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  1. Book: Signal transduction protocols

    Dickson, Robert C.

    (Methods in molecular biology ; 284)

    2004  

    Author's details ed. by Robert C. Dickson
    Series title Methods in molecular biology ; 284
    Collection
    Keywords GTP-Binding Proteins / analysis ; Signal Transduction / physiology ; Signaltransduktion ; Labortechnik
    Subject Laboratorium ; Laboratoriumstechnik ; Labormethode ; Signalübertragung ; Signalvermittlung
    Language English
    Size XII, 327 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014066393
    ISBN 1-58829-245-2 ; 978-1-58829-245-2
    Database Catalogue ZB MED Medicine, Health

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    2004 A 5166

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  2. Article ; Online: Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion.

    Hepowit, Nathaniel L / Moon, Bradley / Ebert, Adam C / Dickson, Robert C / MacGurn, Jason A

    Journal of cell science

    2023  Volume 136, Issue 14

    Abstract: Accumulating evidence in several model organisms indicates that reduced sphingolipid biosynthesis promotes longevity, although underlying mechanisms remain unclear. In yeast, sphingolipid depletion induces a state resembling amino acid restriction, which ...

    Abstract Accumulating evidence in several model organisms indicates that reduced sphingolipid biosynthesis promotes longevity, although underlying mechanisms remain unclear. In yeast, sphingolipid depletion induces a state resembling amino acid restriction, which we hypothesized might be due to altered stability of amino acid transporters at the plasma membrane. To test this, we measured surface abundance for a diverse panel of membrane proteins in the presence of myriocin, a sphingolipid biosynthesis inhibitor, in Saccharomyces cerevisiae. Unexpectedly, we found that surface levels of most proteins examined were either unaffected or increased during myriocin treatment, consistent with an observed decrease in bulk endocytosis. In contrast, sphingolipid depletion triggered selective endocytosis of the methionine transporter Mup1. Unlike methionine-induced Mup1 endocytosis, myriocin triggered Mup1 endocytosis that required the Rsp5 adaptor Art2, C-terminal lysine residues of Mup1 and the formation of K63-linked ubiquitin polymers. These findings reveal cellular adaptation to sphingolipid depletion by ubiquitin-mediated remodeling of nutrient transporter composition at the cell surface.
    MeSH term(s) Endocytosis ; Endosomal Sorting Complexes Required for Transport/metabolism ; Methionine/metabolism ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Sphingolipids/metabolism ; Ubiquitin/metabolism ; Ubiquitination
    Chemical Substances Endosomal Sorting Complexes Required for Transport ; Methionine (AE28F7PNPL) ; Saccharomyces cerevisiae Proteins ; Sphingolipids ; Ubiquitin ; Ecm21 protein, S cerevisiae
    Language English
    Publishing date 2023-07-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2993-2
    ISSN 1477-9137 ; 0021-9533
    ISSN (online) 1477-9137
    ISSN 0021-9533
    DOI 10.1242/jcs.260675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Not all diclofenac is equal.

    Dickson, Robert C

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2013  Volume 185, Issue 8, Page(s) 687

    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Cardiovascular Diseases/chemically induced ; Cross Infection/chemically induced ; Diclofenac/adverse effects ; Enterocolitis, Pseudomembranous/chemically induced ; Humans
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Diclofenac (144O8QL0L1)
    Language English
    Publishing date 2013-06-20
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.113-2117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reduced sphingolipid biosynthesis modulates proteostasis networks to enhance longevity.

    Hepowit, Nathaniel L / Blalock, Eric / Lee, Sangderk / Bretland, Kimberly M / MacGurn, Jason A / Dickson, Robert C

    Aging

    2023  Volume 15, Issue 2, Page(s) 472–491

    Abstract: As the elderly population increases, chronic, age-associated diseases are challenging healthcare systems around the world. Nutrient limitation is well known to slow the aging process and improve health. Regrettably, practicing nutrient restriction to ... ...

    Abstract As the elderly population increases, chronic, age-associated diseases are challenging healthcare systems around the world. Nutrient limitation is well known to slow the aging process and improve health. Regrettably, practicing nutrient restriction to improve health is unachievable for most people. Alternatively, pharmacological strategies are being pursued including myriocin which increases lifespan in budding yeast. Myriocin impairs sphingolipid synthesis, resulting in lowered amino acid pools which promote entry into a quiescent, long-lived state. Here we present transcriptomic data during the first 6 hours of drug treatment that improves our mechanistic understanding of the cellular response to myriocin and reveals a new role for ubiquitin in longevity. Previously we found that the methionine transporter Mup1 traffics to the plasma membrane normally in myriocin-treated cells but is not active and undergoes endocytic clearance. We now show that
    MeSH term(s) Aged ; Humans ; Longevity/genetics ; Proteostasis ; Aging ; Ubiquitin/metabolism ; Sphingolipids/metabolism
    Chemical Substances Ubiquitin ; Sphingolipids
    Language English
    Publishing date 2023-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204485
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  5. Article ; Online: February cover.

    Dickson, Robert C

    Canadian family physician Medecin de famille canadien

    2010  Volume 56, Issue 4, Page(s) 329; author reply 330

    MeSH term(s) Albuterol/administration & dosage ; Anisocoria/pathology ; Bronchodilator Agents/administration & dosage ; Child ; Humans ; Male ; Metered Dose Inhalers ; Strabismus
    Chemical Substances Bronchodilator Agents ; Albuterol (QF8SVZ843E)
    Language English
    Publishing date 2010-04-14
    Publishing country Canada
    Document type Letter
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
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  6. Article ; Online: Predicting spinel solid solutions using a random atom substitution method.

    Dickson, Robert C / Manning, Troy D / Raj, Edwin S / Booth, Jonathan C S / Rosseinsky, Matthew J / Dyer, Matthew S

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 26, Page(s) 16374–16387

    Abstract: Exploration of chemical composition and structural configuration space is the central problem in crystal structure prediction. Even in limiting structure space to a single structure type, many different compositions and configurations are possible. In ... ...

    Abstract Exploration of chemical composition and structural configuration space is the central problem in crystal structure prediction. Even in limiting structure space to a single structure type, many different compositions and configurations are possible. In this work, we attempt to address this problem using an extension to the existing ChemDASH code in which variable compositions can be explored. We show that ChemDASH is an efficient method for exploring a fixed-composition space of spinel structures and build upon this to include variable compositions in the Mn-Fe-Zn-O spinel phase field. This work presents the first basin-hopping crystal structure prediction method that can explore variable compositions.
    Language English
    Publishing date 2022-07-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp02180c
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  7. Article: Roles for sphingolipids in Saccharomyces cerevisiae.

    Dickson, Robert C

    Advances in experimental medicine and biology

    2009  Volume 688, Page(s) 217–231

    Abstract: Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete ... ...

    Abstract Studies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have progressed over the past twenty years from knowing which sphingolipids are present in cells and a basic outline of how they are made to a complete or nearly complete directory of the genes that catalyze their anabolism and catabolism. In addition, cellular processes that depend upon sphingolipids have been identified including protein trafficking/exocytosis, endocytosis and actin cytoskeleton dynamics, membrane microdomains, calcium signaling, regulation of transcription and translation, cell cycle control, stress resistance, nutrient uptake and aging. These will be summarized here along with new data not previously reviewed. Advances in our knowledge of sphingolipids and their roles in yeast are impressive but molecular mechanisms remain elusive and are a primary challenge for further progress in understanding the specific functions of sphingolipids.
    MeSH term(s) Apoptosis/physiology ; Genes, Fungal ; Models, Biological ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction/physiology ; Sphingolipids/biosynthesis ; Sphingolipids/metabolism
    Chemical Substances Sphingolipids
    Language English
    Publishing date 2009-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-1-4419-6741-1_15
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    Einzelsignatur: Show issues

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  8. Article ; Online: A reader and author respond to "The top ten unfounded health scares of the year".

    Dickson, Robert C

    Medscape journal of medicine

    2008  Volume 10, Issue 4, Page(s) 94; author reply 94

    MeSH term(s) Attitude to Health ; Evidence-Based Medicine ; Health Education ; Public Opinion ; United States
    Language English
    Publishing date 2008-04-18
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2624206-0
    ISSN 1934-1997 ; 1934-1997
    ISSN (online) 1934-1997
    ISSN 1934-1997
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  9. Article ; Online: Common sense is not that common.

    Dickson, Robert C

    Canadian family physician Medecin de famille canadien

    2008  Volume 54, Issue 5, Page(s) 681

    MeSH term(s) Clinical Competence ; Complementary Therapies ; Evidence-Based Medicine ; Humans
    Language English
    Publishing date 2008-05-12
    Publishing country Canada
    Document type Comment ; Letter
    ZDB-ID 603565-6
    ISSN 1715-5258 ; 0008-350X
    ISSN (online) 1715-5258
    ISSN 0008-350X
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  10. Article: Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast.

    Dickson, Robert C

    Journal of lipid research

    2008  Volume 49, Issue 5, Page(s) 909–921

    Abstract: Our understanding of sphingolipid metabolism and functions in the baker's yeast Saccharomyces cerevisiae has progressed substantially in the past 2 years. Yeast sphingolipids contain a C26-acyl moiety, all of the genes necessary to make these long-chain ... ...

    Abstract Our understanding of sphingolipid metabolism and functions in the baker's yeast Saccharomyces cerevisiae has progressed substantially in the past 2 years. Yeast sphingolipids contain a C26-acyl moiety, all of the genes necessary to make these long-chain fatty acids have been identified, and a mechanism for how chain length is determined has been proposed. Advances in understanding how the de novo synthesis of ceramide and complex sphingolipids is regulated have been made, and they demonstrate that the Target Of Rapamycin Complex 2 (TORC2) controls ceramide synthase activity. Other work shows that TORC2 regulates the level of complex sphingolipids in a pathway using the Slm1 and Slm2 proteins to control the protein phosphatase calcineurin, which regulates the breakdown of complex sphingolipids. The activity of Slm1 and Slm2 has also been shown to be regulated during heat stress by phosphoinositides and TORC2, along with sphingoid long-chain bases and the Pkh1 and Pkh2 protein kinases, to control the actin cytoskeleton, the trafficking of nutrient transporters, and cell viability. Together, these results provide the first molecular insights into understanding previous genetic interaction data that indicated a connection between sphingolipids and the TORC2 and phosphoinositide signaling networks. This new knowledge provides a foundation for greatly advancing our understanding of sphingolipid biology in yeast.
    MeSH term(s) Cell Death ; Cell Movement ; Ceramides/metabolism ; Endoplasmic Reticulum/metabolism ; Golgi Apparatus/metabolism ; Humans ; Inflammation ; Liposomes ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Sphingolipids/biosynthesis ; Sphingolipids/metabolism
    Chemical Substances Ceramides ; Liposomes ; Sphingolipids
    Language English
    Publishing date 2008-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.R800003-JLR200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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