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Article ; Online: Fracture of the Second Rib

Michail Tsimpinos / Dimosthenis Chrysikos / Theano Demesticha / Maria Piagkou / Theodoros Troupis

Journal of Chest Surgery, Vol 56, Iss 6, Pp 431-

An Indirect Sign of Serious Trauma Like Fracture of the First Rib?

2023 Volume 434

Abstract: Background: The first 3 ribs are anatomically well-protected, shielded by the large thoracic muscles, the shoulder girdle, and the arm. A significant force is required to fracture these ribs; thus, such fractures suggest a high-energy trauma and are ... ...

Abstract	Background: The first 3 ribs are anatomically well-protected, shielded by the large thoracic muscles, the shoulder girdle, and the arm. A significant force is required to fracture these ribs; thus, such fractures suggest a high-energy trauma and are associated with injuries to vital organs of the thorax, such as the aorta, the heart, the lungs and the great vessels. Methods: A retrospective analysis was conducted over a 10-year period at a single hospital. The study assessed patients with fractures of the second rib, including their concurrent injuries and the overall severity of their trauma. Results: Among the 76 patients included in the study, the average age was 47.35 years, 81.5% were men, and 19.5% were women. Thirteen patients (17.1%) survived their injuries. The most common causes of injury were road traffic accidents (63%) and pedestrian injuries (22%). The patients who did not survive sustained injuries to an average of 5 additional organs, while survivors had injuries to an average of 2.07 additional organs. Left rib fractures were the most frequently observed (46%). The most serious concurrent injuries reported were to the aorta (5.26%), heart (10.52%), lung (52.36%), head (57.89%), liver (30.2%), spleen (26.31%), and kidney (17.1%). Conclusion: As indicators of serious injury to vital endothoracic organs, isolated fractures of the second rib should be considered equal to first rib fractures in clinical importance.
Keywords	ribs ; thorax ; aorta ; traffic accidents ; heart injuries ; Medicine (General) ; R5-920
Subject code	380
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Korean Society for Thoracic & Cardiovascular Surgery
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Duplicated gallbladder

Ludmila Baltaga / Dimosthenis Chrysikos / Spiros Delis / Charina Triantopoulou / Dimitrios Filippou / Vasileios Protogerou / Theodore Troupis

Folia Medica, Vol 65, Iss 5, Pp 834-

an incidental anatomical variation in a patient with symptomatic cholelithiasis

2023 Volume 838

Abstract: Congenital malformations of the biliary tract represent a relatively rare entity with which surgeons, radiologists and clinicians are not adequately familiarized. We present a rare case of gallbladder duplication in a 40-year-old female, with the ... ...

Abstract	Congenital malformations of the biliary tract represent a relatively rare entity with which surgeons, radiologists and clinicians are not adequately familiarized. We present a rare case of gallbladder duplication in a 40-year-old female, with the accessory cystic duct entering the left hepatic duct, which depicts the fifth reported case in the international bibliography. Our case illustrates the importance of detailed knowledge of anatomical malformations of the biliary tree, serving the purpose of a preoperative diagnosis of symptomatic cholelithiasis. It is also of paramount importance to take under consideration biliary tract malformations to avoid inadvertent complications such as biliary duct injuries in case of laparoscopic cholecystectomy.
Keywords	Medicine ; R
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The postoperative redox status of patients with diabetes mellitus

Vasileios Karampelias / Ypatios Spanidis / Ioannis Kehagias / Dimosthenis Chrysikos

Folia Medica, Vol 63, Iss 2, Pp 171-

a mini review

2021 Volume 176

Abstract: The human organism is exposed to variable endogenous and exogenous factors that result in the induction of free radicals. Surgeries are associated with increased inflammation and production of free radicals through various mechanisms, including ischemia, ...

Abstract	The human organism is exposed to variable endogenous and exogenous factors that result in the induction of free radicals. Surgeries are associated with increased inflammation and production of free radicals through various mechanisms, including ischemia, hemolysis, or endogenous antioxidant depletion. Importantly, a more oxidized redox status could lead to the condition known as “oxidative stress,” which is related to alterations in insulin signaling and may lead to insulin resistance and diabetes mellitus. Therefore, patients with diabetes who undergo surgery could be more vulnerable compared with healthy individuals. Thus, this review focuses on the currently available literature regarding the link between the redox status and diabetes complications after surgery and the methods used to assess the redox status of patients, which is the first step to designing an appropriate treatment strategy. To this end, we queried PubMed for novel works published up to May 2020.
Keywords	diabetes ; free radicals ; oxidative stress ; reactiv ; Medicine ; R
Subject code	500
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thoughts about “other” patients’ rights during COVID-19 pandemic

Dimosthenis Chrysikos / Constantinos G Zografos / George C Zografos

Journal of Medical Ethics and History of Medicine, Vol

2020 Volume 13

Abstract: NO Abstract NO Abstract NO Abstract NO ... ...

Abstract	NO Abstract NO Abstract NO Abstract NO Abstract
Keywords	COVID-19 pandemic ; Patients’ rights ; History of medicine. Medical expeditions ; R131-687 ; Medical philosophy. Medical ethics ; R723-726
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Tehran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Erectile Dysfunction Treatment Using Stem Cells

Vassilis Protogerou / Dimosthenis Chrysikos / Vasileios Karampelias / Ypatios Spanidis / Sara El Bisari / Theodoros Troupis

Medicines, Vol 8, Iss 1, p

A Review

2021 Volume 2

Abstract: Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. The prediction regarding the incidence of ED is devastating as it is expected that this ... ...

Abstract	Erectile dysfunction (ED) is a disorder that affects the quality of life and the sexual relations of more than half of the male population aged over 40 years. The prediction regarding the incidence of ED is devastating as it is expected that this disorder will affect more than 300 million men in the next five years. Several studies have suggested the use of stem cells for the treatment of ED and showed that this type of treatment is promising in terms of damaged tissue repair as well as of clinical efficacy; however, there are several gaps in the knowledge and evidence is lacking. In order to highlight a few of them in this review, we performed a research of the literature focusing on currently available clinical studies regarding the clinical efficacy of stem cell administration for the treatment of ED. We reviewed the methods of administration, the cell types used in the performed clinical trials and the safety and efficiency of such procedures. We conclude that there are rapidly expanding and promising results from the reported clinical studies indicating that stem cells could indeed be a potential treatment for patients with ED although more studies are necessary.
Keywords	erectile dysfunction ; stem cells ; platelet rich plasma (PRP) ; platelet lysate plasma (PLP) ; adipose tissue-derived stem cell (ADSC) ; bone marrow-derived stem cell (BMSC) ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Circulating miRNA Expression Profiles and Machine Learning Models in Association with Response to Irinotecan-Based Treatment in Metastatic Colorectal Cancer

Evangelia Pliakou / Dimitra Ioanna Lampropoulou / Nikolas Dovrolis / Dimosthenis Chrysikos / Dimitrios Filippou / Christos Papadimitriou / Antonios Vezakis / Gerasimos Aravantinos / Maria Gazouli

International Journal of Molecular Sciences, Vol 24, Iss 1, p

2022 Volume 46

Abstract: Colorectal cancer represents a leading cause of cancer-related morbidity and mortality. Despite improvements, chemotherapy remains the backbone of colorectal cancer treatment. The aim of this study is to investigate the variation of circulating microRNA ... ...

Abstract	Colorectal cancer represents a leading cause of cancer-related morbidity and mortality. Despite improvements, chemotherapy remains the backbone of colorectal cancer treatment. The aim of this study is to investigate the variation of circulating microRNA expression profiles and the response to irinotecan-based treatment in metastatic colorectal cancer and to identify relevant target genes and molecular functions. Serum samples from 95 metastatic colorectal cancer patients were analyzed. The microRNA expression was tested with a NucleoSpin miRNA kit (Machnery-Nagel, Germany), and a machine learning approach was subsequently applied for microRNA profiling. The top 10 upregulated microRNAs in the non-responders group were hsa-miR-181b-5p, hsa-miR-10b-5p, hsa-let-7f-5p, hsa-miR-181a-5p, hsa-miR-181d-5p, hsa-miR-301a-3p, hsa-miR-92a-3p, hsa-miR-155-5p, hsa-miR-30c-5p, and hsa-let-7i-5p. Similarly, the top 10 downregulated microRNAs were hsa-let-7d-5p, hsa-let-7c-5p, hsa-miR-215-5p, hsa-miR-143-3p, hsa-let-7a-5p, hsa-miR-10a-5p, hsa-miR-142-5p, hsa-miR-148a-3p, hsa-miR-122-5p, and hsa-miR-17-5p. The upregulation of microRNAs in the miR-181 family and the downregulation of those in the let-7 family appear to be mostly involved with non-responsiveness to irinotecan-based treatment.
Keywords	microRNAs ; colorectal cancer ; machine learning ; artificial intelligence ; irinotecan ; resistance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	500
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Autoimmune Pancreatitis Type 2

Dimosthenis Chrysikos / Konstantinos Toutouzas / Constantine G Zografos / Olga Bellou

Journal of Clinical and Diagnostic Research, Vol 12, Iss 5, Pp PD01-PD

Disentangling a Rare Entity of Obstructive Jaundice

2018 Volume 04

Abstract: Autoimmune Pancreatitis (AIP) can be a clinical challenge in diagnosis and treatment. It often presents with painless obstructive jaundice, which mimics pancreatic cancer. Surgical treatment is not recommended in the management of AIP. However, there are ...

Abstract	Autoimmune Pancreatitis (AIP) can be a clinical challenge in diagnosis and treatment. It often presents with painless obstructive jaundice, which mimics pancreatic cancer. Surgical treatment is not recommended in the management of AIP. However, there are cases of AIP that were diagnosed after surgical resection, due to suspicion of malignancy. Improvement in radiological imaging modalities, offer an accurate diagnosis. We hereby present the case of a 52-year-old female patient with obstructive jaundice who was diagnosed with AIP Type 2, after a meticulous diagnostic workup. The response to high doses of corticosteroids prevented her from unnecessary surgery. Her symptoms were alleviated by biliary stenting.
Keywords	corticosteroid therapy ; idiopathic pancreatitis ; immunoglobulin g4 ; lymphoplasmacytic sclerosing ; Medicine ; R
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction

Vassilis Protogerou / Sara El Beshari / Efstathios Michalopoulos / Panagiotis Mallis / Dimosthenis Chrysikos / Alexandros A. Samolis / Catherine Stavropoulos-Giokas / Theodoros Troupis

Medicines, Vol 7, Iss 3, p

A Pilot Study–6 Months Results

2020 Volume 14

Abstract: Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that ...

Abstract	Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that can possibly treat erectile dysfunction. Methods: Five patients with erectile disease were treated with Adipose-Derived Stem Cells (ADSCs) and Platelet Lysate Plasma (PLP). ADSCs were obtained through abdominal liposuction and PLP was prepared after obtaining blood samples from peripheral veins. Erectile function was evaluated with the International Index of Erectile Function questionnaire (IIEF-5) questionnaire, penile triplex at the 1st, 3rd, 6th and 12th month post-treatment. A CT scan of the head, thorax and abdomen was done before treatment and at the 12th month. Results: IIEF-5 scores were improved in all patients at the 6th month although not in the same pattern in all patients. Peak Systolic Velocity (PSV) also improved at the 6th month in all patients but also with different patterns in each patient, while End Diastolic Velocity (EDV) was more variable. Two patients decreased the treatment they used in order to obtain erection (from Intracavernosal injections (ICI) they used PDE-5Is), two had unassisted erections and one had an initial improvement which decreased at the 6th month. There were no side effects noted. Conclusions: Stem cell therapy in combination with PLP appears to show some improvement in erectile function and has minimal side effects in the short term.
Keywords	erectile dysfunction ; stem cells ; platelet lysate plasma ; adipose-derived stem cells ; Medicine ; R
Subject code	610
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Non-Recurrent Right Laryngeal Nerve

Dimosthenis Chrysikos / Markos Sgantzos / John Tsiaoussis / George Noussios / Theodore Troupis / Vassilios Protogerou / Eleftherios Spartalis / Tania Triantafyllou / Theodoros Mariolis-Sapsakos

Acta Medica, Vol 62, Iss 2, Pp 69-

a Rare Anatomic Variation Encountered During a Total Thyroidectomy

2019 Volume 71

Abstract: The non-recurrent laryngeal nerve (nRLN) is a rare anatomic variation that every head and neck surgeon must be aware of, in order to avoid intraoperative injury which leads to postoperative morbidity. We are reporting a case of a nRLN in a 47 year old ... ...

Abstract	The non-recurrent laryngeal nerve (nRLN) is a rare anatomic variation that every head and neck surgeon must be aware of, in order to avoid intraoperative injury which leads to postoperative morbidity. We are reporting a case of a nRLN in a 47 year old female patient with medullary thyroid carcinoma who was surgically treated with total thyroidectomy and lymph node dissection. Both two inferior laryngeal nerves were identified, fully exposed and preserved along their cervical courses. However, we found that the right inferior laryngeal nerve was non-recurrent and directly arised from the cervical vagal trunk, entered the larynx after a short transverse course and parallel to the inferior thyroid artery. The safety of thyroid operations is dependent on high index of suspicion, meticulous identification and dissection of laryngeal nerves either recurrent or non-recurrent. This leads to minimum risk of iatrogenic damage of the nerves. Complete knowledge of the anatomy of these neural structures, including all their anatomic variations is of paramount importance.
Keywords	non-recurrent laryngeal nerve ; thyroidectomy ; vagus nerve ; Medicine ; R
Subject code	410
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Karolinum Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Treatment with Molgramostim (Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor, Rhugm-Csf, Mielogen) and Lenograstim (Granulocyte-Colony Stimulating Factor) Improves Experimental Colitis in Rats

Apostolos E. Papalois / Calypso Barbatis / Dimosthenis Chrysikos / Maria Korontzi / Michail Sideris / Theodoros Pittaras / Eleni Triantafyllidi / Alexandros Nomikos / John K. Triantafillidis

BioMed Research International, Vol

2019 Volume 2019

Abstract: Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte ...

Abstract	Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF) in experimental colitis in rats. Methods. Experimental colitis was induced in 62 male Wistar rats, divided into 9 groups, using 2,4,6-trinitrobenzensulfonic acid (TNBS). Group 1: Ten rats with colitis without treatment (control group). Euthanasia after 15 days. Group 2: Ten animals with colitis without treatment (control group). Euthanasia after 30 days. Group 3: Six animals with colitis. Immediate treatment with CSF. Euthanasia after 19 days. Group 4: Six animals with colitis. Treatment started 7 days after the induction of colitis. Animals were kept for 19 days. Group 5: Six animals with colitis. Treatment started 2 weeks after the induction of colitis. Group 6: Six animals with colitis, the same as in group 3. Treatment with GSF. Group 7: Six animals with colitis, the same as in group 4. Treatment with GSF. Group 8. Six animals with colitis, the same as in group 5. Treatment with GSF. Group 9: Six animals with colitis. Immediate treatment with prednisolone. Euthanasia after 15 days. Results. CSF and GSF administration significantly improved the histological score (P<0.05) and reduced malondialdehyde contents (P<0.05), compared to control groups in all animals. CSF was superior to GSF and to prednisolone. Conclusion. Administration of both CSF and GSF could significantly improve the histological score and oxidative stress in experimental colitis in rats.
Keywords	Medicine ; R
Subject code	630
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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