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  1. Article ; Online: In the Clear: Long-term pulmonary function benefits associated with Pseudomonas aeruginosa eradication.

    Dickinson, Kimberly M / Mogayzel, Peter J

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 22, Issue 1, Page(s) 7–8

    MeSH term(s) Humans ; Pseudomonas aeruginosa ; Cystic Fibrosis/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Tobramycin ; Pseudomonas Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Tobramycin (VZ8RRZ51VK)
    Language English
    Publishing date 2022-10-17
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2023.01.009
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  2. Article ; Online: Cystic Fibrosis.

    Dickinson, Kimberly M / Collaco, Joseph M

    Pediatrics in review

    2021  Volume 42, Issue 2, Page(s) 55–67

    Abstract: Cystic fibrosis (CF) is one of the most commonly diagnosed genetic disorders. Clinical characteristics include progressive obstructive lung disease, sinusitis, exocrine pancreatic insufficiency leading to malabsorption and malnutrition, liver and ... ...

    Abstract Cystic fibrosis (CF) is one of the most commonly diagnosed genetic disorders. Clinical characteristics include progressive obstructive lung disease, sinusitis, exocrine pancreatic insufficiency leading to malabsorption and malnutrition, liver and pancreatic dysfunction, and male infertility. Although CF is a life-shortening disease, survival has continued to improve to a median age of 46.2 years due to earlier diagnosis through routine newborn screening, promulgation of evidence-based guidelines to optimize nutritional and pulmonary health, and the development of CF-specific interdisciplinary care centers. Future improvements in health and quality of life for individuals with CF are likely with the recent development of mutation-specific modulator therapies. In this review, we will cover the current understanding of the disease manifestations, diagnosis, and management as well as common complications seen in individuals with CF.
    MeSH term(s) Bone Density ; Child ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/genetics ; Cystic Fibrosis/therapy ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Humans ; Infant ; Infant, Newborn ; Liver Diseases/etiology ; Lung/diagnostic imaging ; Lung Transplantation ; Male ; Respiratory Tract Infections/etiology ; Trypsinogen/blood ; Vitamins/therapeutic use
    Chemical Substances CFTR protein, human ; Vitamins ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Trypsinogen (9002-08-8)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2019-0212
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  3. Article ; Online: Early life growth trajectories in cystic fibrosis are associated with lung function at age six.

    Psoter, Kevin J / Dickinson, Kimberly M / Riekert, Kristin A / Collaco, Joseph M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2023  Volume 22, Issue 3, Page(s) 395–401

    Abstract: Background: Higher growth percentiles are associated with more favorable lung function in cystic fibrosis (CF), prompting the creation of CF Foundation (CFF) nutritional guidelines.: Objectives: To describe early childhood growth trajectories within ... ...

    Abstract Background: Higher growth percentiles are associated with more favorable lung function in cystic fibrosis (CF), prompting the creation of CF Foundation (CFF) nutritional guidelines.
    Objectives: To describe early childhood growth trajectories within CF, to determine if growth trajectories are associated with differences in lung function at age six, and to identify factors that differ between trajectory groups.
    Methods: Retrospective cohort study of children diagnosed with CF and born 2000-2011 using the US CFF Patient Registry. Annualized growth parameters prior to age six were included in group-based trajectory modeling to identify unique early life growth trajectories. FEV1 percent predicted (FEV1pp) at age six was compared between trajectory groups using linear regression. Factors associated with group membership were identified using multinomial logistic regression.
    Results: 6,809 children met inclusion criteria. Six discrete growth trajectories were identified, including three groups that began with growth parameters >50th percentile, termed: "always high", "gradual decliner", "rapid decliner", and three which began with growth parameters <50th percentile, termed: "rapid riser", "gradual riser", "always low". FEV1pp at age six was highest for the Always High trajectory. The Always Low trajectory was nearly 10% lower than the Always High trajectory. Sex, ethnicity, newborn screening and pancreatic function were associated with trajectory class membership.
    Conclusions: Distinct early life growth trajectories were identified within CF. Trajectories that met CFF nutritional guideline recommendations were associated with higher FEV1pp at age six. CF care teams should continue to partner with families to encourage interventions to support optimal growth to improve lung function in CF.
    MeSH term(s) Child ; Infant, Newborn ; Humans ; Child, Preschool ; Cystic Fibrosis/complications ; Cystic Fibrosis/diagnosis ; Retrospective Studies ; Respiratory Function Tests ; Neonatal Screening ; Lung
    Language English
    Publishing date 2023-02-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2023.02.008
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  4. Article ; Online: An emotional journey: caregiver experiences with gastrostomy tube decision-making for children with cystic fibrosis.

    Dickinson, Kimberly M / Smith, Brandon M / Green, Deanna M / Nasr, Samya / Sawicki, Gregory S / Schechter, Michael S / Riekert, Kristin A

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2024  

    Abstract: Background: Nutritional challenges are common in early CF care and stressful for caregivers of children with CF (cwCF) to navigate. Gastrostomy tube (G-tube) placement can improve weight gain, however the decision to proceed with placement is ... ...

    Abstract Background: Nutritional challenges are common in early CF care and stressful for caregivers of children with CF (cwCF) to navigate. Gastrostomy tube (G-tube) placement can improve weight gain, however the decision to proceed with placement is personalized and preference-sensitive. Little is known about the experiences of caregivers of cwCF and the G-tube decision-making process.
    Objectives: The present study used a qualitative approach to explore the perceptions and experiences of caregivers of cwCF with G-tube introductions and recommendations, as well as factors influencing G-tube decision-making.
    Methods: Caregivers of cwCF aged ≤ 10 years completed audio-taped, semi-structured interviews describing their experiences with G-tube placement discussions. Interviews were transcribed and two independent researchers coded the transcripts and conducted content and thematic analysis using an inductive approach.
    Results: Participants included 43 caregivers, 84 % were mothers (36/43). CwCF had a mean age of 4 years (SD=2.6), 84 % were White (36/43), and 60 % reported weights below <50th percentile (26/43). All caregivers knew about G-tubes, 44 % (19/43) were recommended a G-tube and 35 % (15/43) had a G-tube placed. Major findings included descriptions of the stages of G-tube decision-making from a heads up, to the game plan, to making a first difficult decision and finally living with the decision to pursue G-tube placement.
    Conclusion: G-tube decision-making is an emotional and personalized journey for caregivers of cwCF. Efforts to explore the values and priorities of caregivers is imperative to supporting families making difficult decisions in CF care.
    Language English
    Publishing date 2024-02-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2024.01.007
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  5. Article ; Online: Factors guiding gastrostomy tube decision-making for caregivers of children with cystic fibrosis: a scoping review protocol.

    Zientek, Emily / Rane, Sanika / Godfrey, Chelsea / Sisson, Amy / Dickinson, Kimberly M

    BMJ open

    2023  Volume 13, Issue 12, Page(s) e076539

    Abstract: Introduction: While ensuring appropriate growth is essential for all children, optimising nutritional status in children with cystic fibrosis (CF) is critical for improving health outcomes. Nutritional challenges in CF are multifactorial and ... ...

    Abstract Introduction: While ensuring appropriate growth is essential for all children, optimising nutritional status in children with cystic fibrosis (CF) is critical for improving health outcomes. Nutritional challenges in CF are multifactorial and malnutrition is common. While gastrostomy tubes (G-tubes) can improve weight status in individuals with CF, they also have common and chronic complications resulting in clinical equipoise. To date, factors influencing G-tube decision-making among caregivers of children with CF have not been systematically explored. This review aims to chart existing knowledge about caregivers' decisional needs related to G-tube placement, with a focus on caregivers of children with CF, as well as known medical and psychosocial benefits and risks of G-tube feedings in paediatric care.
    Methods and analysis: This scoping review will follow the JBI methodological framework. We will include articles published between 1 January 1985 and 1 November 2023 in English and Spanish from MEDLINE (Ovid), Embase, CINAHL, PsycInfo, Cochrane Database of Systematic Reviews and Web of Science related to G-tube decision-making. Articles published in languages besides English and Spanish will be excluded. Articles will be screened for final eligibility and inclusion according to title and abstract, followed by full texts. Articles will be independently reviewed by two reviewers and any disagreements discussed with a third reviewer for consensus. We will map themes and concepts, and data extracted will be presented in tabular, diagrams and descriptive summaries.
    Ethics and dissemination: As a form of secondary analysis, scoping reviews do not require ethics approval. This review will inform future research with caregivers involved in G-tube decision-making for children with CF. The final review will be submitted to a peer-reviewed scientific journal, disseminated at relevant academic conferences and will be shared with patients and clinicians.
    Trial registration number: Center for Open Science. https://osf.io/g4pdb.
    MeSH term(s) Child ; Humans ; Gastrostomy ; Cystic Fibrosis/complications ; Cystic Fibrosis/therapy ; Caregivers ; Systematic Reviews as Topic ; Consensus ; Research Design ; Review Literature as Topic
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-076539
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  6. Article ; Online: Association between insurance variability and early lung function in children with cystic fibrosis.

    Dickinson, Kimberly M / Psoter, Kevin J / Riekert, Kristin A / Collaco, Joseph M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2021  Volume 21, Issue 1, Page(s) 104–110

    Abstract: Background: Lower socioeconomic status (SES) has consistently been associated with poorer outcomes in individuals with cystic fibrosis (CF). Previous studies have compared outcomes for children with and without private insurance coverage, however the ... ...

    Abstract Background: Lower socioeconomic status (SES) has consistently been associated with poorer outcomes in individuals with cystic fibrosis (CF). Previous studies have compared outcomes for children with and without private insurance coverage, however the potential role of changes in insurance status on early health outcomes in children with CF remains unknown.
    Objectives: To describe the variability in insurance status in early childhood and to evaluate whether insurance variability was associated with poorer outcomes at age 6.
    Methods: Retrospective observational study using the Cystic Fibrosis Foundation Patient Registry. Insurance status was defined as: always private (including Tricare), exclusively public, or intermittent private insurance (private insurance and exclusively public insurance in separate years) during the first 6 years of life. Outcomes at age 6 included body mass index (BMI) and FEV
    Results: From a 2000-2011 birth cohort (n = 8,109), 42.3% always had private insurance, 30.0% had exclusively public insurance, and 27.6% had intermittent private insurance. BMI percentiles did not differ between groups; however, children with intermittent private insurance and exclusively public insurance had a 3.3% and 6.6% lower maxFEV
    Conclusions: A substantial proportion of young children in a modern CF cohort have public or intermittent private insurance coverage. While public insurance has been associated with poorer health outcomes in CF, variability in health insurance coverage may also be associated with an intermediate risk of disparities in lung function as early as age 6.
    MeSH term(s) Body Mass Index ; Child ; Cystic Fibrosis/physiopathology ; Cystic Fibrosis/therapy ; Female ; Health Equity ; Humans ; Insurance Coverage/statistics & numerical data ; Male ; Nutritional Status ; Registries ; Respiratory Function Tests ; Retrospective Studies ; Risk Factors ; Social Determinants of Health
    Language English
    Publishing date 2021-06-24
    Publishing country Netherlands
    Document type Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2021.06.006
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  7. Article ; Online: Clinical outcomes in cystic fibrosis at 6 years of age with tricare insurance coverage.

    Collaco, Joseph M / Vanscoy, Lori L / Psoter, Kevin J / Riekert, Kristin A / Dickinson, Kimberly M

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 21, Issue 6, Page(s) 984–987

    Abstract: Health insurance coverage is associated with outcomes in cystic fibrosis (CF). A fraction of individuals in the United States are covered through Tricare, a federally funded program for military members and their dependents. The role of Tricare on CF ... ...

    Abstract Health insurance coverage is associated with outcomes in cystic fibrosis (CF). A fraction of individuals in the United States are covered through Tricare, a federally funded program for military members and their dependents. The role of Tricare on CF health outcomes is unknown. Using a retrospective CF Foundation Patient Registry cohort born 2000-2011, insurance status was defined as any Tricare (n = 328) with reference groups of always private (n = 3,455) and exclusively public (n = 2,669) during the first 6 years of life. Subjects with Tricare coverage attended more CF care centers and lived in more zip codes by age 6 than their counterparts. BMI did not differ between groups. Subjects with Tricare had a higher FEV
    MeSH term(s) United States/epidemiology ; Humans ; Child ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/epidemiology ; Cystic Fibrosis/therapy ; Retrospective Studies ; Insurance Coverage
    Language English
    Publishing date 2022-02-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.02.004
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  8. Article: Atypical Altered Mental Status in a Toddler.

    Dickinson, Kimberly M / Smith, Brandon / Raees, Madiha / Hofert, Sheila

    Hospital pediatrics

    2017  Volume 7, Issue 10, Page(s) 621–625

    MeSH term(s) Accidents, Home ; Antipsychotic Agents/poisoning ; Aripiprazole/poisoning ; Child, Preschool ; Female ; Humans ; Mental Disorders/chemically induced ; Mental Disorders/diagnosis
    Chemical Substances Antipsychotic Agents ; Aripiprazole (82VFR53I78)
    Language English
    Publishing date 2017-09-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2154-1663
    ISSN 2154-1663
    DOI 10.1542/hpeds.2016-0200
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