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Article ; Online: Guided isolation of enantiomeric lignans from Cimicifuga heracleifolia Kom. by antioxidant activity and molecular networking.

Sun, Yanwen / Chen, Liyi / Zhou, Yan / Han, Fei / Rong, Yifang / Ding, Liqin / Qiu, Feng

2024 Volume 221, Page(s) 114050

Abstract: Under the guidance of antioxidant evaluation combined with molecular networking, six pairs of enantiomeric lignans including seven undescribed ones (1a, 2a/2b-4a/4b), along with five known analogs (1b, 5a/5b-6a/6b) were isolated from Cimicifuga ... ...

Abstract	Under the guidance of antioxidant evaluation combined with molecular networking, six pairs of enantiomeric lignans including seven undescribed ones (1a, 2a/2b-4a/4b), along with five known analogs (1b, 5a/5b-6a/6b) were isolated from Cimicifuga heracleifolia Kom. Their structures were determined by extensive spectroscopic data analysis, including HRESIMS, 1D and 2D NMR, experimental and calculated ECD. All the enantiomeric isolates were evaluated for antioxidation by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2'-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging tests. Compounds 1a and 3a/3b exhibited great DPPH and ABTS scavenging activities. The results are of great value for understanding structurally interesting enantiomeric lignans with antioxidant activity from C. heracleifolia in depth and providing its further development in functional evaluation and drug development.
MeSH term(s)	Lignans/chemistry ; Antioxidants/chemistry ; Cimicifuga ; Molecular Structure ; Sulfonic Acids ; Benzothiazoles
Chemical Substances	Lignans ; Antioxidants ; 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (28752-68-3) ; Sulfonic Acids ; Benzothiazoles
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2024.114050
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Article: Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats.

Feng, Xinchi / Wang, Kun / Cao, Shijie / Ding, Liqin / Qiu, Feng

Frontiers in pharmacology

2021 Volume 11, Page(s) 594852

Abstract: Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects. However, as ... ...

Abstract	Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects. However, as for berberine's metabolites, especially phase II metabolites, pharmacokinetics and excretion studies were rarely reported. The objective of this study was to thoroughly investigate the pharmacokinetic and excretion profiles of berberine and its nine metabolites, namely, berberrubine (M1), demethyleneberberine (M2), jatrorrhizine (M3), jatrorrhizine-3-
Language	English
Publishing date	2021-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.594852
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Article ; Online: Pharmacokinetics of Five Alkaloids and their Metabolites in Normal and Diabetic Rats after Oral Administration of Rhizoma coptidis.

Feng, Xinchi / Wang, Kun / Cao, Shijie / Ding, Liqin / Qiu, Feng

Planta medica

2021 Volume 88, Issue 11, Page(s) 921–932

Abstract: Rhizoma coptidis has been clinically used for a long time for the treatment of various diseases in China, such as hypertension, diabetes, and inflammation. Previous studies have shown that alkaloid components of Rhizoma coptidis extract could be ... ...

Abstract	Rhizoma coptidis has been clinically used for a long time for the treatment of various diseases in China, such as hypertension, diabetes, and inflammation. Previous studies have shown that alkaloid components of Rhizoma coptidis extract could be extensively metabolized and the metabolites were also considered to be the therapeutic material basis. However, until now, pharmacokinetic studies of the
MeSH term(s)	Administration, Oral ; Alkaloids ; Animals ; Berberine ; Berberine Alkaloids/metabolism ; Coptis/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Glucuronides ; Rats
Chemical Substances	Alkaloids ; Berberine Alkaloids ; Drugs, Chinese Herbal ; Glucuronides ; Berberine (0I8Y3P32UF)
Language	English
Publishing date	2021-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1506-1627
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Article ; Online: Current perspectives and trend of nanomedicine in cancer: A review and bibliometric analysis.

Pei, Zerong / Chen, Shuting / Ding, Liqin / Liu, Jingbo / Cui, Xinyi / Li, Fengyun / Qiu, Feng

Journal of controlled release : official journal of the Controlled Release Society

2022 Volume 352, Page(s) 211–241

Abstract: The limitations of traditional cancer treatments are driving the creation and development of new nanomedicines. At present, with the rapid increase of research on nanomedicine in the field of cancer, there is a lack of intuitive analysis of the ... ...

Abstract	The limitations of traditional cancer treatments are driving the creation and development of new nanomedicines. At present, with the rapid increase of research on nanomedicine in the field of cancer, there is a lack of intuitive analysis of the development trend, main authors and research hotspots of nanomedicine in the field of cancer, as well as detailed elaboration of possible research hotspots. In this review, data collected from the Web of Science Core Collection database between January 1st, 2000, and December 31st, 2021, were subjected to a bibliometric analysis. The co-authorship, co-citation, and co-occurrence of countries, institutions, authors, literature, and keywords in this subject were examined using VOSviewer, Citespace, and a well-known online bibliometrics platform. We collected 19,654 published papers, China produced the most publications (36.654%, 7204), followed by the United States (29.594%, 5777), and India (7.780%, 1529). An interesting fact is that, despite China having more publications than the United States, the United States still dominates this field, having the highest H-index and the most citations. Acs Nano, Nano Letters, and Biomaterials are the top three academic publications that publish articles on nanomedicine for cancer out of a total of 7580 academic journals. The most significant increases were shown for the keywords "cancer nanomedicine", "tumor microenvironment", "nanoparticles", "prodrug", "targeted nanomedicine", "combination", and "cancer immunotherapy" indicating the promising area of research. Meanwhile, the development prospects and challenges of nanomedicine in cancer are also discussed and provided some solutions to the major obstacles.
MeSH term(s)	United States ; Humans ; Nanomedicine ; Bibliometrics ; Neoplasms/therapy ; Tumor Microenvironment ; Immunotherapy
Language	English
Publishing date	2022-10-21
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.10.023
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Article ; Online: A Natural Self-Assembled Gel-Sponge with Hierarchical Porous Structure for Rapid Hemostasis and Antibacterial.

Li, Na / Zhang, Guoqin / Liu, Yi / Sun, Lili / Zhao, Xin / Ding, Liqin / Liu, Yanan / Wang, Meng / Ren, Xiaoliang

Advanced healthcare materials

2023 Volume 12, Issue 28, Page(s) e2301465

Abstract: Developing hemostatic agents with reliable biosafety and high efficiency has paramount clinical significance for saving lives. Herein, inspired from traditional Chinese medicine, a sponge (BC-S) with hierarchical porous structure is proposed for the ... ...

Abstract	Developing hemostatic agents with reliable biosafety and high efficiency has paramount clinical significance for saving lives. Herein, inspired from traditional Chinese medicine, a sponge (BC-S) with hierarchical porous structure is proposed for the treatment of bleeding. The BC-S is prepared by a simple self-assembly method employing Bletilla Striata polysaccharide and quaternary amine alkaloids (QA) from Bletilla Striata and Coptidis Rhizoma. The ideal cation donor encapsulated in the helical structure of BSP enlarges the inter-layer space of sponge by the action of electrostatic repulsion, forming wider channels which can accelerate the diversion speed of absorbed blood. Then, platelets and erythrocytes are trapped tightly in the reticular structure and extruded to deformation, activation. Subsequently, fibrin network forms and reinforces the internal multilayer mesh, blocks the outflow of blood. QA is released from the sponge skeleton mainly driven by a combination of surface erosion and potentially solution diffusion among pore to provide long-term antibacterial activity. Benefiting from the well-designed structure and the effective hemostatic mechanism, the BC-S displays more excellent hemostatic performance in different models in vivo and in vitro compared with typical gelatin hemostatic sponge. This work is expected to boost the development of emerging hemostatic agents.
MeSH term(s)	Humans ; Porosity ; Hemostasis ; Hemostatics/pharmacology ; Hemorrhage ; Gelatin/pharmacology ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Hemostatics ; Gelatin (9000-70-8) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-07-23
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202301465
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Article ; Online: Characterization of the metabolites of Eucommiae Cortex in rats provides a further insight into its estrogen-like effective substances.

Ding, Liqin / Qiu, Tianyi / Sun, Yanwen / Ma, Jiantong / Meng, Zhaojun / Zhao, Lin / Zhu, Na / Zhou, Kun / Qiu, Feng

Bioorganic chemistry

2023 Volume 143, Page(s) 107052

Abstract: Eucommiae Cortex is one of important traditional Chinese medicines (TCMs) used in Asia for preventing and treating osteoporosis induced by estrogen deficiency. However, the low exposure of prototype components in Eucommiae Cortex in vivo is difficult to ... ...

Abstract	Eucommiae Cortex is one of important traditional Chinese medicines (TCMs) used in Asia for preventing and treating osteoporosis induced by estrogen deficiency. However, the low exposure of prototype components in Eucommiae Cortex in vivo is difficult to interpret its efficacy. Under the guidance of UPLC-Q/TOF-MS, 42 metabolites including 32 lignans and 10 phenolics, 21 of which were new compounds, were isolated from rat urine and feces after oral administration of aqueous extract of E. ulmoides Oliv. by various chromatographic techniques. Their structures were determined based on extensive physicochemical analyses and spectral data. Their absolute configurations were determined by experimental and calculated ECD spectra, along with the calculated NMR with DP4 evaluation. Additionally, all isolated metabolites were evaluated for their estrogen-like activities, and there are 15 metabolites having estrogen-like effects after assessing influences in MCF-7 cells. Further, Dual Luciferase Reporter Gene Assay was used to determine their activation with estrogen receptor, M10 and M11 mixtures, M14, M19, M33, M27, M31, M38-M41 could activate ERα, and M19 and M41 could activate ERβ. These results not only clarify the pharmacological substances of Eucommiae Cortex, but also provide a basis for guiding its clinical application.
MeSH term(s)	Rats ; Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/analysis ; Chromatography, High Pressure Liquid/methods ; Medicine, Chinese Traditional ; Estrogens/pharmacology ; Lignans/pharmacology
Chemical Substances	Drugs, Chinese Herbal ; Estrogens ; Lignans
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.107052
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Article: Flavonoids from Eucommia ulmoides and their in vitro hepatoprotective activities

Huang, Weixing / Ding, Liqin / Zhang, Nan / Li, Wei / Koike, Kazuo / Qiu, Feng

Natural product research. 2021 Nov. 2, v. 35, no. 21

2021

Abstract: A phytochemical investigation of the barks of Eucommia ulmoides Oliv. resulted in the isolation of 18 flavonoids (1-18). The new compound, eucommiaflavone (1) was structurally elucidated by various spectroscopic analyses. In particular, Mo₂(OAc)₄-induced ...

Abstract	A phytochemical investigation of the barks of Eucommia ulmoides Oliv. resulted in the isolation of 18 flavonoids (1-18). The new compound, eucommiaflavone (1) was structurally elucidated by various spectroscopic analyses. In particular, Mo₂(OAc)₄-induced circular dichroism (ICD) analysis was applied to determine the absolute configuration of 1. Furthermore, five flavonoids (4, 9, 11, 13, and 15) revealed significant in vitro hepatoprotective activity against D-galactosamine-induced cytotoxicity in human hepatoma HepG2 cells.
Keywords	Eucommia ulmoides ; circular dichroism spectroscopy ; cytotoxicity ; flavonoids ; hepatoma ; hepatoprotective effect ; humans ; research
Language	English
Dates of publication	2021-1102
Size	p. 3584-3591.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1715402
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Article ; Online: Puerol and pueroside derivatives from Pueraria lobata and their anti-inflammatory activity.

Sun, Ying-Jie / Cao, Shi-Jie / Liang, Feng-Ni / Li, Jin-Yan / Zhang, Xiang-Yu / Li, Wei / Ding, Li-Qin / Qiu, Feng

Phytochemistry

2022 Volume 205, Page(s) 113507

Abstract: Five undescribed puerols and puerosides and three known analogues were obtained from the roots of Pueraria lobata. Their structures were determined by comprehensive analysis of spectroscopic data and chemical methods. Since puerol D and puerol C were ... ...

Abstract	Five undescribed puerols and puerosides and three known analogues were obtained from the roots of Pueraria lobata. Their structures were determined by comprehensive analysis of spectroscopic data and chemical methods. Since puerol D and puerol C were racemic compounds, resolved into their enantiomers, and their absolute configurations were determined by experimental and calculated ECD spectra. Six of the isolates were evaluated for their inhibitory activities on NO generation and the expression of inflammatory factors in the LPS-stimulated RAW 264.7 macrophage cells. The results showed that (S)-puerol C, (R)-puerol C, isokuzubutenolide A and kuzubutenolide A significantly decreased the NO production (IC
MeSH term(s)	Pueraria ; Anti-Inflammatory Agents/pharmacology
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2022-11-05
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113507
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Article: Pharmacokinetics of Five Alkaloids and their Metabolites in Normal and Diabetic Rats after Oral Administration of Rhizoma coptidis

Feng, Xinchi / Wang, Kun / Cao, Shijie / Ding, Liqin / Qiu, Feng

Planta Medica

2021 Volume 88, Issue 11, Page(s) 921–932

Abstract	Rhizoma coptidis has been clinically used for a long time for the treatment of various diseases in China, such as hypertension, diabetes, and inflammation. Previous studies have shown that alkaloid components of Rhizoma coptidis extract could be extensively metabolized and the metabolites were also considered to be the therapeutic material basis. However, until now, pharmacokinetic studies of the in vivo metabolites have not been revealed yet. The aim of the present study was to characterize the pharmacokinetics and excretions of five main alkaloids (berberine, jatrorrhizine, palmatine, epiberberine, and coptisine) and their seven metabolites (berberrubine, demethyleneberberine, jatrorrhizine-3- O β -D-glucuronide, thalifendine-10- O β -D-glucuronide, berberrubine-9- O β -D-glucuronide, demethyleneberberine-2- O -sulfate, and demethyleneberberine-2- O β -D-glucuronide) in rats after oral administration of Rhizoma coptidis extract. Meanwhile, comparative pharmacokinetics and excretions of these analytes in diabetic model rats were also investigated, since Rhizoma coptidis is widely used for the treatment of diabetes. Our results showed that the in vivo existing forms of alkaloid components were phase II metabolites, highlighting the glucuronidation metabolic pathway. In diabetic model rats, the utilization of Rhizoma coptidis alkaloids was significantly increased and the biotransformation of berberine into berberrubine was significantly inhibited.
Keywords	Ranunculaceae ; pharmacokinetics ; excretion ; diabetic rats ; phase II metabolites
Language	English
Publishing date	2021-06-10
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1506-1627
Database	Thieme publisher's database

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Article: Bioactive Triterpenoid Saponins From the Seeds of

Zhang, Nan / Wei, Shuxiang / Cao, Shijie / Zhang, Qiang / Kang, Ning / Ding, Liqin / Qiu, Feng

Frontiers in chemistry

2020 Volume 7, Page(s) 908

Abstract: Phytochemical investigation ... ...

Abstract	Phytochemical investigation of
Language	English
Publishing date	2020-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2019.00908
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