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  1. Article ; Online: Longitudinal analysis of built environment and aerosol contamination associated with isolated COVID-19 positive individuals.

    Horve, Patrick F / Dietz, Leslie G / Bowles, Garis / MacCrone, Georgia / Olsen-Martinez, Andreas / Northcutt, Dale / Moore, Vincent / Barnatan, Liliana / Parhizkar, Hooman / Van Den Wymelenberg, Kevin G

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7395

    Abstract: The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the ... ...

    Abstract The indoor environment is the primary location for the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), largely driven by respiratory particle accumulation in the air and increased connectivity between the individuals occupying indoor spaces. In this study, we aimed to track a cohort of subjects as they occupied a COVID-19 isolation dormitory to better understand the impact of subject and environmental viral load over time, symptoms, and room ventilation on the detectable viral load within a single room. We find that subject samples demonstrate a decrease in overall viral load over time, symptoms significantly impact environmental viral load, and we provide the first real-world evidence for decreased aerosol SARS-CoV-2 load with increasing ventilation, both from mechanical and window sources. These results may guide environmental viral surveillance strategies and be used to better control the spread of SARS-CoV-2 within built environments and better protect those caring for individuals with COVID-19.
    MeSH term(s) Aerosols ; Built Environment ; COVID-19 ; Humans ; SARS-CoV-2 ; Ventilation
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-11303-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Viable bacterial communities on hospital window components in patient rooms.

    Horve, Patrick F / Dietz, Leslie G / Ishaq, Suzanne L / Kline, Jeff / Fretz, Mark / Van Den Wymelenberg, Kevin G

    PeerJ

    2020  Volume 8, Page(s) e9580

    Abstract: Previous studies demonstrate an exchange of bacteria between hospital room surfaces and patients, and a reduction in survival of microorganisms in dust inside buildings from sunlight exposure. While the transmission of microorganisms between humans and ... ...

    Abstract Previous studies demonstrate an exchange of bacteria between hospital room surfaces and patients, and a reduction in survival of microorganisms in dust inside buildings from sunlight exposure. While the transmission of microorganisms between humans and their local environment is a continuous exchange which generally does not raise cause for alarm, in a hospital setting with immunocompromised patients, these building-source microbial reservoirs may pose a risk. Window glass is often neglected during hospital disinfection protocols, and the microbial communities found there have not previously been examined. This pilot study examined whether living bacterial communities, and specifically the pathogens Methicillin-resistant
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.9580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of SARS-CoV-2 RNA in healthcare heating, ventilation, and air conditioning units.

    Horve, Patrick F / Dietz, Leslie G / Fretz, Mark / Constant, David A / Wilkes, Andrew / Townes, John M / Martindale, Robert G / Messer, William B / Van Den Wymelenberg, Kevin G

    Indoor air

    2021  Volume 31, Issue 6, Page(s) 1826–1832

    Abstract: Evidence continues to grow supporting the aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To assess the potential role of heating, ventilation, and air conditioning (HVAC) systems in airborne viral transmission, this ...

    Abstract Evidence continues to grow supporting the aerosol transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To assess the potential role of heating, ventilation, and air conditioning (HVAC) systems in airborne viral transmission, this study sought to determine the viral presence, if any, on air handling units in a healthcare setting where coronavirus disease 2019 (COVID-19) patients were being treated. The presence of SARS-CoV-2 RNA was detected in approximately 25% of samples taken from ten different locations in multiple air handlers. While samples were not evaluated for viral infectivity, the presence of viral RNA in air handlers raises the possibility that viral particles can enter and travel within the air handling system of a hospital, from room return air through high-efficiency MERV-15 filters and into supply air ducts. Although no known transmission events were determined to be associated with these specimens, the findings suggest the potential for HVAC systems to facilitate transfer of virions to locations remote from areas where infected persons reside. These results are important within and outside of healthcare settings and may present necessary guidance for building operators of facilities that are not equipped with high-efficiency filtration. Furthermore, the identification of SARS-CoV-2 in HVAC components indicates the potential utility as an indoor environmental surveillance location.
    MeSH term(s) Air Conditioning ; Air Microbiology ; Air Pollution, Indoor ; COVID-19 ; Delivery of Health Care ; Heating ; Hospitals ; Humans ; RNA, Viral/isolation & purification ; SARS-CoV-2/isolation & purification ; Ventilation
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.12898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Twenty Important Research Questions in Microbial Exposure and Social Equity.

    Robinson, Jake M / Redvers, Nicole / Camargo, Araceli / Bosch, Christina A / Breed, Martin F / Brenner, Lisa A / Carney, Megan A / Chauhan, Ashvini / Dasari, Mauna / Dietz, Leslie G / Friedman, Michael / Grieneisen, Laura / Hoisington, Andrew J / Horve, Patrick F / Hunter, Ally / Jech, Sierra / Jorgensen, Anna / Lowry, Christopher A / Man, Ioana /
    Mhuireach, Gwynne / Navarro-Pérez, Edauri / Ritchie, Euan G / Stewart, Justin D / Watkins, Harry / Weinstein, Philip / Ishaq, Suzanne L

    mSystems

    2022  Volume 7, Issue 1, Page(s) e0124021

    Abstract: Social and political policy, human activities, and environmental change affect the ways in which microbial communities assemble and interact with people. These factors determine how different social groups are exposed to beneficial and/or harmful ... ...

    Abstract Social and political policy, human activities, and environmental change affect the ways in which microbial communities assemble and interact with people. These factors determine how different social groups are exposed to beneficial and/or harmful microorganisms, meaning microbial exposure has an important socioecological justice context. Therefore, greater consideration of microbial exposure and social equity in research, planning, and policy is imperative. Here, we identify 20 research questions considered fundamentally important to promoting equitable exposure to beneficial microorganisms, along with safeguarding resilient societies and ecosystems. The 20 research questions we identified span seven broad themes, including the following: (i) sociocultural interactions; (ii) Indigenous community health and well-being; (iii) humans, urban ecosystems, and environmental processes; (iv) human psychology and mental health; (v) microbiomes and infectious diseases; (vi) human health and food security; and (vii) microbiome-related planning, policy, and outreach. Our goal was to summarize this growing field and to stimulate impactful research avenues while providing focus for funders and policymakers.
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/msystems.01240-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Introducing the Microbes and Social Equity Working Group: Considering the Microbial Components of Social, Environmental, and Health Justice.

    Ishaq, Suzanne L / Parada, Francisco J / Wolf, Patricia G / Bonilla, Carla Y / Carney, Megan A / Benezra, Amber / Wissel, Emily / Friedman, Michael / DeAngelis, Kristen M / Robinson, Jake M / Fahimipour, Ashkaan K / Manus, Melissa B / Grieneisen, Laura / Dietz, Leslie G / Pathak, Ashish / Chauhan, Ashvini / Kuthyar, Sahana / Stewart, Justin D / Dasari, Mauna R /
    Nonnamaker, Emily / Choudoir, Mallory / Horve, Patrick F / Zimmerman, Naupaka B / Kozik, Ariangela J / Darling, Katherine Weatherford / Romero-Olivares, Adriana L / Hariharan, Janani / Farmer, Nicole / Maki, Katherine A / Collier, Jackie L / O'Doherty, Kieran C / Letourneau, Jeffrey / Kline, Jeff / Moses, Peter L / Morar, Nicolae

    mSystems

    2021  Volume 6, Issue 4, Page(s) e0047121

    Abstract: Humans are inextricably linked to each other and our natural world, and microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, and biochemically rich communities, i.e., microbiomes that are ...

    Abstract Humans are inextricably linked to each other and our natural world, and microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, and biochemically rich communities, i.e., microbiomes that are integral to the health and development of macroorganisms, societies, and ecosystems. Yet engagement with beneficial microbiomes is dictated by access to public resources, such as nutritious food, clean water and air, safe shelter, social interactions, and effective medicine. In this way, microbiomes have sociopolitical contexts that must be considered. The Microbes and Social Equity (MSE) Working Group connects microbiology with social equity research, education, policy, and practice to understand the interplay of microorganisms, individuals, societies, and ecosystems. Here, we outline opportunities for integrating microbiology and social equity work through broadening education and training; diversifying research topics, methods, and perspectives; and advocating for evidence-based public policy that supports sustainable, equitable, and microbial wealth for all.
    Language English
    Publishing date 2021-07-27
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.00471-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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