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  1. Article ; Online: The link between wound healing and escape from tumor dormancy.

    Dillekås, Hanna / Straume, Oddbjørn

    Surgical oncology

    2018  Volume 28, Page(s) 50–56

    Abstract: Tumor dormancy is considered one of the major unsolved questions in cancer biology. Understanding the mechanisms responsible for maintaining and interrupting dormancy would be a major step towards preventing overt metastatic disease. Increasing evidence ... ...

    Abstract Tumor dormancy is considered one of the major unsolved questions in cancer biology. Understanding the mechanisms responsible for maintaining and interrupting dormancy would be a major step towards preventing overt metastatic disease. Increasing evidence points to tissue trauma and subsequent wound healing as contributing events in escape from dormancy. In this review, we outline relevant aspects of the wound healing process, and relate this to mechanisms of tumor dormancy and metastatic progression. In addition to important findings in epidemiological and experimental studies, more direct evidence of such a link has recently been presented. These results can have major implications for treatment and prevention of cancer.
    MeSH term(s) Disease Progression ; Humans ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/physiopathology ; Neoplasms/physiopathology ; Tumor Microenvironment ; Wound Healing
    Language English
    Publishing date 2018-11-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1107810-8
    ISSN 1879-3320 ; 0960-7404
    ISSN (online) 1879-3320
    ISSN 0960-7404
    DOI 10.1016/j.suronc.2018.11.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal.

    Demicheli, Romano / Dillekås, Hanna / Straume, Oddbjørn / Biganzoli, Elia

    Breast cancer research : BCR

    2019  Volume 21, Issue 1, Page(s) 57

    Abstract: Background: The aim of the research was to separate the distant metastasis (DM) enhancing effect due to breast tumour removal from that due to surgical manoeuvre by itself.: Methods: DM dynamics following surgery for ipsilateral breast tumour ... ...

    Abstract Background: The aim of the research was to separate the distant metastasis (DM) enhancing effect due to breast tumour removal from that due to surgical manoeuvre by itself.
    Methods: DM dynamics following surgery for ipsilateral breast tumour recurrence (IBTR), contralateral breast cancer (CBC) and delayed reconstruction (REC), which was performed after the original breast cancer surgical removal, was analysed. A total of 338 patients with IBTR, 239 with CBC and 312 with REC were studied.
    Results: The DM dynamics following IBTR, CBC and REC, when assessed with time origin at their surgical treatment, is similar to the analogous pattern following primary tumour removal, with a first major peak at about 18 months and a second lower one at about 5 years from surgery. The time span between primary tumour removal and the second surgery is influential on DM risk levels for IBTR and CBC patients, not for REC patients.
    Conclusions: The role of breast tumour removal is different from the role of surgery by itself. Our findings suggest that the major effect of reconstructive surgery is microscopic metastasis acceleration, while breast tumour surgical removal (either primary or IBTR or CBC) involves both tumour homeostasis interruption and microscopic metastasis growth acceleration. The removal of a breast tumour would eliminate its homeostatic restrains on metastatic foci, thus allowing metastasis development, which, in turn, would be supported by the forwarding action of the mechanisms triggered by the surgical wounding.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Mastectomy/adverse effects ; Mastectomy/methods ; Middle Aged ; Neoplasm Metastasis ; Postoperative Period ; Tumor Burden ; Young Adult
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2019-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2015059-3
    ISSN 1465-542X ; 1465-5411
    ISSN (online) 1465-542X
    ISSN 1465-5411
    DOI 10.1186/s13058-019-1139-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5494: Show issues Location:
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  3. Article ; Online: Are 90% of deaths from cancer caused by metastases?

    Dillekås, Hanna / Rogers, Michael S / Straume, Oddbjørn

    Cancer medicine

    2019  Volume 8, Issue 12, Page(s) 5574–5576

    Abstract: Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused by metastases. Population-based ... ...

    Abstract Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused by metastases. Population-based data from the Cancer Registry of Norway for the years 2005-2015 was analyzed. We compared all deaths in the Norwegian population where a cancer diagnosis was registered as cause of death. Deaths caused by cancer, with and without metastases, were analyzed, by sex and tumor group. For solid tumors, 66.7% of cancer deaths were registered with metastases as a contributing cause. Proportions varied substantially between tumor groups. Our data support the idea that the majority of deaths from solid tumors are caused by metastases. Thus, a better understanding of the biology of metastases and identification of druggable targets involved in growth at the metastatic site is a promising strategy to reduce cancer mortality.
    MeSH term(s) Cause of Death ; Female ; Humans ; Male ; Neoplasm Metastasis ; Neoplasms/mortality ; Norway/epidemiology ; Registries
    Language English
    Publishing date 2019-08-08
    Publishing country United States
    Document type Journal Article
    ISSN 2045-7634
    ISSN (online) 2045-7634
    DOI 10.1002/cam4.2474
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  4. Article ; Online: Toxic epidermal necrolysis after immune checkpoint inhibition, case report, and review of the literature.

    Sommerfelt, Hanne / Sandvik, Lene F / Bachmann, Ingeborg M / Brekke, Ragnvald Ljones / Svendsen, Henrik Løvendahl / Guttormsen, Anne Berit / Aziz, Sura / Dillekås, Hanna / Straume, Oddbjørn

    Acta oncologica (Stockholm, Sweden)

    2022  Volume 61, Issue 10, Page(s) 1295–1299

    MeSH term(s) Humans ; Stevens-Johnson Syndrome/etiology ; Immune Checkpoint Inhibitors/adverse effects
    Chemical Substances Immune Checkpoint Inhibitors
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Review ; Case Reports ; Letter
    ZDB-ID 896449-x
    ISSN 1651-226X ; 0349-652X ; 0284-186X ; 1100-1704
    ISSN (online) 1651-226X
    ISSN 0349-652X ; 0284-186X ; 1100-1704
    DOI 10.1080/0284186X.2022.2119099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6348: Show issues Location:
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  5. Article ; Online: Differences in metastatic patterns in relation to time between primary surgery and first relapse from breast cancer suggest synchronized growth of dormant micrometastases.

    Dillekås, Hanna / Transeth, Monica / Pilskog, Martin / Assmus, Jörg / Straume, Oddbjørn

    Breast cancer research and treatment

    2014  Volume 146, Issue 3, Page(s) 627–636

    Abstract: A significant variation in the metastatic pattern among breast cancer patients exists. Clinical observations suggest that these differences are related to time to recurrence (TTR), thus suggesting a common systemic growth signal at the time of surgery. ... ...

    Abstract A significant variation in the metastatic pattern among breast cancer patients exists. Clinical observations suggest that these differences are related to time to recurrence (TTR), thus suggesting a common systemic growth signal at the time of surgery. Our goal was to identify a marker for synchronized growth of micrometastases. To quantify the metastatic pattern at first relapse, 180 patients with metastatic breast cancer were studied. Standard deviation (SD) of lesions size and lesion number was calculated and served as a marker for variation. Patients with low SD (multiple/similar sized lesions) were assumed to have synchronized growth, whereas patients with high SD were assumed to have unsynchronized growth. Patients were grouped according to TTR; early (< 3 years-) or late (> 3 years- after surgery). In patients not receiving systemic adjuvant treatment, median SD was significantly lower in the early group (2.5 mm) compared with 6.4 mm in the late group (p = 0.005). In node negative patients, median SD was significantly lower in the early group (3.0 mm) when compared with the late group (5.7 mm, p = 0.02). An additional drop in SD was observed immediately after end of adjuvant endocrine therapy. Our results identify SD as a marker of synchronized metastatic growth in breast cancer. A metastatic phenotype characterized by multiple similar sized metastases, suggesting synchronized onset of growth of micrometastases was predominantly found in patients recurring early after surgery and was counteracted by adjuvant treatment. Systemic growth signals caused by surgery might be antagonized during the time window following surgery.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Micrometastasis/pathology ; Neoplasm Micrometastasis/therapy ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2014-07-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-014-3057-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1655: Show issues Location:
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  6. Article ; Online: The recurrence pattern following delayed breast reconstruction after mastectomy for breast cancer suggests a systemic effect of surgery on occult dormant micrometastases.

    Dillekås, Hanna / Demicheli, Romano / Ardoino, Ilaria / Jensen, Svein A H / Biganzoli, Elia / Straume, Oddbjørn

    Breast cancer research and treatment

    2016  Volume 158, Issue 1, Page(s) 169–178

    Abstract: The purpose of this study was to characterize the recurrence dynamics in breast cancer patients after delayed reconstruction. We hypothesized that surgical reconstruction might stimulate dormant micrometastases and reduce time to recurrence. All ... ...

    Abstract The purpose of this study was to characterize the recurrence dynamics in breast cancer patients after delayed reconstruction. We hypothesized that surgical reconstruction might stimulate dormant micrometastases and reduce time to recurrence. All mastectomy breast cancer patients with delayed surgical reconstruction at Haukeland University Hospital, between 1977 and 2007, n = 312, were studied. Our control group consisted of 1341 breast cancer patients without reconstruction. For each case, all patients in the control group with identical T and N stages and age ±2 years were considered. A paired control was randomly selected from this group. 10 years after primary surgery, 39 of the cases had relapsed, compared to 52 of the matched controls. The reconstructed group was analyzed for relapse dynamics after mastectomy; the first peak in relapses was similarly timed, but smaller than for the controls, while the second peak was similar in time and size. Second, the relapse pattern was analyzed with reconstruction as the starting point. A peak in recurrences was found after 18 months, and a lower peak at the 5th-6th year. The height of the peak correlated with the extent of surgery and initial T and N stages. Timing of the peak was not affected, neither was the cumulative effect. The relapse pattern, when time origin is placed both at mastectomy and at reconstruction, is bimodal with a peak position at the same time points, at 2 years and at 5-6 years. The timing of the transition from dormant micrometastases into clinically detectable macrometastases might be explained by an enhancing effect of surgery.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/epidemiology ; Breast Neoplasms/surgery ; Carcinoma, Intraductal, Noninfiltrating/epidemiology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Disease Progression ; Female ; Humans ; Mammaplasty ; Margins of Excision ; Mastectomy/methods ; Middle Aged ; Neoplasm Micrometastasis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/surgery ; Netherlands/epidemiology ; Time-to-Treatment ; Young Adult
    Language English
    Publishing date 2016-06-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604563-7
    ISSN 1573-7217 ; 0167-6806
    ISSN (online) 1573-7217
    ISSN 0167-6806
    DOI 10.1007/s10549-016-3857-1
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    Zs.A 1655: Show issues Location:
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