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  1. Article: Peritoneal Metastases: Evolution from a Dark Horizon to an Encouraging Present and a Promising Future.

    Diez-Alonso, Manuel / San-Juan, Alberto / Ortega, Miguel Angel / Gutiérrez-Calvo, Alberto

    Journal of clinical medicine

    2023  Volume 12, Issue 24

    Abstract: Peritoneal metastasis (PM) is the primary pattern of metastasis for primary tumours of the appendix, ovary, and peritoneal mesothelioma [ ... ]. ...

    Abstract Peritoneal metastasis (PM) is the primary pattern of metastasis for primary tumours of the appendix, ovary, and peritoneal mesothelioma [...].
    Language English
    Publishing date 2023-12-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12247536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Gallbladder Volvulus in an Elderly Patient: A Case Report and Review of Literature.

    Matías-García, Belén / Sainz-Azara, Carolina / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Gutiérrez-Calvo, Alberto

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45167

    Abstract: Gallbladder volvulus is an uncommon cause of acute cholecystitis that results from the rotation of the gallbladder about its mesentery along the axis of the cystic pedicle. We present the case of an 87-year-old woman with acute abdominal pain in the ... ...

    Abstract Gallbladder volvulus is an uncommon cause of acute cholecystitis that results from the rotation of the gallbladder about its mesentery along the axis of the cystic pedicle. We present the case of an 87-year-old woman with acute abdominal pain in the right upper quadrant that began two days prior with no additional symptoms. The physical examination showed a large abdominal eventration on the right side and tenderness. A CT scan showed a distended gallbladder outside its liver bed and with a twist on its cystic pedicle, suggesting a gallbladder volvulus. Abdominal ultrasonography complementary revealed the gallbladder outside its vesicular fossa with incipient changes of acute cholecystitis but without evidence of gallstones. With the diagnosis of acute abdomen secondary to gallbladder volvulus, an emergency cholecystectomy was performed. The exact etiology of the gallbladder volvulus is unknown, although anatomical variants that predispose to its appearance have been described. The clinical presentation is similar to acute cholecystitis, so preoperative diagnosis can be challenging for both surgeons and radiologists and is often misdiagnosed. This is one of the few cases diagnosed with preoperative imaging techniques. Once diagnosed, the appropriate treatment is emergency cholecystectomy. Early diagnosis and surgical treatment are important before it progresses to necrosis, perforation, biliary peritonitis, and hemodynamic instability. Gallbladder volvulus is an uncommon condition. A high index of suspicion is required because the preoperative diagnosis is unusual. Once the diagnosis is established, the treatment is fundamentally surgical.
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Malignant Bowel Obstruction Due to Intraluminal Metastasis of Endometrial Adenocarcinoma Located in the Sigmoid Colon After Nine Years of Follow-Up.

    Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / D'Angelo, Carolina / Gutiérrez-Calvo, Alberto

    Cureus

    2023  Volume 15, Issue 10, Page(s) e47937

    Abstract: Endometrial adenocarcinoma is currently the most common malignant tumor of the female genital tract. In the early stages, surgical or radiotherapy treatment offers high survival rates and excellent prognosis, although late recurrences have been described. ...

    Abstract Endometrial adenocarcinoma is currently the most common malignant tumor of the female genital tract. In the early stages, surgical or radiotherapy treatment offers high survival rates and excellent prognosis, although late recurrences have been described. Recurrences of endometrial adenocarcinoma are more frequent in the vaginal vault; however, implants are sometimes detected in the serosa of the colon and rectum, resulting in extrinsic compression. Here, we present the case of a 77-year-old patient with a clinical history of hysterectomy, lymphadenectomy, and double adnexectomy for endometrial adenocarcinoma (International Federation of Gynecology and Obstetrics (FIGO) Ia). Nine years after the initial treatment, she presented an endoluminal recurrence in the sigmoid colon, which is exceptional. The patient underwent surgery by performing an oncological sigmoidectomy. The immunohistochemical study revealed the tumor origin as metastasis of endometrial adenocarcinoma. The patient had a favorable postoperative period, subsequently receiving adjuvant therapy and being disease-free after 18 months of follow-up.
    Language English
    Publishing date 2023-10-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.47937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Single metachronous bone metastasis following rectal adenocarcinoma: A case report.

    Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

    Medicine international

    2024  Volume 4, Issue 1, Page(s) 6

    Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of ... ...

    Abstract Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of metastases either at the time of diagnosis or during follow-ups. Unlike certain other types of cancer, such as breast, prostate, or lung cancer, where bone tissue is a common site for secondary dissemination, CRC primarily spreads to the lymph nodes, liver and lungs. The occurrence of bone metastases from CRC is rare and usually coincides with tumor involvement in other locations. Risk factors for bone metastases include the location of the primary tumor, the age of the patients, KRAS mutations and the degree of tumor differentiation. Unlike metastases to the liver and lungs, bone metastases tend to be symptomatic, affecting the patient's quality of life and resulting in a poorer prognosis with shorter survival rates. The approach to patient management needs to be personalized. The present study describes the of a patient who underwent surgery for stage IV rectal adenocarcinoma and later developed a metastasis in the costal wall 79 months post-intervention, with no evidence of recurrence at other sites.
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Case Reports
    ISSN 2754-1304
    ISSN (online) 2754-1304
    DOI 10.3892/mi.2024.130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Thyroid abscess, an uncommon diagnosis: A case report and mini‑review of the literature.

    Urbón-Sánchez, Patricia / Mendoza-Moreno, Fernando / Sánchez De Toca-Gómez, Sofía / Mañes-Jiménez, Félix / Jiménez-Martín, Rubén / Bru-Aparicio, Marta / Laguna-Hernández, Pilar / Allaoua-Moussaoui, Yousef / Soto-Schutte, Sonia / Quiroga-Valcárcel, Ana / Díez-Alonso, Manuel / Lasa Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

    Medicine international

    2024  Volume 4, Issue 3, Page(s) 29

    Abstract: Thyroid abscess is a rare entity, commonly experienced by immunocompromised patients, or those who have anatomical abnormalities or a pre-existing thyroid disease. An early diagnosis continued by treatment with antibiotics and drainage of the abscess is ... ...

    Abstract Thyroid abscess is a rare entity, commonly experienced by immunocompromised patients, or those who have anatomical abnormalities or a pre-existing thyroid disease. An early diagnosis continued by treatment with antibiotics and drainage of the abscess is the recommended therapeutic strategy for such cases. The present study describes a clinical case of this rare event, and also provides a brief literature review. The present study describes the case of a 48-year-old healthy male with no medical antecedents, apart from acute prostatitis treated with antibiotics for 6 days prior, who visited the Emergency Department of the authors' hospital with neck pain and progressive swelling of the mass. Diagnostic imaging confirmed the authors' suspicion of an abscess and revealed the lesion displacing the airway to the contralateral side. This restricted the mobility of the neck of the patient. As an emergency measure, the patient was then taken to the operating room for a neck examination. A hemithyroidectomy was finally performed. Following a prolonged hospital duration, he was discharged from the hospital and his recovery was uneventful without any voice alterations, hypocalcemia or recurrence.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Case Reports
    ISSN 2754-1304
    ISSN (online) 2754-1304
    DOI 10.3892/mi.2024.153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Differences in Colorectal Cancer Survival Based on Primary Tumor Location: Retrospective Study from a Single Institution.

    Diez-Alonso, Manuel / Mendoza-Moreno, Fernando / Ortega, Miguel A / Aguado, Hector / Matías, Belen / Vera, Cristina / Soto, Sonia / Quiroga, Ana / Blazquez, Silvestra Barrena / de Mon, Melchor Alvarez / Gutierrez-Calvo, Alberto

    Journal of Cancer

    2023  Volume 14, Issue 13, Page(s) 2444–2454

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2023-08-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.85695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Hematological Alterations after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

    Pintado, Maria Consuelo / Lasa Unzúe, Inmaculada / Gómez Sanz, Remedios / Diez Alonso, Manuel / Ortega, Miguel A / Álvarez de Mon, Melchor / Nevado Losada, Emilio / Gutierrez Calvo, Alberto

    Journal of clinical medicine

    2023  Volume 12, Issue 13

    Abstract: Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.: Methods: Patients admitted to an ... ...

    Abstract Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%.
    Methods: Patients admitted to an intensive care unit (ICU) after CRS and HIPEC over 78 months. The data recorded were demographic characteristics, the severity of illness, complete blood samples, the type of cancer and extension, HIPEC drug and temperature, ICU and hospital stay and mortality, bleeding, and the need for transfusion of blood products.
    Results: Of the 96 patients included, 77.1% presented hematological complications: 8.3% leukopenia (<4000/mm
    Conclusions: In our study, 77.1% of patients treated with CRS and HIPEC developed hematological complications during the postoperative period; the majority of them were not severe and resolved spontaneously, without an effect on mortality or hospital stay.
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12134323
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  8. Article ; Online: A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions.

    Matias-García, Belén / Mendoza-Moreno, Fernando / Blasco-Martínez, Ana / Busteros-Moraza, José Ignacio / Diez-Alonso, Manuel / Garcia-Moreno Nisa, Francisca

    BMC surgery

    2021  Volume 21, Issue 1, Page(s) 79

    Abstract: Background: At present, the term mucocele is outdated, and mucinous appendiceal neoplasm is preferred. Mucinous appendiceal neoplasm is an uncommon pathology that occurs predominantly in middle-aged women. Its classification and management have been the ...

    Abstract Background: At present, the term mucocele is outdated, and mucinous appendiceal neoplasm is preferred. Mucinous appendiceal neoplasm is an uncommon pathology that occurs predominantly in middle-aged women. Its classification and management have been the subject of debate in recent decades. The aim of this study was to analyse the incidence, clinical management and survival of these tumours diagnosed in our centre in the last 10 years.
    Methods: This was a retrospective observational study of patients with a diagnosis of appendiceal neoplasms between 2009 and 2018 in our centre. Variables such as sex, age, tumour type, clinical status, diagnosis, treatment and survival were collected. All data were analysed using the statistical program IBM SPSS Statistic® version 25.
    Results: Twenty-nine patients with a diagnosis of appendiceal neoplasm were identified, and 24 corresponded to neoplastic appendiceal mucinous lesions (85.7%). The average age was 59.7 ± 17.6 years. Most patients were women (15 cases; 62.5%). Most of them presented with chronic abdominal pain (37.5%), and the diagnosis was performed by computed tomography (CT) (50%). The treatment was surgical in all cases. The surgical technique depended on the findings and histology of the tumour.
    Conclusion: Mucinous appendiceal neoplasms are an uncommon entity, and their pathological classification and management have recently changed.
    Language English
    Publishing date 2021-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-021-01091-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clostridium perfringens

    Sánchez-Gollarte, Ana / Jiménez-Álvarez, Laura / Pérez-González, Marina / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Díez-Alonso, Manuel

    Access microbiology

    2021  Volume 3, Issue 9, Page(s) 261

    Abstract: Pancreatic necrosis infection (PNI) accounts for about 20-40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present, ...

    Abstract Pancreatic necrosis infection (PNI) accounts for about 20-40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present,
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Case Reports
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Surgical Treatment of Gallstone Ileus: Less Is More.

    Vera-Mansilla, Cristina / Sanchez-Gollarte, Ana / Matias, Belen / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Garcia-Moreno Nisa, Francisca

    Visceral medicine

    2021  Volume 38, Issue 1, Page(s) 72–77

    Abstract: Introduction: The objective of this study was to evaluate the need for cholecystectomy in patients who underwent surgery for gallstone ileus.: Methods: This was a retrospective review of the clinical history of patients who underwent surgery for ... ...

    Abstract Introduction: The objective of this study was to evaluate the need for cholecystectomy in patients who underwent surgery for gallstone ileus.
    Methods: This was a retrospective review of the clinical history of patients who underwent surgery for gallstone ileus between December 1992 and December 2018 and follow-up until October 2020. Data regarding the surgical intervention, location of the obstruction, and surgical procedure performed were collected, as well as complications in relation to biliary pathology in the postoperative period.
    Results: Twenty-five patients underwent surgery for gallstone ileus. In all patients, except one, the site of the obstruction was identified. The mean age of the patients was 72 (standard deviation [SD] 13.3) years, with a female predominance (18: 7). The patients presented symptoms, on average, 2.9 (1-7) days before going to the emergency room; the primary symptoms were vomiting associated with abdominal pain and constipation (56%). Fifty-six percent of patients were diagnosed preoperatively by imaging tests. In 72% of patients, an enterolithotomy was performed alone without any other intervention on the gallbladder or bile duct. Eighty-three percent of the patients did not present any cholecystobiliary complications during the entire follow-up period, and urgent or delayed cholecystectomy was not performed after the acute episode.
    Conclusions: Gallstone ileus is a rare entity, and there are no randomized studies that support a preferred treatment. If surgical intervention is required, enterotomy for stone extraction is a safe and effective technique, and in our experience, urgent or delayed cholecystectomy is not necessary.
    Language English
    Publishing date 2021-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2850733-2
    ISSN 2297-475X ; 2297-4725
    ISSN (online) 2297-475X
    ISSN 2297-4725
    DOI 10.1159/000518451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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