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  1. Article: Corrigendum: Methylmercury impact on adult neurogenesis: is the worst yet to come from recent Brazilian environmental disasters?

    Raposo, Ramon da Silva / Pinto, Daniel Vieira / Moreira, Ricardo / Dias, Ronaldo Pereira / Fontes Ribeiro, Carlos Alberto / Oriá, Reinaldo Barreto / Malva, João Oliveira

    Frontiers in aging neuroscience

    2023  Volume 15, Page(s) 1265755

    Abstract: This corrects the article DOI: 10.3389/fnagi.2020.591601.]. ...

    Abstract [This corrects the article DOI: 10.3389/fnagi.2020.591601.].
    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1265755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

    Raposo, Ramon da Silva / Pinto, Daniel Vieira / Moreira, Ricardo / Dias, Ronaldo Pereira / Fontes Ribeiro, Carlos Alberto / Oriá, Reinaldo Barreto / Malva, João Oliveira

    Frontiers in aging neuroscience

    2020  Volume 12, Page(s) 591601

    Abstract: Worldwide environmental tragedies of anthropogenic origin causing massive release of metals and other pollutants have been increasing considerably. These pollution outbreaks affect the ecosystems and impact human health. Among those tragedies, recent ... ...

    Abstract Worldwide environmental tragedies of anthropogenic origin causing massive release of metals and other pollutants have been increasing considerably. These pollution outbreaks affect the ecosystems and impact human health. Among those tragedies, recent large-scale environmental disasters in Brazil strongly affected riverside populations, leading to high-risk exposure to methylmercury (MeHg). MeHg is highly neurotoxic to the developing brain. This toxicant causes neural stem cell dysfunction and neurodevelopmental abnormalities. However, less is known about the effects of MeHg in the postnatal neurogenic niche, which harbors neural stem cells and their progeny, in the adult brain. Therefore, taking in consideration the impact of MeHg in human health it is urgent to clarify possible associations between exposure to mercury, accelerated cognitive decline, and neurodegenerative diseases. In this perspectives paper, we discuss the neurotoxic mechanisms of MeHg on postnatal neurogenesis and the putative implications associated with accelerated brain aging and early-onset cognitive decline in populations highly exposed to this environmental neurotoxicant.
    Language English
    Publishing date 2020-11-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2020.591601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pollutants and nutrition: Are methylmercury effects on blood pressure and lipoprotein profile comparable to high-fat diet in mice?

    Lacerda Leocádio, Paola Caroline / Dias, Ronaldo Pereira / Pinto, Daniel Vieira / Reis, Jonas Martins / Rodrigues Nascimento, José Carlos / Anne de Castro Brito, Gerly / Valença, José Telmo / Foureaux, Giselle / Ferreira, Anderson José / Windmöller, Cláudia Carvalhinho / Crespo-Lopez, Maria Elena / Santos, Flávia Almeida / Oriá, Reinaldo Barreto / Alvarez-Leite, Jacqueline I

    Ecotoxicology and environmental safety

    2020  Volume 204, Page(s) 111036

    Abstract: Human exposure to methylmercury (MeHg) due to contaminated fish intake as part of a high-fat (HFD), high-carbohydrate diets is a reality today for many populations. HFD is associated with hypertension and hyperlipidemia, primary cardiovascular disease ( ... ...

    Abstract Human exposure to methylmercury (MeHg) due to contaminated fish intake as part of a high-fat (HFD), high-carbohydrate diets is a reality today for many populations. HFD is associated with hypertension and hyperlipidemia, primary cardiovascular disease (CVD) risk factors. Some studies suggest that MeHg induces those risk factors. We evaluated the effect of MeHg exposure in mice fed with HFD or control diet for eight weeks. In the last experimental 15 days, the half group received a MeHg solution (20 mg/L) replacing water. Blood pressure (BP), heart rate, lipoprotein concentrations, and paraoxonase activity were evaluated. Liver cholesterol, triacylglycerol, and IBA-1+ cells, as well as transcriptional levels of genes related to lipid metabolism and inflammatory response, were also assessed. HFD and both MeHg groups presented increased BP and total cholesterol (TC). In the liver, HFD but not MeHg was related to an increase in TC. Also, MeHg intoxication reduced paraoxonase activity regardless of diet. MeHg intoxication and HFD increased steatosis and the number of IBA-1+ cells and modified some gene transcripts associated with lipid metabolism. In conclusion, we demonstrated that MeHg effects on CVD risk factors resemble those caused by HFD.
    MeSH term(s) Animals ; Arterial Pressure/drug effects ; Atherosclerosis/chemically induced ; Atherosclerosis/epidemiology ; Diet, High-Fat/adverse effects ; Environmental Pollutants/adverse effects ; Fatty Liver/metabolism ; Female ; Inflammation/chemically induced ; Inflammation/physiopathology ; Lipoproteins/metabolism ; Liver/drug effects ; Liver/metabolism ; Methylmercury Compounds/adverse effects ; Mice ; Mice, Inbred C57BL ; Nutritional Status ; Risk Factors
    Chemical Substances Environmental Pollutants ; Lipoproteins ; Methylmercury Compounds
    Language English
    Publishing date 2020-08-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2020.111036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Medium-term cryopreservation of rabies virus samples.

    Aguiar, Tereza D'ávila de Freitas / Teixeira, Maria Fátima da Silva / Costa, Edmara Chaves / Vitaliano, Allan Bezerra / Teles, Carlos Henrique de Andrade / Barroso, Igor Ciríaco / Dias, Ronaldo Pereira / Moraes, Nélio Batista de

    Revista da Sociedade Brasileira de Medicina Tropical

    2013  Volume 46, Issue 6, Page(s) 678–683

    Abstract: Introduction: The cryopreservation of rabies virus has been described in detail in the literature. To date, little information is available on the use of cryoprotective agents for cold preservation of this virus, and the available data focus only on ... ...

    Abstract Introduction: The cryopreservation of rabies virus has been described in detail in the literature. To date, little information is available on the use of cryoprotective agents for cold preservation of this virus, and the available data focus only on short-term virus preservation. In this study, we investigated the medium-term cryopreservation of samples of rabies virus using different cryopreservation protocols.
    Methods: The cryopreservation protocols for the rabies virus samples were performed at -20°C and were divided according to the variables of time and cryoprotectant type used. The laboratory tests (intracerebral inoculation of mice, viral titration and direct immunofluorescence) were performed at regular intervals (360 and 720 days) to assess the viability of the viral samples according to the different preservation techniques used.
    Results: After 1 year of cryopreservation, the fluorescence intensity of intracellular corpuscles of the rabies virus and the median survival time of the mice differed between the positive controls and the treatments with the cryoprotectants. After 2 years, most of the samples subjected to the cryopreservation protocols (including the controls) did not produce fluorescence. However, the virus samples exposed to the cryoprotectant sucrose (68% solution) responded positively in the direct immunofluorescence assay and in the intracerebral inoculation of the mice.
    Conclusions: Medium-term cryopreservation of the rabies virus inactivates the viral sample. However, the cryoprotectant agent sucrose (68%) produces a preservative effect in cryopreserved rabies virus samples.
    MeSH term(s) Animals ; Brain/virology ; Cryopreservation/methods ; Cryoprotective Agents/pharmacology ; Fluorescent Antibody Technique, Direct ; Mice ; Rabies virus/drug effects ; Rabies virus/physiology
    Chemical Substances Cryoprotective Agents
    Language English
    Publishing date 2013-11
    Publishing country Brazil
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1038126-0
    ISSN 1678-9849 ; 0037-8682
    ISSN (online) 1678-9849
    ISSN 0037-8682
    DOI 10.1590/0037-8682-0135-2013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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