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  1. Article: Analysis of Microbial Diversity and Community Structure of Rhizosphere Soil of Three

    Ding, Jia-Jie / Zhou, Guo-Jun / Chen, Xiao-Jie / Xu, Wei / Gao, Xing-Mei / Zhang, Yong-Zeng / Jiang, Bei / Li, Hai-Feng / Wang, Kai-Ling

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: ... ...

    Abstract Astragalus
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New insights into the reverse of chromium-induced reprotoxicity of pregnant mice by melatonin.

    Ding, Jia-Jie / Jiao, Chan / Qi, Ya-Lei / Guo, Hui-Xia / Yuan, Qin-Qin / Huang, Yu-Nuo / Han, Jian-Qiu / Ma, Xue-Yun / Xu, Juan

    Ecotoxicology and environmental safety

    2022  Volume 238, Page(s) 113608

    Abstract: Hexavalent chromium Cr(VI) is a well-known environmental toxic metal that causes reprotoxicity in pregnant females. There are currently no appropriate interventions or treatments for Cr(VI) exposure during pregnancy. Herein, the protective effect of ... ...

    Abstract Hexavalent chromium Cr(VI) is a well-known environmental toxic metal that causes reprotoxicity in pregnant females. There are currently no appropriate interventions or treatments for Cr(VI) exposure during pregnancy. Herein, the protective effect of melatonin (MLT) against Cr(VI)-induced reprotoxicity is investigated by administrating MLT to pregnant mice exposed to Cr(VI). The results indicate that MLT effectively alleviates Cr(VI)-induced adverse pregnancy outcomes, restoring the decreased fetal weight and increased fetal resorption and malformation caused by Cr(VI) exposure to normal levels. MLT reduces the negative effects of Cr(VI) on follicular atresia and the development of primordial follicle in the maternal ovarian, thereby mitigating the decline in the reserve of primordial follicles. MLT alleviates Cr(VI)-induced oxidative stress, hence reducing the excessive accumulation of malondialdehyde in the maternal ovary. MLT inhibits Cr(VI)-induced apoptosis of ovarian granulosa cells and the expression of cleaved caspase-3 in the ovary. MLT reduces the increase in serum follicle-stimulating hormone caused by Cr(VI) exposure, while elevating anti-Mullerian hormone levels. We demonstrate that MLT reverses Cr(VI)-induced reprotoxicity in pregnant mice, opening up a new avenue for treating reproductive defects caused by environmental stress.
    MeSH term(s) Animals ; Chromium/metabolism ; Female ; Follicular Atresia ; Melatonin/metabolism ; Melatonin/pharmacology ; Mice ; Ovary ; Pregnancy ; Pregnancy Outcome
    Chemical Substances Chromium (0R0008Q3JB) ; Melatonin (JL5DK93RCL)
    Language English
    Publishing date 2022-05-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2022.113608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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