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Article ; Online: Elongation and branching of α-olefins by two ethylene molecules.

Dietel, Thomas / Lukas, Fabian / Kretschmer, Winfried P / Kempe, Rhett

2022 Volume 375, Issue 6584, Page(s) 1021–1024

Abstract: α-Olefins are important starting materials for the production of plastics, pharmaceuticals, and fine and bulk chemicals. However, the selective synthesis of α-olefins from ethylene, a highly abundant and inexpensive feedstock, is restricted, and thus a ... ...

Abstract	α-Olefins are important starting materials for the production of plastics, pharmaceuticals, and fine and bulk chemicals. However, the selective synthesis of α-olefins from ethylene, a highly abundant and inexpensive feedstock, is restricted, and thus a broadly applicable selective α-olefin synthesis using ethylene is highly desirable. Here, we report the catalytic reaction of an α-olefin with two ethylene molecules. The first ethylene molecule forms a 4-ethyl branch and the second a new terminal carbon-carbon double bond (C2 elongation). The key to this reaction is the development of a highly active and stable molecular titanium catalyst that undergoes extremely fast β-hydride elimination and transfer.
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abm5281
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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Article ; Online: Formation of a dimeric tungsten(i) complex via C-H activation.

Noor, Awal / Qayyum, Sadaf / Schwarz, Stefan / Dietel, Thomas / Kempe, Rhett

Dalton transactions (Cambridge, England : 2003)

2020 Volume 49, Issue 6, Page(s) 1992–1996

Abstract: An aminopyridinato ligand stabilized and coordinatively unsaturated dimeric tungsten(0) complex having an electronic structure with six metal centred HOMOs ( ... ...

Abstract	An aminopyridinato ligand stabilized and coordinatively unsaturated dimeric tungsten(0) complex having an electronic structure with six metal centred HOMOs (σ
Language	English
Publishing date	2020-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c9dt04847b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synthesis, structures and cytotoxic effects in vitro of cis- and trans-[Pt

Rehm, Tobias / Rothemund, Matthias / Dietel, Thomas / Kempe, Rhett / Schobert, Rainer

Dalton transactions (Cambridge, England : 2003)

2019 Volume 48, Issue 43, Page(s) 16358–16365

Abstract: Four new bis(N,N-dialkylbenzimidazol-2-ylidene)dichlorido platinum(ii) complexes 2 featuring N-alkyl substituents of increasing size (a: Me, b: Et, c: n-butyl, d: n-octyl) were synthesised and oxidised with ... ...

Abstract	Four new bis(N,N-dialkylbenzimidazol-2-ylidene)dichlorido platinum(ii) complexes 2 featuring N-alkyl substituents of increasing size (a: Me, b: Et, c: n-butyl, d: n-octyl) were synthesised and oxidised with PhICl
Language	English
Publishing date	2019-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c9dt02438g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Manganese-Catalyzed Dehydrogenative Alkylation or α-Olefination of Alkyl-Substituted N-Heteroarenes with Alcohols.

Zhang, Guoying / Irrgang, Torsten / Dietel, Thomas / Kallmeier, Fabian / Kempe, Rhett

Angewandte Chemie (International ed. in English)

2018 Volume 57, Issue 29, Page(s) 9131–9135

Abstract: Catalysis with earth-abundant transition metals is an option to help save our rare noble-metal resources and is especially interesting when novel reactivity or selectivity patterns are observed. We report here on a novel reaction, namely the ... ...

Abstract	Catalysis with earth-abundant transition metals is an option to help save our rare noble-metal resources and is especially interesting when novel reactivity or selectivity patterns are observed. We report here on a novel reaction, namely the dehydrogenative alkylation or α-olefination of alkyl-substituted N-heteroarenes with alcohols. Manganese complexes developed in our laboratory catalyze the reaction with high efficiency whereas iron and cobalt complexes stabilized by the same ligands are essentially inactive. Hydrogen is liberated during the reaction, and bromine and iodine functional groups as well as olefins are tolerated. A variety of alkyl-substituted N-heteroarenes can be functionalized, and benzylic and aliphatic alcohols undergo the reaction.
Language	English
Publishing date	2018-05-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201801573
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Article ; Online: Highly Active and Selective Manganese C=O Bond Hydrogenation Catalysts: The Importance of the Multidentate Ligand, the Ancillary Ligands, and the Oxidation State.

Kallmeier, Fabian / Irrgang, Torsten / Dietel, Thomas / Kempe, Rhett

Angewandte Chemie (International ed. in English)

2016 Volume 55, Issue 39, Page(s) 11806–11809

Abstract: The replacement of expensive noble metals by earth-abundant transition metals is a central topic in catalysis. Herein, we introduce a highly active and selective homogeneous manganese-based C=O bond hydrogenation catalyst. Our catalyst has a broad ... ...

Abstract	The replacement of expensive noble metals by earth-abundant transition metals is a central topic in catalysis. Herein, we introduce a highly active and selective homogeneous manganese-based C=O bond hydrogenation catalyst. Our catalyst has a broad substrate scope, it is able to hydrogenate aryl-alkyl, diaryl, dialkyl, and cycloalkyl ketones as well as aldehydes. A very good functional group tolerance including the quantitative and selective hydrogenation of a ketone in the presence of a non-shielded olefin is observed. In Mn hydrogenation catalysis, the combination of the multidentate ligand, the oxidation state of the metal, and the choice of the right ancillary ligand is crucial for high activity. This observation emphasizes an advantage and the importance of homogeneous catalysts in 3d-metal catalysis. For coordination compounds, fine-tuning of a complex coordination environment is easily accomplished in comparison to enzyme and/or heterogeneous catalysts.
Language	English
Publishing date	2016--19
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201606218
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Article: Das Ivy Sign - Muss man das kennen? The "Ivy sign" - Does one have to know it?

Dietel, T. / Bacher, M. / Bast, T. / Steinhoff, B. J.

Zeitschrift für Epileptologie

2016 Volume 29, Issue 3, Page(s) 130

Language	German
Document type	Article
ZDB-ID	2049814-7
ISSN	1617-6782
Database	Current Contents Medicine

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Zs.A 2440: Show issues

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Article ; Conference proceedings: Therapeutic Consequences of the Identification of KNCQ2 Mutations in Early Onset Epileptic Encephalopathy: A Case Report

Dietel, T. / Lerche, H. / Bast, T.

Neuropediatrics

2014

Abstract: Early onset epileptic encephalopathy (EOEE) is characterized by pharmaco refractory seizures (including tonic spasms) starting in the first weeks of life and typical electroencephalography pattern with suppression-burst and bilateral, multiregional ... ...

Event/congress	Abstracts of the 40th Annual Meeting of the Society of Neuropediatrics, Munich, 2014
Abstract	Early onset epileptic encephalopathy (EOEE) is characterized by pharmaco refractory seizures (including tonic spasms) starting in the first weeks of life and typical electroencephalography pattern with suppression-burst and bilateral, multiregional epileptic discharges. The psychomotor development is severely impaired in most of the cases. Besides structural lesions, variable genetic defects have been identified to be potential etiologies. De novo mutations in KCNQ2 are a more frequent etiology. Although up to 50% of the affected children may become seizure free in the course, the psychomotor development remains severely impaired. While only few patients seem to benefit from retigabine, which directly acts on the KCNQ2 coded potassium channel, many children seem to respond to classical sodium channel blockers. We report the case of a 5-year-and-4-month-old girl with a severe form of EOEE. Therapeutic trials with phenobarbital, topiramate, vigabatrin, levetiracetam, sulthiame, valproate, clonazepam, and corticosteroids failed to control the seizures. The etiology remained unclear although a broad neurometabolic and genetic diagnostic work-up had been performed. At the age of 4.5 years, a molecular-genetic panel diagnosis revealed a most probably pathogenic de novo mutation in KCNQ2 (c.659T>C; p.L220P, het.). The targeted use of retigabine (maximum dose 8 mg/kg/d) was not effective. When oxcarbazepine (up to 20 mg/kg/d) was added to valproate, levetiracetam, and vigabatrin, there was a prompt and definite effect with a reduction of seizures by at least 75%, especially of impairing tonic seizures even so valproate and vigabatrin were stopped. As predicted by the physiologists, the indirect effect of blocking sodium channels seems to be a stabilizing factor in relation to the disturbed potassium flow. Sodium channel blockers are not a typical therapy for early epileptic encephalopathies, and they may even aggravate seizures in these young infants. However, the administration is an important therapeutic option in children with KCNQ2 mutations.
Language	English
Publishing date	2014-09-11
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0034-1390587
Database	Thieme publisher's database

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Zs.A 728: Show issues

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Article ; Online: A broadly tunable synthesis of linear α-olefins.

Gollwitzer, Andreas / Dietel, Thomas / Kretschmer, Winfried P / Kempe, Rhett

Nature communications

2017 Volume 8, Issue 1, Page(s) 1226

Abstract: The catalytic synthesis of linear α-olefins from ethylene is a technologically highly important reaction. A synthesis concept allowing the formation of selective products and various linear α-olefin product distributions with one catalyst system is ... ...

Abstract	The catalytic synthesis of linear α-olefins from ethylene is a technologically highly important reaction. A synthesis concept allowing the formation of selective products and various linear α-olefin product distributions with one catalyst system is highly desirable. Here, we describe a trimetallic catalyst system (Y-Al-Ni) consisting of a rare earth metal polymerization catalyst which can mediate coordinative chain transfer to triethylaluminum combined with a simultaneously operating nickel β-hydride elimination/transfer catalyst. This nickel catalyst displaces the grown alkyl chains forming linear α-olefins and recycles the aluminum-based chain transfer agent. With one catalyst system, we can synthesize product spectra ranging from selective 1-butene formation to α-olefin distributions centered at 850 gmol
Language	English
Publishing date	2017-10-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/s41467-017-01507-2
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Article ; Online: L-Serine Treatment is Associated with Improvements in Behavior, EEG, and Seizure Frequency in Individuals with GRIN-Related Disorders Due to Null Variants.

Krey, Ilona / von Spiczak, Sarah / Johannesen, Kathrine M / Hikel, Christiane / Kurlemann, Gerhard / Muhle, Hiltrud / Beysen, Diane / Dietel, Tobias / Møller, Rikke S / Lemke, Johannes R / Syrbe, Steffen

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2022 Volume 19, Issue 1, Page(s) 334–341

Abstract: Pathogenic missense variants in GRIN2A and GRIN2B may result in gain or loss of function (GoF/LoF) of the N-methyl-D-aspartate receptor (NMDAR). This observation gave rise to the hypothesis of successfully treating GRIN-related disorders due to LoF ... ...

Abstract	Pathogenic missense variants in GRIN2A and GRIN2B may result in gain or loss of function (GoF/LoF) of the N-methyl-D-aspartate receptor (NMDAR). This observation gave rise to the hypothesis of successfully treating GRIN-related disorders due to LoF variants with co-agonists of the NMDAR. In this respect, we describe a retrospectively collected series of ten individuals with GRIN2A- or GRIN2B-related disorders who were treated with L-serine, each within an independent n-of-1 trial. Our cohort comprises one individual with a LoF missense variant with clinical improvements confirming the above hypothesis and replicating a previous n-of-1 trial. A second individual with a GoF missense variant was erroneously treated with L-serine and experienced immediate temporary behavioral deterioration further supporting the supposed functional pathomechanism. Eight additional individuals with null variants (that had been interpreted as loss-of-function variants despite not being missense) again showed clinical improvements. Among all nine individuals with LoF missense or null variants, L-serine treatment was associated with improvements in behavior in eight (89%), in development in four (44%), and/or in EEG or seizure frequency in four (44%). None of these nine individuals experienced side effects or adverse findings in the context of L-serine treatment. In summary, we describe the first evidence that L-serine treatment may not only be associated with clinical improvements in GRIN-related disorders due to LoF missense but particularly also null variants.
MeSH term(s)	Electroencephalography ; Humans ; Receptors, N-Methyl-D-Aspartate/genetics ; Retrospective Studies ; Seizures/drug therapy ; Seizures/genetics ; Serine/genetics
Chemical Substances	Receptors, N-Methyl-D-Aspartate ; Serine (452VLY9402)
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-021-01173-9
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Zs.A 6156: Show issues

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Article ; Conference proceedings: Genotype and phenotype in GNAO1-Mutation – Case report of an unusual course of a childhood epilepsy

Dietel, T. / Haack, T. B. / Schlüter, G. / Cordes, I. / Trollmann, R. / Bast, T.

Neuropediatrics

2016

Abstract: Background: Whole exome sequencing identified de novo mutations in GNAO1 as a cause of an epileptic encephalopathy. Recently, 12 female patients with variable phenotype and relevant mutations were reported. Apart from seizures, the patients presented ... ...

Event/congress	Abstracts of the 42nd Annual Meeting of the Society for Neuropediatrics, Bochum, 2016
Abstract	Background: Whole exome sequencing identified de novo mutations in GNAO1 as a cause of an epileptic encephalopathy. Recently, 12 female patients with variable phenotype and relevant mutations were reported. Apart from seizures, the patients presented with impaired motor and cognitive function as well as disturbed behavior. Patients and Methods: We report the case of a 3-year-old girl with a de novo missense-mutation in GNAO1, c.[607G > A];[=], p.[Gly203 Arg];[=]. Tonic seizures with bilateral seizure pattern started at the age of 9 days. Repetitive video-EEG investigation revealed exclusive temporal left seizure patterns during clusters of vegetative and/or dyscognitive seizures. Spasm-like tonic seizures with turning to the left were accompanied by episodes of agitation with opisthotonus while consciousness remained preserved. There was no EEG seizure pattern during these episodes and they were classified as non-epileptic spasm. While the early EEGs showed an encephalopathy, EEG, at the age of 7 months, the EEG was clearly not encephalopathic but was characterized by delta and theta activity and rare multi-regional, bi-hemispheric epileptic activity. Results: The development was retarded from the beginning. Repeated MRI showed mild atrophy of the brain without a potentially epileptic lesion. FDG-PET revealed a marked hypometabolism of the left temporal lobe. The pharmacoresistant temporal-lobe seizures were very frequent and life-threatening because of distinct bradycardia. Epilepsy surgery was considered seriously but finally not performed. Co-administration of lamotrigine and zonisamide stopped epileptic activity but didn't influence the involuntary movements. Conclusion: In this case, a de-novo mutation in GNAO caused severe focal epilepsy in conjunction with an impressive movement disorder which became clear only after video-EEG monitoring.
Language	English
Publishing date	2016-04-20
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0036-1583625
Database	Thieme publisher's database

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Zs.A 728: Show issues

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