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  1. Article: Recessive

    Maia, Luana Sella Motta / Burger, Bettina / Ghannam, Arije / Nunes, Fernanda Leonel / Ferriani, Mariana Paes Leme / Dias, Marina Mendonça / Arruda, Luisa Karla / Drouet, Christian / Cichon, Sven

    Journal of clinical medicine

    2023  Volume 12, Issue 23

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12237299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to "House dust mite liquid SLIT effective in atopic dermatitis, even with suboptimal dosing".

    Pimentel, Edine Coelho / Zanetti, Maria Eduarda T / Langer, Sarah Sella / Melo, Janaina Michelle L / Ferriani, Mariana P L / Trevisan Neto, Orlando / Dias, Marina Mendonça / Roxo-Junior, Pérsio / Silva, Jorgete / Aragon, Davi Casale / Arruda, L Karla

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 7, Page(s) 1937–1939

    MeSH term(s) Animals ; Antigens, Dermatophagoides ; Dermatitis, Atopic/therapy ; Dermatophagoides pteronyssinus ; Humans ; Pyroglyphidae
    Chemical Substances Antigens, Dermatophagoides
    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.04.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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  3. Article ; Online: Study of angiopoietin and plasminogen genes in hereditary angioedema.

    Kruk, Tatielly / Chong-Neto, Herberto José / Dias, Marina Mendonça / Campos, Wagner Narciso / Moreno, Adriana Santos / Mikami, Liya Regina / Ferrari, Lilian Pereira / Arruda, Luísa Karla de Paula / Rosário Filho, Nelson

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 4, Page(s) 502–506

    Abstract: Objective: To investigate the presence of the Angiopoietin 1 (ANGPT1) and Plasminogen (PLG) mutations in patients with Hereditary Angioedema (HAE) and normal C1 esterase inhibitor (C1-INH) levels, who do not harbor the F12 gene mutation.: Methods: ... ...

    Abstract Objective: To investigate the presence of the Angiopoietin 1 (ANGPT1) and Plasminogen (PLG) mutations in patients with Hereditary Angioedema (HAE) and normal C1 esterase inhibitor (C1-INH) levels, who do not harbor the F12 gene mutation.
    Methods: Patients clinically diagnosed with HAE but without C1-INH deficiency or dysfunction and F12 gene mutation were evaluated. DNA extraction, quantification, and dilution were performed at a concentration of 100 ng/µL, followed by a DNA amplification (PCR) for molecular evaluation of exon 2 of the ANGPT1 gene and exon 9 of the PLG gene for identification of mutations c.807G>T / p.A119S and c.988A>G / p.K330E, respectively. The PCR product was evaluated in 1% agarose gel electrophoresis. Sequencing was performed using the Sanger method. The electropherograms were analyzed using the FASTA® program.
    Results: DNA samples from 15 women were sequenced. Their ages ranged from 10 to 60 years and the normal C1 esterase and C4 inhibitor serum levels ranged from 22 to 39 mg/dL and from 10 to 40 mg/dL, respectively. No mutations were detected in the analyzed exons of ANGPT1 and PLG. However, a single-nucleotide polymorphism (SNP) was detected in two homozygotic and five heterozygotic patients.
    Conclusion: Further studies are needed to evaluate these SNPs and scrutinize their potential for use as molecular markers of HAE and as novel therapeutic targets.
    MeSH term(s) Adolescent ; Adult ; Angioedemas, Hereditary/genetics ; Angiopoietins/genetics ; Child ; Complement C1 Inhibitor Protein ; Female ; Humans ; Middle Aged ; Mutation ; Plasminogen/genetics ; Polymerase Chain Reaction ; Young Adult
    Chemical Substances Angiopoietins ; Complement C1 Inhibitor Protein ; Plasminogen (9001-91-6)
    Language English
    Publishing date 2020-06-23
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.4.502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 654: Show issues Location:
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  4. Article ; Online: Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Trial.

    Langer, Sarah Sella / Cardili, Renata Nahas / Melo, Janaina Michelle Lima / Ferriani, Mariana Paes Leme / Moreno, Adriana Santos / Dias, Marina Mendonça / Bueno-Filho, Roberto / Pocente, Renata Helena Candido / Roxo-Junior, Pérsio / Silva, Jorgete / Valera, Fabiana Cardoso Pereira / Coelho, Eduardo Barbosa / Galvão, Clóvis Eduardo Santos / Carmona, Fábio / Aragon, Davi Casale / Arruda, Luisa Karla

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 2, Page(s) 539–549.e7

    Abstract: Background: Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis.: Objective: To investigate the efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides pteronyssinus extract in patients with atopic ... ...

    Abstract Background: Sensitization to house dust mites (HDMs) is frequent in patients with atopic dermatitis.
    Objective: To investigate the efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides pteronyssinus extract in patients with atopic dermatitis sensitized to HDM.
    Methods: In this randomized, double-blind, placebo-controlled trial, we enrolled 91 patients 3 years or older, with SCORing Atopic Dermatitis (SCORAD) score greater than or equal to 15 and positive skin test result and/or IgE to D pteronyssinus. Patients were stratified according to age (<12 and ≥12 years) to receive HDM SLIT or placebo for 18 months. Primary outcome was a greater than or equal to 15-point decrease in SCORAD score. Secondary outcomes were decreases in SCORAD and objective SCORAD, Eczema Area and Severity Index, visual analog scale for symptoms, and pruritus scale scores; Investigator's Global Assessment 0/1; and decrease greater than or equal to 4 points in Dermatology Life Quality Index. Background therapy was maintained.
    Results: A total of 66 patients completed the study (35 HDM SLIT, 31 placebo). After 18 months, 74.2% and 58% of patients in the HDM SLIT group and the placebo group, respectively, showed greater than or equal to 15-point decrease in SCORAD score (relative risk, 1.28; 95% CI, 0.89-1.83). Significant SCORAD score decreases from baseline of 55.6% and 34.5% in HDM SLIT and placebo groups (mean difference, 20.4; 95% CI, 3.89-37.3), significant objective SCORAD score decreases of 56.8% and 34.9% in HDM SLIT and placebo groups (mean difference, 21.3; 95% CI, 0.66-41.81), and more patients with Investigator's Global Assessment 0/1 in the HDM SLIT group as compared with the placebo group (14 of 35 vs 5 of 31; relative risk, 2.63; 95% CI, 1.09-6.39) were observed at 18 months.
    Conclusions: Our results suggest that HDM SLIT may be effective in HDM-sensitized patients as an add-on treatment for atopic dermatitis.
    MeSH term(s) Animals ; Antigens, Dermatophagoides/therapeutic use ; Child ; Dermatitis, Atopic/drug therapy ; Dermatophagoides pteronyssinus ; Double-Blind Method ; Eczema/drug therapy ; Humans ; Pyroglyphidae ; Sublingual Immunotherapy/methods ; Treatment Outcome
    Chemical Substances Antigens, Dermatophagoides
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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