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Article ; Online: Detection of Intraneural Median Nerve Microvascularity Using Contrast-Enhanced Sonography: A Pilot Study.

Volz, Kevin R / Evans, Kevin D / Kanner, Christopher D / Dickerson, Jennifer A

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

2016 Volume 35, Issue 6, Page(s) 1309–1316

Abstract: Objectives: Demonstrating vascularity within the human median nerve may be difficult using power Doppler sonography. To this end, a pilot study documenting contrast-enhanced vascularity of the median nerve was conducted.: Methods: Patients undergoing ...

Abstract	Objectives: Demonstrating vascularity within the human median nerve may be difficult using power Doppler sonography. To this end, a pilot study documenting contrast-enhanced vascularity of the median nerve was conducted. Methods: Patients undergoing contrast-enhanced transthoracic echocardiography were recruited for this study (n = 24). During echocardiography, a simultaneous contrast-enhanced sonographic examination of the median nerve was conducted. The study and study protocol were built from preclinical evidence. Image analysis was based on the power Doppler pixel intensity within a defined region of interest to obtain quantitative data representing the average pixel intensity, maximum pixel intensity, and power Doppler pixel dot count. Semiquantitative data representing the power Doppler dot count grading were also obtained. Results: Spearman correlations between analytical methods showed strong positive, statistically significant (P< .05) correlations between the average pixel intensity and maximum pixel intensity and between the power Doppler dot count and dot count grading. Statistically significant increases in the average pixel intensity and power Doppler dot count were seen at all but 1 time point throughout the contrast-enhanced sonographic examination when compared to precontrast administration. Statistically significant increases in the maximum pixel intensity were seen at all but 4 time points. Conclusions: These pilot results represent early evidence that contrast-enhanced sonography can be used to image median nerve vascularity. In this convenience sample, median nerve contrast-enhanced sonographic data collection was feasible, safe, and consistent.
MeSH term(s)	Adult ; Aged ; Contrast Media ; Female ; Humans ; Image Enhancement/methods ; Male ; Median Nerve/blood supply ; Median Nerve/diagnostic imaging ; Microvessels/diagnostic imaging ; Middle Aged ; Pilot Projects ; Ultrasonography, Doppler/methods
Chemical Substances	Contrast Media
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604829-8
ISSN	1550-9613 ; 0278-4297
ISSN (online)	1550-9613
ISSN	0278-4297
DOI	10.7863/ultra.15.07012
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Zs.A 1793: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 495: Show issues

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Article ; Online: Comparison of the Safety of Adenosine and Regadenoson in Patients Undergoing Outpatient Cardiac Stress Testing.

Brink, Heidi L / Dickerson, Jennifer A / Stephens, Julie A / Pickworth, Kerry K

Pharmacotherapy

2015 Volume 35, Issue 12, Page(s) 1117–1123

Abstract: Study objective: To compare the adverse effect profiles of adenosine and regadenoson in patients undergoing outpatient cardiac stress testing.: Design: Single-center retrospective cohort study.: Setting: Two outpatient clinics, both of which are ... ...

Abstract	Study objective: To compare the adverse effect profiles of adenosine and regadenoson in patients undergoing outpatient cardiac stress testing. Design: Single-center retrospective cohort study. Setting: Two outpatient clinics, both of which are part of a single tertiary academic medical health system; one clinic exclusively used adenosine for cardiac stress testing, and the other clinic exclusively used regadenoson. Patients: A total of 489 patients who underwent an outpatient cardiac stress test between January 1, 2014, and December 31, 2014; of those patients, 254 received adenosine and 235 received regadenoson. Measurements and main results: Baseline characteristics were similar between groups, except for chronic kidney disease (p<0.001), congestive heart failure (p=0.041), and mean age (p=0.004). The primary outcome was the occurrence of adverse effects-arrhythmia, chest pain or tightness, dizziness, dyspnea, flushing, or headache, and use of the rescue agent aminophylline-in the adenosine and regadenoson groups. A significantly higher proportion of patients who were given regadenoson during cardiac stress testing experienced at least one adverse effect compared with patients who underwent an adenosine stress test (79.6% vs 31.5%, p<0.001). The patients given regadenoson experienced a significantly higher occurrence of arrhythmia (30.6% vs 16.1%, p<0.001), dyspnea (66.0% vs 17.7%, p<0.001), and headache (25.1% vs 3.1%, p<0.001), and they had a significantly higher rate of aminophylline rescue use (19.2% vs 0.8%, p<0.001). A secondary objective evaluated the financial impact of each agent, and adenosine exhibited a medication price that was more than $100/patient lower than regadenoson based on the average wholesale price. Conclusion: Among patients undergoing an outpatient pharmacologic stress test, the use of adenosine was associated with a lower occurrence of adverse effects and lower rate of a rescue agent use and may provide a potential medication cost savings opportunity compared with regadenoson.
MeSH term(s)	Adenosine/administration & dosage ; Adenosine/adverse effects ; Adenosine/pharmacology ; Cohort Studies ; Exercise Test ; Female ; Heart Rate/drug effects ; Humans ; Male ; Middle Aged ; Purines/administration & dosage ; Purines/adverse effects ; Purines/pharmacology ; Pyrazoles/administration & dosage ; Pyrazoles/adverse effects ; Pyrazoles/pharmacology ; Retrospective Studies
Chemical Substances	Purines ; Pyrazoles ; regadenoson (2XLN4Y044H) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1002/phar.1669
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Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Gender-related differences in coronary artery dimensions: a volumetric analysis.

Dickerson, Jennifer A / Nagaraja, Haikady N / Raman, Subha V

Clinical cardiology

2011 Volume 33, Issue 2, Page(s) E44–9

Abstract: Background: Women consistently have poorer revascularization outcomes and more coronary vascular complications compared to men. This has been attributed to smaller coronary arteries, though limited data exist to support this assumption.: Hypothesis: ... ...

Abstract	Background: Women consistently have poorer revascularization outcomes and more coronary vascular complications compared to men. This has been attributed to smaller coronary arteries, though limited data exist to support this assumption. Hypothesis: By using volumetric data obtained from multidetector cardiovascular computed tomography (CCT), we sought to determine to what extent gender influences coronary artery dimensions and test the hypothesis that women would have smaller coronary dimensions even after normalizing for body surface area and cardiac mass. Methods: CCT examinations completed on a 64-slice scanner were identified from a university cardiovascular database. Data sets from 50 women and 44 men without coronary artery disease were selected for analysis. Cross-sectional areas of proximal and distal segments of the left anterior descending (LAD), circumflex (LCx), and right coronary artery (RCA) were measured, blinded to patient gender. Measurements were compared using 2-sample t tests and linear regression analysis techniques accounting for body surface area (BSA) and left ventricular (LV) mass. Results: Analysis of cross-sectional coronary artery areas, unadjusted for BSA and LV mass showed smaller coronary artery size in women compared to men in the proximal portion of both the LAD (P = .01) and RCA (P = .002), but no significant difference in the remaining coronary segments. Conclusion: Gender significantly impacts proximal LAD and RCA size. Differences in coronary artery dimensions may explain some, but not all excess gender-related risk with coronary artery revascularization, underscoring the importance of considering multiple contributing factors.
MeSH term(s)	Adult ; Body Surface Area ; Cardiovascular Diseases/diagnostic imaging ; Coronary Angiography/methods ; Coronary Vessels/pathology ; Female ; Heart Ventricles/pathology ; Humans ; Linear Models ; Male ; Middle Aged ; Predictive Value of Tests ; Sex Factors ; Tomography, X-Ray Computed
Language	English
Publishing date	2011-06-24
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.20509
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Zs.A 1423: Show issues

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Article ; Online: Relationship of cardiac magnetic resonance imaging and myocardial biopsy in the evaluation of nonischemic cardiomyopathy.

Dickerson, Jennifer A / Raman, Subha V / Baker, Peter M / Leier, Carl V

Congestive heart failure (Greenwich, Conn.)

2013 Volume 19, Issue 1, Page(s) 29–38

Abstract: This study was performed to determine the relative role of cardiac magnetic resonance (CMR) imaging and endomyocardial biopsy (EMB) in the evaluation of cardiomyopathy. Sixty-six patients with a clinical diagnosis of nonischemic dilated cardiomyopathy or ...

Abstract	This study was performed to determine the relative role of cardiac magnetic resonance (CMR) imaging and endomyocardial biopsy (EMB) in the evaluation of cardiomyopathy. Sixty-six patients with a clinical diagnosis of nonischemic dilated cardiomyopathy or restrictive cardiomyopathy underwent both EMB and CMR imaging as part of their diagnostic evaluation. The authors retrospectively reviewed the results of these two methods to determine their diagnostic impact and congruency. CMR imaging provided data on cardiac anatomy, left ventricular volumes, mass, and function in 85% of the patients, uncovered fibrosis in 31%, myocardial ischemia in 7%, and fibrofatty infiltration in two patients. EMB provided the histologic findings of cardiomyocyte hypertrophy in 77% of patients and substantial interstitial fibrosis in 59%. Six patients had EMB-proven amyloid heart disease, which was detected by CMR imaging in two. CMR imaging showed patterns of late gadolinium enhancement supportive of infiltrative disease or inflammation in 6 patients with EMB-proven definite (n=3) or borderline (n=3) myocarditis, but failed to do so in two other patients with borderline and two with resolving myocarditis. At the present time, CMR imaging and EMB remain complementary procedures in the evaluation of cardiomyopathic conditions.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy/methods ; Cardiac Catheterization ; Cardiomyopathies/diagnosis ; Female ; Follow-Up Studies ; Humans ; Image Enhancement ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Myocardium/pathology ; Reproducibility of Results ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2013-01
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1239105-0
ISSN	1751-7133 ; 1527-5299 ; 1079-7998
ISSN (online)	1751-7133
ISSN	1527-5299 ; 1079-7998
DOI	10.1111/chf.12003
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Zs.A 4325: Show issues

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Article ; Online: Factors Determining Left Main Coronary Artery Luminal Area.

Boudoulas, Konstantinos Dean / Bittenbender, Peter M / Nagaraja, Haikady N / Kahaly, Omar / Dickerson, Jennifer A / Raman, Subha V / Mazzaferri, Ernest L / Bush, Charles A

The Journal of invasive cardiology

2017 Volume 29, Issue 7, Page(s) 246–249

Abstract: Background: A certain minimal luminal cross-sectional area has been traditionally used in clinical practice as a cut-off value to determine severity of left main coronary artery (LMCA) stenosis. The severity of stenosis, however, depends on the baseline ...

Abstract	Background: A certain minimal luminal cross-sectional area has been traditionally used in clinical practice as a cut-off value to determine severity of left main coronary artery (LMCA) stenosis. The severity of stenosis, however, depends on the baseline luminal area (ie, area prior to stenosis), which may vary among individuals. The present study was undertaken to define normal LMCA luminal area using current technology in vivo. Methods: LMCA luminal area was determined using multislice computed tomography coronary angiography. Eighty-six subjects with normal coronary arteries and calcium score of zero were included in this study. Left ventricular (LV) mass and LV volumes (systolic, diastolic) were also measured. Results: A wide distribution was found in LMCA luminal area, with median value 17.3 mm² and range 8.1-33.9 mm². A relationship was found between log(LMCA luminal area) and log(LV mass) (r=.515; P<.001) and with body surface area (r=.273; P=.01). Significant relationships were also found between LMCA luminal area and LV volumes (systolic, diastolic). In multiple regression analysis, however, the LV mass was the only independent predictor of LMCA luminal area. Conclusion: LMCA luminal area varies substantially among individuals with normal coronary arteries and is related to many other factors. The data suggest that the current practice of using a minimal luminal area cut-off when assessing LMCA stenosis may be misleading, and thus available information should be individualized.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154372-3
ISSN	1557-2501 ; 1042-3931
ISSN (online)	1557-2501
ISSN	1042-3931
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Zs.A 3701: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: 1111 Combined use of real-time cine and first-pass perfusion with dobutamine stress

Simonetti Orlando P / Dickerson Jennifer A / Raman Subha V

Journal of Cardiovascular Magnetic Resonance, Vol 10, Iss Suppl 1, p A

2008 Volume 236

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-10-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia

Dickerson Jennifer A / Raman Subha V / Al-Dahhak Roula

Journal of Cardiovascular Magnetic Resonance, Vol 10, Iss 1, p

2008 Volume 15

Abstract: Abstract We present the first in vivo detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea ... ...

Abstract	Abstract We present the first in vivo detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea prompting referral for cardiac evaluation. These symptoms were reproduced during intravenous adenosine infusion, and simultaneous first-pass perfusion imaging showed a significant subendocardial defect; both symptoms and perfusion deficit were absent at rest. Epicardial coronaries were free of disease by invasive angiography; together, these findings support the notion of impaired myocardial perfusion reserve in FA.
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2008-04-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Myocardial ischemia in the absence of epicardial coronary artery disease in Friedreich's ataxia.

Raman, Subha V / Dickerson, Jennifer A / Al-Dahhak, Roula

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2008 Volume 10, Page(s) 15

Abstract: We present the first in vivo detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea prompting ... ...

Abstract	We present the first in vivo detection of microvascular abnormality in a patient with Friedreich's ataxia (FA) without epicardial coronary artery disease using cardiac magnetic resonance (CMR). The patient had exertional chest pain and dyspnea prompting referral for cardiac evaluation. These symptoms were reproduced during intravenous adenosine infusion, and simultaneous first-pass perfusion imaging showed a significant subendocardial defect; both symptoms and perfusion deficit were absent at rest. Epicardial coronaries were free of disease by invasive angiography; together, these findings support the notion of impaired myocardial perfusion reserve in FA.
MeSH term(s)	Adenosine/administration & dosage ; Adult ; Angina Pectoris/etiology ; Angina Pectoris/pathology ; Coronary Angiography ; Coronary Artery Disease/pathology ; Coronary Circulation ; Dyspnea/etiology ; Dyspnea/pathology ; Female ; Friedreich Ataxia/complications ; Friedreich Ataxia/pathology ; Friedreich Ataxia/physiopathology ; Humans ; Infusions, Intravenous ; Magnetic Resonance Imaging ; Microcirculation/pathology ; Microcirculation/physiopathology ; Myocardial Ischemia/etiology ; Myocardial Ischemia/pathology ; Myocardial Ischemia/physiopathology ; Pericardium/pathology ; Vasodilator Agents/administration & dosage
Chemical Substances	Vasodilator Agents ; Adenosine (K72T3FS567)
Language	English
Publishing date	2008-04-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1186/1532-429X-10-15
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Zs.A 5045: Show issues

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Article ; Online: Lipomatous hypertrophy of the intraatrial septum resulting in right atrial inflow obstruction and atrial flutter.

Dickerson, Jennifer A / Smith, Macy / Kalbfleisch, Steven / Firstenberg, Michael S

The Annals of thoracic surgery

2010 Volume 89, Issue 5, Page(s) 1647–1649

Abstract: Atrial arrhythmias can occasionally be associated with atrial structural abnormalities that may require sophisticated diagnostic imaging for management. Lipomatous hypertrophy of the intraatrial septum is generally considered a benign fatty infiltrative ... ...

Abstract	Atrial arrhythmias can occasionally be associated with atrial structural abnormalities that may require sophisticated diagnostic imaging for management. Lipomatous hypertrophy of the intraatrial septum is generally considered a benign fatty infiltrative process usually limited to the atrial septum. We present a rare case of lipomatous hypertrophy of the intraatrial septum associated with atrial flutter and right atrial inflow obstruction in which atrial reconstruction alleviated not only the obstruction but also helped control a challenging arrhythmia.
MeSH term(s)	Atrial Flutter/etiology ; Atrial Septum/diagnostic imaging ; Atrial Septum/pathology ; Atrial Septum/surgery ; Cardiac Surgical Procedures/methods ; Echocardiography, Transesophageal ; Female ; Follow-Up Studies ; Heart Atria/pathology ; Heart Neoplasms/complications ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Humans ; Hypertrophy/complications ; Hypertrophy/pathology ; Hypertrophy/surgery ; Lipoma/complications ; Lipoma/pathology ; Lipoma/surgery ; Magnetic Resonance Imaging ; Middle Aged ; Risk Assessment ; Treatment Outcome
Language	English
Publishing date	2010-05
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2009.10.001
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Zs.A 252: Show issues

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Article ; Online: In-room treadmill exercise stress cardiac magnetic resonance in patients with suspected ischemic heart disease

Simonetti Orlando P / Foster Eric L / Dickerson Jennifer A / Jekic Mihaela / Raman Subha V

Journal of Cardiovascular Magnetic Resonance, Vol 11, Iss Suppl 1, p O

2009 Volume 40

Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2009-01-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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