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  1. Article: Synthesis and NO

    Wang, Zhenyu / Ding, Haizhen / Liu, Xuefeng / Zhao, Jing

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 16

    Abstract: Semiconductor oxide gas sensors have important applications in environmental protection, domestic health, and other fields. Research has shown that designing the morphology of sensitive materials can effectively improve the sensing characteristics of ... ...

    Abstract Semiconductor oxide gas sensors have important applications in environmental protection, domestic health, and other fields. Research has shown that designing the morphology of sensitive materials can effectively improve the sensing characteristics of sensors. In this paper, by controlling the solvothermal reaction time, a unique hexagonal flower-like structure of In
    Language English
    Publishing date 2023-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13162289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Integrated anti-vascular and immune-chemotherapy for colorectal carcinoma using a pH-responsive polymeric delivery system.

    Ma, Xiaoqian / Yang, Qing / Lin, Nuo / Feng, Yushuo / Liu, Yaqing / Liu, Peifei / Wang, Yiru / Deng, Huaping / Ding, Haizhen / Chen, Hongmin

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 370, Page(s) 230–238

    Abstract: Colorectal carcinoma (CRC) has become one of the most prevalent malignant tumors and exploring a potential therapeutic strategy with diminished drug-associated adverse effects to combat CRC is urgent. Herein, we designed a pH-responsive polymer to ... ...

    Abstract Colorectal carcinoma (CRC) has become one of the most prevalent malignant tumors and exploring a potential therapeutic strategy with diminished drug-associated adverse effects to combat CRC is urgent. Herein, we designed a pH-responsive polymer to efficiently encapsulate a stimulator of interferon genes (STING) agonist (5,6- dimethylxanthenone-4-acetic acid, termed ASA404) and a common clinically used chemotherapeutic agent (1-hexylcarbamoyl-5-fluorouracil, termed HCFU). Investigations in vitro demonstrated that polymer encapsulation endowed the system with a pH-dependent disassembly behavior (pH
    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.04.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2055: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Carbon Dots Derived from Tea Polyphenols as Photosensitizers for Photodynamic Therapy.

    Yang, Yuxiang / Ding, Haizhen / Li, Zijian / Tedesco, Antonio Claudio / Bi, Hong

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 23

    Abstract: Photodynamic therapy (PDT) has become an emerging cancer treatment method. Choosing the photosensitizer (PS) compounds is one of the essential factors that can influence the PDT effect and action. Carbon dots (CDs) have shown great potential as ... ...

    Abstract Photodynamic therapy (PDT) has become an emerging cancer treatment method. Choosing the photosensitizer (PS) compounds is one of the essential factors that can influence the PDT effect and action. Carbon dots (CDs) have shown great potential as photosensitizers in PDT of cancers due to their excellent biocompatibility and high generation of reactive oxygen species (ROS). Here, we used tea polyphenol as raw material for synthesized tea polyphenol carbon dots (T-CDs) that show dual emission bands of red and blue fluorescence and can efficiently generate hydroxyl radicals (OH) under mildly visible irradiation with a LED light (400-500 nm, 15 mW cm
    Language English
    Publishing date 2022-12-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27238627
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: High-Q lasing in Nd

    Huang, Qing / Ding, Haizhen / Zhang, Mingming / Bai, Shengchuang / Dai, Shixun / Nie, Qiuhua / Wen, Lei / Wang, Xunsi

    Optics letters

    2023  Volume 48, Issue 11, Page(s) 3103–3106

    Abstract: ... ...

    Abstract Nd
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.491781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cu

    Ding, Haizhen / Ren, Fangfang / Liu, Peifei / Feng, Yushuo / Ma, Xiaoqian / Shen, Zhiyang / Shi, Qianqian / Xu, Mengjiao / Li, Wenle / Chen, Hongmin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 44, Page(s) e202311549

    Abstract: Both hydrogen ( ... ...

    Abstract Both hydrogen (H
    MeSH term(s) Humans ; Carbon ; Cell Transformation, Neoplastic ; Copper ; Hydrogen ; Water ; Apoptosis
    Chemical Substances Carbon (7440-44-0) ; Copper (789U1901C5) ; Hydrogen (7YNJ3PO35Z) ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-09-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202311549
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  6. Article ; Online: Influence of cooking and texture attributes of far infrared radiated Japonica rice during storage

    Ding, Chao / Chang, Le / Luo, Yao / Tao, Tingting / Atungulu, Griffiths G. / Ding, Haizhen / Huang, Lisong / Simelane, Mthokozisi BC. / Zhao, Siqi / Liu, Qiang

    Journal of Cereal Science. 2023 July, v. 112 p.103710-

    2023  

    Abstract: The impact of ceramic far infrared radiation drying (IRD) pretreatment method on cooking and texture properties based on stabilization of rice protein throughout the storage (8 months) of rough japonica rice was determined. Kinetic analysis showed that ... ...

    Abstract The impact of ceramic far infrared radiation drying (IRD) pretreatment method on cooking and texture properties based on stabilization of rice protein throughout the storage (8 months) of rough japonica rice was determined. Kinetic analysis showed that IRD significantly reduced the production of carbonyl compounds and free sulfhydryl groups by oxidation of byproducts. This may because of IRD prevented the transformation of ordered secondary structures into disordered, with a 3.3% and 6.6% increase in the content of α-helix and β-fold and the exposed hydrophobic area is reduced. During 8 months of storage at 35 °C, water uptake ratio and volume expansion ratio are 13.5% and 74.3% lower than that of air drying. Therefore, IRD can slow down protein oxidation of stored rice and promote the water absorption ability, expansion of rice kernel during gelatinization, and improve rice cooking quality and texture characteristics.
    Keywords air ; ceramics ; gelatinization ; hydrophobicity ; kinetics ; oxidation ; rice ; rice protein ; seeds ; stored grain ; terrestrial radiation ; texture ; water uptake ; Paddy rice ; Storage ; Infrared radiation drying ; Protein oxidation
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 408468-8
    ISSN 0733-5210
    ISSN 0733-5210
    DOI 10.1016/j.jcs.2023.103710
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    In stock of ZB MED Bonn / Germany

    Z 3775: Show issues

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  7. Article ; Online: Effect on lipoxygenase pathway and flavor stabilization of postharvest strawberries by intense pulsed light treatment

    Liu, Qiang / Ding, Haizhen / Zhang, Tingting / Zhou, Dandan / Zhu, Tong / Pan, Leiqing / Ma, Gaoxing / Lan, Weijie / Zhao, Siqi / Hu, Qiuhui / Ding, Chao

    Postharvest Biology and Technology. 2023 Oct., v. 204 p.112472-

    2023  

    Abstract: A non-thermal pretreatment method was developed to improve the flavor stability of strawberries using an intense pulsed light during postharvest storage. The physicochemical properties, volatile organic compounds (free and bound), enzyme activities, and ... ...

    Abstract A non-thermal pretreatment method was developed to improve the flavor stability of strawberries using an intense pulsed light during postharvest storage. The physicochemical properties, volatile organic compounds (free and bound), enzyme activities, and key gene expressions were investigated during 7-day storage. A 23.67% decrease in the decay ratio was obtained in IPL-treated with 2.0 Hz frequency for 60 s compared to the control. A more stable surface color was obtained at the end of the storage period. A total of 21 f-VOCs and 13 b-VOCs were quantitatively identified. IPL treatment promoted the contents of free aldehydes, esters, and ketones. The content of (E)− 2-heptenal in the IPL-treated strawberries was 1.90 times higher than that in control. The variation in the total content of b-VOCs was less than 31.61% that in the control group. Correspondingly, IPL treatment inhibited the activities of fatty acid metabolism enzymes and decreased LOX activity by 26.3% after storage. Aroma-related genes, including FaLOX, FaADH, and FaAAT, were down-regulated in the metabolism of specific VOCs following IPL treatment. This work provided evidence about the practical application of IPL in inhibiting the activity of enzyme in the LOX pathway, thereby improving the flavor stability of strawberries under non-thermal process conditions.
    Keywords color ; enzyme activity ; fatty acid metabolism ; flavor ; genes ; lipoxygenases ; phototherapy ; postharvest storage ; pulsed light irradiation ; storage time ; volatile organic compounds ; Intense pulsed light ; Strawberry fruit ; Volatiles organic components ; Gene expression
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1082798-5
    ISSN 1873-2356 ; 0925-5214
    ISSN (online) 1873-2356
    ISSN 0925-5214
    DOI 10.1016/j.postharvbio.2023.112472
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    In stock of ZB MED Bonn / Germany

    Z 5311: Show issues

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  8. Article: Current Advances on Structure-Function Relationships of Pyridoxal 5'-Phosphate-Dependent Enzymes.

    Liang, Jing / Han, Qian / Tan, Yang / Ding, Haizhen / Li, Jianyong

    Frontiers in molecular biosciences

    2019  Volume 6, Page(s) 4

    Abstract: Pyridoxal 5'-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others. Enzymes, requiring PLP, are commonly termed PLP-dependent enzymes, and they are widely ... ...

    Abstract Pyridoxal 5'-phosphate (PLP) functions as a coenzyme in many enzymatic processes, including decarboxylation, deamination, transamination, racemization, and others. Enzymes, requiring PLP, are commonly termed PLP-dependent enzymes, and they are widely involved in crucial cellular metabolic pathways in most of (if not all) living organisms. The chemical mechanisms for PLP-mediated reactions have been well elaborated and accepted with an emphasis on the pure chemical steps, but how the chemical steps are processed by enzymes, especially by functions of active site residues, are not fully elucidated. Furthermore, the specific mechanism of an enzyme in relation to the one for a similar class of enzymes seems scarcely described or discussed. This discussion aims to link the specific mechanism described for the individual enzyme to the same types of enzymes from different species with aminotransferases, decarboxylases, racemase, aldolase, cystathionine β-synthase, aromatic phenylacetaldehyde synthase, et al. as models. The structural factors that contribute to the reaction mechanisms, particularly active site residues critical for dictating the reaction specificity, are summarized in this review.
    Language English
    Publishing date 2019-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2019.00004
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  9. Article: Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions

    Liang, Jing / Ding, Haizhen / Han, Qian / Li, Jianyong

    Insect biochemistry and molecular biology. 2017 Dec., v. 91

    2017  

    Abstract: In available insect genomes, there are several L-3,4-dihydroxyphenylalanine (L-dopa) decarboxylase (DDC)-like or aromatic amino acid decarboxylase (AAAD) sequences. This contrasts to those of mammals whose genomes contain only one DDC. Our previous ... ...

    Abstract In available insect genomes, there are several L-3,4-dihydroxyphenylalanine (L-dopa) decarboxylase (DDC)-like or aromatic amino acid decarboxylase (AAAD) sequences. This contrasts to those of mammals whose genomes contain only one DDC. Our previous experiments established that two DDC-like proteins from Drosophila actually mediate a complicated decarboxylation-oxidative deamination process of dopa in the presence of oxygen, leading to the formation of 3,4-dihydroxyphenylacetaldehyde (DHPA), CO2, NH3, and H2O2. This contrasts to the typical DDC-catalyzed reaction, which produces CO2 and dopamine. These DDC-like proteins were arbitrarily named DHPA synthases based on their critical role in insect soft cuticle formation. Establishment of reactions catalyzed by these AAAD-like proteins solved a puzzle that perplexed researchers for years, but to tell a true DHPA synthase from a DDC in the insect AAAD family remains problematic due to high sequence similarity. In this study, we performed extensive structural and biochemical comparisons between DHPA synthase and DDC. These comparisons identified several target residues potentially dictating DDC-catalyzed and DHPA synthase-catalyzed reactions, respectively. Comparison of DHPA synthase homology models with crystal structures of typical DDC proteins, particularly residues in the active sites, provided further insights for the roles these identified target residues play. Subsequent site-directed mutagenesis of the tentative target residues and activity evaluations of their corresponding mutants determined that active site His192 and Asn192 are essential signature residues for DDC- and DHPA synthase-catalyzed reactions, respectively. Oxygen is required in DHPA synthase-mediated process and this oxidizing agent is reduced to H2O2 in the process. Biochemical assessment established that H2O2, formed in DHPA synthase-mediated process, can be reused as oxidizing agent and this active oxygen species is reduced to H2O; thereby avoiding oxidative stress by H2O2. Results of our structural and functional analyses provide a reasonable explanation of mechanisms involved in DHPA synthase-mediated reactions. Based on the key active site residue Asn192, identified in Drosophila DHPA synthase, we were able to distinguish all available insect DHPA synthases from DDC sequences primarily.
    Keywords active oxygen species ; active sites ; ammonia ; carbon dioxide ; crystal structure ; deamination ; dopamine ; Drosophila ; genome ; hydrogen peroxide ; insects ; L-dopa ; mammals ; models ; mutants ; oxidants ; oxidative stress ; oxygen ; proteins ; sequence homology ; site-directed mutagenesis
    Language English
    Dates of publication 2017-12
    Size p. 34-43.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1483248-3
    ISSN 1879-0240 ; 0965-1748
    ISSN (online) 1879-0240
    ISSN 0965-1748
    DOI 10.1016/j.ibmb.2017.10.001
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  10. Article ; Online: Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions.

    Liang, Jing / Han, Qian / Ding, Haizhen / Li, Jianyong

    Insect biochemistry and molecular biology

    2017  Volume 91, Page(s) 34–43

    Abstract: In available insect genomes, there are several L-3,4-dihydroxyphenylalanine (L-dopa) decarboxylase (DDC)-like or aromatic amino acid decarboxylase (AAAD) sequences. This contrasts to those of mammals whose genomes contain only one DDC. Our previous ... ...

    Abstract In available insect genomes, there are several L-3,4-dihydroxyphenylalanine (L-dopa) decarboxylase (DDC)-like or aromatic amino acid decarboxylase (AAAD) sequences. This contrasts to those of mammals whose genomes contain only one DDC. Our previous experiments established that two DDC-like proteins from Drosophila actually mediate a complicated decarboxylation-oxidative deamination process of dopa in the presence of oxygen, leading to the formation of 3,4-dihydroxyphenylacetaldehyde (DHPA), CO
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1483248-3
    ISSN 1879-0240 ; 0965-1748
    ISSN (online) 1879-0240
    ISSN 0965-1748
    DOI 10.1016/j.ibmb.2017.10.001
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