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  1. Article ; Online: Hemoglobin Denver, a cause of desaturated pulse oximetry. A pediatric case report.

    Rossetti, Estefanía / Eandi Eberle, Silvia / Aguirre, Fernando / Pepe, Carolina / Díaz, Lilian / Harris, Verónica / Ávalos, Vanesa

    Archivos argentinos de pediatria

    2023  Volume 121, Issue 5, Page(s) e202202801

    Abstract: Hemoglobinopathies are genetic disorders that affect the hemoglobin (Hb) molecule. Mutations in the alpha or beta chains altering the Hb tetramer may modify the molecule's oxygen-binding capacity. Hemoglobinopathies with low oxygen affinity may occur ... ...

    Title translation Hemoglobina Denver, una causa de desaturación en oximetría de pulso. Reporte de caso en un paciente pediátrico.
    Abstract Hemoglobinopathies are genetic disorders that affect the hemoglobin (Hb) molecule. Mutations in the alpha or beta chains altering the Hb tetramer may modify the molecule's oxygen-binding capacity. Hemoglobinopathies with low oxygen affinity may occur with cyanosis and an altered pulse oximetry reading, leading to unnecessary and sometimes invasive tests to rule out cardiovascular and respiratory conditions. In the case report described here, we present an asymptomatic pediatric patient who consulted for desaturated pulse oximetry. Her initial laboratory tests showed normocytic, normochromic anemia. Venous blood gas samples showed an elevated p50. After using extensive diagnostic tools, a variant of Hb with low oxygen affinity was diagnosed: Hb Denver.
    MeSH term(s) Humans ; Child ; Female ; Hemoglobins, Abnormal/genetics ; Hemoglobins, Abnormal/analysis ; Hemoglobins, Abnormal/chemistry ; Oximetry ; Hemoglobinopathies/diagnosis ; Hemoglobinopathies/genetics ; Oxygen ; Anemia
    Chemical Substances hemoglobin Denver ; Hemoglobins, Abnormal ; Oxygen (S88TT14065)
    Language Spanish
    Publishing date 2023-03-09
    Publishing country Argentina
    Document type Case Reports ; Journal Article
    ZDB-ID 424449-7
    ISSN 1668-3501 ; 0325-0075 ; 0004-0487
    ISSN (online) 1668-3501
    ISSN 0325-0075 ; 0004-0487
    DOI 10.5546/aap.2022-02801.eng
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  2. Article ; Online: Mobilized and apheresis-collected endothelial progenitor cells with plerixafor.

    Perdomo, Susana / Brugnini, Andreina / Trias, Natalia / Menyou, Alba / Silveira, Gonzalo / Ranero, Sabrina / Lens, Daniela / Díaz, Lilián / Grille, Sofía

    Journal of clinical apheresis

    2022  Volume 37, Issue 3, Page(s) 245–252

    Abstract: Background: Endothelial progenitor cells (EPCs) are immature cells able to proliferate and contribute to endothelial repair, vascular homeostasis, neovascularization, and angiogenesis. It therefore seems likely that circulating EPCs have therapeutic ... ...

    Abstract Background: Endothelial progenitor cells (EPCs) are immature cells able to proliferate and contribute to endothelial repair, vascular homeostasis, neovascularization, and angiogenesis. It therefore seems likely that circulating EPCs have therapeutic potential in ischemic and vascular diseases. In this study we evaluated the efficiency of EPC mobilization and collection by large volume leukapheresis in subjects with hematological diseases, treated with plerixafor in association with G-CSF.
    Methods: Twenty-two patients with lymphoid malignancies underwent rHuG-CSF and plerixafor treatment followed by leukapheresis. Blood samples before and after treatment and apheresis liquid sample were taken and analyzed by flow cytometry in order to quantified EPC.
    Results: The percentage of CD34+ cells and EPCs among circulating total nuclear cells (TNCs) increased significantly by approximately 2-fold and 3-fold, respectively, after plerixafor treatment. Consequently, the absolute number of CD34+ cells and EPCs were increased 4-fold after plerixafor treatment. The median PB concentration of EPCs before and after treatment were 0.77/μL (0.31-2.15) and 3.41/μL (1.78-4.54), respectively, P < .0001. The total EPCs collected per patient were 3.3×10
    Conclusion: We have shown that plerixafor in combination with G-CSF allows the mobilization and collection of large amounts of EPCs along with CD34+ cells in lymphoid neoplasm patients. The possibility to collect and to store these cells could represent a promising therapeutic tool for the treatment of ischemic complications without the need of in vitro expansion.
    MeSH term(s) Antigens, CD34/metabolism ; Benzylamines ; Blood Component Removal ; Cyclams ; Endothelial Progenitor Cells/metabolism ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hematopoietic Stem Cell Mobilization ; Heterocyclic Compounds/pharmacology ; Heterocyclic Compounds/therapeutic use ; Humans
    Chemical Substances Antigens, CD34 ; Benzylamines ; Cyclams ; Heterocyclic Compounds ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; plerixafor (S915P5499N)
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21967
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  3. Article ; Online: 5-Azacytidine restores interleukin 6-increased production in mesenchymal stromal cells from myelodysplastic patients.

    Boada, Matilde / Echarte, Lourdes / Guillermo, Cecilia / Diaz, Lilián / Touriño, Cristina / Grille, Sofía

    Hematology, transfusion and cell therapy

    2020  Volume 43, Issue 1, Page(s) 35–42

    Abstract: Introduction: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological diseases. In addition to defects in hematologic progenitor and stem cells, dysfunctions in the bone marrow microenvironment (BMM) participate in the MDS ... ...

    Abstract Introduction: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological diseases. In addition to defects in hematologic progenitor and stem cells, dysfunctions in the bone marrow microenvironment (BMM) participate in the MDS pathogenesis. Furthermore, the immune response is deregulated by the pro-inflammatory response prevailing in low-risk MDS, while immunosuppression predominates in high-risk MDS. Mesenchymal stromal cells (MSC), part of the BMM, are characterized by plastic adherent growth and multipotentiality. They exhibit immunomodulatory properties and sustain hematopoiesis. There is conflicting evidence regarding their status in MDS. The aim of this study was to characterize MDS-MSC and evaluate the effect of 5-Azacytidine.
    Methods: The MSC from MDS patients and controls were cultured and characterized according to the International Society of Cell Therapy recommendations. Immunomodulatory properties were assessed by studying the MSD cytokine production, using the cytometric bead array. We evaluated the effect of 5-Azacytidine on the MSC cytokine production.
    Results: We included 35 MDS patients and 22 controls. The MSC from patients and controls were cultured and characterized. The MSC from patients showed morphological differences, but there were no differences in immunophenotype or multipotentiality. The interleukin 6 (IL-6) was the main MSC secreted cytokine. The MDS-MSC produced higher levels of IL-6, IL-17, interferon gamma, or interferon γ (INF-γ), and tumor necrosis factor alpha (TNF-α). The in vitro 5-Azacytidine treatment induced a significant decrease in the IL-6 production by MDS-MSC.
    Conclusions: The MDS-MSC show an increased production of pro-inflammatory cytokines. The in vitro treatment with 5-Azacytidine lead to a significant reduction in the IL-6 production by the MDS-MSC, restoring the IL-6 levels to those found in controls. The MSC produced inflammatory cytokines involved in the MDS pathogenesis, representing a potential future therapeutic target. Moreover, 5-Azacytidine may have a stromal effect, modulating the immune response in MDS.
    Language English
    Publishing date 2020-01-27
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2019.12.002
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  4. Article ; Online: Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma.

    Irigoín, Victoria / Oliver, Carolina / López, Stefanía / Landoni, Ana Inés / Gabús, Raúl / Díaz, Lilián

    Revista medica de Chile

    2020  Volume 147, Issue 12, Page(s) 1553–1560

    Abstract: Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International ... ...

    Abstract Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols ; Female ; Humans ; Immunotherapy ; Leukocyte Count ; Lymphoma, Large B-Cell, Diffuse/blood ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Middle Aged ; Monocytes ; Prognosis ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2020-03-18
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872019001201553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Digital Ischemia as an Unusual Manifestation of Hodgkin's Lymphoma.

    Villano, Fiorella / Peixoto, Adriana / Riva, Eloísa / Di Matteo, Carina / Díaz, Lilián

    Case reports in hematology

    2018  Volume 2018, Page(s) 1980749

    Abstract: Digital ischemia is associated with atherosclerotic, thromboembolic, or connective tissue diseases. Less often, it can be related to malignancy. Paraneoplastic vascular acrosyndromes (Raynaud's syndrome, acrocianosis, and acronecrosis) are associated ... ...

    Abstract Digital ischemia is associated with atherosclerotic, thromboembolic, or connective tissue diseases. Less often, it can be related to malignancy. Paraneoplastic vascular acrosyndromes (Raynaud's syndrome, acrocianosis, and acronecrosis) are associated with adenocarcinoma and less frequently with hematological malignancies. We report the case of a 45-year-old male, smoker, with a 10-day history of pain, cyanosis, and progressive digital necrosis in both hands. In the previous four months, he noticed painless mass in the right axillary gap, drenching night sweats, and weight loss. Physical examination at admission highlighted necrotic lesions on the distal phalanges of both hands (except the thumbs), enlarged lymph nodes in right axillary, and right supraclavicular gaps. Arteriography of upper limbs demonstrated a distal stop in all bilateral digital arteries. Digital ischemia was interpreted as a paraneoplastic phenomenon after other common etiologies were ruled out. Amputation of three phalanges was required due to necrosis. Biopsy of axillary nodes demonstrated nodular sclerosis classical Hodgkin's lymphoma (HL). The patient started conventional ABVD protocol (doxorubicin, bleomycin, vinblastine, and dacarbazine). After 6 cycles, he remained asymptomatic and symptoms of digital ischemia were completely resolved. It was concluded that the presence of acral vascular syndromes should alert the physician about the possibility of underlying malignant disease. Prompt investigation and treatment should be rapidly performed to avoid digital sequelae.
    Language English
    Publishing date 2018-08-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627639-2
    ISSN 2090-6579 ; 2090-6560
    ISSN (online) 2090-6579
    ISSN 2090-6560
    DOI 10.1155/2018/1980749
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  6. Article: Un caso de leucemia/linfoma T del adulto en Uruguay.

    Boada, Matilde / Grille, Sofía / Brugnini, Andreina / Trias, Natalia / Canesa, Cecilia / Díaz, Lilián / Lens, Daniela

    Medicina

    2017  Volume 77, Issue 3, Page(s) 235–238

    Abstract: Adult T-cell leukemia/lymphoma belongs to the group of mature T-cell malignancies according to the WHO classification. It constitutes a rare entity and has a strong association with infection by human T-lymphotropic virus 1. In Uruguay, this viral ... ...

    Title translation Adult T-cell leukemia/lymphoma. Report of a case in Uruguay.
    Abstract Adult T-cell leukemia/lymphoma belongs to the group of mature T-cell malignancies according to the WHO classification. It constitutes a rare entity and has a strong association with infection by human T-lymphotropic virus 1. In Uruguay, this viral infection is very infrequent and, to our knowledge, no case of adult T-cell leukemia/lymphoma has been previously reported. We describe the case of a woman, immigrant from Peru, who presented with persistent lymphocytosis, intestinal parasitic diseases, and skin involvement. The diagnosis was delayed and the patient died before initiating oncological treatment. We therefore emphasize the relevance of an early clinical suspicion and serology for this virus, especially in patients coming from endemic countries like Peru.
    MeSH term(s) Fatal Outcome ; Female ; Human T-lymphotropic virus 1 ; Humans ; Leukemia-Lymphoma, Adult T-Cell/diagnosis ; Leukemia-Lymphoma, Adult T-Cell/virology ; Middle Aged ; Uruguay
    Language Spanish
    Publishing date 2017
    Publishing country Argentina
    Document type Case Reports
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
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  7. Article ; Online: Comparación entre CHOP-like y R-CHOP en pacientes con linfoma no Hodgkin difuso de grandes células B y folicular: 10 años de experiencia del Hospital de Clínicas de Montevideo, Uruguay.

    Oliver, Carolina / Guillermo, Cecilia / Martínez, Paula / Díaz, Lilián

    Revista medica de Chile

    2013  Volume 141, Issue 7, Page(s) 844–852

    Abstract: Background: The most common types of non-Hodgkin lymphoma (NHL) are diffuse large B cell (DLBCL) and follicular (FL).: Aim: To analyze the benefit of Rituxi-mab in overall survival (OS) of patients with NHL.: Material and methods: Review of ... ...

    Title translation Comparison between CHOP-like and R-CHOP in diffuse large B cell and follicular lymphoma.
    Abstract Background: The most common types of non-Hodgkin lymphoma (NHL) are diffuse large B cell (DLBCL) and follicular (FL).
    Aim: To analyze the benefit of Rituxi-mab in overall survival (OS) of patients with NHL.
    Material and methods: Review of medical record of 230 adult patients with a first episode of NHL admitted between 2002 and 2011. We included 67 patients with DLBCL and 36 patients with FL.
    Results: The overall response (OR) was 64% with 39% complete remissions (CR) in DLBCL treated with CHOP-like and 100% with 89% CR with R-CHOP. The median OS with CHOP-like was 21 months versus not attained R-CHOP (p = 0.016). There was a statistically significant difference in median event-free survival (EvFS) in favor of R-CHOP: not attained versus 8.3 months for CHOP-like (log rank (p = 0.002)). In FL, the OR in patients treated with R-CHOP or R-CHOP-like was 85%) with 54% CR. With CHOP-like the OR was 59%> with 18% CR. The OS at 24 and 36 months in patients treated with R-CHOP or R-CHOP-like was 83 and 65%. The figures for patients treated with CHOP-like were 80 and 66%> respectively. The progression free survival (PFS) was 21 months with CHOP-like versus not attained with R-QT (p = 0,043).
    Conclusions: When Rituximab was added to CHOP, there was a higher CR, EvFS and OS in DLBCL and higher CR and PFS in FL.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/administration & dosage ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Female ; Humans ; Lymphoma, Follicular/drug therapy ; Lymphoma, Follicular/mortality ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Male ; Middle Aged ; Neoplasm Staging ; Prednisone/administration & dosage ; Prognosis ; Treatment Outcome ; Vincristine/administration & dosage ; Young Adult
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; R-CHOP protocol ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
    Language Spanish
    Publishing date 2013-07
    Publishing country Chile
    Document type Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/S0034-98872013000700003
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  8. Article ; Online: Resonancia magnética como screening inicial de diagnóstico de compromiso secundario del sistema nervioso central en LNH difuso de grandes Células B.

    Oliver, Ana Carolina / Irigoin, Victoria / Sgarbi, Nicolas / Peixoto, Adriana / Turcatti, Paola / Diaz, Lilian / Zunino, Juan

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2018  Volume 75, Issue 2, Page(s) 67–71

    Abstract: Background: Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to ... ...

    Title translation Magnetic resonance as initial screening diagnosis of secondary involvement of central nervous system in NHL diffuse large B cell lymphoma
    Abstract Background: Background: Central Nervous System (CNS) relapse in Diffuse Large B-cell Lymphoma occurs mostly 6-8 months after disease onset. This has led to propose that CNS infiltration is an early event in the evolution of the disease. We intend to evaluate the role of magnetic resonance imaging (MR) at diagnosis to detect early SNC compromise.
    Methods: Prospective longitudinal cohort’s study in DGCB patients treated at Hospital de Clínicas between 2013 and 2015. Skull MRI was performed in all patients at diagnosis and lumbar puncture was done according to predefined risk factors.
    Results: 35 patients were analyzed. Median age: 68 years (24-85 years). Stage III-IV: 62%, 57% good prognosis according to RIPI score and 43% poor prognosis. MRI was performed in all patients, with no pathological findings in any of them. Twenty-one patients fullfilled criteria for cerebrospinal fluid study. Twenty-two patients were studied and received intrathecal methotrexate prophylaxis. Meningeal relapse was observed in a single patient who had negative studies at diagnosis and had received complete prophylaxis at the end of the 6 R-CHOP series.
    Conclusions: Only one of the 35 patients relapsed in the CNS. This patient had a noral MRI and CSF study at diagnosis and had received prophylaxis with intrathecal chemotherapy. This results lead us to believe that the value of MRI to detect early infiltration in asymptomatic patients at diagnosis is low.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents, Immunological/therapeutic use ; Central Nervous System Neoplasms/cerebrospinal fluid ; Central Nervous System Neoplasms/diagnostic imaging ; Central Nervous System Neoplasms/drug therapy ; Early Detection of Cancer/methods ; Female ; Humans ; Longitudinal Studies ; Lymphoma, Large B-Cell, Diffuse/cerebrospinal fluid ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prospective Studies ; Rituximab/therapeutic use ; Skull Base/diagnostic imaging
    Chemical Substances Antineoplastic Agents, Immunological ; Rituximab (4F4X42SYQ6)
    Language Spanish
    Publishing date 2018-06-10
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v75.n2.17517
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  9. Article ; Online: Case with chronic myeloid leukemia and T315I mutation, but still in complete molecular response under high dose imatinib therapy.

    Moro, Maria Isabel / Manrique, Gonzalo / Uriarte, Rosario / Díaz, Lilián

    Leukemia & lymphoma

    2013  Volume 55, Issue 7, Page(s) 1684–1686

    MeSH term(s) Antineoplastic Agents/administration & dosage ; Fusion Proteins, bcr-abl/genetics ; Humans ; Imatinib Mesylate/administration & dosage ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Mutation ; Protein Kinase Inhibitors/administration & dosage ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Protein Kinase Inhibitors ; Imatinib Mesylate (8A1O1M485B) ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2013-11-14
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.3109/10428194.2013.850164
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  10. Article ; Online: Current imaging follow-up of non-Hodgkin lymphoma exposes patients to significant radiation but does not detect asymptomatic relapses.

    Riva, Eloisa / Oliver, Carolina / Pérez, Maria del Carmen / Telis, Osmar / Díaz, Lilian / Mikhael, Joseph R

    Leukemia & lymphoma

    2015  Volume 57, Issue 6, Page(s) 1363–1366

    Abstract: The standard approach to the follow-up of lymphoma includes computed tomography (CT) every 6-12 months for the first 2 years and, then, as clinically indicated. Recent evidence suggests that most relapses are detected clinically, outside scheduled CT ... ...

    Abstract The standard approach to the follow-up of lymphoma includes computed tomography (CT) every 6-12 months for the first 2 years and, then, as clinically indicated. Recent evidence suggests that most relapses are detected clinically, outside scheduled CT which, on the other hand, increases risk of second malignancies and cost. In early-stage lymphomas, involved site CT instead of full body CT may be a reasonable alternative to reduce radiation dose. We analyzed whether regular CT surveillance detects asymptomatic relapses in a single-center Uruguayan early stage non-Hodgkin lymphoma (NHL) population. We evaluated utility of full body CT halfway and at the end-of-treatment evaluation and calculated the radiation exposure. In our study, CT surveillance added nothing to clinical follow-up. Moreover, 44% of our patients received a cumulative effective dose that doubles the risk of malignancies. Involved-site CT scan would be enough to monitor response during treatment in early stage NHL.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Humans ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/mortality ; Lymphoma, Non-Hodgkin/pathology ; Lymphoma, Non-Hodgkin/therapy ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Radiation Dosage ; Radiation Effects ; Sensitivity and Specificity ; Tomography, X-Ray Computed/adverse effects ; Tomography, X-Ray Computed/standards ; Young Adult
    Language English
    Publishing date 2015-10-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.3109/10428194.2015.1094694
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