Article ; Online: Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists.
Bioorganic & medicinal chemistry letters
2022 Volume 77, Page(s) 129005
Abstract: Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate ... ...
| Abstract | Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate molecules. |
|---|---|
| MeSH term(s) | Receptors, Adrenergic, alpha-2 |
| Chemical Substances | Receptors, Adrenergic, alpha-2 |
| Language | English |
| Publishing date | 2022-09-26 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1063195-1 |
| ISSN | 1464-3405 ; 0960-894X |
| ISSN (online) | 1464-3405 |
| ISSN | 0960-894X |
| DOI | 10.1016/j.bmcl.2022.129005 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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