LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 229

Search options

  1. Book: Side effects of medical cancer therapy

    Dicato, Mario

    prevention and treatment

    2013  

    Author's details Mario A. Dicato ed
    Keywords Cancer--Chemotherapy--Complications--Handbooks, manuals, etc.
    Language English
    Size XIII, 654 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017501161
    ISBN 978-0-85729-786-0 ; 9780857297877 ; 0-85729-786-4 ; 0857297872
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4662 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book ; Conference proceedings: ESMO conference: 11th World Congress on Gastrointestinal Cancer

    Dicato, Mario

    24 - 27 June, 2009: Barcelona, Spain

    (Annals of oncology ; 20, Suppl. 7)

    2009  

    Institution European Society for Medical Oncology
    Event/congress World Congress on Gastrointestinal Cancer (11, 2009, Barcelona)
    Author's details chairs: Mario Dicato
    Series title Annals of oncology ; 20, Suppl. 7
    Collection
    Language English
    Size vii127 S.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT016003394
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2862 -20,Suppl.7- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Book ; Conference proceedings: ESMO international symposium: 10th World Congress on Gastrointestinal Cancer

    Dicato, Mario

    25 - 28 June, 2008: Barcelona, Spain

    (Annals of oncology ; 19, Suppl. 6)

    2008  

    Institution European Society for Medical Oncology
    Event/congress World Congress on Gastrointestinal Cancer (10, 2008, Barcelona)
    Author's details chairs: Mario Dicato
    Series title Annals of oncology ; 19, Suppl. 6
    Collection
    Language English
    Size vi114 S.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015629613
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2862 -19,Suppl.6- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Enhancing personalized immune checkpoint therapy by immune archetyping and pharmacological targeting.

    Cerella, Claudia / Dicato, Mario / Diederich, Marc

    Pharmacological research

    2023  Volume 196, Page(s) 106914

    Abstract: Immune checkpoint inhibitors (ICIs) are an expanding class of immunotherapeutic agents with the potential to cure cancer. Despite the outstanding clinical response in patient subsets, most individuals become refractory or develop resistance. Patient ... ...

    Abstract Immune checkpoint inhibitors (ICIs) are an expanding class of immunotherapeutic agents with the potential to cure cancer. Despite the outstanding clinical response in patient subsets, most individuals become refractory or develop resistance. Patient stratification and personalized immunotherapies are limited by the absence of predictive response markers. Recent findings show that dominant patterns of immune cell composition, T-cell status and heterogeneity, and spatiotemporal distribution of immune cells within the tumor microenvironment (TME) are becoming essential determinants of prognosis and therapeutic response. In this context, ICIs also function as investigational tools and proof of concept, allowing the validation of the identified mechanisms. After reviewing the current state of ICIs, this article will explore new comprehensive predictive markers for ICIs based on recent discoveries. We will discuss the recent establishment of a classification of TMEs into immune archetypes as a tool for personalized immune profiling, allowing patient stratification before ICI treatment. We will discuss the developing comprehension of T-cell diversity and its role in shaping the immune profile of patients. We describe the potential of strategies that score the mutual spatiotemporal modulation between T-cells and other cellular components of the TME. Additionally, we will provide an overview of a range of synthetic and naturally occurring or derived small molecules. We will compare compounds that were recently identified by in silico prediction to wet lab-validated drug candidates with the potential to function as ICIs and/or modulators of the cellular components of the TME.
    Language English
    Publishing date 2023-09-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2023.106914
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 721: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book ; Conference proceedings: 2007 World Congress on Gastrointestinal Cancer

    Dicato, Mario

    28 June - July 1, 2007, Barcelona, Spain

    (Annals of oncology ; 18, Suppl. 7)

    2007  

    Event/congress World Congress on Gastrointestinal Cancer (9, 2007, Barcelona)
    Author's details chairs: Mario Dicato
    Series title Annals of oncology ; 18, Suppl. 7
    Collection
    Language English
    Size 137 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015245595
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2862 -18,Suppl.7- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Book ; Conference proceedings: Optimizing hemoglobin levels and beyond: strength for living and meaningful survival?

    Dicato, Mario

    proceedings of the 3rd Educational Symposium on Cancer Anemia Management ; Vienna, Austria, March 20 - 23, 2003

    (Oncology ; 68, Suppl. 1)

    2005  

    Event/congress Educational Symposium on Advances in Cancer Anemia Management (3, 2003, Wien)
    Author's details guest ed. Mario Dicato
    Series title Oncology ; 68, Suppl. 1
    Collection
    Keywords Krebs ; Anämie
    Subject Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung ; Blutarmut
    Language English
    Size 32 S. : graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT014343673
    ISBN 3-8055-7912-8 ; 978-3-8055-7912-4
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 151 -68,Suppl.1- verfügbar in Königswinter Königswinter

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Assessment of Mitochondrial Cell Metabolism by Respiratory Chain Electron Flow Assays.

    Radogna, Flavia / Gérard, Déborah / Dicato, Mario / Diederich, Marc

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2276, Page(s) 129–141

    Abstract: Cellular energy metabolism is regulated by complex metabolic pathways. Although anaerobic glycolysis was reported as a primary source of energy in cancer leading to a high rate of lactate production, current evidence shows that the main energy source ... ...

    Abstract Cellular energy metabolism is regulated by complex metabolic pathways. Although anaerobic glycolysis was reported as a primary source of energy in cancer leading to a high rate of lactate production, current evidence shows that the main energy source supporting cancer cell metabolism relies on mitochondrial metabolism. Mitochondria are the key organelle maintaining optimal cellular energy levels. MitoPlate™ S-1 provides a highly reproducible bioenergetics tool to analyze the electron flow rate in live cells. Measuring the rates of electron flow into and through the electron transport chain using different NADH and FADH
    MeSH term(s) Cell Line, Tumor ; Electron Transport ; High-Throughput Screening Assays/methods ; Humans ; Metabolic Networks and Pathways ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism ; Neoplasms/metabolism ; Neoplasms/pathology ; Oxidation-Reduction
    Language English
    Publishing date 2021-05-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1266-8_9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article ; Online: Susceptibility of multiple myeloma to B-cell lymphoma 2 family inhibitors.

    Lernoux, Manon / Schnekenburger, Michael / Dicato, Mario / Diederich, Marc

    Biochemical pharmacology

    2021  Volume 188, Page(s) 114526

    Abstract: Multiple myeloma (MM) is a biologically complex hematological disorder defined by the clonal proliferation of malignant plasma cells producing excessive monoclonal immunoglobulin that interacts with components of the bone marrow microenvironment, ... ...

    Abstract Multiple myeloma (MM) is a biologically complex hematological disorder defined by the clonal proliferation of malignant plasma cells producing excessive monoclonal immunoglobulin that interacts with components of the bone marrow microenvironment, resulting in the major clinical features of MM. Despite the development of numerous protocols to treat MM patients, this cancer remains currently incurable; due in part to the emergence of resistant clones, highlighting the unmet need for innovative therapeutic approaches. Accumulating evidence suggests that the survival of MM molecular subgroups depends on the expression profiles of specific subsets of anti-apoptotic B-cell lymphoma (BCL)-2 family members. This review summarizes the mechanisms underlying the anti-myeloma activities of the potent BCL-2 family protein inhibitors, individually or in combination with conventional therapeutic options, and provides an overview of the strong rationale to clinically investigate such interventions for MM therapy.
    MeSH term(s) Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/physiology ; Humans ; Immunotherapy/methods ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/immunology ; Lymphoma, B-Cell/metabolism ; Multiple Myeloma/drug therapy ; Multiple Myeloma/immunology ; Multiple Myeloma/metabolism ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/immunology ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/physiology
    Chemical Substances Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2021.114526
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book ; Conference proceedings: ESMO 13th World Congress on Gastrointestinal Cancer

    Dicato, Mario / Van Cutsem, Eric

    22 - 25 June 2011, Barcelona, Spain

    (Annals of oncology ; 22, Suppl. 5)

    2011  

    Institution European Society for Medical Oncology
    Event/congress World Congress on Gastrointestinal Cancer (13, 2011, Barcelona)
    Author's details chairs: Mario Dicato ; Eric van Cutsem
    Series title Annals of oncology ; 22, Suppl. 5
    Collection
    Language English
    Size 144 S. : graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT016888919
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2862 -22,Suppl.5- not available for loan Zeitschriften-Lesesaal

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Book: Side effects of medical cancer therapy

    Dicato, Mario

    prevention and treatment

    2013  

    Author's details Mario A. Dicato, editor
    MeSH term(s) Antineoplastic Agents/adverse effects ; Drug Interactions ; Drug-Related Side Effects and Adverse Reactions/prevention & control
    Language English
    Size xiii, 654 pages :, illustrations
    Document type Book
    ISBN 9780857297860 ; 9780857297877 ; 0857297864 ; 0857297872
    Database Catalogue of the US National Library of Medicine (NLM)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top