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  1. Article ; Online: Cas13d-mediated gene knockdown in CAR T cells: towards off-the-shelf cancer treatment.

    Johnston, Midori / Urban, Nadine / Dincer, Can

    Signal transduction and targeted therapy

    2024  Volume 9, Issue 1, Page(s) 113

    MeSH term(s) Humans ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy ; Immunotherapy, Adoptive ; Gene Knockdown Techniques ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Journal Article
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-024-01830-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity.

    Saglam-Metiner, Pelin / Yildirim, Ender / Dincer, Can / Basak, Onur / Yesil-Celiktas, Ozlem

    Mikrochimica acta

    2024  Volume 191, Issue 1, Page(s) 71

    Abstract: The complex structure and function of the human central nervous system that develops from the neural tube made in vitro modeling quite challenging until the discovery of brain organoids. Human-induced pluripotent stem cells-derived brain organoids offer ... ...

    Abstract The complex structure and function of the human central nervous system that develops from the neural tube made in vitro modeling quite challenging until the discovery of brain organoids. Human-induced pluripotent stem cells-derived brain organoids offer recapitulation of the features of early human neurodevelopment in vitro, including the generation, proliferation, and differentiation into mature neurons and micro-macroglial cells, as well as the complex interactions among these diverse cell types of the developing brain. Recent advancements in brain organoids, microfluidic systems, real-time sensing technologies, and their cutting-edge integrated use provide excellent models and tools for emulation of fundamental neurodevelopmental processes, the pathology of neurological disorders, personalized transplantation therapy, and high-throughput neurotoxicity testing by bridging the gap between two-dimensional models and the complex three-dimensional environment in vivo. In this review, we summarize how bioengineering approaches are applied to mitigate the limitations of brain organoids for biomedical and clinical research. We further provide an extensive overview and future perspectives of the humanized brain organoids-on-chip platforms with integrated sensors toward brain organoid intelligence and biocomputing studies. Such approaches might pave the way for increasing approvable clinical applications by solving their current limitations.
    MeSH term(s) Humans ; Brain ; Neurons ; Nervous System Diseases ; Induced Pluripotent Stem Cells/metabolism ; Organoids
    Language English
    Publishing date 2024-01-03
    Publishing country Austria
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-023-06165-4
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
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  3. Article: Editorial: Integrated biosensors towards clinical and point-of-care diagnostics.

    Dincer, Can / Chandra, Pranjal / Morales-Narváez, Eden

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 1008603

    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1008603
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  4. Article ; Online: The impact of biosensing in a pandemic outbreak: COVID-19.

    Morales-Narváez, Eden / Dincer, Can

    Biosensors & bioelectronics

    2020  Volume 163, Page(s) 112274

    Abstract: COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI century. In this opinionated review, we underscore the crucial role of biosensing to handle with such situations. As a matter of fact, testing accelerates life-saving ... ...

    Abstract COVID-19 pandemic outbreak is the most astounding scene ever experienced in the XXI century. In this opinionated review, we underscore the crucial role of biosensing to handle with such situations. As a matter of fact, testing accelerates life-saving decisions on treatment and isolation of COVID-19 patients in an early stage, and thereby, decelerating or even preventing the spread of such emerging infectious diseases. Meanwhile, it is also proven that a timely and broad application of testing leads to lower mortality rates in countries like Germany or South Korea. Besides, biosensors are also powerful tools for effective assessment of clinical progress and to provide alertness on severity or critical trends of infection. In view hereof, we critically discuss the state-of-the-art biosensing devices for COVID-19 testing. We spot the urgent needs and highlight innovative diagnostic approaches for targeting various COVID-19 related biomarkers. Finally, we outline our recommendations on biosensors and biosensing-related issues towards pandemic outbreaks.
    MeSH term(s) Betacoronavirus/isolation & purification ; Biomarkers/analysis ; Biosensing Techniques/instrumentation ; Biosensing Techniques/methods ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/instrumentation ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Equipment Design ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
    Chemical Substances Biomarkers
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2020.112274
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Next-generation digital biomarkers: continuous molecular health monitoring using wearable devices.

    Brasier, Noé / Wang, Joseph / Dincer, Can / Güder, Firat / Schauwecker, Ivo / Schaffarczyk, Dietmar / Ghaffari, Roozbeh / Goldhahn, Jörg

    Trends in biotechnology

    2024  Volume 42, Issue 3, Page(s) 255–257

    MeSH term(s) Wearable Electronic Devices ; Monitoring, Physiologic ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.12.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
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  6. Article ; Online: Microfluidic Roadmap for Translational Nanotheranostics.

    Kabay, Gozde / Manz, Andreas / Dincer, Can

    Small methods

    2021  Volume 6, Issue 2, Page(s) e2101217

    Abstract: Nanotheranostic materials (NTMs) shed light on the mechanisms responsible for complex diseases such as cancer because they enable making a diagnosis, monitoring the disease progression, and applying a targeted therapy simultaneously. However, several ... ...

    Abstract Nanotheranostic materials (NTMs) shed light on the mechanisms responsible for complex diseases such as cancer because they enable making a diagnosis, monitoring the disease progression, and applying a targeted therapy simultaneously. However, several issues such as the reproducibility and mass production of NTMs hamper their application for clinical practice. To address these issues and facilitate the clinical application of NTMs, microfluidic systems have been increasingly used. This perspective provides a glimpse into the current state-of-art of NTM research, emphasizing the methods currently employed at each development stage of NTMs and the related open problems. This work reviews microfluidic technologies used to develop NTMs, ranging from the fabrication and testing of a single NTM up to their manufacturing on a large scale. Ultimately, a step-by-step vision on the future development of NTMs for clinical practice enabled by microfluidics techniques is provided.
    MeSH term(s) Animals ; Humans ; Lab-On-A-Chip Devices ; Theranostic Nanomedicine/instrumentation ; Theranostic Nanomedicine/methods
    Language English
    Publishing date 2021-12-26
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202101217
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  7. Article ; Online: Sensors in blockchain.

    Altay, Alara / Learney, Robert / Güder, Firat / Dincer, Can

    Trends in biotechnology

    2021  Volume 40, Issue 2, Page(s) 141–144

    Abstract: Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measurements, exchange ... ...

    Abstract Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measurements, exchange data, and make decisions automatically over decentralized networks; these systems could improve healthcare, the quality of goods, and supply chain efficiency.
    MeSH term(s) Blockchain ; Internet of Things ; Technology
    Language English
    Publishing date 2021-05-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2021.04.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Sensors in blockchain

    Altay, Alara / Learney, Robert / Güder, Firat / Dincer, Can

    Trends in biotechnology. 2021,

    2021  

    Abstract: Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measurements, exchange ... ...

    Abstract Blockchain, the technology behind bitcoin, has stimulated global conversation around digital decentralization to connect societies and economies. Connected low-cost sensors within Internet of Things (IoT) networks may soon perform measurements, exchange data, and make decisions automatically over decentralized networks; these systems could improve healthcare, the quality of goods, and supply chain efficiency.
    Keywords Internet ; biotechnology ; blockchain ; decentralization ; health services ; supply chain
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2021.04.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2750: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Personalisierte Antibiotikatherapie

    Dincer, Can

    Hygiene + Medizin: Zeitschrift für angewandte Hygiene in Krankenhäusern und Praxis

    2016  Volume 42, Issue 11, Page(s) 290–291

    Abstract: Freiburger Forscher haben eine Sensor-Plattform entwickelt, die das Medikament in wenigen Minuten im Blut nachweist. ...

    Abstract Freiburger Forscher haben eine Sensor-Plattform entwickelt, die das Medikament in wenigen Minuten im Blut nachweist.
    Keywords Antibiotikatherapie
    Language German
    Document type Article
    ZDB-ID 518696-1
    ISSN 0172-3790
    ISSN 0172-3790
    Database bibnet.org

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1725: Show issues Location:
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  10. Article ; Online: Wearable sweat analysis to determine biological age

    Niederberger, Carmela / Vermeersch, Arthur / Davidhi, Flavia / Ewald, Collin Y. / Havenith, George / Goldhahn, Jörg / Dincer, Can / Brasier, Noé

    Elsevier Ltd Trends in Biotechnology. 2023 Sept., v. 41, no. 9 p.1113-1116

    2023  

    Abstract: A real-time, noninvasive, and clinically applicable aging test in humans has yet to be established. Herein we propose a sweat- and wearable-based test to determine biological age. This test would empower users to monitor their aging process and take an ... ...

    Abstract A real-time, noninvasive, and clinically applicable aging test in humans has yet to be established. Herein we propose a sweat- and wearable-based test to determine biological age. This test would empower users to monitor their aging process and take an active role in managing their lifestyle and health.
    Keywords biotechnology ; lifestyle ; sweat ; wearable sensors ; sweat diagnostics ; aging
    Language English
    Dates of publication 2023-09
    Size p. 1113-1116.
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2023.02.001
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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