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  1. Article: Molecular and Genetic Biomarkers in Idiopathic Pulmonary Fibrosis: Where Are We Now?

    Tomos, Ioannis / Roussis, Ioannis / Matthaiou, Andreas M / Dimakou, Katerina

    Biomedicines

    2023  Volume 11, Issue 10

    Abstract: Idiopathic pulmonary fibrosis (IPF) represents a chronic progressive fibrotic interstitial lung disease of unknown cause with an ominous prognosis. It remains an unprecedent clinical challenge due to its delayed diagnosis and unpredictable clinical ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) represents a chronic progressive fibrotic interstitial lung disease of unknown cause with an ominous prognosis. It remains an unprecedent clinical challenge due to its delayed diagnosis and unpredictable clinical course. The need for accurate diagnostic, prognostic and predisposition biomarkers in everyday clinical practice becomes more necessary than ever to ensure prompt diagnoses and early treatment. The identification of such blood biomarkers may also unravel novel drug targets against IPF development and progression. So far, the role of diverse blood biomarkers, implicated in various pathogenetic pathways, such as in fibrogenesis (S100A4), extracellular matrix remodelling (YKL-40, MMP-7, ICAM-1, LOXL2, periostin), chemotaxis (CCL-18, IL-8), epithelial cell injury (KL-6, SP-A, SP-D), autophagy and unfolded protein response has been investigated in IPF with various results. Moreover, the recent progress in genetics in IPF allows for a better understanding of the underlying disease mechanisms. So far, the causative mutations in pulmonary fibrosis include mutations in telomere-related genes and in surfactant-related genes, markers that could act as predisposition biomarkers in IPF. The aim of this review is to provide a comprehensive overview from the bench to bedside of current knowledge and recent insights on biomarkers in IPF, and to suggest future directions for research. Large-scale studies are still needed to confirm the exact role of these biomarkers.
    Language English
    Publishing date 2023-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11102796
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Asthma with Fixed Airflow Obstruction: From Fixed to Personalized Approach.

    Bakakos, Agamemnon / Vogli, Stamatina / Dimakou, Katerina / Hillas, Georgios

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: Asthma is generally characterized by variable symptoms such as dyspnea and wheezing and variable airflow obstruction. This review focuses on a subset of patients suffering from asthma with persistent airflow limitation that is not fully reversible ( ... ...

    Abstract Asthma is generally characterized by variable symptoms such as dyspnea and wheezing and variable airflow obstruction. This review focuses on a subset of patients suffering from asthma with persistent airflow limitation that is not fully reversible (asthma with fixed airflow obstruction, FAO). The pathophysiology, the risk factors and the clinical outcomes associated with FAO are presented, as well as the distinct clinical entity of severe asthma and its inflammatory subtypes (T2 and non-T2). The current strategies for the treatment of these endotypes and treatment of the distinct Asthma/COPD overlap (ACO) phenotype are described. Management and medical interventions in FAO and/or ACO patients demand a holistic approach, which is not yet clearly established in guidelines worldwide. Finally, a treatment algorithm that includes FAO/ACO management based on pharmacological and non-pharmacological treatment, guideline-based management for specific co-morbidities, and modification of the risk factors is proposed.
    Language English
    Publishing date 2022-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030333
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  3. Article ; Online: Updated simplified approach of pharmacological treatment of stable COPD: Do common co-morbidities have a role?

    Hillas, Georgios / Papaporfyriou, Anastasia / Dimakou, Katerina / Papaioannou, Andriana I

    Postgraduate medicine

    2021  Volume 133, Issue 8, Page(s) 873–874

    MeSH term(s) Algorithms ; Bronchodilator Agents/therapeutic use ; Comorbidity ; Drug Therapy, Combination ; Glucocorticoids/therapeutic use ; Humans ; Nebulizers and Vaporizers ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Bronchodilator Agents ; Glucocorticoids
    Language English
    Publishing date 2021-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 410138-8
    ISSN 1941-9260 ; 0032-5481
    ISSN (online) 1941-9260
    ISSN 0032-5481
    DOI 10.1080/00325481.2021.1962612
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  4. Article ; Online: Smoking cessation and the lung

    Dimakou Katerina

    Tobacco Induced Diseases, Vol 3, Iss 1, p

    benefits

    2005  Volume 32

    Keywords Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Internal medicine ; DOAJ:Medicine (General) ; DOAJ:Health Sciences ; Social pathology. Social and public welfare. Criminology ; HV1-9960 ; Social Sciences ; H ; DOAJ:Social and Public Welfare ; DOAJ:Sociology ; DOAJ:Social Sciences
    Publishing date 2005-12-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Endobronchial metastasis from renal cell carcinoma as a reason for recurrent pulmonary infections.

    Chrysikos, Serafeim / Karampitsakos, Theodoros / Tzouvelekis, Argyrios / Dimakou, Katerina

    Advances in respiratory medicine

    2018  Volume 86, Issue 5, Page(s) 245–248

    Abstract: Endobronchial metastases (EBM) secondary to extrathoracic malignancies are very rare. Breast cancer, colorectal cancer and renal cell carcinoma represent the most common types of cancer leading to endobronchial metastases. They usually represent a late ... ...

    Abstract Endobronchial metastases (EBM) secondary to extrathoracic malignancies are very rare. Breast cancer, colorectal cancer and renal cell carcinoma represent the most common types of cancer leading to endobronchial metastases. They usually represent a late manifestation of other types of cancer and their prognosis is generally poor averaging a survival of 1-2 years in most case series. Due to their rarity, they remain a challenge for clinicians regarding whether they are primary lung tumors or not. This case report article intends to present a case of a young man with a left nephrectomy due to Clear-Cell Renal Cell Carcinoma, who developed EBM 7 years later and to summarize available data in the field. Furthermore, the utility of diathermic snare as a treatment approach for this entity is highlighted.
    MeSH term(s) Adult ; Bronchial Neoplasms/secondary ; Carcinoma, Renal Cell/diagnostic imaging ; Carcinoma, Renal Cell/secondary ; Humans ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/pathology ; Male ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-10-31
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.2018.0039
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  6. Article ; Online: Coexistence of Tracheobronchopathia Osteochondroplastica and Sarcoidosis: Accidental Finding or Something More?

    Chrysikos, Serafeim / Karampitsakos, Theodoros / Tzouvelekis, Argyrios / Dimakou, Katerina

    Journal of bronchology & interventional pulmonology

    2018  Volume 26, Issue 1, Page(s) e7–e8

    MeSH term(s) Aged ; Axilla/pathology ; Bronchi/diagnostic imaging ; Bronchi/pathology ; Bronchial Diseases/diagnostic imaging ; Bronchial Diseases/pathology ; Bronchoscopy/methods ; Endosonography/instrumentation ; Female ; Humans ; Incidental Findings ; Lymph Nodes/pathology ; Osteochondrodysplasias/complications ; Osteochondrodysplasias/diagnostic imaging ; Osteochondrodysplasias/pathology ; Patient Outcome Assessment ; Sarcoidosis/complications ; Sarcoidosis/pathology ; Trachea/diagnostic imaging ; Trachea/pathology ; Tracheal Diseases/complications ; Tracheal Diseases/diagnostic imaging ; Tracheal Diseases/pathology
    Language English
    Publishing date 2018-12-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000521
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4027: Show issues Location:
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  7. Article ; Online: Depression Levels Influence the Rate of Asthma Exacerbations in Females

    Papaporfyriou Anastasia / Tseliou Eleni / Mizi Eleftheria / Ntontsi Xenia / Papathanasiou Eygenia / Souliotis Kyriakos / Dimakou Katerina / Bakakos Petros / Loukides Stelios / Hillas Georgios

    Journal of Personalized Medicine, Vol 11, Iss 6, p

    2021  Volume 586

    Abstract: Background : Anxiety and depression are common psychological disturbances among asthmatic patients. The aim of the present study is the assessment of anxiety and depression in asthmatic patients and their correlation with symptoms control level and ... ...

    Abstract Background : Anxiety and depression are common psychological disturbances among asthmatic patients. The aim of the present study is the assessment of anxiety and depression in asthmatic patients and their correlation with symptoms control level and number of exacerbations per year. Methods : One hundred patients with asthma diagnosis, according to the Global Initiative for Asthma (GINA), aged > 18 years old, having a stable disease, were included. Emotional status was evaluated using the Hospital Anxiety Depression Scale (HADS). Patients were followed up for a year to assess the number and severity of exacerbations. Results : Most of our patients were female (58%), middle-aged (mean = 54 ± 13), and married (81%), with low frequency of smoking habits (smokers, ex-smokers and non-smokers were 26%, 30% and 37%, respectively) and low levels of both anxiety and depression [median (interquartile range (IQR)) = 4(2) and median (IQR) = 4(2), respectively]. At the low and moderate level of the depression subscale, female patients experienced asthma exacerbations more frequently compared to male patients (adjusted Incidence Rate Ratio (aIRR) = 4.30; 95% Confidence Interval (CI): 1.94–9.53 and aIRR = 1.82; 95% CI: 1.07–3.13, respectively). Conclusions. Clinicians should evaluate asthma patients for depression, as gender differentially influences outcomes among those with low and moderate levels of depression, with female asthmatics presenting more frequent exacerbations.
    Keywords asthma ; control ; exacerbations ; depression ; anxiety ; gender ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: A 52-Year-Old Man Presented With Cough, Chest Pain, and a Mass in the Right Lung.

    Chrysikos, Serafeim / Papaioannou, Ourania / Anyfanti, Maria / Karampitsakos, Theodoros / Vamvakaris, Ioannis / Tzouvelekis, Argyrios / Dimakou, Katerina

    Chest

    2020  Volume 158, Issue 5, Page(s) e241–e244

    Abstract: Case presentation: A 52-year-old man, current smoker with a 50 pack-year history, presented to our department with cough, yellow sputum, and localized right chest pain. Chest radiograph revealed a large mass in the right upper lobe. He denied the ... ...

    Abstract Case presentation: A 52-year-old man, current smoker with a 50 pack-year history, presented to our department with cough, yellow sputum, and localized right chest pain. Chest radiograph revealed a large mass in the right upper lobe. He denied the presence of fever, night sweats, or weight loss. He has a medical history of COPD and anxiety disorder. He was receiving long-acting beta agonists/long-acting muscarinic antagonists as a treatment for COPD and quetiapine 100 mg for anxiety disorder.
    MeSH term(s) Biopsy/methods ; Chest Pain/diagnosis ; Chest Pain/etiology ; Cough/diagnosis ; Cough/etiology ; Diagnosis, Differential ; Granuloma, Respiratory Tract/diagnostic imaging ; Granuloma, Respiratory Tract/physiopathology ; Granuloma, Respiratory Tract/surgery ; Humans ; Inflammation ; Lung/diagnostic imaging ; Lung/pathology ; Male ; Middle Aged ; Necrosis ; Pneumonectomy/methods ; Radiography, Thoracic/methods ; Solitary Pulmonary Nodule/diagnosis ; Thoracotomy/methods ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Language English
    Publishing date 2020-11-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.06.030
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    Ui III Zs.45: Show issues Location:
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  9. Article: Association of Broad-Spectrum Antibiotic Therapy and Vitamin E Supplementation with Vitamin K Deficiency-Induced Coagulopathy: A Case Report and Narrative Review of the Literature.

    Matthaiou, Andreas M / Tomos, Ioannis / Chaniotaki, Sofia / Liakopoulos, Dimitrios / Sakellaropoulou, Katerina / Koukidou, Sofia / Gheorghe, Loredana-Mariana / Eskioglou, Stefanos / Paspalli, Angeliki / Hillas, Georgios / Dimakou, Katerina

    Journal of personalized medicine

    2023  Volume 13, Issue 9

    Abstract: Vitamin K is a lipid-soluble vitamin that is normally maintained within appropriate levels by means of dietary intake and bacterial production in the intestinal microflora. It holds a central role in coagulation homeostasis, and thus its depletion leads ... ...

    Abstract Vitamin K is a lipid-soluble vitamin that is normally maintained within appropriate levels by means of dietary intake and bacterial production in the intestinal microflora. It holds a central role in coagulation homeostasis, and thus its depletion leads to hypocoagulation and haemorrhagic diathesis. The association of antibiotic therapy and vitamin E supplementation with vitamin K deficiency was previously described in animal experiments, clinical studies, and case reports. Broad-spectrum antibiotic therapy potentially leads to intestinal microflora dysbiosis and restriction of vitamin K-producing bacterial populations, resulting in decreased vitamin K levels, whereas antibiotics of the cephalosporin class with 1-
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13091349
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  10. Article ; Online: Telavancin in the treatment of Staphylococcus aureus hospital-acquired and ventilator-associated pneumonia: clinical evidence and experience.

    Liapikou, Adamantia / Dimakou, Katerina / Toumbis, Michael

    Therapeutic advances in respiratory disease

    2016  Volume 10, Issue 4, Page(s) 368–378

    Abstract: Telavancin (TLV) is a lipoglycopeptide derivative of vancomycin (VAN), which has activity against Gram-positive aerobic bacteria, and is especially effective against methicillin-resistant Staphylococcus aureus (MRSA) and Gram-positive bacteria resistant ... ...

    Abstract Telavancin (TLV) is a lipoglycopeptide derivative of vancomycin (VAN), which has activity against Gram-positive aerobic bacteria, and is especially effective against methicillin-resistant Staphylococcus aureus (MRSA) and Gram-positive bacteria resistant to VAN. Comparative clinical studies of TLV have demonstrated noninferiority compared with VAN in the treatment of hospital-acquired Gram-positive pneumonia, with high cure rates for TLV-treated patients with monomicrobial S. aureus infection, including isolates with reduced VAN susceptibility. The results based on the patients' clinical response were supported by supplemental post-hoc analyses of 28-day mortality. In Europe and the USA, TLV is approved as a useful alternative for patients with difficult-to-treat, hospital-acquired MRSA pneumonia when there are very few alternatives. The present article reviews TLV's pharmacological characteristics and clinical efficacy resulting from clinical trials giving a detailed picture of its properties and position in the management of hospital-acquired pneumonia.
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2476459-0
    ISSN 1753-4666 ; 1753-4658
    ISSN (online) 1753-4666
    ISSN 1753-4658
    DOI 10.1177/1753465816651594
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    Zs.A 6753: Show issues Location:
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