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  1. Article ; Online: Progressive supranuclear palsy can mimic idiopathic normal pressure hydrocephalus: A case series.

    Kawazoe, Miki / Koga, Shunsuke / Dickson, Dennis W

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 12, Page(s) 1033–1036

    MeSH term(s) Humans ; Supranuclear Palsy, Progressive/diagnosis ; Hydrocephalus, Normal Pressure/diagnosis
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad090
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  2. Article ; Online: Comments on an autopsy case of progressive supranuclear palsy treated with monoclonal antibody against tau.

    Koga, Shunsuke / Dickson, Dennis W / Wszolek, Zbigniew K

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2023  Volume 43, Issue 6, Page(s) 500–502

    MeSH term(s) Humans ; Supranuclear Palsy, Progressive/pathology ; Antibodies, Monoclonal/therapeutic use ; Autopsy ; tau Proteins
    Chemical Substances Antibodies, Monoclonal ; tau Proteins
    Language English
    Publishing date 2023-05-16
    Publishing country Australia
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1111/neup.12910
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  3. Article ; Online: Evaluating the performance of large language models: ChatGPT and Google Bard in generating differential diagnoses in clinicopathological conferences of neurodegenerative disorders.

    Koga, Shunsuke / Martin, Nicholas B / Dickson, Dennis W

    Brain pathology (Zurich, Switzerland)

    2023  Volume 34, Issue 3, Page(s) e13207

    Abstract: This study explores the utility of the large language models (LLMs), specifically ChatGPT and Google Bard, in predicting neuropathologic diagnoses from clinical summaries. A total of 25 cases of neurodegenerative disorders presented at Mayo Clinic brain ... ...

    Abstract This study explores the utility of the large language models (LLMs), specifically ChatGPT and Google Bard, in predicting neuropathologic diagnoses from clinical summaries. A total of 25 cases of neurodegenerative disorders presented at Mayo Clinic brain bank Clinico-Pathological Conferences were analyzed. The LLMs provided multiple pathologic diagnoses and their rationales, which were compared with the final clinical diagnoses made by physicians. ChatGPT-3.5, ChatGPT-4, and Google Bard correctly made primary diagnoses in 32%, 52%, and 40% of cases, respectively, while correct diagnoses were included in 76%, 84%, and 76% of cases, respectively. These findings highlight the potential of artificial intelligence tools like ChatGPT in neuropathology, suggesting they may facilitate more comprehensive discussions in clinicopathological conferences.
    MeSH term(s) Humans ; Diagnosis, Differential ; Artificial Intelligence ; Search Engine ; Neurodegenerative Diseases/diagnosis ; Language
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 1051484-3
    ISSN 1750-3639 ; 1015-6305
    ISSN (online) 1750-3639
    ISSN 1015-6305
    DOI 10.1111/bpa.13207
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  4. Book: Neurodegeneration

    Dickson, Dennis W. / Weller, Roy O.

    the molecular pathology of dementia and movement disorders

    2011  

    Institution International Society of Neuropathology
    Author's details ed. by Dennis W. Dickson ; Roy O. Weller. The International Society of neuropathology
    Keywords Neurodegenerative Diseases ; Dementia / pathology ; Movement Disorders / pathology
    Language English
    Size XVII, 477 S. : zahlr. Ill., graph. Darst.
    Edition 2. ed.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017035208
    ISBN 978-1-4051-9693-2 ; 1-4051-9693-9 ; 9781444341256 ; 9781444341225 ; 1444341251 ; 1444341227
    Database Catalogue ZB MED Medicine, Health

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    2011 A 4809 order for loan Magazin

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  5. Article ; Online: Neuropathology of Parkinson disease.

    Dickson, Dennis W

    Parkinsonism & related disorders

    2017  Volume 46 Suppl 1, Page(s) S30–S33

    Abstract: Introduction: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein ( ...

    Abstract Introduction: Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD.
    Methods: The neuropathologic features of PD are reviewed based upon personal experience and review of the literature. Molecular pathology of PD is summarized from cell biological and animal studies.
    Results: The pathologic feature that correlates with signs and symptoms of PD is neuronal loss in the substantia nigra with dopaminergic denervation of the striatum. Neuronal degeneration in the substantia nigra preferentially affects the ventrolateral cell group that projects to posterolateral putamen and is accompanied by formation of Lewy bodies composed of aggregated α-synuclein. Some patients with PD are found at autopsy to have other pathologic processes, such as multiple system atrophy, progressive supranuclear palsy and cerebrovascular disease (vascular Parkinsonism). The peripheral autonomic nervous system is also affected. The triggering event in PD is unknown, but recent studies suggest a role for loss of nuclear membrane integrity. Once α-synuclein aggregates forms, evidence supports cell-to-cell propagation.
    Conclusion: PD is a multisystem synucleinopathy caused by poorly characterized genetic and environmental factors that produces degeneration in selectively vulnerable neuronal populations.
    MeSH term(s) Brain/pathology ; Humans ; Neuropathology ; Parkinson Disease/pathology
    Language English
    Publishing date 2017-08-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2017.07.033
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  6. Article ; Online: Globular glial tauopathy presenting clinically as atypical parkinsonism with dementia: A clinicopathological case report.

    Hoag, Thomas / Koga, Shunsuke / Dickson, Dennis W / Kumar, Rajeev

    Clinical parkinsonism & related disorders

    2023  Volume 9, Page(s) 100210

    Abstract: Globular Glial Tauopathy presents as atypical parkinsonism with dementia.•Globular Glial Tauopathy is underrecognized among movement disorders specialists.•Globular Glial Tauopathy type III without preferential language dysfunction or semantic dementia. ...

    Abstract •Globular Glial Tauopathy presents as atypical parkinsonism with dementia.•Globular Glial Tauopathy is underrecognized among movement disorders specialists.•Globular Glial Tauopathy type III without preferential language dysfunction or semantic dementia.
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Case Reports
    ISSN 2590-1125
    ISSN (online) 2590-1125
    DOI 10.1016/j.prdoa.2023.100210
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  7. Article ; Online: Report of A Family with Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP) Without Mutations in

    Dulski, Jarosław / Koga, Shunsuke / Dickson, Dennis W / Wszolek, Zbigniew K

    Movement disorders clinical practice

    2023  Volume 10, Issue 2, Page(s) 307–312

    Abstract: Background: Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare neurodegenerative disorder with characteristic clinicopathological features. Identification of pathogenic mutations in : Objectives: This paper ... ...

    Abstract Background: Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare neurodegenerative disorder with characteristic clinicopathological features. Identification of pathogenic mutations in
    Objectives: This paper presents the first family with typical clinical, radiological, and pathological features of ALSP, yet negative for
    Methods: The index case was a 30-year-old male who presented with gait difficulty, followed by cognitive decline and incontinence.
    Results: Neurological examination evidenced progressive dementia, dysarthria, spasticity, parkinsonism, and severe gait disturbances. Brain MRI showed confluent white matter abnormalities with scattered foci of restricted diffusion, and atrophy of the corpus callosum. He was suspected of ALSP; however, the extensive genetic work-up did not find pathogenic mutation. He died at 33 years, and brain autopsy was performed. He had myelin staining pallor and axonal swellings, spheroids, and pigmented glia in affected white matter. His father developed similar symptoms in his early 40s and died at 46 years. Neuropathological examination also confirmed ALSP diagnosis. We found two similar cases in the literature with typical ALSP features but negative for
    Conclusions: We draw attention to a new entity within the ALSP disease spectrum that needs further investigation. As the disease-modifying therapy is already available for ALSP-
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13650
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  8. Article ; Online: The frequency and distribution of TDP-43 pathology in argyrophilic grain disease.

    Koga, Shunsuke / Murakami, Aya / Martin, Nicholas B / Dickson, Dennis W

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 8, Page(s) 739–741

    MeSH term(s) Humans ; Alzheimer Disease/pathology ; DNA-Binding Proteins/metabolism ; tau Proteins/metabolism ; Brain/pathology
    Chemical Substances DNA-Binding Proteins ; tau Proteins
    Language English
    Publishing date 2023-06-18
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad042
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  9. Article ; Online: Asymmetrical Primary Lateral Sclerosis Presenting as Corticobasal Syndrome.

    Murakami, Aya / Koga, Shunsuke / Dickson, Dennis W

    Journal of neuropathology and experimental neurology

    2022  Volume 81, Issue 2, Page(s) 154–156

    MeSH term(s) Aged ; Brain/pathology ; Corticobasal Degeneration/etiology ; Female ; Humans ; Motor Neuron Disease/complications ; Motor Neuron Disease/pathology
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Case Reports ; Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlab104
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  10. Article ; Online: Diffuse Lewy body disease presenting as Parkinson's disease with progressive aphasia.

    Koga, Shunsuke / Murakami, Aya / Josephs, Keith A / Dickson, Dennis W

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2022  Volume 42, Issue 1, Page(s) 82–89

    Abstract: Primary progressive aphasia (PPA) is a progressive language disorder often due to an underlying neurodegenerative disease. The most common pathologies associated with PPA include frontotemporal lobar degeneration (FTLD)-tau, FTLD-associated with ... ...

    Abstract Primary progressive aphasia (PPA) is a progressive language disorder often due to an underlying neurodegenerative disease. The most common pathologies associated with PPA include frontotemporal lobar degeneration (FTLD)-tau, FTLD-associated with transactivation response DNA-binding protein of 43 kDa (TDP-43) (FTLD-TDP), and Alzheimer's disease (AD). Accumulating evidence has suggested that Lewy body disease (LBD) can also be associated with PPA. We herein report a 78-year-old Caucasian woman who initially presented with levodopa-responsive parkinsonism at age 67 and later developed cognitive impairment, visual hallucinations, rapid eye movement sleep behavior disorder, and progressive aphasia, characterized by reduced spontaneous speech, word-finding difficulty, and difficulties in writing and reading.
    MeSH term(s) Aged ; Alzheimer Disease ; Aphasia, Primary Progressive ; Female ; Humans ; Lewy Body Disease/complications ; Neurodegenerative Diseases ; Parkinson Disease
    Language English
    Publishing date 2022-01-13
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1111/neup.12780
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