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  1. AU="Dimulescu, Cristiana"
  2. AU="Socas, María"
  3. AU=Critchett G.

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  1. Article: Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia.

    Metzner, Christoph / Dimulescu, Cristiana / Kamp, Fabian / Fromm, Sophie / Uhlhaas, Peter J / Obermayer, Klaus

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1352641

    Abstract: Introduction: We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and ... ...

    Abstract Introduction: We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and computational modelling.
    Methods: The rs-fMRI measurements from patients with chronic ScZ (n=38) and matched healthy controls (n=43), were obtained through the public schizConnect repository. Computational models were constructed based on diffusion-weighted MRI scans and fit to the experimental rs-fMRI data.
    Results: We found decreased large-scale functional connectivity across sensory and association areas and for all functional subnetworks for the ScZ group. Additionally global synchrony was reduced in patients while metastability was unaltered. Perturbations of the computational model revealed that decreased global coupling and increased background noise levels both explained the experimentally found deficits better than local changes to the GABAergic or glutamatergic system.
    Discussion: The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1352641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Improving the detection of sleep slow oscillations in electroencephalographic data.

    Dimulescu, Cristiana / Donle, Leonhard / Cakan, Caglar / Goerttler, Thomas / Khakimova, Lilia / Ladenbauer, Julia / Flöel, Agnes / Obermayer, Klaus

    Frontiers in neuroinformatics

    2024  Volume 18, Page(s) 1338886

    Abstract: Study objectives: We aimed to build a tool which facilitates manual labeling of sleep slow oscillations (SOs) and evaluate the performance of traditional sleep SO detection algorithms on such a manually labeled data set. We sought to develop improved ... ...

    Abstract Study objectives: We aimed to build a tool which facilitates manual labeling of sleep slow oscillations (SOs) and evaluate the performance of traditional sleep SO detection algorithms on such a manually labeled data set. We sought to develop improved methods for SO detection.
    Method: SOs in polysomnographic recordings acquired during nap time from ten older adults were manually labeled using a custom built graphical user interface tool. Three automatic SO detection algorithms previously used in the literature were evaluated on this data set. Additional machine learning and deep learning algorithms were trained on the manually labeled data set.
    Results: Our custom built tool significantly decreased the time needed for manual labeling, allowing us to manually inspect 96,277 potential SO events. The three automatic SO detection algorithms showed relatively low accuracy (max. 61.08%), but results were qualitatively similar, with SO density and amplitude increasing with sleep depth. The machine learning and deep learning algorithms showed higher accuracy (best: 99.20%) while maintaining a low prediction time.
    Conclusions: Accurate detection of SO events is important for investigating their role in memory consolidation. In this context, our tool and proposed methods can provide significant help in identifying these events.
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452979-5
    ISSN 1662-5196
    ISSN 1662-5196
    DOI 10.3389/fninf.2024.1338886
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Spatiotemporal Patterns of Adaptation-Induced Slow Oscillations in a Whole-Brain Model of Slow-Wave Sleep.

    Cakan, Caglar / Dimulescu, Cristiana / Khakimova, Liliia / Obst, Daniela / Flöel, Agnes / Obermayer, Klaus

    Frontiers in computational neuroscience

    2022  Volume 15, Page(s) 800101

    Abstract: During slow-wave sleep, the brain is in a self-organized regime in which slow oscillations (SOs) between up- and down-states travel across the cortex. While an isolated piece of cortex can produce SOs, the brain-wide propagation of these oscillations are ...

    Abstract During slow-wave sleep, the brain is in a self-organized regime in which slow oscillations (SOs) between up- and down-states travel across the cortex. While an isolated piece of cortex can produce SOs, the brain-wide propagation of these oscillations are thought to be mediated by the long-range axonal connections. We address the mechanism of how SOs emerge and recruit large parts of the brain using a whole-brain model constructed from empirical connectivity data in which SOs are induced independently in each brain area by a local adaptation mechanism. Using an evolutionary optimization approach, good fits to human resting-state fMRI data and sleep EEG data are found at values of the adaptation strength close to a bifurcation where the model produces a balance between local and global SOs with realistic spatiotemporal statistics. Local oscillations are more frequent, last shorter, and have a lower amplitude. Global oscillations spread as waves of silence across the undirected brain graph, traveling from anterior to posterior regions. These traveling waves are caused by heterogeneities in the brain network in which the connection strengths between brain areas determine which areas transition to a down-state first, and thus initiate traveling waves across the cortex. Our results demonstrate the utility of whole-brain models for explaining the origin of large-scale cortical oscillations and how they are shaped by the connectome.
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452964-3
    ISSN 1662-5188
    ISSN 1662-5188
    DOI 10.3389/fncom.2021.800101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Structural Differences Between Healthy Subjects and Patients With Schizophrenia or Schizoaffective Disorder: A Graph and Control Theoretical Perspective.

    Dimulescu, Cristiana / Gareayaghi, Serdar / Kamp, Fabian / Fromm, Sophie / Obermayer, Klaus / Metzner, Christoph

    Frontiers in psychiatry

    2021  Volume 12, Page(s) 669783

    Abstract: The coordinated dynamic interactions of large-scale brain circuits and networks have been associated with cognitive functions and behavior. Recent advances in network neuroscience have suggested that the anatomical organization of such networks puts ... ...

    Abstract The coordinated dynamic interactions of large-scale brain circuits and networks have been associated with cognitive functions and behavior. Recent advances in network neuroscience have suggested that the anatomical organization of such networks puts fundamental constraints on the dynamical landscape of brain activity, i.e., the different states, or patterns of regional activation, and transition between states the brain can display. Specifically, it has been shown that densely connected, central regions control the transition between states that are "easily" reachable (in terms of expended energy), whereas weakly connected areas control transitions to states that are hard-to-reach. Changes in large-scale brain activity have been hypothesized to underlie many neurological and psychiatric disorders. Evidence has emerged that large-scale dysconnectivity might play a crucial role in the pathophysiology of schizophrenia, especially regarding cognitive symptoms. Therefore, an analysis of graph and control theoretic measures of large-scale brain connectivity in patients offers to give insight into the emergence of cognitive disturbances in the disorder. To investigate these potential differences between patients with schizophrenia (SCZ), patients with schizoaffective disorder (SCZaff) and matched healthy controls (HC), we used structural MRI data to assess the microstructural organization of white matter. We first calculate seven graph measures of integration, segregation, centrality and resilience and test for group differences. Second, we extend our analysis beyond these traditional measures and employ a simplified noise-free linear discrete-time and time-invariant network model to calculate two complementary measures of controllability. Average controllability, which identifies brain areas that can guide brain activity into different, easily reachable states with little input energy and modal controllability, which characterizes regions that can push the brain into difficult-to-reach states, i.e., states that require substantial input energy. We identified differences in standard network and controllability measures for both patient groups compared to HCs. We found a strong reduction of betweenness centrality for both patient groups and a strong reduction in average controllability for the SCZ group again in comparison to the HC group. Our findings of network level deficits might help to explain the many cognitive deficits associated with these disorders.
    Language English
    Publishing date 2021-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.669783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: EEG resting activity in highly sensitive and non-highly sensitive persons

    Dimulescu, Cristiana / Schreier, Margrit / Godde, Benjamin

    Journal of European Psychology Students

    2020  Volume 11, Issue 1, Page(s) 32–40

    Abstract: Sensory processing sensitivity (SPS) is a trait correlated with increased sensitivity to internal and external stimuli. FMRI studies indicate that increased activation in areas associated with attention, empathy, and higher-order visual processing ... ...

    Title translation EEG-Ruheaktivität bei hochsensiblen und nicht-hochsensiblen Personen (DeepL)
    Abstract Sensory processing sensitivity (SPS) is a trait correlated with increased sensitivity to internal and external stimuli. FMRI studies indicate that increased activation in areas associated with attention, empathy, and higher-order visual processing correlate with high SPS. We used electroencephalography frequency power spectra in four frequency bands (delta, theta, alpha, and beta) during resting state to examine differences between highly sensitive and non-highly sensitive persons. Results show that high SPS relates to higher absolute power in all frequency bands, pointing to higher activity of cortical pyramidal cells. Additionally, this trait similarly relates to higher relative power in the delta and lower relative power in the alpha band, suggesting that high SPS persons are better able to shift attention from the external environment to the internal state.
    Keywords Attention ; Aufmerksamkeit ; Brain ; Cognitive Processes ; Electrical Activity ; Electroencephalography ; Elektrische Aktivität ; Elektroenzephalographie ; Empathie ; Empathy ; Gehirn ; Kognitive Prozesse ; Pyramidal Neurons ; Pyramiden-Neuronen ; Sensibilität (Persönlichkeit) ; Sensitivity (Personality)
    Language English
    Document type Article
    ZDB-ID 2675869-6
    ISSN 2222-6931
    ISSN 2222-6931
    DOI 10.5334/jeps.486
    Database PSYNDEX

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  6. Article: Segregated Co-activation Patterns in the Emergence of Decision Confidence During Visual Perception.

    Jaeger, Cilia / Glim, Sarah / Dimulescu, Cristiana / Ries, Anja / Sorg, Christian / Wohlschläger, Afra

    Frontiers in systems neuroscience

    2020  Volume 14, Page(s) 557693

    Abstract: Visual metacognition-the introspection and evaluation of one's own visual perceptual processes-is measured through both decision confidence and "metacognitive efficiency." Metacognitive efficiency refers to an individual's ability to accurately judge ... ...

    Abstract Visual metacognition-the introspection and evaluation of one's own visual perceptual processes-is measured through both decision confidence and "metacognitive efficiency." Metacognitive efficiency refers to an individual's ability to accurately judge incorrect and correct decisions through confidence ratings given their task performance. Previous imaging studies in humans and nonhuman primates reported widely distributed brain regions being involved in decision confidence and metacognition. However, the neural correlates of metacognition are remarkably inconsistent across studies concerning spatial outline. Therefore, this study investigates the neural correlates of visual metacognition by examining co-activation across regions that scale with visual decision confidence. We hypothesized that interacting processes of perceptual and metacognitive performance contribute to the arising decision confidence in distributed, but segregable co-activating brain regions. To test this hypothesis, we performed task-fMRI in healthy humans during a visual backward masking task with four-scale, post-decision confidence ratings. We measured blood oxygenation covariation patterns, which served as a physiological proxy for co-activation across brain regions. Decision confidence ratings and an individual's metacognitive efficiency served as behavioral measures for metacognition. We found three distinct co-activation clusters involved in decision confidence: the first included right-centered fronto-temporal-parietal regions, the second included left temporal and parietal regions, and the left basal forebrain (BF), and the third included cerebellar regions. The right fronto-temporal-parietal cluster including the supplementary eye field and the right basal forebrain showed stronger co-activation in subjects with higher metacognitive efficiency. Our results provide novel evidence for co-activation of widely distributed fronto-parieto-temporal regions involved in visual confidence. The supplementary eye field was the only region that activated for both decision confidence and metacognitive efficiency, suggesting the supplementary eye field plays a key role in visual metacognition. Our results link findings in electrophysiology studies and human fMRI studies and provide evidence that confidence estimates arise from the integration of multiple information processing pathways.
    Language English
    Publishing date 2020-11-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2453005-0
    ISSN 1662-5137
    ISSN 1662-5137
    DOI 10.3389/fnsys.2020.557693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Structural differences between healthy subjects and patients with schizophrenia or schizoaffective disorder

    Dimulescu, Cristiana / Gareayaghi, Serdar / Kamp, Fabian / Fromm, Sophie / Obermayer, Klaus / Metzner, Christoph

    Frontiers in Psychiatry

    A graph and control theoretical perspective

    2021  

    Abstract: The coordinated dynamic interactions of large-scale brain circuits and networks have been associated with cognitive functions and behavior. Recent advances in network neuroscience have suggested that the anatomical organization of such networks puts ... ...

    Title translation Strukturelle Unterschiede zwischen gesunden Personen und Patientinnen sowie Patienten mit Schizophrenie oder schizoaffektiver Störung: Eine graph- und kontrolltheoretische Perspektive
    Abstract The coordinated dynamic interactions of large-scale brain circuits and networks have been associated with cognitive functions and behavior. Recent advances in network neuroscience have suggested that the anatomical organization of such networks puts fundamental constraints on the dynamical landscape of brain activity, i.e., the different states, or patterns of regional activation, and transition between states the brain can display. Specifically, it has been shown that densely connected, central regions control the transition between states that are "easily" reachable (in terms of expended energy), whereas weakly connected areas control transitions to states that are hard-to-reach. Changes in large-scale brain activity have been hypothesized to underlie many neurological and psychiatric disorders. Evidence has emerged that large-scale dysconnectivity might play a crucial role in the pathophysiology of schizophrenia, especially regarding cognitive symptoms. Therefore, an analysis of graph and control theoretic measures of large-scale brain connectivity in patients offers to give insight into the emergence of cognitive disturbances in the disorder. To investigate these potential differences between patients with schizophrenia (SCZ), patients with schizoaffective disorder (SCZaff) and matched healthy controls (HC), we used structural MRI data to assess the microstructural organization of white matter. We first calculate seven graph measures of integration, segregation, centrality and resilience and test for group differences. Second, we extend our analysis beyond these traditional measures and employ a simplified noise-free linear discrete-time and time-invariant network model to calculate two complementary measures of controllability. Average controllability, which identifies brain areas that can guide brain activity into different, easily reachable states with little input energy and modal controllability, which characterizes regions that can push the brain into difficult-to-reach states, i.e., states that require substantial input energy. We identified differences in standard network and controllability measures for both patient groups compared to HCs. We found a strong reduction of betweenness centrality for both patient groups and a strong reduction in average controllability for the SCZ group again in comparison to the HC group. Our findings of network level deficits might help to explain the many cognitive deficits associated with these disorders.
    Keywords Brain Connectivity ; Cognitive Impairment ; Energieeinsatz ; Energy Expenditure ; Kognitive Beeinträchtigung ; Konnektivität (Gehirn) ; Neural Networks ; Neuronale Netzwerke ; Schizoaffective Disorder ; Schizoaffektive Störung ; Schizophrenia ; Schizophrenie ; Weiße Substanz (Gehirn) ; White Matter
    Language English
    Document type Article
    DOI 10.3389/fpsyt.2021.669783
    Database PSYNDEX

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  8. Book ; Online: Spatiotemporal patterns of adaptation-induced slow oscillations in a whole-brain model of slow-wave sleep

    Cakan, Caglar / Dimulescu, Cristiana / Khakimova, Liliia / Obst, Daniela / Flöel, Agnes / Obermayer, Klaus

    2020  

    Abstract: During slow-wave sleep, the brain is in a self-organized regime in which slow oscillations (SOs) between up- and down-states travel across the cortex. While an isolated piece of cortex can produce SOs, the brain-wide propagation of these oscillations are ...

    Abstract During slow-wave sleep, the brain is in a self-organized regime in which slow oscillations (SOs) between up- and down-states travel across the cortex. While an isolated piece of cortex can produce SOs, the brain-wide propagation of these oscillations are thought to be mediated by the long-range axonal connections. We address the mechanism of how SOs emerge and recruit large parts of the brain using a whole-brain model constructed from empirical connectivity data in which SOs are induced independently in each brain area by a local adaptation mechanism. Using an evolutionary optimization approach, good fits to human resting-state fMRI data and sleep EEG data are found at values of the adaptation strength close to a bifurcation where the model produces a balance between local and global SOs with realistic spatiotemporal statistics. Local oscillations are more frequent, last shorter, and have a lower amplitude. Global oscillations spread as waves of silence across the brain, traveling from anterior to posterior regions. These traveling waves are caused by heterogeneities in the brain network in which the connection strengths between brain areas determine which areas transition to a down-state first, and thus initiate traveling waves across the cortex. Our results demonstrate the utility of whole-brain models for explaining the origin of large-scale cortical oscillations and how they are shaped by the connectome.

    Comment: For the simulations, the whole-brain neural mass modeling framework neurolib (https://github.com/neurolib-dev/neurolib) was used. Code for reproducing all figures can be found at https://github.com/caglarcakan/sleeping_brain
    Keywords Quantitative Biology - Neurons and Cognition ; Nonlinear Sciences - Adaptation and Self-Organizing Systems
    Subject code 612
    Publishing date 2020-11-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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