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  1. Article ; Online: Ferroptosis in viral infection: a potential therapeutic target.

    Ding, Liqiong

    Future microbiology

    2024  

    Abstract: Ferroptosis, known as a type of programmed cell death that is iron dependent, is characterized by intracellular iron accumulation, glutathione depletion, glutathione peroxidase inactivation and lipid peroxidation. More and more research in recent years ... ...

    Abstract Ferroptosis, known as a type of programmed cell death that is iron dependent, is characterized by intracellular iron accumulation, glutathione depletion, glutathione peroxidase inactivation and lipid peroxidation. More and more research in recent years has demonstrated the tight connection between viral infections and ferroptosis. This article reviews the potential role and mechanism of ferroptosis in viral infection, and these findings will help in the prevention and treatment of the virus.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2023-0186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of PD-1 and immune cells in HSV infection and latency.

    Ding, Liqiong

    Future microbiology

    2024  Volume 19, Page(s) 349–354

    Abstract: A large proportion of the world's population is infected with HSV-1. Antiviral ... ...

    Abstract A large proportion of the world's population is infected with HSV-1. Antiviral CD8
    MeSH term(s) Humans ; CD8-Positive T-Lymphocytes ; Programmed Cell Death 1 Receptor/genetics ; Virus Latency ; Herpes Simplex ; Herpesvirus 1, Human/genetics
    Chemical Substances Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2023-0151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: THE EFFECT OF CHILDHOOD SUBJECTIVE SOCIOECONOMIC STATUS ON MENTAL HEALTH: THE MEDIATING ROLES OF PERCEIVED DISCRIMINATION AND STATUS ANXIETY.

    Ding, L / Huang, L

    Georgian medical news

    2024  , Issue 346, Page(s) 56–62

    Abstract: This study explored the effect of childhood subjective socioeconomic status on mental health and the chain-mediating mechanism of perceived discrimination and status anxiety. A random survey was conducted via an online survey platform with 999 college ... ...

    Abstract This study explored the effect of childhood subjective socioeconomic status on mental health and the chain-mediating mechanism of perceived discrimination and status anxiety. A random survey was conducted via an online survey platform with 999 college students in east China. Participants completed the Childhood Subjective Socioeconomic Status Scale, General Health Questionnaire, Status Anxiety Scale, and the Perceived Personal Discrimination Scale. The sample comprised 323 men and 676 women. The mean age was 20.49±2.70 years. Mediation analysis using Model 6 and 5,000 bootstrap samples was employed to explore the mediating role of perceived discrimination and status anxiety in the relationship between childhood subjective socioeconomic status and mental health. Mental health was significantly positively correlated with childhood socioeconomic status, and significantly negatively correlated with perceived discrimination and status anxiety. Perceived discrimination and status anxiety played a partial chain mediating role between childhood socioeconomic status and mental health. The mediation model accounted for 31% of the variance in mental health. Moreover, the results indicated that the significant mediating effect of perceived discrimination between childhood subjective SES and mental health had a value of 0.029 and a 95% confidence interval of [0.019, 0.041]. Furthermore, the significant mediating effect of status anxiety between childhood subjective SES and mental health had a value of 0.010 and a 95% confidence interval of [0.006, 0.014]. The results provide an explanation of how childhood subjective socioeconomic status influences their mental health. Interventions to address perceived discrimination and status anxiety can improve the mental health status of children who experience childhood adversity. The study's findings contribute to understanding mental health in childhood and inform potential interventions to improve the well-being of individuals who have experienced childhood adversity. The limitations of the study were self-report scales and potential biases in the sample population. Addressing these limitations will enhance the credibility of the research and pave the way for future studies.
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Young Adult ; Anxiety/psychology ; Anxiety Disorders ; Mental Health ; Perceived Discrimination ; Social Class
    Language English
    Publishing date 2024-03-15
    Publishing country Georgia (Republic)
    Document type Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
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  4. Article ; Online: Online teaching emotion analysis based on GRU and nonlinear transformer algorithm.

    Ding, Lan

    PeerJ. Computer science

    2023  Volume 9, Page(s) e1696

    Abstract: Nonlinear models of neural networks demonstrate the ability to autonomously extract significant attributes from a given target, thus facilitating automatic analysis of classroom emotions. This article introduces an online auxiliary tool for analyzing ... ...

    Abstract Nonlinear models of neural networks demonstrate the ability to autonomously extract significant attributes from a given target, thus facilitating automatic analysis of classroom emotions. This article introduces an online auxiliary tool for analyzing emotional states in virtual classrooms using the nonlinear vision algorithm Transformer. This research uses multimodal fusion, students' auditory input, facial expression and text data as the foundational elements of sentiment analysis. In addition, a modal feature extractor has been developed to extract multimodal emotions using convolutional and gated cycle unit (GRU) architectures. In addition, inspired by the Transformer algorithm, a cross-modal Transformer algorithm is proposed to enhance the processing of multimodal information. The experiments demonstrate that the training performance of the proposed model surpasses that of similar methods, with its recall, precision, accuracy, and F1 values achieving 0.8587, 0.8365, 0.8890, and 0.8754, respectively, which is superior accuracy in capturing students' emotional states, thus having important implications in assessing students' engagement in educational courses.
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 2376-5992
    ISSN (online) 2376-5992
    DOI 10.7717/peerj-cs.1696
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  5. Article ; Online: Contributions of the Basal Ganglia to Visual Perceptual Decisions.

    Ding, Long

    Annual review of vision science

    2023  Volume 9, Page(s) 385–407

    Abstract: The basal ganglia (BG) make up a prominent nexus between visual and motor-related brain regions. In contrast to the BG's well-established roles in movement control and value-based decision making, their contributions to the transformation of visual input ...

    Abstract The basal ganglia (BG) make up a prominent nexus between visual and motor-related brain regions. In contrast to the BG's well-established roles in movement control and value-based decision making, their contributions to the transformation of visual input into an action remain unclear, especially in the context of perceptual decisions based on uncertain visual evidence. This article reviews recent progress in our understanding of the BG's contributions to the formation, evaluation, and adjustment of such decisions. From theoretical and experimental perspectives, the review focuses on four key stations in the BG network, namely, the striatum, pallidum, subthalamic nucleus, and midbrain dopamine neurons, which can have different roles and together support the decision process.
    MeSH term(s) Basal Ganglia ; Gap Junctions ; Uncertainty
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2805730-2
    ISSN 2374-4650 ; 2374-4642
    ISSN (online) 2374-4650
    ISSN 2374-4642
    DOI 10.1146/annurev-vision-111022-123804
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  6. Book ; Thesis: AAV-mediated gene transfer of OCTN2 and L2HGDH in mice ameliorates heart failure in a pressure overload model

    Ding, Lin

    2018  

    Institution Universität Heidelberg
    Author's details vorgelegt von Lin Ding ; Doktorvater: Herr Prof. Dr. med. Oliver Müller
    Language German
    Size 107 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2019
    HBZ-ID HT020246064
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 E 1336 order for loan Magazin

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  7. Article ; Online: Multiple disadvantages: class, social capital, and well-being of ethnic minority groups in the UK during the COVID-19 pandemic.

    Li, Yaojun / Ding, Lin

    Frontiers in sociology

    2024  Volume 9, Page(s) 1215676

    Abstract: Introduction: The COVID-19 pandemic has caused untold damage to the socio-economic lives of people all over the world. Research has also demonstrated great inequality in the pandemic experience. In the UK as in many other countries, people from ethnic ... ...

    Abstract Introduction: The COVID-19 pandemic has caused untold damage to the socio-economic lives of people all over the world. Research has also demonstrated great inequality in the pandemic experience. In the UK as in many other countries, people from ethnic minority backgrounds and in working-class positions have suffered disproportionately more than the majority group and those in salariat positions in terms of income loss, financial difficulty, and vulnerability to infection. Yet little is known about how people coped in the daily lives and tried to maintain their well-being during the most difficult days of the pandemic through social capital.
    Methods: In this paper, we draw data from the COVID-19 Survey in Five National Longitudinal Studies to address these questions. The survey covered the period from May 2020 to February 2021, the height of the pandemic in the UK. It contains numerous questions on contact, help and support among family, friends, community members, socio-political trust, and physical and mental health. We conceptualise three types of social capital and one type of overall well-being and we construct latent variables from categorical indicator variables. We analyse the ethnic and socio-economic determinants of the three types of social capital and their impacts on well-being.
    Results: Our analysis shows that social capital plays very important roles on well-being, and that ethnic minority groups, particularly those of Pakistani/Bangladeshi and Black heritages, faced multiple disadvantages: their poorer socio-economic positions prevented them from gaining similar levels of social capital to those of the white group. However, for people with the same levels of social capital, the effects on well-being are generally similar.
    Discussion: Socio-economic (class) inequality is the root cause for ethnic differences in social capital which in turn affects people's well-being.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2024.1215676
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  8. Article ; Online: Mechanistic study of electroacupuncture preconditioning in alleviating myocardial ischemia-reperfusion injury in rats: involvement of mTOR/ROS signaling pathway to inhibit ferroptosis.

    Xiao, Yan / Ding, Liang

    The International journal of neuroscience

    2024  , Page(s) 1–9

    Abstract: Purpose: The objective of this study was to investigate the mechanism of electroacupuncture pretreatment in reducing myocardial ischemia-reperfusion injury in rats.: Materials and methods: The comparison of HR among the different groups did not yield ...

    Abstract Purpose: The objective of this study was to investigate the mechanism of electroacupuncture pretreatment in reducing myocardial ischemia-reperfusion injury in rats.
    Materials and methods: The comparison of HR among the different groups did not yield statistically significant differences (
    Results: Compared to the Sham group, rats in the I/R group and EA control group showed a significant decrease in EF, FS, SOD, p-mTOR/mTOR, GPX4, and FTH1, and an increase in CK-MB, cTnI, LDH, iron, ROS, MDA, ACSL4, and NCOA4 (
    Conclusions: Electroacupuncture preconditioning confers protective effects against myocardial ischemia-reperfusion injury in rats. Its mechanism may involve the activation of the mTOR/ROS signaling pathway by electroacupuncture to inhibit ferroptosis.
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1563-5279 ; 1543-5245 ; 0020-7454
    ISSN (online) 1563-5279 ; 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207454.2023.2299315
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 657: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Occurrence, ecotoxicity and ecological risks of psychoactive substances in surface waters.

    Ding, Lin / Zhang, Chong-Miao

    The Science of the total environment

    2024  Volume 926, Page(s) 171788

    Abstract: Psychoactive substances (PSs) represent a subset of emerging contaminants. Their widespread production and utilization contribute to a growing ecological burden and risk on a global scale. Conventional wastewater treatment methods have proven ... ...

    Abstract Psychoactive substances (PSs) represent a subset of emerging contaminants. Their widespread production and utilization contribute to a growing ecological burden and risk on a global scale. Conventional wastewater treatment methods have proven insufficient in adequately removing psychoactive substances, leading to their occurrence in surface water ecosystems worldwide. As of present, however, a thorough understanding of their geographical prevalence and distribution patterns remains elusive. Further, in the existing literature, there is a scarcity of comprehensive overviews that systematically summarize the toxicity of various psychoactive substances towards aquatic organisms. Through summarizing almost 140 articles, the present study provides an overview of the sources, pollution status, and biotoxicity of psychoactive substances in surface waters, as well as an assessment of their ecological risks. Concentrations of several psychoactive substances in surface waters were found to be as high as hundreds or even thousands of ng·L
    MeSH term(s) Ecosystem ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Central Nervous System Agents ; Wastewater ; Water ; Environmental Monitoring/methods ; Risk Assessment
    Chemical Substances Water Pollutants, Chemical ; Central Nervous System Agents ; Wastewater ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-03-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: METTL3: Melting the tumor microenvironment for improved immunotherapy.

    Gao, Longfei / Ding, Lei

    Cell chemical biology

    2024  Volume 31, Issue 4, Page(s) 629–631

    Abstract: The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al. ...

    Abstract The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.
    MeSH term(s) Tumor Microenvironment ; Immunotherapy
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2451-9448
    ISSN (online) 2451-9448
    DOI 10.1016/j.chembiol.2024.03.005
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