatriz Oliveira / Dias, Heloísa Helena / Borges, Luiza Delazari / Machado, Juliana Costa / Cotta, Rosângela Minardi Mitre

BMC nephrology

2020 Volume 21, Issue 1, Page(s) 502

Abstract: Background: optimal management of end-stage renal disease (ESRD) in hemodialysis (HD) patients should be more studied because it is a serious risk factor for mortality, being considered an unquestionable global priority.: Methods: we performed a ... ...

Abstract	Background: optimal management of end-stage renal disease (ESRD) in hemodialysis (HD) patients should be more studied because it is a serious risk factor for mortality, being considered an unquestionable global priority. Methods: we performed a retrospective cohort study from the Nephrology Service in Brazil evaluating the survival of patients with ESRD in HD during 20 years. Kaplan-Meier method with the Log-Rank and Cox's proportional hazards model explored the association between survival time and demographic factors, quality of treatment and laboratory values. Results: Data from 422 patients were included. The mean survival time was 6.79 ± 0.37. The overall survival rates at first year was 82,3%. The survival time correlated significantly with clinical prognostic factors. Prognostic analyses with the Cox proportional hazards regression model and Kaplan-Meier survival curves further identified that leukocyte count (HR = 2.665, 95% CI: 1.39-5.12), serum iron (HR = 8.396, 95% CI: 2.02-34.96), serum calcium (HR = 4.102, 95% CI: 1.35-12.46) and serum protein (HR = 4.630, 95% CI: 2.07-10.34) as an independent risk factor for the prognosis of survival time, while patients with chronic obstructive pyelonephritis (HR = 0.085, 95% CI: 0.01-0.74), high ferritin values (HR = 0.392, 95% CI: 0.19-0.80), serum phosphorus (HR = 0.290, 95% CI: 0.19-0.61) and serum albumin (HR = 0.230, 95% CI: 0.10-0.54) were less risk to die. Conclusion: survival remains low in the early years of ESRD treatment. The present study identified that elevated values of ferritin, serum calcium, phosphorus, albumin, leukocyte, serum protein and serum iron values as a useful prognostic factor for the survival time.
MeSH term(s)	Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Proteins/analysis ; Calcium/blood ; Female ; Humans ; Iron/blood ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Leukocyte Count ; Male ; Middle Aged ; Phosphorus/blood ; Prognosis ; Proportional Hazards Models ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/therapy ; Renal Replacement Therapy ; Retrospective Studies ; Risk Factors ; Serum Albumin ; Survival Rate
Chemical Substances	Biomarkers ; Blood Proteins ; Serum Albumin ; Phosphorus (27YLU75U4W) ; Iron (E1UOL152H7) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-020-02135-7
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Article ; Online: Prevalence of chronic kidney disease in Brazilians with arterial hypertension and/or diabetes mellitus.

Comini, Luma de Oliveira / de Oliveira, Laura Camargo / Borges, Luiza Delazari / Dias, Heloísa Helena / Batistelli, Clara Regina Santos / Ferreira, Emily de Souza / da Silva, Luciana Saraiva / Moreira, Tiago Ricardo / da Costa, Glauce Dias / da Silva, Rodrigo Gomes / Cotta, Rosângela Minardi Mitre

Journal of clinical hypertension (Greenwich, Conn.)

2020 Volume 22, Issue 9, Page(s) 1666–1673

Abstract: The present study aimed to evaluate the prevalence of chronic kidney disease (CKD) in individuals with arterial hypertension (AH) and/or diabetes mellitus (DM) accompanied by Primary Health Care (PHC) in Brazil. The estimated glomerular filtration rate ( ... ...

Abstract	The present study aimed to evaluate the prevalence of chronic kidney disease (CKD) in individuals with arterial hypertension (AH) and/or diabetes mellitus (DM) accompanied by Primary Health Care (PHC) in Brazil. The estimated glomerular filtration rate (eGFR) based on creatinine, and urinary albumin-to-creatinine ratio (ACR) were measured in 841 subjects with AH and/or DM, followed by PHC in the city of Viçosa. The CKD was diagnosed according to KDIGO criteria. Sociodemographic, clinical, and anthropometric factors related to the prevalence of CKD were investigated through multiple logistic regression. The prevalence of hidden CKD was 15.4%. Of these, 7.5% were identified by albuminuria (ACR ≥30 mg/g) with slightly decreased eGFR. Age, baseline disease, waist circumference (WC), and systolic blood pressure remained associated with CKD after multivariate analysis. The two major risk factors for hidden CKD were the presence of AH in association with DM and an increase in age. Hidden CKD was more common within people with AH and DM, and with high WC, glycosylated hemoglobin, and serum phosphorus as well as male gender and decreased serum albumin. This knowledge of risk associations can help avoid progression to CKD.
MeSH term(s)	Albuminuria/epidemiology ; Brazil/epidemiology ; Creatinine ; Cross-Sectional Studies ; Diabetes Complications ; Diabetes Mellitus/epidemiology ; Glomerular Filtration Rate ; Humans ; Hypertension/complications ; Hypertension/epidemiology ; Male ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Risk Factors
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2020-08-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.13980
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Article ; Online: Associating portal congestive gastropathy and hepatic fibrosis in hepatosplenic mansoni schistosomiasis.

Dias, Heloisa Soares / Domingues, Ana Lúcia Coutinho / Cordeiro, Fernando Tarcísio Miranda / Jucá, Norma / Lopes, Edmundo Pessoa

Acta tropica

2013 Volume 126, Issue 3, Page(s) 240–243

Abstract: Upper digestive bleeding is one of the most serious complications of mansoni schistosomiasis, and portal congestive gastropathy (PCG) is responsible for 25-30% of the cases of bleeding instead of bleeding due to esophageal varices. This study aimed to ... ...

Abstract	Upper digestive bleeding is one of the most serious complications of mansoni schistosomiasis, and portal congestive gastropathy (PCG) is responsible for 25-30% of the cases of bleeding instead of bleeding due to esophageal varices. This study aimed to investigate the association between PCG with parameters of portal hypertension and the intensity of periportal fibrosis assessed by ultrasonography, in patients with mansoni schistosomiasis. A prospective study was made of 71 patients whether or not they had a history of upper digestive bleeding, and who had not been previously treated for portal hypertension (splenectomy, use of beta blockers or endoscopic treatment). Patients with other liver diseases were excluded. After signing a form of consent, the patients underwent endoscopy, as well as ultrasonography of the abdomen, and hematological, biochemical and viral markers tests. Chi-square and Fischer's exact tests were used in the statistical analysis. The mean age of the 71 patients was 50 ± 14.5 years of whom 59.2% were women. 45.1% had antecedents of upper digestive bleeding. PCG was observed in 39 patients (54.9%): severe in 8.5%, and mild in 46.5%. A positive association was observed between PCG and the grade of esophageal varices (p=0.017); and the pattern of periportal fibrosis (p=0.041). A negative association was observed between PCG and red spots on the varices (p=0.024). PCG in patients with mansoni schistosomiasis not submitted to treatment for portal hypertension is associated with the sonographic pattern of hepatic fibrosis, as well as with the grade of esophageal varices.
MeSH term(s)	Adult ; Aged ; Esophageal and Gastric Varices/epidemiology ; Esophageal and Gastric Varices/pathology ; Female ; Gastrointestinal Hemorrhage/epidemiology ; Gastrointestinal Hemorrhage/etiology ; Humans ; Hypertension, Portal/complications ; Liver Cirrhosis/complications ; Liver Cirrhosis/parasitology ; Liver Cirrhosis/pathology ; Male ; Middle Aged ; Prospective Studies ; Schistosomiasis mansoni/pathology ; Stomach Diseases/complications ; Stomach Diseases/parasitology ; Stomach Diseases/pathology
Language	English
Publishing date	2013-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2013.02.011
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In stock of ZB MED Cologne/Königswinter

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