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Book ; Online: La pêche artisanale en Haïti

Alaric, Jean-Paul / Célestin, Wilson / Diaz, Nicolas / Failler, Pierre / Gilles, Sylvain / Hardy, Pierre-Yves / Lafontant, Pierre-Guy / Millien, Max François / Morand, Pierre / Pioch, Sylvain / Quod, Jean-Pascal / Reynal, Lionel / Sabinot, Catherine / Touron-Gardic, Grégoire / Trouillet, Brice / Vallès, Henri / Vendeville, Philippe / Gilbert, David

(Expertise collective)

2021

Series title	Expertise collective
Keywords	Political science & theory ; Insects (entomology) ; food security ; small-scale fishing ; fishing systems ; aquaculture ; species ecology ; economy ; food ; sustainable development ; governance of the environment and living things ; Haiti
Language	fra
Size	1 electronic resource (250 pages)
Publisher	IRD Éditions
Publishing place	Marseille
Document type	Book ; Online
Note	French
HBZ-ID	HT030647329
ISBN	9782709929196 ; 2709929198
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Circadian Oscillations in the Murine Preoptic Area Are Reset by Temperature, but Not Light.

Díaz, Nicolás M / Gordon, Shannon A / Lang, Richard A / Buhr, Ethan D

Frontiers in physiology

2022 Volume 13, Page(s) 934591

Abstract: Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. ...

Abstract	Mammals maintain their internal body temperature within a physiologically optimal range. This involves the regulation of core body temperature in response to changing environmental temperatures and a natural circadian oscillation of internal temperatures. The preoptic area (POA) of the hypothalamus coordinates body temperature by responding to both external temperature cues and internal brain temperature. Here we describe an autonomous circadian clock system in the murine ventromedial POA (VMPO) in close proximity to cells which express the atypical violet-light sensitive opsin, Opn5. We analyzed the light-sensitivity and thermal-sensitivity of the VMPO circadian clocks
Language	English
Publishing date	2022-07-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.934591
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Roles and dynamics of 3-methylcytidine in cellular RNAs.

Bohnsack, Katherine E / Kleiber, Nicole / Lemus-Diaz, Nicolas / Bohnsack, Markus T

Trends in biochemical sciences

2022 Volume 47, Issue 7, Page(s) 596–608

Abstract: Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine ( ... ...

Abstract	Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m
MeSH term(s)	Cytidine/analogs & derivatives ; Cytidine/metabolism ; Humans ; Methyltransferases/metabolism ; RNA ; RNA, Transfer/metabolism
Chemical Substances	3-methylcytidine (2140-64-9) ; Cytidine (5CSZ8459RP) ; RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2022.03.004
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Article ; Online: Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer's Disease: Experimental and Computational Insights.

Puentes-Díaz, Nicolás / Chaparro, Diego / Morales-Morales, David / Flores-Gaspar, Areli / Alí-Torres, Jorge

ACS omega

2023 Volume 8, Issue 5, Page(s) 4508–4526

Abstract: Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people around the world. Even though the causes of AD are not completely understood due to its multifactorial nature, some neuropathological hallmarks of its development ... ...

Abstract	Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people around the world. Even though the causes of AD are not completely understood due to its multifactorial nature, some neuropathological hallmarks of its development have been related to the high concentration of some metal cations. These roles include the participation of these metal cations in the production of reactive oxygen species, which have been involved in neuronal damage. In order to avoid the increment in the oxidative stress, multifunctional ligands used to coordinate these metal cations have been proposed as a possible treatment to AD. In this review, we present the recent advances in experimental and computational works aiming to understand the role of two redox active and essential transition-metal cations (Cu and Fe) and one nonbiological metal (Al) and the recent proposals on the development of multifunctional ligands to stop or revert the damaging effects promoted by these metal cations.
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c06939
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dataset for detecting motorcyclists in pedestrian areas.

Díaz, Nicolás Hernández / Peñaloza, Yersica C / Rios, Y Yuliana / Martinez-Santos, Juan Carlos / Puertas, Edwin

Data in brief

2023 Volume 50, Page(s) 109610

Abstract: This paper presents a semi-automated, scalable, and homologous methodology towards IoT implemented in Python for extracting and integrating images in pedestrian and motorcyclist areas on the road for constructing a multiclass object classifier. It ... ...

Abstract	This paper presents a semi-automated, scalable, and homologous methodology towards IoT implemented in Python for extracting and integrating images in pedestrian and motorcyclist areas on the road for constructing a multiclass object classifier. It consists of two stages. The first stage deals with creating a non-debugged data set by acquiring images related to the semantic context previously mentioned, using an embedded device connected 24/7 via Wi-Fi to a free and public CCTV service in Medellin, Colombia. Through artificial vision techniques, and automatically performs a comparative chronological analysis to download the images observed by 80 cameras that report data asynchronously. The second stage proposes two algorithms focused on debugging the previously obtained data set. The first one facilitates the user in labeling the data set not debugged through Regions of Interest (ROI) and hotkeys. It decomposes the information in the nth image of the data set in the same dictionary to store it in a binary Pickle file. The second one is nothing more than an observer of the classification performed by the user through the first algorithm to allow the user to verify if the information contained in the Pickle file built is correct.
Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2023.109610
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Article ; Online: Pincer Ligands as Multifunctional Agents for Alzheimer's Copper Dysregulation and Oxidative Stress: A Computational Evaluation.

Puentes-Díaz, Nicolás / Chaparro, Diego / Morales-Morales, David / Alí-Torres, Jorge / Flores-Gaspar, Areli

ChemPlusChem

2023 Volume 88, Issue 12, Page(s) e202300405

Abstract: Alzheimer's disease (AD) is the most common form of dementia worldwide, affecting millions of people around the globe. AD is characterized by different pathologies being beta-amyloid (Aβ) plaque formation, metal ion dysregulation, and oxidative stress ( ... ...

Abstract	Alzheimer's disease (AD) is the most common form of dementia worldwide, affecting millions of people around the globe. AD is characterized by different pathologies being beta-amyloid (Aβ) plaque formation, metal ion dysregulation, and oxidative stress (OS) central topics under investigation. Copper-Aβ complexes have been shown to induce catalytic hydrogen peroxide formation and increase OS in the brain leading to neuronal death. Pincer-type compounds are tridentate ligands that coordinate metals in a planar fashion whose properties can be tuned via group substitutions, giving rise to many possibilities in catalysis and drug discovery. In this work we evaluated the potential pharmaceutical activity of 26 pincer compounds in AD's copper ion-related oxidative stress framework. In this sense, four key aspects were considered: 1) Lipinski's rule of five, 2) blood-brain barrier permeation, 3) standard reduction potential (SRP) of the formed copper complexes, and 4) the ligand's affinity towards copper cations. The evaluation of these criteria was performed by means of bioinformatic tools and electronic structure calculations at the DFT level of theory. Our results suggest that two compounds from this set are potential antioxidant agents, whereas five of them are promissory distributor-like compounds in the context of AD.
MeSH term(s)	Humans ; Copper/chemistry ; Alzheimer Disease/drug therapy ; Ligands ; Oxidative Stress ; Amyloid beta-Peptides/chemistry ; Metals
Chemical Substances	Copper (789U1901C5) ; Ligands ; Amyloid beta-Peptides ; Metals
Language	English
Publishing date	2023-10-24
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2192-6506
ISSN (online)	2192-6506
DOI	10.1002/cplu.202300405
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Roles and dynamics of 3-methylcytidine in cellular RNAs

Bohnsack, Katherine E. / Kleiber, Nicole / Lemus-Diaz, Nicolas / Bohnsack, Markus T.

Trends in biochemical sciences. 2022,

2022

Abstract: Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m³C) has recently come to the fore through the identification of the methyltransferases responsible for ... ...

Abstract	Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m³C) has recently come to the fore through the identification of the methyltransferases responsible for installing m³C₃₂ in human tRNAs. Mechanistic details of how m³C₃₂ methyltransferases recognize their substrate tRNAs have been uncovered and the biogenetic and functional relevance of interconnections between m³C₃₂ and modified adenosines at position 37 highlighted. Functional insights into the role of m³C₃₂ modifications indicate that they influence tRNA structure and, consistently, lack of m³C₃₂ modifications impairs translation. Development of quantitative, transcriptome-wide m³C mapping approaches and the discovery of an m³C demethylase reveal m³C to be dynamic, raising the possibility that it contributes to fine-tuning gene expression in different conditions.
Keywords	biogenesis ; gene expression ; humans ; methyltransferases ; nucleotides
Language	English
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	194220-7
ISSN	0968-0004 ; 0376-5067
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2022.03.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Infección del sistema nervioso central por el virus de Epstein-Barr: manifestaciones clínicas y pronóstico.

Lagarejos-González, E / Gilarranz-Luengo, R / Chamizo-López, F J / Díaz-Nicolás, S / Redondo-Betancor, G / Pena-López, M J

Revista de neurologia

2021 Volume 74, Issue 2, Page(s) 48–54

Abstract: Introduction: The role of Epstein-Barr virus (EBV) in central nervous system (CNS) infections is not fully resolved. We wanted to describe the clinical manifestations of patients with EBV infection in cerebrospinal fluid.: Patients and methods: We ... ...

Title translation	Infection of the central nervous system by Epstein-Barr virus: clinical manifestations and prognosis.
Abstract	Introduction: The role of Epstein-Barr virus (EBV) in central nervous system (CNS) infections is not fully resolved. We wanted to describe the clinical manifestations of patients with EBV infection in cerebrospinal fluid. Patients and methods: We reviewed the clinical records of all adult patients EBV PCR-positive in cerebrospinal fluid, without lymphoproliferative disease, during 2004 to 2020. Results: We identified 27 patients, 22 (81.5%) were men, and median age was 54 years. Twenty-three (82.1%) patients were immunosuppressed, 16 HIV-positive. In 15 (55.6%) patients coinfection with another microorganism was diagnosed and in 12 (44.4%) patients it was detected as the only pathogen. Of the 12 patients, three (25%) was immunocompetent patients, one had Guillain Barre syndrome (GBS), another had disseminated multiphasic encephalitis, and another had lymphocytic meningitis; 9 (75%) immunosuppressed, 7 HIV-positive, 4 had encephalitis that resolved without sequelae and 4 had encephalopathy, two HIH-positive had moderate cognitive impairment as a sequela. Conclusions: In our study, EBV produced encephalitis, meningitis, polyradiculomyelitis and GBS, mainly in immunosuppressed patients. In more than half of the cases, it is associated with other pathogens where the role of EBV is unclear. In immunocompetent patient, the infection can be serious and leave sequelae and in HIV-positive patients with encephalopatic involvement without encephalitis, the neurological damage could be greater, so we consider it of interest to carry out studies to evaluate the prognosis as well as the role of antivirals in the evolucion of these clinical pictures.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Central Nervous System Viral Diseases/diagnosis ; Epstein-Barr Virus Infections/diagnosis ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Young Adult
Language	Spanish
Publishing date	2021-12-17
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
DOI	10.33588/rn.7402.2021406
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Article ; Online: Computational Evaluation of the Potential Pharmacological Activity of Salen-Type Ligands in Alzheimer's Disease.

Puentes-Díaz, Nicolás / Chaparro, Diego / Reyes-Marquez, Viviana / Morales-Morales, David / Flores-Gaspar, Areli / Alí-Torres, Jorge

Journal of Alzheimer's disease : JAD

2023 Volume 99, Issue s2, Page(s) S383–S396

Abstract: Background: Alzheimer's disease (AD) is the most common form of dementia representing from 60% to 70% of the cases globally. It is a multifactorial disease that, among its many pathological characteristics, has been found to provoke the metal ion ... ...

Abstract	Background: Alzheimer's disease (AD) is the most common form of dementia representing from 60% to 70% of the cases globally. It is a multifactorial disease that, among its many pathological characteristics, has been found to provoke the metal ion dysregulation in the brain, along with an increase in the oxidative stress. There is proof that metallic complexes formed by the amyloid-β peptide (Aβ) and extraneuronal copper can catalyze the production of reactive oxygen species, leading to an increase in oxidative stress, promoting neuronal death. Due to this interaction, bioavailable copper has become an important redox active target to consider within the search protocols of multifunctional agents for AD's treatment. Objective: In this study, we examined by using bioinformatics and electronic structure calculations the potential application of 44 salen-type copper chelating ligands and 12 further proposed molecules as possible multifunctional agents in the context of AD. Methods: The candidates were evaluated by combining bioinformatic tools and electronic structure calculations, which allowed us to classify the molecules as potential antioxidants, redistributor-like compounds, and the newly proposed suppressor mechanism. Results: This evaluation demonstrate that salen-type ligands exhibit properties suitable for interfering in the chain of copper-induced oxidative stress reactions present in AD and potential redistributor and suppressor activity for copper ions. Finally, a novel set of plausible candidates is proposed and evaluated. Conclusion: According to the evaluated criteria, a subset of 13 salen-type candidates was found to exhibit promissory pharmacological properties in the AD framework and were classified according to three plausible action mechanisms.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Humans ; Copper ; Ligands ; Computational Biology ; Chelating Agents/pharmacology ; Antioxidants/pharmacology ; Oxidative Stress/drug effects ; Amyloid beta-Peptides/metabolism
Chemical Substances	Copper (789U1901C5) ; Ligands ; Chelating Agents ; Antioxidants ; Amyloid beta-Peptides
Language	English
Publishing date	2023-07-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-230542
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Article ; Online: Intellectual Disability, Falls and Gait Disturbances: A Misdiagnosis.

Lorenzo Villalba, Noel / Díaz Nicolas, Santiago / Alonso Ortiz, Maria Belen / Cordoba Sosa, Zaida / Suárez Ortega, Saturnino / Zulfiqar, Abrar-Ahmad

European journal of case reports in internal medicine

2020 Volume 7, Issue 3, Page(s) 1488

Abstract: We report the case of a 27-year-old man presenting with slowly progressive extrapyramidal dysfunction and learning disability considered to have a syndromic intellectual disability. The re-evaluation of the clinical features and the investigations ... ...

Abstract	We report the case of a 27-year-old man presenting with slowly progressive extrapyramidal dysfunction and learning disability considered to have a syndromic intellectual disability. The re-evaluation of the clinical features and the investigations performed led to the diagnosis of atypical pantothenate kinase-associated neurodegeneration (PKAN). Learning points: Patients with an intellectual disability should be carefully evaluated.In the evaluation of a patient with extrapyramidal dysfunction for several years, with gradual progression, spasticity and psychiatric disturbances, PKAN should be considered.
Language	English
Publishing date	2020-02-13
Publishing country	Italy
Document type	Journal Article
ISSN	2284-2594
ISSN (online)	2284-2594
DOI	10.12890/2020_001488
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