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  1. Book: Dementia

    Dickerson, Bradford C. / Atri, Alireza

    comprehensive principles and practice

    2014  

    Author's details ed. by Bradford C. Dickerson and Alireza Atri
    Keywords Dementia
    Language English
    Size XX, 666 S., [8] Bl. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references
    HBZ-ID HT018431214
    ISBN 978-0-19-992845-3 ; 0-19-992845-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 3970 available for loan (reading room) Lesesaal EG

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  2. Book: Hodges' frontotemporal dementia

    Hodges, John R. / Dickerson, Bradford C.

    (Cambridge medicine)

    2016  

    Title variant Frontotemporal dementia
    Author's details edited by Bradford C. Dickerson
    Series title Cambridge medicine
    Keywords Frontotemporal Dementia
    Language English
    Size xix, 280 Seiten, 16 ungezählte Seiten, Illustrationen, Diagramme
    Edition Second edition
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018971173
    ISBN 978-1-107-08663-0 ; 1-107-08663-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1186 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: A Step Forward in the Fight Against Dementia-Are We There Yet?

    Wolk, David A / Rabinovici, Gil D / Dickerson, Bradford C

    JAMA neurology

    2023  Volume 80, Issue 5, Page(s) 429–430

    MeSH term(s) Humans ; Alzheimer Disease
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.0123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Auditory naming is impaired in posterior cortical atrophy and early-onset Alzheimer's disease.

    Putcha, Deepti / Eustace, Ana / Carvalho, Nicole / Wong, Bonnie / Quimby, Megan / Dickerson, Bradford C

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1342928

    Abstract: Introduction: Visual naming ability reflects semantic memory retrieval and is a hallmark deficit of Alzheimer's disease (AD). Naming impairment is most prominently observed in the late-onset amnestic and logopenic variant Primary Progressive Aphasia ( ... ...

    Abstract Introduction: Visual naming ability reflects semantic memory retrieval and is a hallmark deficit of Alzheimer's disease (AD). Naming impairment is most prominently observed in the late-onset amnestic and logopenic variant Primary Progressive Aphasia (lvPPA) syndromes. However, little is known about how other patients across the atypical AD syndromic spectrum perform on tests of auditory naming, particularly those with primary visuospatial deficits (Posterior Cortical Atrophy; PCA) and early onset (EOAD) syndromes. Auditory naming tests may be of particular relevance to more accurately measuring anomia in PCA syndrome and in others with visual perceptual deficits.
    Methods: Forty-six patients with biomarker-confirmed AD (16 PCA, 12 lvPPA, 18 multi-domain EOAD), at the stage of mild cognitive impairment or mild dementia, were administered the Auditory Naming Test (ANT). Performance differences between groups were evaluated using one-way ANOVA and
    Results: Based on published cutoffs, out of a total possible score of 50 on the ANT, 56% of PCA patients (mean score = 45.3), 83% of EOAD patients (mean = 39.2), and 83% of lvPPA patients (mean = 29.8) were impaired. Total uncued ANT performance differed across groups, with lvPPA performing most poorly, followed by EOAD, and then PCA. ANT performance was still impaired in lvPPA and EOAD after cuing, while performance in PCA patients improved to the normal range with phonemic cues. ANT performance was also directly correlated with measures of verbal fluency and working memory, and was associated with cortical atrophy in a circumscribed semantic language network.
    Discussion: Auditory confrontation naming is impaired across the syndromic spectrum of AD including in PCA and EOAD, and is likely related to auditory-verbal working memory and verbal fluency which represent the nexus of language and executive functions. The left-lateralized semantic language network was implicated in ANT performance. Auditory naming, in the absence of a visual perceptual demand, may be particularly sensitive to measuring naming deficits in PCA.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1342928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Semantic Clustering during Verbal Episodic Memory Encoding and Retrieval in Older Adults: One Cognitive Mechanism of Superaging.

    Shaffer, Clare / Andreano, Joseph M / Touroutoglou, Alexandra / Barrett, Lisa Feldman / Dickerson, Bradford C / Wong, Bonnie

    Brain sciences

    2024  Volume 14, Issue 2

    Abstract: Normal aging is commonly accompanied by a decline in cognitive abilities, including memory, yet some individuals maintain these abilities as they get older. We hypothesize that semantic clustering, as an effective strategy for improving performance on ... ...

    Abstract Normal aging is commonly accompanied by a decline in cognitive abilities, including memory, yet some individuals maintain these abilities as they get older. We hypothesize that semantic clustering, as an effective strategy for improving performance on episodic recall tasks, may contribute to the maintenance of youthful memory in older adults. We investigated the dynamics of spontaneous production and utilization of the semantic clustering strategy in two independent samples of older adults who completed a list learning paradigm (N
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14020171
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  6. Article ; Online: Transcranial Magnetic Stimulation for the Neurological Patient: Scientific Principles and Applications.

    Eldaief, Mark C / Dickerson, Bradford C / Camprodon, Joan A

    Seminars in neurology

    2022  Volume 42, Issue 2, Page(s) 149–157

    Abstract: Non-invasive brain stimulation has been increasingly recognized for its potential as an investigational, diagnostic and therapeutic tool across the clinical neurosciences. Transcranial magnetic stimulation (TMS) is a non-invasive method of focal ... ...

    Abstract Non-invasive brain stimulation has been increasingly recognized for its potential as an investigational, diagnostic and therapeutic tool across the clinical neurosciences. Transcranial magnetic stimulation (TMS) is a non-invasive method of focal neuromodulation. Diagnostically, TMS can be used to probe cortical excitability and plasticity, as well as for functional mapping. Therapeutically, depending on the pattern employed, TMS can either facilitate or inhibit stimulated cortex potentially modulating maladaptive physiology through its effects on neuroplasticity. Despite this potential, applications of TMS in neurology have only been approved for diagnostic clinical neurophysiology, pre-surgical mapping of motor and language cortex, and the treatment of migraines. In this article, we discuss the principles of TMS and its clinical applications in neurology, including experimental applications in stroke rehabilitation, seizures, autism spectrum disorder, neurodegenerative disorders, movement disorders, tinnitus, chronic pain and functional neurological disorder. To promote increased cross-talk across neurology and psychiatry, we also succinctly review the TMS literature for the treatment of major depression and obsessive compulsive disorder. Overall, we argue that larger clinical trials that are better informed by circuit-level biomarkers and pathophysiological models will lead to an expansion of the application of TMS for patients cared for by neurologists.
    MeSH term(s) Autism Spectrum Disorder/therapy ; Humans ; Neurology ; Seizures ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0041-1742265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dysfunction of social cognition and behavior.

    Dickerson, Bradford C

    Continuum (Minneapolis, Minn.)

    2015  Volume 21, Issue 3 Behavioral Neurology and Neuropsychiatry, Page(s) 660–677

    Abstract: Purpose of review: Neurologists have generally paid relatively little attention to social behavior and its disorders. As a result, many individuals with suspected brain disorders primarily involving changes in social behavior have sought evaluations by ... ...

    Abstract Purpose of review: Neurologists have generally paid relatively little attention to social behavior and its disorders. As a result, many individuals with suspected brain disorders primarily involving changes in social behavior have sought evaluations by psychiatrists or psychologists. This review summarizes recent findings from the growing field of social neuroscience and illustrates the relevance of this knowledge for the neurologist by reviewing contemporary research on frontotemporal dementia and its differential diagnosis.
    Recent findings: An explosion of research over the past 10 to 15 years has illuminated specific psychological processes involved in core facets of social behavior and their neural bases. In parallel, knowledge of the genetics, neurobiology, neuroimaging features, and clinical phenomenology of frontotemporal dementia has grown dramatically.
    Summary: As the understanding of specific component processes involved in social behavior and their neural underpinnings deepen, neurologists may lead the way in using this knowledge to provide sophisticated evaluation and monitoring for patients with disorders of social behavior and ultimately may develop new therapeutic options to treat these brain disorders.
    MeSH term(s) Adult ; Brain/pathology ; Cognition Disorders/diagnosis ; Cognition Disorders/psychology ; Cognition Disorders/therapy ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Perceptual Disorders/etiology ; Social Behavior Disorders/diagnosis ; Social Behavior Disorders/psychology ; Social Behavior Disorders/therapy ; Theory of Mind
    Language English
    Publishing date 2015-04-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/01.CON.0000466659.05156.1d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neuroimaging in Frontotemporal Lobar Degeneration: Research and Clinical Utility.

    Dev, Sheena I / Dickerson, Bradford C / Touroutoglou, Alexandra

    Advances in experimental medicine and biology

    2021  Volume 1281, Page(s) 93–112

    Abstract: Frontotemporal lobar dementia (FTLD) is a clinically and pathologically complex disease. Advances in neuroimaging techniques have provided a specialized set of tools to investigate underlying pathophysiology and identify clinical biomarkers that aid in ... ...

    Abstract Frontotemporal lobar dementia (FTLD) is a clinically and pathologically complex disease. Advances in neuroimaging techniques have provided a specialized set of tools to investigate underlying pathophysiology and identify clinical biomarkers that aid in diagnosis, prognostication, monitoring, and identification of appropriate endpoints in clinical trials. In this chapter, we review data discussing the utility of neuroimaging biomarkers in sporadic FTLD, with an emphasis on current and future clinical applications. Among those modalities readily utilized in clinical settings, T1-weighted structural magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) are best supported in differential diagnosis and as targets for clinical trial endpoints. However, a number of nonclinical neuroimaging modalities, including diffusion tensor imaging and resting-state functional connectivity MRI, show promise as biomarkers to predict progression and as clinical trial endpoints. Other neuroimaging modalities, including amyloid PET, Tau PET, and arterial spin labeling MRI, are also discussed, though more work is required to establish their utility in FTLD in clinical settings.
    MeSH term(s) Brain ; Diffusion Tensor Imaging ; Frontotemporal Dementia ; Frontotemporal Lobar Degeneration/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Neuroimaging
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-51140-1_7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Language uncovers visuospatial dysfunction in posterior cortical atrophy: a natural language processing approach.

    Rezaii, Neguine / Hochberg, Daisy / Quimby, Megan / Wong, Bonnie / McGinnis, Scott / Dickerson, Bradford C / Putcha, Deepti

    Frontiers in neuroscience

    2024  Volume 18, Page(s) 1342909

    Abstract: Introduction: Posterior Cortical Atrophy (PCA) is a syndrome characterized by a progressive decline in higher-order visuospatial processing, leading to symptoms such as space perception deficit, simultanagnosia, and object perception impairment. While ... ...

    Abstract Introduction: Posterior Cortical Atrophy (PCA) is a syndrome characterized by a progressive decline in higher-order visuospatial processing, leading to symptoms such as space perception deficit, simultanagnosia, and object perception impairment. While PCA is primarily known for its impact on visuospatial abilities, recent studies have documented language abnormalities in PCA patients. This study aims to delineate the nature and origin of language impairments in PCA, hypothesizing that language deficits reflect the visuospatial processing impairments of the disease.
    Methods: We compared the language samples of 25 patients with PCA with age-matched cognitively normal (CN) individuals across two distinct tasks: a visually-dependent picture description and a visually-independent job description task. We extracted word frequency, word utterance latency, and spatial relational words for this comparison. We then conducted an in-depth analysis of the language used in the picture description task to identify specific linguistic indicators that reflect the visuospatial processing deficits of PCA.
    Results: Patients with PCA showed significant language deficits in the visually-dependent task, characterized by higher word frequency, prolonged utterance latency, and fewer spatial relational words, but not in the visually-independent task. An in-depth analysis of the picture description task further showed that PCA patients struggled to identify certain visual elements as well as the overall theme of the picture. A predictive model based on these language features distinguished PCA patients from CN individuals with high classification accuracy.
    Discussion: The findings indicate that language is a sensitive behavioral construct to detect visuospatial processing abnormalities of PCA. These insights offer theoretical and clinical avenues for understanding and managing PCA, underscoring language as a crucial marker for the visuospatial deficits of this atypical variant of Alzheimer's disease.
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2024.1342909
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  10. Article ; Online: Brain structural indicators of β-amyloid neuropathology.

    Jang, Ikbeom / Li, Binyin / Rashid, Barnaly / Jacoby, John / Huang, Susie Y / Dickerson, Bradford C / Salat, David H

    Neurobiology of aging

    2024  Volume 136, Page(s) 157–170

    Abstract: Recent efforts demonstrated the efficacy of identifying early-stage neuropathology of Alzheimer's disease (AD) through lumbar puncture cerebrospinal fluid assessment and positron emission tomography (PET) radiotracer imaging. These methods are effective ... ...

    Abstract Recent efforts demonstrated the efficacy of identifying early-stage neuropathology of Alzheimer's disease (AD) through lumbar puncture cerebrospinal fluid assessment and positron emission tomography (PET) radiotracer imaging. These methods are effective yet are invasive, expensive, and not widely accessible. We extend and improve the multiscale structural mapping (MSSM) procedure to develop structural indicators of β-amyloid neuropathology in preclinical AD, by capturing both macrostructural and microstructural properties throughout the cerebral cortex using a structural MRI. We find that the MSSM signal is regionally altered in clear positive and negative cases of preclinical amyloid pathology (N = 220) when cortical thickness alone or hippocampal volume is not. It exhibits widespread effects of amyloid positivity across the posterior temporal, parietal, and medial prefrontal cortex, surprisingly consistent with the typical pattern of amyloid deposition. The MSSM signal is significantly correlated with amyloid PET in almost half of the cortex, much of which overlaps with regions where beta-amyloid accumulates, suggesting it could provide a regional brain 'map' that is not available from systemic markers such as plasma markers.
    MeSH term(s) Humans ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Alzheimer Disease/pathology ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging/methods ; Amyloid/metabolism
    Chemical Substances Amyloid beta-Peptides ; Amyloid
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2024.01.005
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